Cacna2d2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2) - Rat Genome Database

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Pathways
Gene: Cacna2d2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2) Rattus norvegicus
Analyze
Symbol: Cacna2d2
Name: calcium voltage-gated channel auxiliary subunit alpha2delta 2
RGD ID: 631360
Description: Enables voltage-gated calcium channel activity. Involved in calcium ion transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Predicted to be active in GABA-ergic synapse and presynaptic active zone membrane. Orthologous to human CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; androgen antagonist.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium channel, voltage dependent, alpha2/delta subunit 2; calcium channel, voltage-dependent, alpha 2/delta subunit 2; voltage-dependent calcium channel subunit alpha-2/delta-2; voltage-gated calcium channel subunit alpha-2/delta-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,950,860 - 117,082,159 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8116,950,907 - 117,081,759 (+)EnsemblGRCr8
mRatBN7.28108,072,208 - 108,203,516 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,072,454 - 108,203,173 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,699,122 - 113,828,659 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,898,292 - 112,027,815 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,741,072 - 109,870,596 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,154,661 - 116,285,643 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,154,736 - 116,284,985 (+)Ensemblrn6Rnor6.0
Rnor_5.08115,510,729 - 115,641,903 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,643,409 - 112,775,460 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8107,381,970 - 107,508,046 (+)NCBICelera
RGSC_v3.18112,662,863 - 112,794,915 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
arrhythmogenic right ventricular cardiomyopathy pathway  (IEA)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
felodipine pharmacokinetics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
gliclazide pharmacodynamics pathway  (ISO)
glyburide pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
hypertrophic cardiomyopathy pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway   (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway   (ISO)
potassium channel inhibitors pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of calcium channel alpha(2)delta-subunits from rat atria and the differential regulation of their expression by IGF-1. Chu PJ and Best PM, J Mol Cell Cardiol 2003 Feb;35(2):207-15.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. miR-1231 exacerbates arrhythmia by targeting calciumchannel geneCACNA2D2in myocardial infarction. Zhang J, etal., Am J Transl Res. 2017 Apr 15;9(4):1822-1833. eCollection 2017.
Additional References at PubMed
PMID:9349522   PMID:11487633   PMID:16134135   PMID:16474392   PMID:16636499   PMID:17320843   PMID:19818485   PMID:21700703   PMID:24055266  


