Wnk4 (WNK lysine deficient protein kinase 4) - Rat Genome Database

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Gene: Wnk4 (WNK lysine deficient protein kinase 4) Rattus norvegicus
Analyze
Symbol: Wnk4 (Ensembl: Vps25)
Name: WNK lysine deficient protein kinase 4 (Ensembl:vacuolar protein sorting 25 homolog)
RGD ID: 631401
Description: Enables protein serine/threonine kinase activity. Involved in negative regulation of sodium ion transport and protein phosphorylation. Located in cytosol and membrane. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac2-059; Prkwnk4; protein kinase lysine-deficient 4; protein kinase with no lysine 4; protein kinase, lysine deficient 4; protein kinase, lysine-deficient 4; serine/threonine-protein kinase WNK4; WNK4 Ser/Thr kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,702,828 - 86,719,917 (+)NCBIGRCr8
mRatBN7.21086,202,552 - 86,219,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,240,610 - 91,257,398 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,715,120 - 90,731,930 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,108,283 - 86,125,098 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,181,139 - 89,198,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,181,165 - 89,198,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,979,661 - 88,997,344 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,289,273 - 90,306,225 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,303,667 - 90,320,558 (+)NCBI
Celera1084,920,709 - 84,937,662 (+)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Bhuiyan MIH, etal., J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes. Kamide K, etal., Am J Hypertens. 2004 May;17(5 Pt 1):446-9.
4. The role of Wnk4 in polygenic hypertension: a candidate gene analysis on rat chromosome 10. Monti J, etal., Hypertension 2003 Apr;41(4):938-42.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. WNK Kinases, Renal Ion Transport and Hypertension. San-Cristobal P, etal., Am J Nephrol. 2008 Jun 12;28(5):860-870.
11. Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. Subramanya AR, etal., Am J Physiol Renal Physiol. 2006 Mar;290(3):F619-24. Epub 2005 Oct 4.
12. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Vitari AC, etal., Biochem J. 2005 Oct 1;391(Pt 1):17-24.
13. Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses. Vorontsova I, etal., Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):310-21. doi: 10.1167/iovs.14-15911.
14. Human hypertension caused by mutations in WNK kinases. Wilson FH, etal., Science. 2001 Aug 10;293(5532):1107-12.
Additional References at PubMed
PMID:8889548   PMID:12515852   PMID:12671053   PMID:14608358   PMID:14769928   PMID:15350218   PMID:17182532   PMID:17194447   PMID:17360470   PMID:17651736   PMID:17673510   PMID:21317537  
PMID:21499270   PMID:21670282   PMID:23453970   PMID:23576762   PMID:24811174  


Genomics

Comparative Map Data
Wnk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,702,828 - 86,719,917 (+)NCBIGRCr8
mRatBN7.21086,202,552 - 86,219,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,240,610 - 91,257,398 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,715,120 - 90,731,930 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,108,283 - 86,125,098 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,181,139 - 89,198,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,181,165 - 89,198,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,979,661 - 88,997,344 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,289,273 - 90,306,225 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,303,667 - 90,320,558 (+)NCBI
Celera1084,920,709 - 84,937,662 (+)NCBICelera
Cytogenetic Map10q31NCBI
WNK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,780,610 - 42,797,066 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,780,610 - 42,797,066 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,932,628 - 40,949,084 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,186,222 - 38,202,610 (+)NCBINCBI36Build 36hg18NCBI36
Build 341738,186,221 - 38,202,605NCBI
Celera1737,588,637 - 37,605,071 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,697,144 - 36,713,472 (+)NCBIHuRef
CHM1_11741,168,235 - 41,184,670 (+)NCBICHM1_1
T2T-CHM13v2.01743,637,750 - 43,654,206 (+)NCBIT2T-CHM13v2.0
