Mfn2 (mitofusin 2) - Rat Genome Database

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Gene: Mfn2 (mitofusin 2) Rattus norvegicus
Analyze
Symbol: Mfn2
Name: mitofusin 2
RGD ID: 628843
Description: Enables several functions, including GTP binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of steroid hormone secretion; regulation of cell development; and regulation of reactive oxygen species biosynthetic process. Located in cytosol and mitochondrial outer membrane. Used to study carotid stenosis. Biomarker of several diseases, including artery disease (multiple); obesity; prediabetes syndrome; steatotic liver disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; Charcot-Marie-Tooth disease type 6; and multiple symmetric lipomatosis. Orthologous to human MFN2 (mitofusin 2); PARTICIPATES IN apoptotic cell death pathway; mitochondria fusion pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HSG; hypertension-related protein; LOC100911485; mitochondrial transmembrane GTPase FZO1A; mitofusin-2; mitofusin-2-like; transmembrane GTPase MFN2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: GeneIDs: 64476 and 100911485 are annotated independently on Rnor_6.0 but may be redundant loci. [09 Feb 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,587,463 - 163,617,363 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5163,587,463 - 163,618,495 (-)EnsemblGRCr8
mRatBN7.25158,304,285 - 158,335,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,304,287 - 158,335,342 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5161,021,313 - 161,050,945 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,848,902 - 162,878,457 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,805,236 - 162,834,795 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,684,244 - 164,715,414 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,684,509 - 164,714,145 (-)Ensemblrn6Rnor6.0
Rnor_5.05168,342,707 - 168,373,926 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45164,951,252 - 164,980,763 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5156,587,853 - 156,617,496 (-)NCBICelera
RGSC_v3.15164,961,175 - 164,992,083 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (IEP)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (ISO)
Auditory Neuropathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy 14  (ISO)
axonal neuropathy  (ISO)
Cardiac Fibrosis  (IEP)
Cardiomegaly  (IEP,ISO)
carotid stenosis  (IMP)
cerebellar ataxia  (ISO)
cerebral palsy  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 1  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth Disease Type 2A2  (ISO)
Charcot-Marie-Tooth disease type 2A2A  (ISO,ISS)
Charcot-Marie-Tooth disease type 2A2B  (ISO)
Charcot-Marie-Tooth disease type 4  (ISO)
Charcot-Marie-Tooth disease type 6  (ISO)
Charcot-Marie-Tooth Disease Type 6A  (ISO)
Charcot-Marie-Tooth Disease, Type 2A  (ISO)
Cicatrix  (ISO)
depressive disorder  (IEP)
Developmental Disabilities  (ISO)
Diabetic Nephropathies  (IEP,IMP,ISO)
diabetic retinopathy  (IEP)
dilated cardiomyopathy  (ISO)
distal myopathy  (ISO)
Dwarfism  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP)
Failure to Thrive  (ISO)
fundus dystrophy  (ISO)
genetic disease  (ISO)
Hyperalgesia  (IEP,ISO)
Hyperpigmentation  (ISO)
hypertension  (IEP)
Insulin Resistance  (IEP)
Liver Reperfusion Injury  (IEP)
Manganese Poisoning  (IEP)
metabolic dysfunction-associated steatotic liver disease  (IEP)
microcephaly  (ISO)
motor peripheral neuropathy  (ISO)
multiple symmetric lipomatosis  (ISO)
multiple system atrophy  (ISO)
myocardial infarction  (IEP)
Myocardial Ischemia  (IEP)
Myocardial Reperfusion Injury  (IEP)
neuropathy  (ISO)
obesity  (IEP,ISO)
optic atrophy  (ISO)
prediabetes syndrome  (IEP)
primary pulmonary hypertension  (ISO)
progressive myoclonus epilepsy 6  (ISO)
Pulmonary Edema of Mountaineers  (IEP)
pulmonary fibrosis  (IEP)
Pulmonary Hypertension, Hypoxia-Induced  (IEP)
retinitis pigmentosa 1  (ISO)
Sarcopenia  (IEP)
Sepsis  (IEP)
Spinal Cord Injuries  (IEP)
steatotic liver disease  (IEP)
transient cerebral ischemia  (IEP)
type 2 diabetes mellitus  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-DAMP(1+)  (EXP)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
A-967079  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alloxan  (EXP)
alpha-D-galactose  (EXP,ISO)
AM-251  (ISO)
amiodarone  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (EXP,ISO)
azide  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
berberine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
Calpeptin  (EXP,ISO)
Candesartan cilexetil  (EXP)
carbon monoxide  (EXP)
carnosic acid  (ISO)
Carnosol  (ISO)
CCCP  (EXP,ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (EXP,ISO)
diclofenac  (EXP)
dihydroxyacetone  (EXP)
diosgenin  (EXP,ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
elemental selenium  (EXP)
