LOC100912195 (protein BEX1-like) - Rat Genome Database

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Gene: LOC100912195 (protein BEX1-like) Rattus norvegicus
Analyze
Symbol: LOC100912195
Name: protein BEX1-like
RGD ID: 6488322
Description: Predicted to enable signaling receptor binding activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to several human genes including BEX1 (brain expressed X-linked 1); INTERACTS WITH acrylamide (ortholog); aflatoxin B1 (ortholog); belinostat (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100361937
RGD Orthologs
Human
Bonobo
Dog
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81119,181,370 - 119,202,904 (-)NCBIGRCr8
mRatBN7.21110,047,861 - 110,051,812 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.01116,565,779 - 116,567,283 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1116,565,790 - 116,567,189 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01117,724,191 - 117,725,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41110,708,014 - 110,708,403 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12911636   PMID:20731761   PMID:23376485  


Genomics

Comparative Map Data
LOC100912195
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81119,181,370 - 119,202,904 (-)NCBIGRCr8
mRatBN7.21110,047,861 - 110,051,812 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.01116,565,779 - 116,567,283 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1116,565,790 - 116,567,189 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01117,724,191 - 117,725,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41110,708,014 - 110,708,403 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map1q22NCBI
BEX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X102,153,712 - 102,155,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX102,153,708 - 102,155,977 (-)EnsemblGRCh38hg38GRCh38
GRCh37X101,408,684 - 101,410,949 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X101,295,340 - 101,297,685 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX101,929,239 - 101,931,548 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX91,216,777 - 91,219,086 (-)NCBIHuRef
CHM1_1X101,302,593 - 101,304,902 (-)NCBICHM1_1
T2T-CHM13v2.0X100,598,297 - 100,600,564 (-)NCBIT2T-CHM13v2.0
BEX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X101,758,145 - 101,760,446 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X101,761,750 - 101,764,050 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X91,361,030 - 91,363,335 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X101,488,813 - 101,491,117 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX101,489,036 - 101,489,371 (-)Ensemblpanpan1.1panPan2
BEX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X75,930,148 - 75,932,618 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX75,930,633 - 75,930,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX62,295,892 - 62,298,114 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X77,352,165 - 77,354,387 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX77,350,158 - 77,354,311 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X74,922,191 - 74,924,413 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X76,565,330 - 76,568,459 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X76,328,317 - 76,331,446 (-)NCBIUU_Cfam_GSD_1.0
Bex5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X61,938,894 - 61,941,173 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937070148,400 - 150,529 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937070148,270 - 150,535 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BEX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX83,607,375 - 83,609,794 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X83,607,366 - 83,609,797 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X97,469,217 - 97,471,660 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in LOC100912195
4 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847121834139Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat

Markers in Region
RH134506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X99,219,051 - 99,219,259 (+)MAPPERmRatBN7.2
Rnor_6.0X106,763,333 - 106,763,533NCBIRnor6.0
Rnor_6.01116,565,827 - 116,566,034NCBIRnor6.0
Rnor_5.01117,724,239 - 117,724,446UniSTSRnor5.0
RGSC_v3.4X123,527,774 - 123,527,981UniSTSRGSC3.4
CeleraX99,926,796 - 99,927,003UniSTS
Cytogenetic MapXq35UniSTS
RH126864  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X99,219,015 - 99,219,251 (+)MAPPERmRatBN7.2
Rnor_6.01116,565,791 - 116,566,026NCBIRnor6.0
Rnor_5.01117,724,203 - 117,724,438UniSTSRnor5.0
Rnor_5.0X106,565,167 - 106,565,438UniSTSRnor5.0
Cytogenetic MapXq35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 28 20 8 20 5 6 74 27 32 11 5
Low 8 18 10 11 10 3 5 8 9 3
Below cutoff 11 11 11

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000048996   ⟹   ENSRNOP00000039471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX99,219,014 - 99,220,958 (-)Ensembl
Rnor_6.0 Ensembl1116,565,790 - 116,567,189 (-)Ensembl
RefSeq Acc Id: XM_063278646   ⟹   XP_063134716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,181,370 - 119,202,904 (-)NCBI
Protein Sequences
Protein RefSeqs XP_063134716 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000039471   ⟸   ENSRNOT00000048996
RefSeq Acc Id: XP_063134716   ⟸   XM_063278646

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MIT8-F1-model_v2 AlphaFold A0A096MIT8 1-128 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6488322 AgrOrtholog
BioCyc Gene G2FUF-59423 BioCyc
Ensembl Genes ENSRNOG00000033844 Ensembl
NCBI Gene LOC100912195 ENTREZGENE
PhenoGen LOC100912195 PhenoGen
RatGTEx ENSRNOG00000033844 RatGTEx


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 LOC100912195  protein BEX1-like  LOC100361937  protein BEX1-like  Data merged from RGD:2319143 737654 PROVISIONAL
2012-07-05 LOC100912195  protein BEX1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-05 LOC100361937  protein BEX1-like      Symbol and Name status set to provisional 70820 PROVISIONAL