Itgb5 (integrin subunit beta 5) - Rat Genome Database

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Gene: Itgb5 (integrin subunit beta 5) Rattus norvegicus
Analyze
Symbol: Itgb5
Name: integrin subunit beta 5
RGD ID: 628869
Description: Enables signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; endodermal cell differentiation; and stress fiber assembly. Predicted to be located in cell leading edge. Predicted to be part of integrin alphav-beta5 complex. Predicted to be active in several cellular components, including focal adhesion; glutamatergic synapse; and synaptic membrane. Orthologous to human ITGB5 (integrin subunit beta 5); PARTICIPATES IN integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: integrin beta-5; integrin, beta 5; LOC498091; RGD1563276; similar to integrin beta-5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81180,333,588 - 80,449,373 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1180,333,590 - 80,449,373 (-)EnsemblGRCr8
mRatBN7.21166,828,428 - 66,944,231 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,829,285 - 66,944,472 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1175,661,894 - 75,777,337 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,323,780 - 68,439,208 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01167,354,354 - 67,469,799 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,056,500 - 70,172,164 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,056,500 - 70,172,372 (-)Ensemblrn6Rnor6.0
Rnor_5.01173,146,146 - 73,261,215 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1166,279,067 - 66,394,763 (-)NCBICelera
RGSC_v3.11168,699,866 - 68,710,334 (+)NCBI
Cytogenetic Map11q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
acrolein  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitrole  (EXP,ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
dabrafenib  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dimercaprol  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fenvalerate  (ISO)
folic acid  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
indometacin  (EXP,ISO)
Iopanoic acid  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methidathion  (ISO)
methimazole  (EXP,ISO)
methoxychlor  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
nickel atom  (ISO)
nicotine  (EXP)
nitrates  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis. Chang Y and Finnemann SC, J Cell Sci. 2007 Sep 1;120(Pt 17):3053-63. Epub 2007 Aug 7.
2. Regulation of cell migration by the integrin beta subunit ectodomain. Filardo EJ, etal., J Cell Sci. 1996 Jun;109 ( Pt 6):1615-22.
3. Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors. Finnemann SC EMBO J 2003 Aug 15;22(16):4143-54.
4. Identification of a novel V1-type AVP receptor based on the molecular recognition theory. Herrera VL and Ruiz-Opazo N, Mol Med 2001 Jul;7(7):499-506.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
11. Calcium-sensing receptor modulates cell adhesion and migration via integrins. Tharmalingam S, etal., J Biol Chem. 2011 Nov 25;286(47):40922-33. doi: 10.1074/jbc.M111.265454. Epub 2011 Oct 3.
12. cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing. Zhang H, etal., Biochem J 1998 Apr 15;331 ( Pt 2):631-7.
Additional References at PubMed
PMID:7525578   PMID:8601592   PMID:8889548   PMID:15326124   PMID:16467530   PMID:18794329   PMID:20463011   PMID:20826760   PMID:21423176   PMID:22262456   PMID:23154389   PMID:23376485  
PMID:23382219   PMID:23533145   PMID:23658023   PMID:24036928   PMID:24556923   PMID:25063885   PMID:30541573   PMID:31010681   PMID:37344798  


Genomics

Comparative Map Data
Itgb5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81180,333,588 - 80,449,373 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1180,333,590 - 80,449,373 (-)EnsemblGRCr8
mRatBN7.21166,828,428 - 66,944,231 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,829,285 - 66,944,472 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1175,661,894 - 75,777,337 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,323,780 - 68,439,208 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01167,354,354 - 67,469,799 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,056,500 - 70,172,164 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,056,500 - 70,172,372 (-)Ensemblrn6Rnor6.0
Rnor_5.01173,146,146 - 73,261,215 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1166,279,067 - 66,394,763 (-)NCBICelera
RGSC_v3.11168,699,866 - 68,710,334 (+)NCBI
Cytogenetic Map11q22NCBI
ITGB5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383124,761,948 - 124,901,418 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3124,761,948 - 124,901,418 (-)Ensemblhg38GRCh38
GRCh373124,480,795 - 124,620,265 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363125,964,485 - 126,088,834 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343125,964,485 - 126,088,834NCBI
Celera3122,889,001 - 123,012,953 (-)NCBICelera
Cytogenetic Map3q21.2NCBI
HuRef3121,856,362 - 121,980,193 (-)NCBIHuRef
CHM1_13124,444,943 - 124,568,708 (-)NCBICHM1_1
T2T-CHM13v2.03127,487,791 - 127,626,839 (-)NCBIT2T-CHM13v2.0
Itgb5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391633,650,021 - 33,769,708 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1633,650,035 - 33,769,708 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381633,829,665 - 33,949,338 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1633,829,665 - 33,949,338 (+)Ensemblmm10GRCm38
MGSCv371633,829,751 - 33,949,424 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361633,749,506 - 33,868,893 (+)NCBIMGSCv36mm8
Celera1634,313,798 - 34,433,456 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1624.22NCBI
Itgb5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542723,850,261 - 23,939,950 (-)Ensembl
ChiLan1.0NW_00495542723,851,475 - 23,952,211 (-)NCBIChiLan1.0ChiLan1.0
ITGB5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22122,722,310 - 122,883,230 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13122,727,098 - 122,887,634 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03121,863,676 - 122,013,438 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13128,762,200 - 128,873,887 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3128,762,200 - 128,877,172 (-)EnsemblpanPan2panpan1.1
ITGB5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13327,797,204 - 27,912,558 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3327,797,667 - 27,912,584 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3327,820,964 - 27,935,930 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03328,033,980 - 28,149,103 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3328,033,989 - 28,149,299 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13327,829,232 - 27,945,045 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03327,873,552 - 27,988,833 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03328,492,316 - 28,607,994 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itgb5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602126,509,750 - 126,622,528 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936725417,433 - 532,760 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936725417,824 - 530,993 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13135,467,798 - 135,587,473 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113135,468,111 - 135,587,483 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213145,042,442 - 145,111,929 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12255,944,810 - 56,070,605 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2255,944,865 - 56,069,930 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041110,252,879 - 110,375,605 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624731802,854 - 914,167 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624731804,272 - 914,204 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Itgb5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1418,625,201 - 18,742,296 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Itgb5
625 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:136
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000049974
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
AA475909  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21166,830,546 - 66,831,914 (+)MAPPERmRatBN7.2
Rnor_6.01170,058,619 - 70,059,986NCBIRnor6.0
Rnor_5.01173,148,265 - 73,149,632UniSTSRnor5.0
RGSC_v3.41168,644,273 - 68,645,640UniSTSRGSC3.4
Celera1166,281,186 - 66,282,553UniSTS
Cytogenetic Map11q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000049974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1166,829,584 - 66,944,472 (-)Ensembl
Rnor_6.0 Ensembl1170,056,502 - 70,172,164 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1180,333,590 - 80,449,373 (-)Ensembl
mRatBN7.2 Ensembl1166,829,285 - 66,944,472 (-)Ensembl
Rnor_6.0 Ensembl1170,056,500 - 70,172,372 (-)Ensembl
RefSeq Acc Id: NM_147139   ⟹   NP_671480
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,333,588 - 80,449,373 (-)NCBI
mRatBN7.21166,828,428 - 66,944,231 (-)NCBI
Rnor_6.01170,056,500 - 70,172,164 (-)NCBI
Celera1166,279,067 - 66,394,763 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_671480 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077937
  ENSRNOP00000077937.1
RefSeq Acc Id: NP_671480   ⟸   NM_147139
- Peptide Label: precursor
- UniProtKB: A0A8I5ZKE8 (UniProtKB/TrEMBL),   A0A8I6AQL1 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Integrin beta subunit cytoplasmic   Integrin beta subunit tail   Integrin beta subunit VWA   PSI   VWFA

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628869 AgrOrtholog
BioCyc Gene G2FUF-21135 BioCyc
Ensembl Genes ENSRNOG00000001795 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076955 ENTREZGENE
  ENSRNOT00000076955.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
  4.10.1240.30 UniProtKB/TrEMBL
  Cytochrome c1, transmembrane anchor, C-terminal UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  ligand-binding face of the semaphorins, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
InterPro EGF_extracell UniProtKB/TrEMBL
  EGF_integrin_2 UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_beta_N UniProtKB/TrEMBL
  Integrin_bsu UniProtKB/TrEMBL
  Integrin_bsu_cyt_dom UniProtKB/TrEMBL
  Integrin_bsu_tail UniProtKB/TrEMBL
  Integrin_bsu_tail_dom_sf UniProtKB/TrEMBL
  Integrin_bsu_VWA UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report rno:257645 UniProtKB/TrEMBL
NCBI Gene 257645 ENTREZGENE
PANTHER PTHR10082 UniProtKB/TrEMBL
  PTHR10082:SF26 UniProtKB/TrEMBL
Pfam EGF_2 UniProtKB/TrEMBL
  EGF_integrin UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  Integrin_beta UniProtKB/TrEMBL
  PSI_integrin UniProtKB/TrEMBL
PhenoGen Itgb5 PhenoGen
PIRSF Integrin_B UniProtKB/TrEMBL
PRINTS INTEGRINB UniProtKB/TrEMBL
PROSITE I_EGF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001795 RatGTEx
SMART INB UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Plexin repeat UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69687 UniProtKB/TrEMBL
UniProt A0A8I5ZKE8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQL1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itgb5  integrin subunit beta 5  Itgb5  integrin, beta 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-10-22 Itgb5  integrin, beta 5  RGD1563276_predicted  similar to integrin beta-5 (predicted)  Data merged from RGD:1563276 737654 APPROVED
2006-03-07 RGD1563276_predicted  similar to integrin beta-5 (predicted)  LOC498091  similar to integrin beta-5  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498091  similar to integrin beta-5      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Itgb5  integrin, beta 5      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Itgb5  integrin, beta 5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function binds focal adhesion kinase (FAK 1299194
gene_process plays a role in retinal pigment epithelium phagocytosis which is critical for retinal function 1299194