enalapril  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
excitatory amino acid agonist  (EXP,ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
ferulic acid  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
galactose  (EXP,ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Rg1  (EXP)
glafenine  (EXP)
glucose  (EXP,ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
Honokiol  (EXP)
hydrogen peroxide  (EXP)
imisopasem manganese  (EXP)
isoliquiritigenin  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
lamivudine  (ISO)
lanthanum trichloride  (EXP)
lenvatinib  (EXP)
linuron  (EXP)
lipoic acid  (ISO)
lovastatin  (ISO)
lycopene  (ISO)
mabuterol  (EXP)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (ISO)
Mitoquinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-hexadecanoylsphingosine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrates  (ISO)
nitrogen dioxide  (ISO)
nobiletin  (ISO)
NSC 23766  (ISO)
okadaic acid  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
phenethyl caffeate  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
poly(guanylic acid)  (EXP)
ponasterone A  (EXP)
potassium dichromate  (EXP)
psoralen  (ISO)
pyrroloquinoline quinone  (EXP,ISO)
reactive oxygen species  (EXP,ISO)
regorafenib  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rotenone  (EXP,ISO)
ruthenium red  (EXP)
Salvianolic acid A  (EXP,ISO)
selenium atom  (EXP)
sevoflurane  (EXP)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (EXP)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trans-cinnamic acid  (EXP)
trans-piceid  (ISO)
tricalcium bis(phosphate)  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
valproic acid  (ISO)
vanillic acid  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aerobic respiration  (IEA,ISO,ISS)
apoptotic process  (IEA)
autophagy  (IEA)
blastocyst formation  (ISO)
camera-type eye morphogenesis  (ISO)
cellular response to dexamethasone stimulus  (IEA,IEP)
cellular response to glucose stimulus  (IEA,IEP)
cellular response to hypoxia  (IEP)
cellular response to ionizing radiation  (IEP)
cellular response to L-glutamate  (IEP)
cellular response to low-density lipoprotein particle stimulus  (IEP)
cellular response to manganese ion  (IEP)
cellular response to mercaptoethanol  (IEP)
cellular response to testosterone stimulus  (IEP)
gonad development  (IEA)
intracellular distribution of mitochondria  (IEA,IMP)
male gonad development  (IEP)
mitochondrial calcium ion homeostasis  (IMP)
mitochondrial fusion  (IBA,IEA,IMP,ISO,ISS)
mitochondrial membrane organization  (IEA,ISO,ISS)
mitochondrion localization  (IBA,IEA,ISO)
mitochondrion organization  (IEA,IMP)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell cycle  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of cell size  (IMP)
negative regulation of cellular process  (IMP)
negative regulation of glial cell proliferation  (IMP)
negative regulation of mitochondrial fission  (IEA,IMP)
negative regulation of Ras protein signal transduction  (IEA,ISO)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
negative regulation of release of cytochrome c from mitochondria  (IMP)
negative regulation of sarcomere organization  (IMP)
negative regulation of smooth muscle cell proliferation  (IDA)
negative regulation of vascular associated smooth muscle cell proliferation  (IMP)
positive regulation of cellular respiration  (IMP)
positive regulation of chromatin binding  (IMP)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of D-glucose import across plasma membrane  (IMP)
positive regulation of dendritic spine morphogenesis  (IEA,IMP)
positive regulation of estradiol secretion  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of hydrogen peroxide biosynthetic process  (IMP)
positive regulation of insulin receptor signaling pathway  (IMP)
positive regulation of mitochondrial membrane potential  (IMP)
positive regulation of ovarian follicle development  (IMP)
positive regulation of progesterone secretion  (IMP)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of vascular associated smooth muscle cell apoptotic process  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
protein localization to phagophore assembly site  (ISO)
protein targeting to mitochondrion  (IEA,ISO,ISS)
response to axon injury  (IEP)
response to cadmium ion  (IEP)
response to calcium ion  (IEA,IEP)
response to D-galactose  (IEP)
response to electrical stimulus  (IEA,IEP)
response to fatty acid  (IEP)
response to flavonoid  (IEA,IEP)
response to hypobaric hypoxia  (IEA,IEP)
response to L-arginine  (IEP)
response to manganese ion  (IEA)
response to muscle activity  (IEA,IEP)
response to nutrient levels  (IEP)
response to testosterone  (IEP)
response to unfolded protein  (IEA)
spermatogenesis  (IEP)
type 2 mitophagy  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Bach D, etal., Diabetes. 2005 Sep;54(9):2685-93.
2. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. Bach D, etal., J Biol Chem. 2003 May 9;278(19):17190-7. Epub 2003 Feb 21.
3. Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension. Batt J, etal., Am J Respir Cell Mol Biol. 2014 Jan;50(1):74-86. doi: 10.1165/rcmb.2012-0506OC.
4. In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Borengasser SJ, etal., Physiol Genomics. 2014 Dec 1;46(23):841-50. doi: 10.1152/physiolgenomics.00059.2014. Epub 2014 Oct 21.
5. Dysregulation of HSG triggers vascular proliferative disorders. Chen KH, etal., Nat Cell Biol 2004 Sep;6(9):872-83. Epub 2004 Aug 22.
6. Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Chen Y, etal., Circ Res. 2011 Dec 9;109(12):1327-31. doi: 10.1161/CIRCRESAHA.111.258723. Epub 2011 Nov 3.
7. Low-dose ionizing radiation induces mitochondrial fusion and increases expression of mitochondrial complexes I and III in hippocampal neurons. Chien L, etal., Oncotarget. 2015 Oct 13;6(31):30628-39. doi: 10.18632/oncotarget.5790.
8. Adaptability to hypobaric hypoxia is facilitated through mitochondrial bioenergetics: an in vivo study. Chitra L and Boopathy R, Br J Pharmacol. 2013 Jul;169(5):1035-47. doi: 10.1111/bph.12179.
9. Mitochondria dynamism: of shape, transport and cell migration. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
10. Response of mitochondrial fusion and fission protein gene expression to exercise in rat skeletal muscle. Ding H, etal., Biochim Biophys Acta. 2010 Mar;1800(3):250-6. doi: 10.1016/j.bbagen.2009.08.007. Epub 2009 Aug 28.
11. Agrin requires specific proteins to selectively activate ¿-aminobutyric acid neurons for pain suppression. Erasso D, etal., Exp Neurol. 2014 Nov;261:646-53. doi: 10.1016/j.expneurol.2014.08.014. Epub 2014 Aug 21.
12. Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion. Eura Y, etal., J Biochem (Tokyo) 2003 Sep;134(3):333-44.
13. Mitofusin 2 Downregulation Triggers Pulmonary Artery Smooth Muscle Cell Proliferation and Apoptosis Imbalance in Rats With Hypoxic Pulmonary Hypertension Via the PI3K/Akt and Mitochondrial Apoptosis Pathways. Fang X, etal., J Cardiovasc Pharmacol. 2016 Feb;67(2):164-74. doi: 10.1097/FJC.0000000000000333.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats. Ge L, etal., Oncotarget. 2017 Mar 3. doi: 10.18632/oncotarget.15876.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Calcium-induced alteration of mitochondrial morphology and mitochondrial-endoplasmic reticulum contacts in rat brown adipocytes. Golic I, etal., Eur J Histochem. 2014 Sep 9;58(3):2377. doi: 10.4081/ejh.2014.2377.
18. Abnormal mitochondrial fusion-fission balance contributes to the progression of experimental sepsis. Gonzalez AS, etal., Free Radic Res. 2014 Jul;48(7):769-83. doi: 10.3109/10715762.2014.906592. Epub 2014 Apr 10.
19. miR-106a promotes cardiac hypertrophy by targeting mitofusin 2. Guan X, etal., J Mol Cell Cardiol. 2016 Oct;99:207-217. doi: 10.1016/j.yjmcc.2016.08.016. Epub 2016 Aug 23.
