Amigo3 (adhesion molecule with Ig like domain 3)

Gene: Amigo3 (adhesion molecule with Ig like domain 3) Rattus norvegicus

Analyze

Symbol:

Amigo3

Name:

adhesion molecule with Ig like domain 3

RGD ID:

631413

Description:

Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; negative regulation of neuron projection development; and nervous system development. Biomarker of sciatic neuropathy. Orthologous to human AMIGO3 (adhesion molecule with Ig like domain 3); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

alivin-3; AMIGO-3; amphoterin induced gene and ORF 3; amphoterin-induced protein 3; transmembrane protein AMIGO3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,620,499 - 117,622,025 (+)	NCBI		GRCr8
mRatBN7.2	8	108,741,899 - 108,743,425 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,693,060 - 108,744,555 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	114,368,162 - 114,369,688 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,567,486 - 112,569,012 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,410,126 - 110,411,652 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,830,773 - 116,832,299 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	116,185,095 - 116,186,621 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	113,321,258 - 113,322,784 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	113,340,712 - 113,342,239 (+)	NCBI
Celera	8	108,046,611 - 108,048,137 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 1 (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

genetic disease (ISO)

Optic Nerve Injuries (IEP)

sciatic neuropathy (IEP)

Spinal Cord Compression (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-palmitoylglycerol (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP,ISO)

cisplatin (ISO)

cocaine (EXP)

dexamethasone (ISO)

folic acid (ISO)

glafenine (EXP)

indometacin (ISO)

manganese(II) chloride (EXP)

orphenadrine (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

progesterone (EXP)

rotenone (ISO)

Soman (EXP)

testosterone (ISO)

triptonide (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (IBA)

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (IPI)

negative regulation of neuron projection development (IMP)

nervous system development (IDA)

positive regulation of synapse assembly (ISO)

Cellular Component

membrane (IBA,NAS)

Molecular Function

protein binding (IPI)

protein-containing complex binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	AMIGO3 is an NgR1/p75 co-receptor signalling axon growth inhibition in the acute phase of adult central nervous system injury.	Ahmed Z, etal., PLoS One. 2013 Apr 16;8(4):e61878. doi: 10.1371/journal.pone.0061878. Print 2013.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats.	Kuja-Panula J, etal., J Cell Biol 2003 Mar 17;160(6):963-73.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:24613359

Genomics

Comparative Map Data

Amigo3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,620,499 - 117,622,025 (+)	NCBI		GRCr8
mRatBN7.2	8	108,741,899 - 108,743,425 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,693,060 - 108,744,555 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	114,368,162 - 114,369,688 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,567,486 - 112,569,012 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,410,126 - 110,411,652 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,830,773 - 116,832,299 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	116,185,095 - 116,186,621 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	113,321,258 - 113,322,784 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	113,340,712 - 113,342,239 (+)	NCBI
Celera	8	108,046,611 - 108,048,137 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

AMIGO3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	49,716,829 - 49,719,684 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	49,716,829 - 49,719,684 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	49,754,262 - 49,757,117 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	49,729,969 - 49,732,127 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	49,718,958 - 49,721,929 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	49,813,243 - 49,816,214 (-)	NCBI		HuRef
CHM1_1	3	49,706,322 - 49,709,293 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	49,746,115 - 49,748,970 (-)	NCBI		T2T-CHM13v2.0

Amigo3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,930,358 - 107,932,900 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	107,930,358 - 107,932,900 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	108,053,159 - 108,055,701 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	108,053,159 - 108,055,701 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	107,955,490 - 107,958,032 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	107,911,260 - 107,913,802 (+)	NCBI		MGSCv36	mm8
Celera	9	107,663,009 - 107,665,551 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	59.07	NCBI

Amigo3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	1,619,532 - 1,621,064 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	1,618,659 - 1,621,706 (-)	NCBI	ChiLan1.0	ChiLan1.0