Genomics

Comparative Map Data
Cacna2d2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,950,860 - 117,082,159 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8116,950,907 - 117,081,759 (+)EnsemblGRCr8
mRatBN7.28108,072,208 - 108,203,516 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,072,454 - 108,203,173 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,699,122 - 113,828,659 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,898,292 - 112,027,815 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,741,072 - 109,870,596 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,154,661 - 116,285,643 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,154,736 - 116,284,985 (+)Ensemblrn6Rnor6.0
Rnor_5.08115,510,729 - 115,641,903 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,643,409 - 112,775,460 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8107,381,970 - 107,508,046 (+)NCBICelera
RGSC_v3.18112,662,863 - 112,794,915 (+)NCBI
Cytogenetic Map8q32NCBI
CACNA2D2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,362,613 - 50,504,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,362,613 - 50,504,244 (-)Ensemblhg38GRCh38
GRCh37350,400,044 - 50,541,675 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,375,234 - 50,515,896 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34350,375,233 - 50,515,896NCBI
Celera350,373,061 - 50,513,724 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,455,831 - 50,596,932 (-)NCBIHuRef
CHM1_1350,352,505 - 50,493,122 (-)NCBICHM1_1
T2T-CHM13v2.0350,392,335 - 50,534,145 (-)NCBIT2T-CHM13v2.0
Cacna2d2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,276,948 - 107,406,545 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,276,811 - 107,406,542 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389107,399,733 - 107,529,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,399,612 - 107,529,343 (+)Ensemblmm10GRCm38
MGSCv379107,302,211 - 107,431,674 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369107,257,713 - 107,387,159 (+)NCBIMGSCv36mm8
Celera9107,007,997 - 107,138,095 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.02NCBI
Cacna2d2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,163,529 - 2,283,508 (-)Ensembl
ChiLan1.0NW_0049555322,163,529 - 2,283,509 (-)NCBIChiLan1.0ChiLan1.0
CACNA2D2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,343,478 - 50,484,673 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,348,253 - 50,489,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,288,926 - 50,430,152 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,524,200 - 51,638,249 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,526,075 - 51,640,406 (-)EnsemblpanPan2panpan1.1
CACNA2D2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12038,859,047 - 38,995,239 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2038,883,530 - 38,993,273 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2038,778,136 - 38,916,454 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02039,213,098 - 39,351,432 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,212,486 - 39,351,069 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,580,983 - 38,719,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02038,984,749 - 39,122,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,264,526 - 39,402,846 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cacna2d2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,127,442 - 65,263,213 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,889,846 - 2,023,715 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,889,811 - 2,023,710 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA2D2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,845,115 - 32,988,774 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11332,845,110 - 32,988,851 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21336,023,325 - 36,167,052 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CACNA2D2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,751,026 - 11,891,407 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,749,727 - 11,890,924 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041155,095,234 - 155,235,652 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacna2d2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,212,901 - 4,345,849 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247304,211,189 - 4,346,119 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cacna2d2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1898,714,996 - 98,845,896 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cacna2d2
1019 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000021218
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 87 59 6 348 187 11 141 78 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021218   ⟹   ENSRNOP00000021216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8116,950,907 - 117,080,262 (+)Ensembl
mRatBN7.2 Ensembl8108,072,454 - 108,201,619 (+)Ensembl
Rnor_6.0 Ensembl8116,154,736 - 116,283,746 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081242   ⟹   ENSRNOP00000071469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8116,951,106 - 117,081,759 (+)Ensembl
mRatBN7.2 Ensembl8108,072,454 - 108,203,173 (+)Ensembl
Rnor_6.0 Ensembl8116,154,913 - 116,284,985 (+)Ensembl
RefSeq Acc Id: NM_175592   ⟹   NP_783182
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,951,106 - 117,080,262 (+)NCBI
mRatBN7.28108,072,454 - 108,201,619 (+)NCBI
Rnor_6.08116,154,736 - 116,283,746 (+)NCBI
Rnor_5.08115,510,729 - 115,641,903 (+)NCBI
RGSC_v3.48112,643,409 - 112,775,460 (+)RGD
Celera8107,381,970 - 107,508,046 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243735   ⟹   XP_006243797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,950,860 - 117,082,159 (+)NCBI
mRatBN7.28108,072,208 - 108,203,516 (+)NCBI
Rnor_6.08116,154,661 - 116,285,643 (+)NCBI
Rnor_5.08115,510,729 - 115,641,903 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243736   ⟹   XP_006243798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,950,860 - 117,082,159 (+)NCBI
mRatBN7.28108,072,208 - 108,203,516 (+)NCBI
Rnor_6.08116,154,661 - 116,285,643 (+)NCBI
Rnor_5.08115,510,729 - 115,641,903 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243737   ⟹   XP_006243799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,950,860 - 117,082,159 (+)NCBI
mRatBN7.28108,072,208 - 108,203,516 (+)NCBI
Rnor_6.08116,154,661 - 116,285,643 (+)NCBI
Rnor_5.08115,510,729 - 115,641,903 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063265241   ⟹   XP_063121311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,950,860 - 117,082,159 (+)NCBI
RefSeq Acc Id: XM_063265242   ⟹   XP_063121312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,950,860 - 117,082,159 (+)NCBI
RefSeq Acc Id: XM_063265243   ⟹   XP_063121313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,950,860 - 117,082,159 (+)NCBI
RefSeq Acc Id: XM_063265244   ⟹   XP_063121314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,950,860 - 117,082,159 (+)NCBI
RefSeq Acc Id: NP_783182   ⟸   NM_175592
- Peptide Label: precursor
- UniProtKB: Q8CFG6 (UniProtKB/Swiss-Prot),   A6I2X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243797   ⟸   XM_006243735
- Peptide Label: isoform X3
- UniProtKB: Q8CFG6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243798   ⟸   XM_006243736
- Peptide Label: isoform X6
- UniProtKB: Q8CFG6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243799   ⟸   XM_006243737
- Peptide Label: isoform X7
- Sequence:
Ensembl Acc Id: ENSRNOP00000021216   ⟸   ENSRNOT00000021218
Ensembl Acc Id: ENSRNOP00000071469   ⟸   ENSRNOT00000081242
RefSeq Acc Id: XP_063121311   ⟸   XM_063265241
- Peptide Label: isoform X1
- UniProtKB: Q8CFG6 (UniProtKB/Swiss-Prot),   A6I2X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121312   ⟸   XM_063265242
- Peptide Label: isoform X2
- UniProtKB: Q8CFG6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063121313   ⟸   XM_063265243
- Peptide Label: isoform X4
- UniProtKB: Q8CFG6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063121314   ⟸   XM_063265244
- Peptide Label: isoform X5
- UniProtKB: Q8CFG6 (UniProtKB/Swiss-Prot)
Protein Domains
Cache   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CFG6-F1-model_v2 AlphaFold Q8CFG6 1-1157 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631360 AgrOrtholog
BioCyc Gene G2FUF-29205 BioCyc
Ensembl Genes ENSRNOG00000015835 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021218 ENTREZGENE
  ENSRNOT00000081242 ENTREZGENE
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot
  PAS domain UniProtKB/Swiss-Prot
InterPro Ca_channel_alpha-2/delta UniProtKB/Swiss-Prot
  VDCC_a2/dsu UniProtKB/Swiss-Prot
  VWA_N UniProtKB/Swiss-Prot
  VWF_A UniProtKB/Swiss-Prot
  vWFA_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:300992 UniProtKB/Swiss-Prot
NCBI Gene 300992 ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-2 UniProtKB/Swiss-Prot
  VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED UniProtKB/Swiss-Prot
Pfam VGCC_alpha2 UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
  VWA_N UniProtKB/Swiss-Prot
PhenoGen Cacna2d2 PhenoGen
PROSITE VWFA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015835 RatGTEx
SMART VWA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53300 UniProtKB/Swiss-Prot
UniProt A0A0G2K0J2_RAT UniProtKB/TrEMBL
  A6I2X1 ENTREZGENE, UniProtKB/TrEMBL
  CA2D2_RAT UniProtKB/Swiss-Prot
  F1M9X7_RAT UniProtKB/TrEMBL
  Q8CFG6 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacna2d2  calcium voltage-gated channel auxiliary subunit alpha2delta 2  Cacna2d2  calcium channel, voltage-dependent, alpha 2/delta subunit 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cacna2d2  calcium channel, voltage-dependent, alpha 2/delta subunit 2    calcium channel, voltage dependent, alpha2/delta subunit 2  Name updated 1299863 APPROVED
2004-02-11 Slc1a7  calcium channel, voltage dependent, alpha2/delta subunit 2  Cacna2d2  calcium channel, voltage-dependent, alpha 2/delta subunit 2  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is increased by IGF-1 632381