20. Glucocorticoid modulation of mitochondrial function in hepatoma cells requires the mitochondrial fission protein Drp1. Hernández-Alvarez MI, etal., Antioxid Redox Signal. 2013 Aug 1;19(4):366-78. doi: 10.1089/ars.2011.4269. Epub 2012 Aug 6.
21. Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis. Honda S and Hirose S, Biochem Biophys Res Commun. 2003 Nov 14;311(2):424-32.
22. [The interventional effect of Xuebijing injection on expression of mitochondrial fusion protein 2 and the ultrastructure changes in lung tissues in rats with paraquat poisoning]. Hu M, etal., Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014 Jun;26(6):388-93. doi: 10.3760/cma.j.issn.2095-4352.2014.06.005.
23. Lentivirus vector-mediated mitofusin-2 overexpression in rat ovary changes endocrine function and promotes follicular development in vivo. Hu X, etal., Exp Ther Med. 2014 Sep;8(3):731-736. Epub 2014 Jul 9.
24. Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition. Javadov S, etal., Basic Res Cardiol. 2011 Jan;106(1):99-109. doi: 10.1007/s00395-010-0122-3. Epub 2010 Oct 1.
25. Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis. Kang JW, etal., J Pineal Res. 2016 May;60(4):383-93. doi: 10.1111/jpi.12319. Epub 2016 Mar 7.
26. Effect of electrical stimulation-induced resistance exercise on mitochondrial fission and fusion proteins in rat skeletal muscle. Kitaoka Y, etal., Appl Physiol Nutr Metab. 2015 Nov;40(11):1137-42. doi: 10.1139/apnm-2015-0184. Epub 2015 Jul 14.
27. Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress. Koncsos G, etal., Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H927-H943. doi: 10.1152/ajpheart.00049.2016. Epub 2016 Aug 12.
28. Swimming attenuates d-galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics. Kou X, etal., J Appl Physiol (1985). 2017 Jun 1;122(6):1462-1469. doi: 10.1152/japplphysiol.00018.2017. Epub 2017 Mar 16.
29. Mitofusin-2-mediated tethering of mitochondria and endoplasmic reticulum promotes cell cycle arrest of vascular smooth muscle cells in G0/G1 phase. Li D, etal., Acta Biochim Biophys Sin (Shanghai). 2015 Jun;47(6):441-50. doi: 10.1093/abbs/gmv035. Epub 2015 Apr 29.
30. Tumour necrosis factor-a promotes liver ischaemia-reperfusion injury through the PGC-1a/Mfn2 pathway. Li J, etal., J Cell Mol Med. 2014 Sep;18(9):1863-73. doi: 10.1111/jcmm.12320. Epub 2014 Jun 4.
31. Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. Li R, etal., Chem Res Toxicol. 2015 Mar 16;28(3):408-18. doi: 10.1021/tx5003723. Epub 2015 Jan 16.
32. The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan. Lin KP, etal., PLoS One. 2011;6(12):e29393. doi: 10.1371/journal.pone.0029393. Epub 2011 Dec 19.
33. Effect of breviscapine against hepatic ischemia reperfusion injury. Lin YZ, etal., J Surg Res. 2016 Jun 15;203(2):268-74. doi: 10.1016/j.jss.2016.02.013. Epub 2016 Feb 19.
34. High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria. Lionetti L, etal., PLoS One. 2014 Mar 24;9(3):e92753. doi: 10.1371/journal.pone.0092753. eCollection 2014.
35. Overexpression of mitofusin 2 inhibits reactive astrogliosis proliferation in vitro. Liu T, etal., Neurosci Lett. 2014 Sep 5;579:24-9. doi: 10.1016/j.neulet.2014.07.002. Epub 2014 Jul 11.
36. Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning. Liu W and Zhou C, Psychoneuroendocrinology. 2012 Jul;37(7):1057-70. doi: 10.1016/j.psyneuen.2011.12.003. Epub 2012 Jan 14.
37. Downregulation of Mfn2 participates in manganese-induced neuronal apoptosis in rat striatum and PC12 cells. Liu X, etal., Neurochem Int. 2017 Feb 21. pii: S0197-0186(16)30405-3. doi: 10.1016/j.neuint.2017.02.008.
38. [Changes in mitochondria fusion protein-2 hepatic expression in conditions of liver cirrhosis and acute on chronic liver failure]. Liu X, etal., Zhonghua Gan Zang Bing Za Zhi. 2014 Sep;22(9):671-5. doi: 10.3760/cma.j.issn.1007-3418.2014.09.008.
39. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. Mahdaviani K, etal., EMBO Rep. 2017 Jul;18(7):1123-1138. doi: 10.15252/embr.201643827. Epub 2017 May 24.
40. Dynamin-related protein inhibitor downregulates reactive oxygen species levels to indirectly suppress high glucose-induced hyperproliferation of vascular smooth muscle cells. Maimaitijiang A, etal., Biochem Biophys Res Commun. 2016 Mar 18;471(4):474-8. doi: 10.1016/j.bbrc.2016.02.051. Epub 2016 Feb 20.
41. Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death. Martorell-Riera A, etal., EMBO J. 2014 Oct 16;33(20):2388-407. doi: 10.15252/embj.201488327. Epub 2014 Aug 21.
42. Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3 dependent manner. Meng G, etal., Br J Pharmacol. 2017 May 15. doi: 10.1111/bph.13861.
43. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
44. Mitofusin 2 attenuates the histone acetylation at collagen IV promoter in diabetic nephropathy. Mi X, etal., J Mol Endocrinol. 2016 Nov;57(4):233-249. doi: 10.1530/JME-16-0031.
45. Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney. Nair AR, etal., Arch Toxicol. 2015 Dec;89(12):2273-89. doi: 10.1007/s00204-014-1401-9. Epub 2014 Nov 12.
46. Mitofusin 2 deficiency leads to oxidative stress that contributes to insulin resistance in rat skeletal muscle cells. Nie Q, etal., Mol Biol Rep. 2014 Oct;41(10):6975-83. doi: 10.1007/s11033-014-3584-9. Epub 2014 Jul 18.
47. Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle. O'Leary MF, etal., Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C422-30. doi: 10.1152/ajpcell.00240.2012. Epub 2012 Dec 5.
48. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
49. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
50. Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Parra V, etal., Cardiovasc Res. 2008 Jan 15;77(2):387-97. Epub 2007 Oct 4.
51. Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway. Pennanen C, etal., J Cell Sci. 2014 Jun 15;127(Pt 12):2659-71. doi: 10.1242/jcs.139394. Epub 2014 Apr 28.
52. GOA pipeline RGD automated data pipeline
53. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
54. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
55. Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. Rojo M, etal., J Cell Sci. 2002 Apr 15;115(Pt 8):1663-74.
56. Swimming improves high-fat induced insulin resistance by regulating lipid and energy metabolism and the insulin pathway in rats. Song A, etal., Int J Mol Med. 2014 Jun;33(6):1671-9. doi: 10.3892/ijmm.2014.1738. Epub 2014 Apr 9.
57. Early energy metabolism-related molecular events in skeletal muscle of diabetic rats: The effects of l-arginine and SOD mimic. Stancic A, etal., Chem Biol Interact. 2017 Jun 25;272:188-196. doi: 10.1016/j.cbi.2017.05.003. Epub 2017 May 5.
58. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
59. MicroRNA-214 Mediates Isoproterenol-induced Proliferation and Collagen Synthesis in Cardiac Fibroblasts. Sun M, etal., Sci Rep. 2015 Dec 22;5:18351. doi: 10.1038/srep18351.
60. Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats. Sun W, etal., Neuropharmacology. 2017 Feb;113(Pt A):556-566. doi: 10.1016/j.neuropharm.2016.11.010. Epub 2016 Nov 12.
61. Doxorubicin-induced cardiomyocyte apoptosis: Role of mitofusin 2. Tang H, etal., Int J Biochem Cell Biol. 2017 May 5;88:55-59. doi: 10.1016/j.biocel.2017.05.006.
62. Testosterone replacement attenuates mitochondrial damage in a rat model of myocardial infarction. Wang F, etal., J Endocrinol. 2015 May;225(2):101-11. doi: 10.1530/JOE-14-0638. Epub 2015 Mar 13.
63. MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons. Wang W, etal., J Biol Chem. 2015 Jan 2;290(1):168-82. doi: 10.1074/jbc.M114.617167. Epub 2014 Nov 21.
64. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. Wang X, etal., J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.
65. Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway. Wang Y, etal., Cell Death Dis. 2017 May 18;8(5):e2799. doi: 10.1038/cddis.2017.193.
