Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | decreases expression | ISO | Bex2 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of BEX1 mRNA | CTD | PMID:26682919 | 1,2-dichloroethane | decreases expression | ISO | Bex2 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of BEX1 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | Bex2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of BEX1 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | Bex2 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of BEX1 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | ISO | Bex2 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of BEX1 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | Bex2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of BEX1 mRNA | CTD | PMID:17942748 | 2,2',5,5'-tetrachlorobiphenyl | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:36804509 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Bex2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of BEX1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of BEX1 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of BEX1 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Bex2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of BEX1 mRNA | CTD | PMID:19770486 | 2-hydroxypropanoic acid | increases expression | EXP | | 6480464 | Lactic Acid results in increased expression of BEX1 mRNA | CTD | PMID:30851411 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BEX1 mRNA more ... | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of BEX1 mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | increases expression | ISO | Bex2 (Mus musculus) | 6480464 | Fenretinide results in increased expression of BEX1 mRNA | CTD | PMID:28973697 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of BEX1 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases expression | ISO | Bex2 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of BEX1 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Aflatoxin B1 results in increased expression of BEX1 mRNA | CTD | PMID:23630614 and PMID:25378103 | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of BEX1 mRNA | CTD | PMID:21934132 | arsane | affects methylation | EXP | | 6480464 | Arsenic affects the methylation of BEX1 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | EXP | | 6480464 | Arsenic affects the methylation of BEX1 gene | CTD | PMID:25304211 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of BEX1 mRNA | CTD | PMID:19152381 and PMID:20064835 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of BEX1 3' UTR and Benzo(a)pyrene affects the methylation of BEX1 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of BEX1 mRNA] | CTD | PMID:19152381 | bis(2-chloroethyl) sulfide | increases expression | EXP | | 6480464 | Mustard Gas results in increased expression of BEX1 mRNA | CTD | PMID:25102026 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of BEX1 mRNA | CTD | PMID:27685785 and PMID:33670352 | bisphenol A | decreases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of BEX1 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BEX1 mRNA | CTD | PMID:28628672 | bisphenol F | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BEX1 mRNA | CTD | PMID:28628672 | butan-1-ol | multiple interactions | EXP | | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of BEX1 mRNA | CTD | PMID:29432896 | butanal | increases expression | EXP | | 6480464 | butyraldehyde results in increased expression of BEX1 mRNA | CTD | PMID:26079696 | carbamazepine | affects expression | EXP | | 6480464 | Carbamazepine affects the expression of BEX1 mRNA | CTD | PMID:25979313 | carbon nanotube | decreases expression | ISO | Bex2 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of BEX1 mRNA | CTD | PMID:25554681 | carbon nanotube | affects expression | ISO | Bex2 (Mus musculus) | 6480464 | Nanotubes and Carbon analog affects the expression of BEX1 mRNA | CTD | PMID:25554681 | cefaloridine | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Cephaloridine results in increased expression of BEX1 mRNA | CTD | PMID:18500788 | chlorpyrifos | decreases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Chlorpyrifos results in decreased expression of BEX1 mRNA | CTD | PMID:18668222 | choline | multiple interactions | ISO | Bex2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BEX1 mRNA | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Cisplatin results in decreased expression of BEX1 mRNA | CTD | PMID:22023808 | copper(II) sulfate | decreases expression | EXP | | 6480464 | Copper Sulfate results in decreased expression of BEX1 mRNA | CTD | PMID:19549813 | corticosterone | decreases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Corticosterone results in decreased expression of BEX1 mRNA | CTD | PMID:15755911 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of BEX1 mRNA | CTD | PMID:25562108 and PMID:27989131 | dexamethasone | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BEX1 mRNA more ... | CTD | PMID:28628672 | dicrotophos | decreases expression | EXP | | 6480464 | dicrotophos results in decreased expression of BEX1 mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | increases expression | EXP | | 6480464 | Doxorubicin results in increased expression of BEX1 mRNA | CTD | PMID:29803840 | ethanol | multiple interactions | EXP | | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of BEX1 mRNA and [Ethanol co-treated with Folic Acid] results in decreased expression of BEX1 mRNA | CTD | PMID:23378141 and PMID:29432896 | ethanol | increases expression | ISO | Bex2 (Mus musculus) | 6480464 | Ethanol results in increased expression of BEX1 mRNA | CTD | PMID:30319688 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of BEX1 mRNA | CTD | PMID:23378141 | fenvalerate | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | fenvalerate results in increased expression of BEX1 mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | ISO | Bex2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BEX1 mRNA | CTD | PMID:20938992 | folic acid | multiple interactions | EXP | | 6480464 | [Ethanol