AMIGO3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	49,703,422 - 49,707,110 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	49,708,212 - 49,711,890 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	49,648,967 - 49,652,285 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	50,884,810 - 50,888,081 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	50,885,925 - 50,887,439 (-)	Ensembl	panpan1.1		panPan2

AMIGO3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	39,554,028 - 39,557,129 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	39,554,629 - 39,556,155 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	39,474,061 - 39,478,072 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	39,910,656 - 39,914,667 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	39,912,148 - 39,913,674 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	39,277,728 - 39,281,739 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	39,681,098 - 39,685,108 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	39,960,928 - 39,964,939 (+)	NCBI		UU_Cfam_GSD_1.0

Amigo3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	64,571,400 - 64,574,166 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	1,332,874 - 1,334,403 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	1,331,610 - 1,335,058 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AMIGO3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,111,871 - 11,115,104 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	11,112,953 - 11,114,467 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	155,885,731 - 155,888,589 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Amigo3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	3,642,603 - 3,644,135 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	3,641,716 - 3,644,504 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat
631217	Activ1	Activity QTL 1	15.9		voluntary movement trait (VT:0003491)	number of photobeam interruptions in an experimental apparatus (CMO:0001517)	8	102370617	108923645	Rat

Markers in Region

RH139593

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	108,741,840 - 108,742,025 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,830,715 - 116,830,899	NCBI	Rnor6.0
Rnor_5.0	8	116,185,037 - 116,185,221	UniSTS	Rnor5.0
RGSC_v3.4	8	113,321,200 - 113,321,384	UniSTS	RGSC3.4
Celera	8	108,046,553 - 108,046,737	UniSTS
RH 3.4 Map	8	1118.6	UniSTS
Cytogenetic Map	8	q32	UniSTS

BE119447

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	108,742,655 - 108,742,810 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,831,530 - 116,831,684	NCBI	Rnor6.0
Rnor_5.0	8	116,185,852 - 116,186,006	UniSTS	Rnor5.0
RGSC_v3.4	8	113,322,015 - 113,322,169	UniSTS	RGSC3.4
Celera	8	108,047,368 - 108,047,522	UniSTS
RH 3.4 Map	8	1119.2	UniSTS
Cytogenetic Map	8	q32	UniSTS

Amigo3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	108,742,329 - 108,743,321 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,831,204 - 116,832,195	NCBI	Rnor6.0
Rnor_5.0	8	116,185,526 - 116,186,517	UniSTS	Rnor5.0
RGSC_v3.4	8	113,321,689 - 113,322,680	UniSTS	RGSC3.4
Celera	8	108,047,042 - 108,048,033	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_178144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY237731	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000100102 ⟹ ENSRNOP00000093720

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	108,693,060 - 108,744,555 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101890 ⟹ ENSRNOP00000082203

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	108,693,060 - 108,744,555 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114148 ⟹ ENSRNOP00000076680

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	108,693,060 - 108,744,555 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118165 ⟹ ENSRNOP00000081738

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	108,737,656 - 108,744,533 (+)	Ensembl

RefSeq Acc Id:

NM_178144 ⟹ NP_835280

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,620,499 - 117,622,025 (+)	NCBI
mRatBN7.2	8	108,741,899 - 108,743,425 (+)	NCBI
Rnor_6.0	8	116,830,773 - 116,832,299 (+)	NCBI
Rnor_5.0	8	116,185,095 - 116,186,621 (+)	NCBI
RGSC_v3.4	8	113,321,258 - 113,322,784 (+)	RGD
Celera	8	108,046,611 - 108,048,137 (+)	RGD

