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Gene: Sostdc1 (sclerostin domain containing 1) Rattus norvegicus

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Symbol:

Sostdc1

Name:

sclerostin domain containing 1

RGD ID:

628877

Description:

Predicted to enable BMP binding activity and BMP receptor activity. Predicted to be involved in negative regulation of determination of dorsal identity; negative regulation of myoblast differentiation; and negative regulation of signal transduction. Predicted to act upstream of or within several processes, including morphogenesis of an epithelium; negative regulation of canonical Wnt signaling pathway; and odontogenesis of dentin-containing tooth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human SOSTDC1 (sclerostin domain containing 1); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; Wnt signaling, canonical pathway; INTERACTS WITH 17alpha-ethynylestradiol; 3,7-dihydropurine-6-thione; 4-tert-Octylphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

context-dependent activator and inhibitor of Wnt signalling protein Wise; sclerostin domain-containing protein 1; USAG-1; Usag1; uterine sensitization-associated gene 1 protein; Wise; wnt-signaling modulator

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	58,778,623 - 58,782,797 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	58,778,623 - 58,782,866 (+)	Ensembl				GRCr8
mRatBN7.2	6	53,051,336 - 53,055,510 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	53,051,354 - 53,055,579 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	53,344,009 - 53,348,187 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	53,658,884 - 53,663,061 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	53,129,317 - 53,133,490 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	55,812,820 - 55,816,994 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	55,812,747 - 55,817,066 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	65,423,740 - 65,427,914 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	55,066,277 - 55,070,451 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	52,193,795 - 52,197,969 (+)	NCBI		Celera
RGSC_v3.1	6	55,069,402 - 55,073,577 (+)	NCBI
Cytogenetic Map	6	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,7-dihydropurine-6-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

4-tert-Octylphenol (EXP)

6-propyl-2-thiouracil (EXP,ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

capsaicin (EXP)

carbon monoxide (ISO)

CGP 52608 (ISO)

chloroprene (EXP)

ciguatoxin CTX1B (ISO)

copper atom (EXP)

copper(0) (EXP)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

diazinon (EXP)

dibutyl phthalate (EXP,ISO)

diethylstilbestrol (EXP)

diiodine (ISO)

dorsomorphin (ISO)

entinostat (ISO)

flusilazole (EXP)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

glycidol (EXP)

glycine betaine (EXP)

glyphosate (EXP)

lead diacetate (ISO)

manganese atom (EXP)

manganese(0) (EXP)

manganese(II) chloride (EXP)

mercaptopurine (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-methyl-4-phenylpyridinium (EXP)

nickel atom (ISO)

nitrofen (EXP)

p-tert-Amylphenol (EXP)

PCB138 (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (ISO)

purine-6-thiol (EXP)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium chloride (EXP)

sodium dichromate (EXP)

sodium fluoride (ISO)

sulfur dioxide (ISO)

tamoxifen (ISO)

Theaflavin 3,3'-digallate (ISO)

titanium dioxide (EXP,ISO)

toluene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

BMP signaling pathway (IEA)

embryo implantation (NAS)

hair follicle morphogenesis (ISO)

mammary gland bud morphogenesis (ISO)

negative regulation of BMP signaling pathway (IBA,IEA,ISO)

negative regulation of canonical Wnt signaling pathway (ISO)

negative regulation of cell differentiation (IEA)

negative regulation of cell fate commitment (ISO)

negative regulation of determination of dorsal identity (IEA,ISO)

negative regulation of myoblast differentiation (IEA,ISO)

negative regulation of Wnt signaling pathway (IBA,IEA,ISO)

odontogenesis of dentin-containing tooth (ISO)

pattern specification process (ISO)

Wnt signaling pathway (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,IEA,ISO)

Molecular Function

BMP binding (IBA,IEA,ISO)

BMP receptor activity (IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Bone morphogenetic proteins signaling pathway (ISO)

Wnt signaling, canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Secreted and transmembrane wnt inhibitors and activators.	Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Uterine sensitization-associated gene-1: a novel gene induced within the rat endometrium at the time of uterine receptivity/sensitization for the decidual cell reaction.	Simmons DG and Kennedy TG, Biol Reprod 2002 Nov;67(5):1638-45.
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:14623234	PMID:15020244	PMID:15373764	PMID:15489334	PMID:16179481	PMID:19103603	PMID:22509524	PMID:23184054	PMID:26865179	PMID:31313025	PMID:31391487	PMID:38152045

Genomics

Comparative Map Data

Sostdc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	58,778,623 - 58,782,797 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	58,778,623 - 58,782,866 (+)	Ensembl				GRCr8
mRatBN7.2	6	53,051,336 - 53,055,510 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	53,051,354 - 53,055,579 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	53,344,009 - 53,348,187 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	53,658,884 - 53,663,061 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	53,129,317 - 53,133,490 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	55,812,820 - 55,816,994 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	55,812,747 - 55,817,066 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	65,423,740 - 65,427,914 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	55,066,277 - 55,070,451 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	52,193,795 - 52,197,969 (+)	NCBI		Celera
RGSC_v3.1	6	55,069,402 - 55,073,577 (+)	NCBI
Cytogenetic Map	6	q16	NCBI

SOSTDC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	16,461,481 - 16,465,738 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	16,461,481 - 16,530,580 (-)	Ensembl			hg38	GRCh38
GRCh37	7	16,501,106 - 16,505,363 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	16,467,631 - 16,471,999 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	16,274,347 - 16,278,714	NCBI
Celera	7	16,480,854 - 16,485,222 (-)	NCBI		Celera
Cytogenetic Map	7	p21.2	NCBI
HuRef	7	16,387,637 - 16,392,005 (-)	NCBI		HuRef
CHM1_1	7	16,500,852 - 16,505,220 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	16,591,217 - 16,595,471 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	16,554,239 - 16,558,607 (-)	NCBI

Sostdc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	36,364,168 - 36,368,451 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	36,364,138 - 36,368,451 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	36,314,169 - 36,318,452 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	36,314,139 - 36,318,452 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	37,040,756 - 37,045,039 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	36,824,492 - 36,828,711 (+)	NCBI		MGSCv36	mm8
Celera	12	37,763,054 - 37,767,254 (+)	NCBI		Celera
Cytogenetic Map	12	A3	NCBI
cM Map	12	16.82	NCBI

Sostdc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	19,657,029 - 19,662,131 (-)	Ensembl
ChiLan1.0	NW_004955410	19,657,805 - 19,662,121 (-)	NCBI	ChiLan1.0	ChiLan1.0

SOSTDC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	21,295,189 - 21,408,065 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	69,619,912 - 69,732,876 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	17,193,531 - 17,229,769 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	16,443,703 - 16,448,076 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	16,443,703 - 16,448,076 (-)	Ensembl			panPan2	panpan1.1
PanPan1.1 Ensembl	7	16,443,703 - 16,448,076 (-)	NCBI			panPan2	panpan1.1

SOSTDC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	31,035,759 - 31,079,139 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	31,022,766 - 31,026,737 (-)	Ensembl			canFam3	CanFam3.1
CanFam3.1 Ensembl	14	31,022,766 - 31,026,737 (-)	NCBI			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	30,543,856 - 30,600,514 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	30,942,576 - 30,998,969 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	30,942,759 - 30,947,128 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	31,045,159 - 31,101,747 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	30,757,610 - 30,813,982 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	31,070,106 - 31,126,811 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sostdc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	75,301,027 - 75,305,460 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936546	2,975,606 - 2,980,514 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936546	2,976,045 - 2,980,487 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SOSTDC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	85,743,341 - 85,747,591 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	85,743,332 - 85,747,893 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	94,581,754 - 94,585,919 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SOSTDC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	41,645,884 - 41,651,360 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	41,647,079 - 41,652,093 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666042	62,859,358 - 62,864,068 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sostdc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624739	13,766,815 - 13,772,322 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624739	13,767,523 - 13,771,708 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sostdc1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	50,230,035 - 50,234,336 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sostdc1
14 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	117
Count of miRNA genes:	86
Interacting mature miRNAs:	109
Transcripts:	ENSRNOT00000008106
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	44510974	89510974	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	39028659	63457441	Rat
4889933	Bss88	Bone structure and strength QTL 88	3.8		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	6	53684921	98684921	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	40957564	85957564	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	45153786	90153786	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	22653889	67653889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
5684992	Bmd83	Bone mineral density QTL 82	4.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	6	53684921	98684921	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	31185002	76185002	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	46050607	116278722	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	46047353	91047353	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	44510974	89510974	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	44510974	89510974	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	33328841	78328841	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	30937632	75937632	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	33328841	78328841	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	39028659	86867923	Rat
5684963	Bss99	Bone structure and strength QTL 99	3.1		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	6	53684921	98684921	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	22288257	67288257	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	40163183	85163183	Rat

Markers in Region

UniSTS:464692

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	53,054,460 - 53,054,576 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	55,815,945 - 55,816,060	NCBI	Rnor6.0
Rnor_5.0	6	65,426,865 - 65,426,980	UniSTS	Rnor5.0
RGSC_v3.4	6	55,069,402 - 55,069,517	UniSTS	RGSC3.4
Celera	6	52,196,920 - 52,197,035	UniSTS
Cytogenetic Map	6	q16	UniSTS

Sostdc1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	53,054,293 - 53,054,491 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	55,815,778 - 55,815,975	NCBI	Rnor6.0
Rnor_5.0	6	65,426,698 - 65,426,895	UniSTS	Rnor5.0
RGSC_v3.4	6	55,069,235 - 55,069,432	UniSTS	RGSC3.4
Celera	6	52,196,753 - 52,196,950	UniSTS
Cytogenetic Map	6	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
10	11	65	158	59	58	27	31	27	6	254	128	9	137	81	84	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_153737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF411056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214520	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000008106 ⟹ ENSRNOP00000008106

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	58,778,623 - 58,782,866 (+)	Ensembl
mRatBN7.2 Ensembl	6	53,051,354 - 53,055,579 (+)	Ensembl
Rnor_6.0 Ensembl	6	55,812,747 - 55,817,066 (+)	Ensembl

RefSeq Acc Id:

NM_153737 ⟹ NP_714959

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	58,778,623 - 58,782,797 (+)	NCBI
mRatBN7.2	6	53,051,336 - 53,055,510 (+)	NCBI
Rnor_6.0	6	55,812,820 - 55,816,994 (+)	NCBI
Rnor_5.0	6	65,423,740 - 65,427,914 (+)	NCBI
RGSC_v3.4	6	55,066,277 - 55,070,451 (+)	RGD
Celera	6	52,193,795 - 52,197,969 (+)	RGD

Sequence:

show sequence

ACGCGGGGACAGTCAATAGCGCAGAAGCAGGGGGAAAGAATTCACCGCCTCAGCCGAGTAAATC
CTCCACTCATCATGCTTCCTCCTGCCATTCATCTCTCTCTCATTCCCCTGCTCTGCATCCTGAT
GAAAAACTGTTTGGCTTTTAAAAATGATGCCACAGAAATCCTTTATTCACATGTGGTTAAACCT
GTTTCAGCACACCCCAGCAGCAACAGCACCTTGAATCAAGCCAGGAATGGAGGCAGGCACTTCA
GTAGCACGGGACTGGATCGAAATAGTCGAGTTCAAGTGGGCTGCAGGGAACTGCGGTCCACCAA
ATACATCTCGGATGGCCAGTGCACCAGCATCAGCCCTCTGAAGGAGCTGGTGTGCGCGGGTGAG
TGCTTGCCCTTGCCAGTGCTTCCCAACTGGATCGGAGGAGGCTACGGAACAAAGTACTGGAGCC
GGAGGAGCTCCCAGGAGTGGCGGTGTGTCAACGACAAGACGCGCACCCAGAGAATCCAGCTGCA
GTGTCAGGACGGCAGCACACGCACCTACAAAATCACCGTGGTCACAGCGTGCAAGTGCAAGAGG
TACACCCGGCAGCACAACGAGTCCAGCCACAACTTTGAAAGCGTGTCTCCCGCCAAGCTCGCCC
AGCACCACAGAGAGCGGAAGAGAGCCAGCAAATCCAGCAAGCACAGTCTGAGCTAGAGCTGGAC
TGACTAGAAAGCATCTGCTCCCCAGATTTGATTGCGTGGAAGACTCGCTCGAGCCTGCCATTGC
TCTTTTCTCACTTGAAAGTATATGCTTTCTGCTTTGATCAGGCCCAGCAGGCTGTCCTTCTCTG
GGACCTTCTCTGGGACTAGCTTTTCCTTTGCAAGTTTCTCAAGATGTAATGAGTAGTTTGCAGT
GAAAGCCAGGCATCCCATAGTTTCACCCCCTCCCCCAGTCATTTCTTTCAAAAGCACCTGATGC
TGCATCCTGTTACAGTTTAAACCGCGCTCCATTCCCTAGCCCACCCTTTACCCTTCCCAAACTA
AATCCCTCCGAACCGGAGAAGTTCAATCAAAAAAAAAAATGTATCTTCACAGAACATTTCACAA
AGGGGCTTTTCCAGTAGTTTTTATGGGAATAGTTTGACAGCCAGGGGTTAGCTTCCTTTGAAAG
AGAGGCAAACCTTGTGACATTTCACTTCAAAAATAAGCCCGGTGGCATTTTCCAGTCTCAGTGT
GAAATTATCCCCCTCGTGTTGACCTCTCTTGGAGTGGAATGCCAGCAATGCAAGGCAGCAGCTA
ATAGGTAAAGCCGGTTATTTATTTGTCGATGTTGTTATTTAATGAGCTCGCGCATGTGATTTTT
TTTCCAAATGTTAATTTTTTTTTATATTTTGAAGCTTTTTCATGTACCTAAATATTTCCCAATA
CGATTTGTGGTTGGTCTAGAAATATGAAAATACATGTTGTAGATATGTAAAAATAAATATTTTA
GACTCCTTATATATTACACGGTTCCTCATACACTTTGTCATTAGCGTGGTTCCCTGTAAAGCTG
AAGTTATGTAATACTTTATTATTTAGTCCATGAAATCAGAAGGCAGCTTGACCTTCGGTGCCAT
CGGTTTCTTTTAATAAACATAAATATCCGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAATTAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_714959	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81710	(Get FASTA)	NCBI Sequence Viewer
	AAN45848	(Get FASTA)	NCBI Sequence Viewer
	EDM03317	(Get FASTA)	NCBI Sequence Viewer
	EDM03318	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008106
	ENSRNOP00000008106.3
GenBank Protein	Q642G2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_714959 ⟸ NM_153737
- Peptide Label:	precursor
- UniProtKB:	Q642G2 (UniProtKB/Swiss-Prot), Q8CJA4 (UniProtKB/Swiss-Prot), A6HBB2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLPPAIHLSLIPLLCILMKNCLAFKNDATEILYSHVVKPVSAHPSSNSTLNQARNGGRHFSSTG LDRNSRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSS QEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESVSPAKLAQHHR ERKRASKSSKHSLS hide sequence

Ensembl Acc Id:

ENSRNOP00000008106 ⟸ ENSRNOT00000008106

Protein Domains

CTCK

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q642G2-F1-model_v2	AlphaFold	Q642G2	1-206	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694562

Promoter ID:

EPDNEW_R5087

Type:

single initiation site

Name:

Sostdc1_1

Description:

sclerostin domain containing 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	55,812,820 - 55,812,880	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628877	AgrOrtholog
BioCyc Gene	G2FUF-37794	BioCyc
Ensembl Genes	ENSRNOG00000005770	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000008106	ENTREZGENE
	ENSRNOT00000008106.7	UniProtKB/Swiss-Prot
Gene3D-CATH	2.10.90.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7191839	IMAGE-MGC_LOAD
InterPro	Cys_knot_C	UniProtKB/Swiss-Prot
	Cystine-knot_cytokine	UniProtKB/Swiss-Prot
	Sclerostin/SOSTDC1	UniProtKB/Swiss-Prot
KEGG Report	rno:266803	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93115	IMAGE-MGC_LOAD
NCBI Gene	266803	ENTREZGENE
PANTHER	PTHR14903	UniProtKB/Swiss-Prot
	SCLEROSTIN DOMAIN-CONTAINING PROTEIN 1	UniProtKB/Swiss-Prot
Pfam	Sclerostin	UniProtKB/Swiss-Prot
PhenoGen	Sostdc1	PhenoGen
PROSITE	CTCK_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000005770	RatGTEx
UniProt	A6HBB2	ENTREZGENE, UniProtKB/TrEMBL
	A6HBB3_RAT	UniProtKB/TrEMBL
	Q642G2	ENTREZGENE
	Q8CJA4	ENTREZGENE
	SOSD1_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q8CJA4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Sostdc1	sclerostin domain containing 1		uterine sensitization-associated gene 1 protein	Name updated	1299863	APPROVED
2004-09-10	Sostdc1	uterine sensitization-associated gene 1 protein	Usag1		Symbol and Name updated	1299863	APPROVED
2003-02-27	Usag1	uterine sensitization-associated gene 1 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains an N-terminal secretion signal and a C-terminal cystine knotlike motif	634485

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - PID (archival)

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RGD Manual Annotations

Imported Annotations - PID (archival)