co-treated with Folic Acid] results in decreased expression of BEX1 mRNA | CTD | PMID:23378141 | genistein | decreases expression | ISO | Bex2 (Mus musculus) | 6480464 | Genistein results in decreased expression of BEX1 mRNA | CTD | PMID:32186404 | gentamycin | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of BEX1 mRNA | CTD | PMID:22061828 and PMID:33387578 | hydrogen peroxide | affects expression | EXP | | 6480464 | Hydrogen Peroxide affects the expression of BEX1 mRNA | CTD | PMID:21179406 | indometacin | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BEX1 mRNA more ... | CTD | PMID:28628672 | isobutanol | multiple interactions | EXP | | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of BEX1 mRNA | CTD | PMID:29432896 | L-methionine | multiple interactions | ISO | Bex2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BEX1 mRNA | CTD | PMID:20938992 | maneb | multiple interactions | ISO | Bex2 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of BEX1 mRNA | CTD | PMID:36117858 | microcystin-LR | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | cyanoginosin LR results in increased expression of BEX1 mRNA | CTD | PMID:34740672 | microcystin-LR | multiple interactions | ISO | Bex2 (Rattus norvegicus) | 6480464 | [Dietary Fats co-treated with Cholesterol and Dietary co-treated with cyanoginosin LR] results in increased expression of BEX1 mRNA | CTD | PMID:34740672 | N-methyl-4-phenylpyridinium | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of BEX1 mRNA | CTD | PMID:28801915 | N-nitrosodiethylamine | increases expression | ISO | Bex2 (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of BEX1 mRNA | CTD | PMID:24535843 | N-nitrosodiethylamine | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Diethylnitrosamine results in increased expression of BEX1 mRNA | CTD | PMID:19638242 | N-nitrosodiethylamine | multiple interactions | ISO | Bex2 (Rattus norvegicus) | 6480464 | [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BEX1 mRNA | CTD | PMID:28943392 | N-nitrosodiethylamine | multiple interactions | ISO | Bex2 (Mus musculus) | 6480464 | Diethylnitrosamine promotes the reaction [Carbon Tetrachloride results in increased expression of BEX1 mRNA] | CTD | PMID:23288052 | N-nitrosodimethylamine | multiple interactions | ISO | Bex2 (Rattus norvegicus) | 6480464 | [GJB1 protein affects the susceptibility to [Dietary Fats co-treated with Dimethylnitrosamine]] which affects the expression of BEX1 mRNA | CTD | PMID:32833043 | nickel sulfate | decreases expression | EXP | | 6480464 | nickel sulfate results in decreased expression of BEX1 mRNA | CTD | PMID:22714537 | nitrofen | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | nitrofen results in increased expression of BEX1 mRNA | CTD | PMID:33484710 | ozone | multiple interactions | ISO | Bex2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of BEX1 mRNA | CTD | PMID:27106289 | paracetamol | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of BEX1 mRNA | CTD | PMID:33387578 | paraquat | multiple interactions | ISO | Bex2 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of BEX1 mRNA | CTD | PMID:36117858 | phenformin | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Phenformin results in increased expression of BEX1 mRNA | CTD | PMID:31324951 | phenobarbital | increases expression | ISO | Bex2 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of BEX1 mRNA | CTD | PMID:19482888 | phenobarbital | multiple interactions | ISO | Bex2 (Mus musculus) | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of BEX1 mRNA] | CTD | PMID:19482888 | phenylmercury acetate | decreases expression | EXP | | 6480464 | Phenylmercuric Acetate results in decreased expression of BEX1 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BEX1 mRNA | CTD | PMID:27188386 | quercetin | decreases expression | EXP | | 6480464 | Quercetin results in decreased expression of BEX1 mRNA | CTD | PMID:21632981 | rac-lactic acid | increases expression | EXP | | 6480464 | Lactic Acid results in increased expression of BEX1 mRNA | CTD | PMID:30851411 | rotenone | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Rotenone results in increased expression of BEX1 mRNA | CTD | PMID:28374803 | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases methylation | EXP | | 6480464 | Silicon Dioxide results in increased methylation of BEX1 promoter | CTD | PMID:34973136 | sunitinib | decreases expression | EXP | | 6480464 | Sunitinib results in decreased expression of BEX1 mRNA | CTD | PMID:31533062 | tamoxifen | affects expression | ISO | Bex2 (Mus musculus) | 6480464 | Tamoxifen affects the expression of BEX1 mRNA | CTD | PMID:17555576 | tert-butyl hydroperoxide | increases expression | EXP | | 6480464 | tert-Butylhydroperoxide results in increased expression of BEX1 mRNA | CTD | PMID:15336504 | tetrachloromethane | multiple interactions | ISO | Bex2 (Mus musculus) | 6480464 | Diethylnitrosamine promotes the reaction [Carbon Tetrachloride results in increased expression of BEX1 mRNA] | CTD | PMID:23288052 | tetrachloromethane | increases expression | ISO | Bex2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of BEX1 mRNA | CTD | PMID:23288052 | thioacetamide | multiple interactions | ISO | Bex2 (Rattus norvegicus) | 6480464 | [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BEX1 mRNA | CTD | PMID:28943392 | thioacetamide | increases expression | ISO | Bex2 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of BEX1 mRNA | CTD | PMID:23411599 | titanium dioxide | decreases expression | ISO | Bex2 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of BEX1 mRNA | CTD | PMID:23557971 | triptonide | increases expression | ISO | Bex2 (Mus musculus) | 6480464 | triptonide results in increased expression of BEX1 mRNA | CTD | PMID:33045310 | tunicamycin | decreases expression | EXP | | 6480464 | Tunicamycin results in decreased expression of BEX1 mRNA | CTD | PMID:22378314 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of BEX1 mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BEX1 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of BEX1 mRNA | CTD | PMID:23179753 more ... | |