Sequence:

show sequence

ATGGCCTGGTTGGTGCTACTGGGTCTACTACTGTGCATGTTGGGGGCTGGATCAGGCACTTCAG
ATTTGGAGGGTGTTCTGCCCCCTGATCCCCACAACTGCCCCAATAAATGTGTCTGTGCTGCCGA
TGTGTTGAGCTGTGCGGGCCGTGGGTTACAGGACTTGCCGGCAGCACTGCCTGCCACTGCTGCA
GAACTTGATTTGAGCCACAATGCACTCAAACGCCTGCACCCAGGATGGCTGGCGCCCCTCTCCC
GGCTGCGTGCCTTGTACCTAGGCTACAATAAGTTGGATGTCCTGGGCCGCGGTGTGTTCACTAA
CGCCAGTGGGCTGAGGATACTCGATCTGTCCTCTAACCTGCTGAGGAGACTCCGTACCTATGAC
CTGGATGGACTGGAGGAGCTGGAGAAGTTACTTCTGTTCAATAACCGCCTGATGCACTTGGACC
TGGATGCTTTCCAGGGCCTGAGCATGCTCAGCCACCTCTATCTCAGCTGCAACGAACTCTCCTC
TTTCTCTTTCAACCACCTGCACGGCCTGGGGTTAACCCGCCTACGCACTCTAGACCTCTCCTCC
AACTGGCTGGGCCATGTCTCCGTCCCTGAACTGGCTGCACTGCCCACTTTCCTCAAGAATCGGC
TCTACTTGCACAACAACCCACTGCCCTGCGACTGCAGCCTCTACCACCTGCTCCGGCGCTGGCA
CCAGCGGGGCCTAAGTGCTCTGCACGACTTTGAACGTGAGTACACATGCTTGGCCTTTAAGGTG
GCAGAATCCCGAGTGCGCTTCTTCGAGCACAGCCGGGTCTTCAAGAACTGCTCAGTGGCTGCAG
CTCCAGGCTTAGAGCTGCCCGAGGAAGAGCTGCACACACACGTGGGCCAGTCCCTGAGGCTCTT
CTGCAACACCACAGTGCCTGCTGCACGAGTGGCCTGGGTTTCCCCGAAAAACGAGCTGCTGGTC
GCGCCAGGCTCCCAGGATGGCAGCATTGCTGTGTTGGCGGATGGCAGCTTAGCCATAGGCAGGG
TGCAAGAACAGCACGCAGGCCTCTTTGTGTGCCTGGCAAGTGGGCCCCGCCTGCACCACAACCA
GACGCTTGAGTACAATGTGAGTGTACATAAGCCTCGCCCCGAGCCGGAGGCTTTCAACACGGGC
TTCACCACACTGCTGGGCTGTATCGTGGGCCTGGTGCTGGTGCTGCTCTACCTGTTTGCACCAC
CCTGTCGTGGCTGCTGTCGCTGTTGTCGGCGGGCCTGCCGCAACCGTTGCTGGCCCCGGGCATC
CAGTCCACTCCAGGAGCTGAGTGCACAGTCCTCGGTGCTCAGCACTACACCGCCAGATGCACCC
AGCCGCAAGGCCAGCGTCCACAAGCATGTGGCCTTCCTGGAGCCGGGCAAGAAAGGCCTCAATG
GCCGTGTGCAGCTAGCAGTAGCTGAAGACTTTGATCTGTGCAACCCCATGGGCTTGCAACTCAA
GGCTGGCTCTGAGTCAGCCAGTTCCACAGGCTCAGAGGGTCTCATGATGAGCTAG