66. Effects of salvianolic acid B on liver mitochondria of rats with nonalcoholic steatohepatitis. Wang YC, etal., World J Gastroenterol. 2015 Sep 21;21(35):10104-12. doi: 10.3748/wjg.v21.i35.10104.
67. Mitofusin 2 ameliorates aortic remodeling by suppressing ras/raf/ERK pathway and regulating mitochondrial function in vascular smooth muscle cells. Wang Z, etal., Int J Cardiol. 2015 Jan 15;178:165-7. doi: 10.1016/j.ijcard.2014.10.122. Epub 2014 Oct 22.
68. Candesartan cilexetil attenuated cardiac remodeling by improving expression and function of mitofusin 2 in SHR. Wang Z, etal., Int J Cardiol. 2016 Jul 1;214:348-57. doi: 10.1016/j.ijcard.2016.04.007. Epub 2016 Apr 5.
69. Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures. Wappler EA, etal., PLoS One. 2013 May 2;8(5):e63206. doi: 10.1371/journal.pone.0063206. Print 2013.
70. Activation of FoxO1/ PGC-1alpha prevents mitochondrial dysfunction and ameliorates mesangial cell injury in diabetic rats. Wu L, etal., Mol Cell Endocrinol. 2015 Sep 15;413:1-12. doi: 10.1016/j.mce.2015.06.007. Epub 2015 Jun 27.
71. Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor/CaMKKß/AMPK pathway in isoproterenol-induced myocardial ischaemia. Xue RQ, etal., J Cell Mol Med. 2017 Jan;21(1):58-71. doi: 10.1111/jcmm.12938. Epub 2016 Aug 5.
72. Involvement of Charcot-Marie-Tooth disease gene mitofusin 2 expression in paclitaxel-induced mechanical allodynia in rats. Yamashita Y, etal., Neurosci Lett. 2017 Jun 3;653:337-340. doi: 10.1016/j.neulet.2017.05.069.
73. Exogenous H2S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes. Yang F, etal., Am J Physiol Endocrinol Metab. 2017 Mar 1;312(3):E190-E203. doi: 10.1152/ajpendo.00196.2016. Epub 2016 Dec 20.
74. Upregulation of miR-195 accelerates oxidative stress-induced retinal endothelial cell injury by targeting mitofusin 2 in diabetic rats. Zhang R, etal., Mol Cell Endocrinol. 2017 Sep 5;452:33-43. doi: 10.1016/j.mce.2017.05.009. Epub 2017 May 6.
75. Acetyl-L-carnitine ameliorates mitochondrial damage and apoptosis following spinal cord injury in rats. Zhang ZY, etal., Neurosci Lett. 2015 Sep 14;604:18-23. doi: 10.1016/j.neulet.2015.06.021. Epub 2015 Jun 12.
76. [Atorvastatin inhibits cardiomyocyte apoptosis via down-cegulation the expression mitofusin 2 after myocardial ischemia/reperfusion injury in rats]. Zhou W, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Apr;30(4):388-90.
77. [Testosterone suppresses oxidized low-density lipoprotein-induced vascular smooth muscle cell phenotypic transition and proliferation]. Zhou W, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Jun;31(6):775-8.
78. Epigallocatechin-3-gallate ameliorates hypoxia-induced pulmonary vascular remodeling by promoting mitofusin-2-mediated mitochondrial fusion. Zhu TT, etal., Eur J Pharmacol. 2017 Aug 15;809:42-51. doi: 10.1016/j.ejphar.2017.05.003. Epub 2017 May 3.
79. Dihydromyricetin improves physical performance under simulated high altitude. Zou D, etal., Med Sci Sports Exerc. 2014 Nov;46(11):2077-84. doi: 10.1249/MSS.0000000000000336.
80. Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2. Zuchner S, etal., Ann Neurol. 2006 Feb;59(2):276-81.
81. Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Zuchner S, etal., Nat Genet. 2004 May;36(5):449-51. Epub 2004 Apr 4.
Additional References at PubMed
PMID:11181170   PMID:12527753   PMID:12589796   PMID:15899901   PMID:16083859   PMID:16104381   PMID:16936636   PMID:17035996   PMID:17093923   PMID:17499311   PMID:17532093   PMID:17562700  
PMID:17901359   PMID:18614015   PMID:18931719   PMID:19961739   PMID:20303493   PMID:20671748   PMID:20711222   PMID:20871098   PMID:21106870   PMID:21245373   PMID:22282241   PMID:22493254  
PMID:22771393   PMID:23383258   PMID:23455425   PMID:23494933   PMID:23592132   PMID:23620051   PMID:23652351   PMID:23815800   PMID:23921378   PMID:24513856   PMID:26593335   PMID:27640178  
PMID:28013092   PMID:29097872   PMID:29445732   PMID:29762821   PMID:31017259   PMID:31247293   PMID:31295012   PMID:31322244   PMID:31557386   PMID:31829064   PMID:31926268   PMID:32283113  
PMID:32313015   PMID:32416221   PMID:32593899   PMID:33149811   PMID:33347533   PMID:34120306   PMID:35627214   PMID:35962299   PMID:36689810   PMID:36997314   PMID:37193907   PMID:37252276  
PMID:37401731   PMID:37440411   PMID:37579836   PMID:37828353   PMID:39094924  


Genomics

Comparative Map Data
Mfn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,587,463 - 163,617,363 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5163,587,463 - 163,618,495 (-)EnsemblGRCr8
mRatBN7.25158,304,285 - 158,335,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,304,287 - 158,335,342 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5161,021,313 - 161,050,945 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,848,902 - 162,878,457 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,805,236 - 162,834,795 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,684,244 - 164,715,414 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,684,509 - 164,714,145 (-)Ensemblrn6Rnor6.0
Rnor_5.05168,342,707 - 168,373,926 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45164,951,252 - 164,980,763 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5156,587,853 - 156,617,496 (-)NCBICelera
RGSC_v3.15164,961,175 - 164,992,083 (-)NCBI
Cytogenetic Map5q36NCBI
MFN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,980,444 - 12,013,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,980,181 - 12,015,211 (+)Ensemblhg38GRCh38
GRCh37112,040,501 - 12,073,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,962,956 - 11,996,152 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34111,974,634 - 12,007,833NCBI
Celera111,153,903 - 11,187,236 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,195,001 - 11,228,266 (+)NCBIHuRef
CHM1_1112,028,020 - 12,061,326 (+)NCBICHM1_1
T2T-CHM13v2.0111,524,563 - 11,557,644 (+)NCBIT2T-CHM13v2.0
Mfn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394147,958,043 - 147,989,527 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4147,958,056 - 147,989,161 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384147,873,586 - 147,904,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4147,873,599 - 147,904,704 (-)Ensemblmm10GRCm38
MGSCv374147,247,704 - 147,278,928 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364146,717,399 - 146,748,504 (-)NCBIMGSCv36mm8
Celera4150,136,809 - 150,169,620 (-)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.56NCBI
Mfn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554861,937,802 - 1,962,772 (-)Ensembl
ChiLan1.0NW_0049554861,937,873 - 1,962,577 (-)NCBIChiLan1.0ChiLan1.0
MFN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,221,413 - 216,256,365 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,868,444 - 214,903,510 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,729,933 - 10,764,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,945,849 - 11,981,077 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,945,880 - 11,981,077 (+)EnsemblpanPan2panpan1.1
MFN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,284,719 - 84,310,715 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,284,719 - 84,308,225 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha280,817,285 - 80,840,793 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0284,945,233 - 84,971,271 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,940,926 - 84,971,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,694,915 - 81,718,430 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,694,894 - 82,718,409 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,760,479 - 83,784,201 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mfn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,943,043 - 34,970,476 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474767,671 - 796,556 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936474767,754 - 795,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl672,028,499 - 72,056,438 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1672,026,512 - 72,056,439 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,936,375 - 65,955,312 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MFN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,787,700 - 119,818,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,787,370 - 119,816,693 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605423,645,802 - 23,677,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,041,369 - 1,065,023 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248181,041,371 - 1,065,061 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mfn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1112,870,233 - 12,900,603 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mfn2
102 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:427
Count of miRNA genes:175
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000055680, ENSRNOT00000065985
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
RH128167  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,305,395 - 158,305,597 (+)MAPPERmRatBN7.2
Rnor_6.05164,685,355 - 164,685,556NCBIRnor6.0
Rnor_6.05164,561,548 - 164,561,749NCBIRnor6.0
Rnor_5.05168,343,818 - 168,344,019UniSTSRnor5.0
Rnor_5.05168,228,411 - 168,228,612UniSTSRnor5.0
RGSC_v3.45164,952,099 - 164,952,300UniSTSRGSC3.4
Celera5156,588,700 - 156,588,901UniSTS
RH 3.4 Map51089.21UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_130894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB084165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC097784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U41803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000055680   ⟹   ENSRNOP00000052539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5163,587,463 - 163,618,495 (-)Ensembl
mRatBN7.2 Ensembl5158,304,287 - 158,335,342 (-)Ensembl
Rnor_6.0 Ensembl5164,684,509 - 164,714,145 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091132   ⟹   ENSRNOP00000070746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5164,685,956 - 164,709,441 (-)Ensembl
RefSeq Acc Id: NM_130894   ⟹   NP_570964
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,587,727 - 163,617,363 (-)NCBI
mRatBN7.25158,304,549 - 158,334,190 (-)NCBI
Rnor_6.05164,684,508 - 164,714,145 (-)NCBI
Rnor_5.05168,342,707 - 168,373,926 (-)NCBI
RGSC_v3.45164,951,252 - 164,980,763 (-)RGD
Celera5156,587,853 - 156,617,496 (-)RGD
Sequence:
RefSeq Acc Id: XM_008764288   ⟹   XP_008762510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,587,463 - 163,617,360 (-)NCBI
mRatBN7.25158,304,285 - 158,335,457 (-)NCBI
Rnor_6.05164,684,244 - 164,715,414 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063288356   ⟹   XP_063144426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,587,463 - 163,617,357 (-)NCBI
RefSeq Acc Id: NP_570964   ⟸   NM_130894
- UniProtKB: Q8R500 (UniProtKB/Swiss-Prot),   O09013 (UniProtKB/Swiss-Prot),   Q6IRL2 (UniProtKB/TrEMBL),   D4A9N3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762510   ⟸   XM_008764288
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000052539   ⟸   ENSRNOT00000055680
Ensembl Acc Id: ENSRNOP00000070746   ⟸   ENSRNOT00000091132
RefSeq Acc Id: XP_063144426   ⟸   XM_063288356
- Peptide Label: isoform X1
Protein Domains
Dynamin-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R500-F1-model_v2 AlphaFold Q8R500 1-757 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694250
Promoter ID:EPDNEW_R4775
Type:single initiation site
Name:LOC100911485_1
Description:mitofusin-2-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05164,714,147 - 164,714,207EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628843 AgrOrtholog
BioCyc Gene G2FUF-39205 BioCyc
Ensembl Genes ENSRNOG00000046424 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000055680 ENTREZGENE
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096620 IMAGE-MGC_LOAD
InterPro Dynamin_N UniProtKB/Swiss-Prot
  Fzo/mitofusin_HR2 UniProtKB/Swiss-Prot
  G_DYNAMIN_dom UniProtKB/Swiss-Prot
  Mitofusin_fam UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
MGC_CLONE MGC:91421 IMAGE-MGC_LOAD
NCBI Gene 64476 ENTREZGENE
PANTHER PTHR10465 UniProtKB/Swiss-Prot
  PTHR10465:SF1 UniProtKB/Swiss-Prot
Pfam Dynamin_N UniProtKB/Swiss-Prot
  Fzo_mitofusin UniProtKB/Swiss-Prot
PhenoGen Mfn2 PhenoGen
PROSITE G_DYNAMIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046424 RatGTEx
Superfamily-SCOP Fzo-like conserved region UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8J8XEU2_RAT UniProtKB/TrEMBL
  A6IU33_RAT UniProtKB/TrEMBL
  D4A9N3 ENTREZGENE
  MFN2_RAT UniProtKB/Swiss-Prot
  O09013 ENTREZGENE
  Q6IRL2 ENTREZGENE, UniProtKB/TrEMBL
  Q8R500 ENTREZGENE
UniProt Secondary O09013 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mfn2  mitofusin 2  LOC100911485  mitofusin-2-like  Data merged from RGD:6492845 737654 PROVISIONAL
2012-07-05 LOC100911485  mitofusin-2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Mfn2  mitofusin 2      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Mfn2  mitofusin 2      Symbol and Name status set to provisional 70820 PROVISIONAL