Wnk4 (WNK lysine deficient protein kinase 4) - Rat Genome Database

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Gene: Wnk4 (WNK lysine deficient protein kinase 4) Rattus norvegicus
Analyze
Symbol: Wnk4
Name: WNK lysine deficient protein kinase 4
RGD ID: 631401
Description: Enables protein serine/threonine kinase activity. Involved in negative regulation of sodium ion transport. Located in cytosol and membrane. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac2-059; Prkwnk4; protein kinase lysine-deficient 4; protein kinase with no lysine 4; protein kinase, lysine deficient 4; protein kinase, lysine-deficient 4; serine/threonine-protein kinase WNK4; WNK4 Ser/Thr kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,702,828 - 86,719,917 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,702,865 - 86,720,198 (+)EnsemblGRCr8
mRatBN7.21086,202,552 - 86,219,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,240,610 - 91,257,398 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,715,120 - 90,731,930 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,108,283 - 86,125,098 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,181,139 - 89,198,213 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,181,165 - 89,198,213 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,979,661 - 88,997,344 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,289,273 - 90,306,225 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,920,709 - 84,937,662 (+)NCBICelera
RGSC_v3.11090,303,667 - 90,320,558 (+)NCBI
Cytogenetic Map10q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylparaben  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dicrotophos  (ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycine betaine  (EXP)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
methotrexate  (ISO)
methylparaben  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tacrolimus hydrate  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
bicellular tight junction  (IEA,ISO,ISS)
cell body  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IDA)
membrane  (IDA)
protein-containing complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Bhuiyan MIH, etal., J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes. Kamide K, etal., Am J Hypertens. 2004 May;17(5 Pt 1):446-9.
4. The role of Wnk4 in polygenic hypertension: a candidate gene analysis on rat chromosome 10. Monti J, etal., Hypertension 2003 Apr;41(4):938-42.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. WNK Kinases, Renal Ion Transport and Hypertension. San-Cristobal P, etal., Am J Nephrol. 2008 Jun 12;28(5):860-870.
11. Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. Subramanya AR, etal., Am J Physiol Renal Physiol. 2006 Mar;290(3):F619-24. Epub 2005 Oct 4.
12. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Vitari AC, etal., Biochem J. 2005 Oct 1;391(Pt 1):17-24.
13. Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses. Vorontsova I, etal., Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):310-21. doi: 10.1167/iovs.14-15911.
14. Human hypertension caused by mutations in WNK kinases. Wilson FH, etal., Science. 2001 Aug 10;293(5532):1107-12.
Additional References at PubMed
PMID:8889548   PMID:12515852   PMID:12671053   PMID:14608358   PMID:14769928   PMID:15350218   PMID:17182532   PMID:17194447   PMID:17360470   PMID:17651736   PMID:17673510   PMID:21317537  
PMID:21499270   PMID:21670282   PMID:23453970   PMID:23576762   PMID:24811174  


Genomics

Comparative Map Data
Wnk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,702,828 - 86,719,917 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,702,865 - 86,720,198 (+)EnsemblGRCr8
mRatBN7.21086,202,552 - 86,219,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,240,610 - 91,257,398 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,715,120 - 90,731,930 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,108,283 - 86,125,098 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,181,139 - 89,198,213 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,181,165 - 89,198,213 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,979,661 - 88,997,344 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,289,273 - 90,306,225 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,920,709 - 84,937,662 (+)NCBICelera
RGSC_v3.11090,303,667 - 90,320,558 (+)NCBI
Cytogenetic Map10q31NCBI
WNK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,780,610 - 42,797,066 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,780,610 - 42,797,066 (+)Ensemblhg38GRCh38
GRCh371740,932,628 - 40,949,084 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,186,222 - 38,202,610 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341738,186,221 - 38,202,605NCBI
Celera1737,588,637 - 37,605,071 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,697,144 - 36,713,472 (+)NCBIHuRef
CHM1_11741,168,235 - 41,184,670 (+)NCBICHM1_1
T2T-CHM13v2.01743,637,750 - 43,654,206 (+)NCBIT2T-CHM13v2.0
Wnk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,151,363 - 101,168,235 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,151,393 - 101,168,235 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811101,260,537 - 101,277,409 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,260,567 - 101,277,409 (+)Ensemblmm10GRCm38
MGSCv3711101,121,881 - 101,138,723 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611101,076,701 - 101,093,499 (+)NCBIMGSCv36mm8
MGSCv3611102,039,322 - 102,056,494 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1164.51NCBI
Wnk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,594,408 - 16,606,410 (+)Ensembl
ChiLan1.0NW_00495545116,593,840 - 16,606,817 (+)NCBIChiLan1.0ChiLan1.0
WNK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,188,275 - 22,205,551 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,078,401 - 24,095,648 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,520,448 - 14,537,799 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,746,058 - 14,762,513 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,746,365 - 14,762,423 (-)EnsemblpanPan2panpan1.1
VPS25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,242,230 - 20,247,396 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,703,536 - 19,708,691 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0920,960,604 - 20,965,761 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,960,860 - 20,965,682 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,745,515 - 19,750,667 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,011,720 - 20,016,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,114,439 - 20,119,596 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wnk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,567,157 - 19,582,658 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,492,753 - 17,509,582 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,492,718 - 17,508,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,065,061 - 20,081,762 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11220,064,688 - 20,081,781 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,279,617 - 20,296,819 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,494,090 - 63,512,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607734,286,917 - 34,303,255 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,416,886 - 1,427,811 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247951,416,479 - 1,428,350 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Wnk4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1960,564,723 - 60,581,426 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Wnk4
89 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH128509  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,201,392 - 86,201,583 (+)MAPPERmRatBN7.2
Rnor_6.01089,179,952 - 89,180,142NCBIRnor6.0
Rnor_5.01088,978,448 - 88,978,638UniSTSRnor5.0
RGSC_v3.41090,287,947 - 90,288,137UniSTSRGSC3.4
Celera1084,918,315 - 84,918,505UniSTS
RH 3.4 Map10877.1UniSTS
Cytogenetic Map10q32.1UniSTS
RH134547  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,219,437 - 86,219,617 (+)MAPPERmRatBN7.2
Rnor_6.01089,197,996 - 89,198,175NCBIRnor6.0
Rnor_5.01088,996,382 - 88,996,561UniSTSRnor5.0
RGSC_v3.41090,306,008 - 90,306,187UniSTSRGSC3.4
Celera1084,937,445 - 84,937,624UniSTS
RH 3.4 Map10860.3UniSTS
Cytogenetic Map10q32.1UniSTS
AW107467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,201,138 - 86,201,230 (+)MAPPERmRatBN7.2
Rnor_6.01089,179,698 - 89,179,789NCBIRnor6.0
Rnor_5.01088,978,194 - 88,978,285UniSTSRnor5.0
RGSC_v3.41090,287,693 - 90,287,784UniSTSRGSC3.4
Celera1084,918,061 - 84,918,152UniSTS
Cytogenetic Map10q32.1UniSTS
RH137051  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,208,703 - 86,208,921 (+)MAPPERmRatBN7.2
mRatBN7.21042,211,767 - 42,211,985 (+)MAPPERmRatBN7.2
Rnor_6.01089,187,263 - 89,187,480NCBIRnor6.0
Rnor_6.01043,465,374 - 43,465,591NCBIRnor6.0
Rnor_5.01088,985,759 - 88,985,976UniSTSRnor5.0
Rnor_5.01043,262,608 - 43,262,825UniSTSRnor5.0
RGSC_v3.41043,631,779 - 43,631,996UniSTSRGSC3.4
RGSC_v3.41090,295,283 - 90,295,500UniSTSRGSC3.4
Celera1084,926,705 - 84,926,922UniSTS
Celera1041,501,879 - 41,502,096UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map1q54UniSTS
RH124894  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,201,327 - 86,201,466 (+)MAPPERmRatBN7.2
Rnor_6.01089,179,887 - 89,180,025NCBIRnor6.0
Rnor_5.01088,978,383 - 88,978,521UniSTSRnor5.0
RGSC_v3.41090,287,882 - 90,288,020UniSTSRGSC3.4
Celera1084,918,250 - 84,918,388UniSTS
Cytogenetic Map10q32.1UniSTS
PMC357052P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81086,711,637 - 86,712,257 (+)Marker Load Pipeline
mRatBN7.21086,211,372 - 86,211,993 (+)MAPPERmRatBN7.2
Rnor_6.01089,189,932 - 89,190,552NCBIRnor6.0
Rnor_5.01088,988,428 - 88,989,048UniSTSRnor5.0
RGSC_v3.41090,297,952 - 90,298,572UniSTSRGSC3.4
Celera1084,929,375 - 84,929,995UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 89 88 57 92 57 6 354 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027770   ⟹   ENSRNOP00000027770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,702,865 - 86,719,909 (+)Ensembl
mRatBN7.2 Ensembl1086,202,693 - 86,219,629 (+)Ensembl
Rnor_6.0 Ensembl1089,181,253 - 89,198,176 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000043754   ⟹   ENSRNOP00000044397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,188,854 - 86,201,601 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000043953   ⟹   ENSRNOP00000043210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,188,812 - 86,190,687 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075953   ⟹   ENSRNOP00000068003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,196,099 - 86,201,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076056   ⟹   ENSRNOP00000080834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,203,829 - 86,231,829 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076366   ⟹   ENSRNOP00000068513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,702,865 - 86,720,198 (+)Ensembl
mRatBN7.2 Ensembl1086,202,693 - 86,231,829 (+)Ensembl
Rnor_6.0 Ensembl1089,181,165 - 89,198,213 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076658   ⟹   ENSRNOP00000095750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,196,268 - 86,201,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076944   ⟹   ENSRNOP00000082243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,195,281 - 86,200,277 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078931   ⟹   ENSRNOP00000072084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,196,048 - 86,231,812 (+)Ensembl
Rnor_6.0 Ensembl1089,181,180 - 89,198,026 (+)Ensembl
RefSeq Acc Id: NM_175579   ⟹   NP_783169
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,958 - 86,719,917 (+)NCBI
mRatBN7.21086,202,693 - 86,219,655 (+)NCBI
Rnor_6.01089,181,253 - 89,198,213 (+)NCBI
Rnor_5.01088,979,661 - 88,997,344 (+)NCBI
RGSC_v3.41090,289,273 - 90,306,225 (+)RGD
Celera1084,920,709 - 84,937,662 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247278   ⟹   XP_006247340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,840 - 86,719,915 (+)NCBI
mRatBN7.21086,202,558 - 86,219,655 (+)NCBI
Rnor_6.01089,181,139 - 89,198,213 (+)NCBI
Rnor_5.01088,979,661 - 88,997,344 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247279   ⟹   XP_006247341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,839 - 86,719,915 (+)NCBI
mRatBN7.21086,202,558 - 86,219,655 (+)NCBI
Rnor_6.01089,181,139 - 89,198,213 (+)NCBI
Rnor_5.01088,979,661 - 88,997,344 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247280   ⟹   XP_006247342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,703,453 - 86,719,915 (+)NCBI
mRatBN7.21086,203,193 - 86,219,655 (+)NCBI
Rnor_6.01089,181,810 - 89,198,213 (+)NCBI
Rnor_5.01088,979,661 - 88,997,344 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247281   ⟹   XP_006247343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,705,042 - 86,719,915 (+)NCBI
mRatBN7.21086,204,776 - 86,219,655 (+)NCBI
Rnor_6.01089,183,383 - 89,198,213 (+)NCBI
Rnor_5.01088,979,661 - 88,997,344 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085617   ⟹   XP_038941545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,839 - 86,719,915 (+)NCBI
mRatBN7.21086,202,558 - 86,219,204 (+)NCBI
RefSeq Acc Id: XM_039085619   ⟹   XP_038941547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,828 - 86,711,898 (+)NCBI