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Protein Sequences


Protein RefSeqs	NP_835280	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAO48952	(Get FASTA)	NCBI Sequence Viewer
	EDL77198	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000076680.1
	ENSRNOP00000081738
	ENSRNOP00000081738.1
	ENSRNOP00000082203.1
	ENSRNOP00000093720.1
	ENSRNOP00065001659
GenBank Protein	Q80ZD5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_835280 ⟸ NM_178144
- Peptide Label:	precursor
- UniProtKB:	Q80ZD5 (UniProtKB/Swiss-Prot), A6I331 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAWLVLLGLLLCMLGAGSGTSDLEGVLPPDPHNCPNKCVCAADVLSCAGRGLQDLPAALPATAA ELDLSHNALKRLHPGWLAPLSRLRALYLGYNKLDVLGRGVFTNASGLRILDLSSNLLRRLRTYD LDGLEELEKLLLFNNRLMHLDLDAFQGLSMLSHLYLSCNELSSFSFNHLHGLGLTRLRTLDLSS NWLGHVSVPELAALPTFLKNRLYLHNNPLPCDCSLYHLLRRWHQRGLSALHDFEREYTCLAFKV AESRVRFFEHSRVFKNCSVAAAPGLELPEEELHTHVGQSLRLFCNTTVPAARVAWVSPKNELLV APGSQDGSIAVLADGSLAIGRVQEQHAGLFVCLASGPRLHHNQTLEYNVSVHKPRPEPEAFNTG FTTLLGCIVGLVLVLLYLFAPPCRGCCRCCRRACRNRCWPRASSPLQELSAQSSVLSTTPPDAP SRKASVHKHVAFLEPGKKGLNGRVQLAVAEDFDLCNPMGLQLKAGSESASSTGSEGLMMS hide sequence

RefSeq Acc Id:

ENSRNOP00000076680 ⟸ ENSRNOT00000114148

RefSeq Acc Id:

ENSRNOP00000081738 ⟸ ENSRNOT00000118165

RefSeq Acc Id:

ENSRNOP00000082203 ⟸ ENSRNOT00000101890

RefSeq Acc Id:

ENSRNOP00000093720 ⟸ ENSRNOT00000100102

Protein Domains

Ig-like Ig-like C2-type LRRCT LRRNT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q80ZD5-F1-model_v2	AlphaFold	Q80ZD5	1-508	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:631413	AgrOrtholog
BioCyc Gene	G2FUF-29159	BioCyc
Ensembl Genes	ENSRNOG00000064183	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00065001772	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000100102.1	UniProtKB/Swiss-Prot
	ENSRNOT00000101890.1	UniProtKB/Swiss-Prot
	ENSRNOT00000114148.1	UniProtKB/Swiss-Prot
	ENSRNOT00000118165	ENTREZGENE
	ENSRNOT00000118165.1	UniProtKB/Swiss-Prot
	ENSRNOT00065002368	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
	3.80.10.10	UniProtKB/Swiss-Prot
	Immunoglobulins	UniProtKB/TrEMBL
	Ribonuclease Inhibitor	UniProtKB/TrEMBL
InterPro	AMIGO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:316003	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	316003	ENTREZGENE
PANTHER	AMPHOTERIN-INDUCED PROTEIN	UniProtKB/TrEMBL
	AMPHOTERIN-INDUCED PROTEIN 3	UniProtKB/TrEMBL
	PTHR24368	UniProtKB/Swiss-Prot
	PTHR24368:SF62	UniProtKB/Swiss-Prot
Pfam	LRR_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Amigo3	PhenoGen
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000064183	RatGTEx
	ENSRNOG00065001772	RatGTEx
SMART	IGc2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00409	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Immunoglobulin	UniProtKB/TrEMBL
	L domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF48726	UniProtKB/Swiss-Prot
UniProt	A6I331	ENTREZGENE, UniProtKB/TrEMBL
	AMGO3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-25	Amigo3	adhesion molecule with Ig like domain 3	Amigo3	amphoterin induced gene and ORF 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-11	Slc1a7	amphoterin induced gene and ORF 3	Amigo3	transmembrane protein AMIGO3	Name updated to reflect Human and Mouse nomenclature	625702	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains six leucine-rich repeats (LRRs) flanked by cysteine-rich LRR NH2- and COOH-terminal domains and by one immunoglobulin domain close to the transmembrane region	634626
gene_regulation	induced in neurons by the neurite-promoting protein amphoterin	634626

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar