RGD Reference Report - WNK Kinases, Renal Ion Transport and Hypertension. - Rat Genome Database

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WNK Kinases, Renal Ion Transport and Hypertension.

Authors: San-Cristobal, P  De Los Heros, P  Ponce-Coria, J  Moreno, E  Gamba, G 
Citation: San-Cristobal P, etal., Am J Nephrol. 2008 Jun 12;28(5):860-870.
RGD ID: 2298790
Pubmed: PMID:18547946   (View Abstract at PubMed)
PMCID: PMC2820349   (View Article at PubMed Central)
DOI: DOI:10.1159/000139639   (Journal Full-text)

Two members of a recently discovered family of protein kinases are the cause of an inherited disease known as pseudohypoaldosteronism type II (PHAII). These patients exhibit arterial hypertension together with hyperkalemia and metabolic acidosis. This is a mirror image of Gitelman disease that is due to inactivating mutations of the SLC12A3 gene that encodes the thiazide-sensitive Na(+):Cl(-) cotransporter. The uncovered genes causing PHAII encode for serine/threonine kinases known as WNK1 and WNK4. Physiological and biochemical studies have revealed that WNK1 and WNK4 modulate the activity of several transport pathways of the aldosterone-sensitive distal nephron, thus increasing our understanding of how diverse renal ion transport proteins are coordinated to regulate normal blood pressure levels. Observations discussed in the present work place WNK1 and WNK4 as genes involved in the genesis of essential hypertension and as potential targets for the development of antihypertensive drugs.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Wnk1  (WNK lysine deficient protein kinase 1)
Wnk4  (WNK lysine deficient protein kinase 4)

Genes (Mus musculus)
Wnk1  (WNK lysine deficient protein kinase 1)
Wnk4  (WNK lysine deficient protein kinase 4)

Genes (Homo sapiens)
WNK1  (WNK lysine deficient protein kinase 1)
WNK4  (WNK lysine deficient protein kinase 4)


Additional Information