mRatBN7.21086,202,552 - 86,211,638 (+)NCBI
RefSeq Acc Id: XM_063268738   ⟹   XP_063124808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,702,840 - 86,719,915 (+)NCBI
RefSeq Acc Id: XM_063268739   ⟹   XP_063124809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,703,453 - 86,719,915 (+)NCBI
RefSeq Acc Id: XM_063268740   ⟹   XP_063124810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,710,890 - 86,719,915 (+)NCBI
RefSeq Acc Id: NP_783169   ⟸   NM_175579
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A6HJA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247340   ⟸   XM_006247278
- Peptide Label: isoform X1
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A0A096MKH1 (UniProtKB/TrEMBL),   A6HJA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247341   ⟸   XM_006247279
- Peptide Label: isoform X2
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A6HJA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247342   ⟸   XM_006247280
- Peptide Label: isoform X5
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A0A8I5ZQR6 (UniProtKB/TrEMBL),   A6HJA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247343   ⟸   XM_006247281
- Peptide Label: isoform X6
- Sequence:
Ensembl Acc Id: ENSRNOP00000068513   ⟸   ENSRNOT00000076366
Ensembl Acc Id: ENSRNOP00000072084   ⟸   ENSRNOT00000078931
Ensembl Acc Id: ENSRNOP00000027770   ⟸   ENSRNOT00000027770
RefSeq Acc Id: XP_038941547   ⟸   XM_039085619
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038941545   ⟸   XM_039085617
- Peptide Label: isoform X4
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A6HJA0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000068003   ⟸   ENSRNOT00000075953
Ensembl Acc Id: ENSRNOP00000080834   ⟸   ENSRNOT00000076056
Ensembl Acc Id: ENSRNOP00000082243   ⟸   ENSRNOT00000076944
Ensembl Acc Id: ENSRNOP00000044397   ⟸   ENSRNOT00000043754
Ensembl Acc Id: ENSRNOP00000043210   ⟸   ENSRNOT00000043953
Ensembl Acc Id: ENSRNOP00000095750   ⟸   ENSRNOT00000076658
RefSeq Acc Id: XP_063124808   ⟸   XM_063268738
- Peptide Label: isoform X3
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A6HJA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124809   ⟸   XM_063268739
- Peptide Label: isoform X7
- UniProtKB: Q811R5 (UniProtKB/Swiss-Prot),   Q810H4 (UniProtKB/Swiss-Prot),   Q7TPK6 (UniProtKB/Swiss-Prot),   A6HJA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124810   ⟸   XM_063268740
- Peptide Label: isoform X8
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TPK6-F1-model_v2 AlphaFold Q7TPK6 1-1222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697749
Promoter ID:EPDNEW_R8273
Type:multiple initiation site
Name:Wnk4_1
Description:WNK lysine deficient protein kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,181,190 - 89,181,250EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631401 AgrOrtholog
BioCyc Gene G2FUF-23187 BioCyc
Ensembl Genes ENSRNOG00000020441 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027770 ENTREZGENE
  ENSRNOT00000027770.8 UniProtKB/Swiss-Prot
  ENSRNOT00000076366 ENTREZGENE
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro CCTL2_WNK UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Kinase_OSR1/WNK_CCT UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  WNK_Ser-Thr_kinase UniProtKB/Swiss-Prot
KEGG Report rno:287715 UniProtKB/Swiss-Prot
NCBI Gene 287715 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED UniProtKB/Swiss-Prot
Pfam CCTL2_WNK UniProtKB/Swiss-Prot
  OSR1_C UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Wnk4 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020441 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A096MKH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQR6 ENTREZGENE
  A6HJA0 ENTREZGENE, UniProtKB/TrEMBL
  Q7TPK6 ENTREZGENE
  Q810H4 ENTREZGENE
  Q811R5 ENTREZGENE
  WNK4_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q810H4 UniProtKB/Swiss-Prot
  Q811R5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Wnk4  WNK lysine deficient protein kinase 4  Prkwnk4  protein kinase, lysine deficient 4  Symbol and Name updated 1299863 APPROVED
2004-02-11 Prkwnk4  protein kinase, lysine deficient 4      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mapping maps within the chromW.S-(D10Mgh6-D10Mgh4) 629611
gene_other can most likely be excluded as a candidate gene for contributing to a chromosome 10 blood pressure QTL 629611