Wnk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,151,363 - 101,168,235 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,151,393 - 101,168,235 (+)EnsemblGRCm39 Ensembl
GRCm3811101,260,537 - 101,277,409 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,260,567 - 101,277,409 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,121,881 - 101,138,723 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,076,701 - 101,093,499 (+)NCBIMGSCv36mm8
MGSCv3611102,039,322 - 102,056,494 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1164.51NCBI
Wnk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,594,408 - 16,606,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,593,840 - 16,606,817 (+)NCBIChiLan1.0ChiLan1.0
WNK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,188,275 - 22,205,551 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,078,401 - 24,095,648 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,520,448 - 14,537,799 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,746,058 - 14,762,513 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,746,365 - 14,762,423 (-)Ensemblpanpan1.1panPan2
VPS25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,242,230 - 20,247,396 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,703,536 - 19,708,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,960,604 - 20,965,761 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,960,860 - 20,965,682 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,745,515 - 19,750,667 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,011,720 - 20,016,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,114,439 - 20,119,596 (-)NCBIUU_Cfam_GSD_1.0
Wnk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,567,157 - 19,582,658 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,492,753 - 17,509,582 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,492,718 - 17,508,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,065,061 - 20,081,762 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,064,688 - 20,081,781 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,279,617 - 20,296,819 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,494,090 - 63,512,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607734,286,917 - 34,303,255 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,416,886 - 1,427,811 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,416,479 - 1,428,350 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wnk4
41 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
RH128509  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,201,392 - 86,201,583 (+)MAPPERmRatBN7.2
Rnor_6.01089,179,952 - 89,180,142NCBIRnor6.0
Rnor_5.01088,978,448 - 88,978,638UniSTSRnor5.0
RGSC_v3.41090,287,947 - 90,288,137UniSTSRGSC3.4
Celera1084,918,315 - 84,918,505UniSTS
RH 3.4 Map10877.1UniSTS
Cytogenetic Map10q32.1UniSTS
RH134547  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,219,437 - 86,219,617 (+)MAPPERmRatBN7.2
Rnor_6.01089,197,996 - 89,198,175NCBIRnor6.0
Rnor_5.01088,996,382 - 88,996,561UniSTSRnor5.0
RGSC_v3.41090,306,008 - 90,306,187UniSTSRGSC3.4
Celera1084,937,445 - 84,937,624UniSTS
RH 3.4 Map10860.3UniSTS
Cytogenetic Map10q32.1UniSTS
AW107467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,201,138 - 86,201,230 (+)MAPPERmRatBN7.2
Rnor_6.01089,179,698 - 89,179,789NCBIRnor6.0
Rnor_5.01088,978,194 - 88,978,285UniSTSRnor5.0
RGSC_v3.41090,287,693 - 90,287,784UniSTSRGSC3.4
Celera1084,918,061 - 84,918,152UniSTS
Cytogenetic Map10q32.1UniSTS
RH137051  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,208,703 - 86,208,921 (+)MAPPERmRatBN7.2
mRatBN7.21042,211,767 - 42,211,985 (+)MAPPERmRatBN7.2
Rnor_6.01089,187,263 - 89,187,480NCBIRnor6.0
Rnor_6.01043,465,374 - 43,465,591NCBIRnor6.0
Rnor_5.01088,985,759 - 88,985,976UniSTSRnor5.0
Rnor_5.01043,262,608 - 43,262,825UniSTSRnor5.0
RGSC_v3.41043,631,779 - 43,631,996UniSTSRGSC3.4
RGSC_v3.41090,295,283 - 90,295,500UniSTSRGSC3.4
Celera1084,926,705 - 84,926,922UniSTS
Celera1041,501,879 - 41,502,096UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map1q54UniSTS
RH124894  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,201,327 - 86,201,466 (+)MAPPERmRatBN7.2
Rnor_6.01089,179,887 - 89,180,025NCBIRnor6.0
Rnor_5.01088,978,383 - 88,978,521UniSTSRnor5.0
RGSC_v3.41090,287,882 - 90,288,020UniSTSRGSC3.4
Celera1084,918,250 - 84,918,388UniSTS
Cytogenetic Map10q32.1UniSTS
PMC357052P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,211,372 - 86,211,993 (+)MAPPERmRatBN7.2
Rnor_6.01089,189,932 - 89,190,552NCBIRnor6.0
Rnor_5.01088,988,428 - 88,989,048UniSTSRnor5.0
RGSC_v3.41090,297,952 - 90,298,572UniSTSRGSC3.4
Celera1084,929,375 - 84,929,995UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 89 88 57 25 57 6 216 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000027770   ⟹   ENSRNOP00000027770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,202,693 - 86,219,629 (+)Ensembl
Rnor_6.0 Ensembl1089,181,253 - 89,198,176 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000043754   ⟹   ENSRNOP00000044397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,188,854 - 86,201,601 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000043953   ⟹   ENSRNOP00000043210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,188,812 - 86,190,687 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075953   ⟹   ENSRNOP00000068003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,196,099 - 86,201,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076056   ⟹   ENSRNOP00000080834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,203,829 - 86,231,829 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076366   ⟹   ENSRNOP00000068513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,202,693 - 86,231,829 (+)Ensembl
Rnor_6.0 Ensembl1089,181,165 - 89,198,213 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076658   ⟹   ENSRNOP00000095750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,196,268 - 86,201,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076944   ⟹   ENSRNOP00000082243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,195,281 - 86,200,277 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078931   ⟹   ENSRNOP00000072084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,196,048 - 86,231,812 (+)Ensembl
Rnor_6.0 Ensembl1089,181,180 - 89,198,026 (+)Ensembl
RefSeq Acc Id: NM_175579   ⟹   NP_783169
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,958 - 86,719,917 (+)NCBI
mRatBN7.21086,202,693 - 86,219,655 (+)NCBI
Rnor_6.01089,181,253 - 89,198,213 (+)NCBI
Rnor_5.01088,979,661 - 88,997,344 (+)NCBI
RGSC_v3.41090,289,273 - 90,306,225 (+)RGD
Celera1084,920,709 - 84,937,662 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247278   ⟹   XP_006247340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,840 - 86,719,915 (+)NCBI
mRatBN7.21086,202,558 - 86,219,655 (+)NCBI
Rnor_6.01089,181,139 - 89,198,213 (+)NCBI
Rnor_5.01088,979,661 - 88,997,344 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247279   ⟹   XP_006247341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,839 - 86,719,915 (+)NCBI
mRatBN7.21086,202,558 - 86,219,655 (+)NCBI
Rnor_6.01089,181,139 - 89,198,213 (+)NCBI
Rnor_5.01088,979,661 - 88,997,344 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247280   ⟹   XP_006247342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,703,453 - 86,719,915 (+)NCBI
mRatBN7.21086,203,193 - 86,219,655 (+)NCBI
Rnor_6.01089,181,810 - 89,198,213 (+)NCBI
Rnor_5.01088,979,661 - 88,997,344 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247281   ⟹   XP_006247343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,705,042 - 86,719,915 (+)NCBI
mRatBN7.21086,204,776 - 86,219,655 (+)NCBI
Rnor_6.01089,183,383 - 89,198,213 (+)NCBI
Rnor_5.01088,979,661 - 88,997,344 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085617   ⟹   XP_038941545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,839 - 86,719,915 (+)NCBI
mRatBN7.21086,202,558 - 86,219,204 (+)NCBI
RefSeq Acc Id: XM_039085619   ⟹   XP_038941547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,828 - 86,711,898 (+)NCBI
mRatBN7.21086,202,552 - 86,211,638 (+)NCBI
RefSeq Acc Id: XM_063268738   ⟹   XP_063124808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,840 - 86,719,915 (+)NCBI
RefSeq Acc Id: XM_063268739   ⟹   XP_063124809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,703,453 - 86,719,915 (+)NCBI
RefSeq Acc Id: XM_063268740   ⟹   XP_063124810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,710,890 - 86,719,915 (+)NCBI
RefSeq Acc Id: NP_783169   ⟸   NM_175579
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A6HJA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247340   ⟸   XM_006247278
- Peptide Label: isoform X1
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A0A096MKH1 (UniProtKB/TrEMBL),   A6HJA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247341   ⟸   XM_006247279
- Peptide Label: isoform X2
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A6HJA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247342   ⟸   XM_006247280
- Peptide Label: isoform X5
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A0A8I5ZQR6 (UniProtKB/TrEMBL),   A6HJA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247343   ⟸   XM_006247281
- Peptide Label: isoform X6
- Sequence:
Ensembl Acc Id: ENSRNOP00000068513   ⟸   ENSRNOT00000076366
Ensembl Acc Id: ENSRNOP00000072084   ⟸   ENSRNOT00000078931
Ensembl Acc Id: ENSRNOP00000027770   ⟸   ENSRNOT00000027770
RefSeq Acc Id: XP_038941547   ⟸   XM_039085619
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038941545   ⟸   XM_039085617
- Peptide Label: isoform X4
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A6HJA0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000068003   ⟸   ENSRNOT00000075953
Ensembl Acc Id: ENSRNOP00000080834   ⟸   ENSRNOT00000076056
Ensembl Acc Id: ENSRNOP00000082243   ⟸   ENSRNOT00000076944
Ensembl Acc Id: ENSRNOP00000044397   ⟸   ENSRNOT00000043754
Ensembl Acc Id: ENSRNOP00000043210   ⟸   ENSRNOT00000043953
Ensembl Acc Id: ENSRNOP00000095750   ⟸   ENSRNOT00000076658
RefSeq Acc Id: XP_063124808   ⟸   XM_063268738
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124809   ⟸   XM_063268739
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063124810   ⟸   XM_063268740
- Peptide Label: isoform X8
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TPK6-F1-model_v2 AlphaFold Q7TPK6 1-1222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697749
Promoter ID:EPDNEW_R8273
Type:multiple initiation site
Name:Wnk4_1
Description:WNK lysine deficient protein kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,181,190 - 89,181,250EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631401 AgrOrtholog
BioCyc Gene G2FUF-23187 BioCyc
Ensembl Genes ENSRNOG00000020441 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055033521 UniProtKB/Swiss-Prot
  ENSRNOG00060015511 UniProtKB/Swiss-Prot
  ENSRNOG00065033320 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027770.8 UniProtKB/Swiss-Prot
  ENSRNOT00000043754.5 UniProtKB/TrEMBL
  ENSRNOT00000076056.3 UniProtKB/TrEMBL
  ENSRNOT00000076366.2 UniProtKB/TrEMBL
  ENSRNOT00000076658.3 UniProtKB/TrEMBL
  ENSRNOT00000076944.3 UniProtKB/TrEMBL
  ENSRNOT00000078931.2 UniProtKB/TrEMBL
  ENSRNOT00055057942 UniProtKB/Swiss-Prot
  ENSRNOT00060026655 UniProtKB/Swiss-Prot
  ENSRNOT00065057292 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.10.570 UniProtKB/TrEMBL
  Cyclin-like UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyclin-like_sf UniProtKB/TrEMBL
  ESCRT-II_cplx_Vps25-sub UniProtKB/TrEMBL
  ESCRT-II_cplx_Vps25-sub_N UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
  WNK_Ser-Thr_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287715 UniProtKB/Swiss-Prot
NCBI Gene 287715 ENTREZGENE
PANTHER PTHR13149 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE WNK4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25 UniProtKB/TrEMBL
Pfam ESCRT-II UniProtKB/TrEMBL
  OSR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wnk4 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020441 RatGTEx
  ENSRNOG00055033521 RatGTEx
  ENSRNOG00060015511 RatGTEx
  ENSRNOG00065033320 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF47954 UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MKH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K231_RAT UniProtKB/TrEMBL
  A0A8I5ZQR6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZT86_RAT UniProtKB/TrEMBL
  A0A8I6APN0_RAT UniProtKB/TrEMBL
  A0A8L2QP36_RAT UniProtKB/TrEMBL
  A6HJA0 ENTREZGENE, UniProtKB/TrEMBL
  Q7TPK6 ENTREZGENE
  Q810H4 ENTREZGENE
  Q811R5 ENTREZGENE
  WNK4_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q810H4 UniProtKB/Swiss-Prot
  Q811R5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Wnk4  WNK lysine deficient protein kinase 4  Prkwnk4  protein kinase, lysine deficient 4  Symbol and Name updated 1299863 APPROVED
2004-02-11 Prkwnk4  protein kinase, lysine deficient 4      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mapping maps within the chromW.S-(D10Mgh6-D10Mgh4) 629611
gene_other can most likely be excluded as a candidate gene for contributing to a chromosome 10 blood pressure QTL 629611