RGD Reference Report - Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity.

Authors: Bach, D  Pich, S  Soriano, FX  Vega, N  Baumgartner, B  Oriola, J  Daugaard, JR  Lloberas, J  Camps, M  Zierath, JR  Rabasa-Lhoret, R  Wallberg-Henriksson, H  Laville, M  Palacin, M  Vidal, H  Rivera, F  Brand, M  Zorzano, A 
Citation: Bach D, etal., J Biol Chem. 2003 May 9;278(19):17190-7. Epub 2003 Feb 21.
RGD ID: 1601412
Pubmed: PMID:12598526   (View Abstract at PubMed)
DOI: DOI:10.1074/jbc.M212754200   (Journal Full-text)

In many cells and specially in muscle, mitochondria form elongated filaments or a branched reticulum. We show that Mfn2 (mitofusin 2), a mitochondrial membrane protein that participates in mitochondrial fusion in mammalian cells, is induced during myogenesis and contributes to the maintenance and operation of the mitochondrial network. Repression of Mfn2 caused morphological and functional fragmentation of the mitochondrial network into independent clusters. Concomitantly, repression of Mfn2 reduced glucose oxidation, mitochondrial membrane potential, cell respiration, and mitochondrial proton leak. We also show that the Mfn2-dependent mechanism of mitochondrial control is disturbed in obesity by reduced Mfn2 expression. In all, our data indicate that Mfn2 expression is crucial in mitochondrial metabolism through the maintenance of the mitochondrial network architecture, and reduced Mfn2 expression may explain some of the metabolic alterations associated with obesity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MFN2Humanobesity  IEP mRNA:decreased expression:skeletal muscle tissue (human)RGD 
Mfn2Ratobesity  ISOMFN2 (Homo sapiens)mRNA:decreased expression:skeletal muscle tissue (human)RGD 
Mfn2Mouseobesity  ISOMFN2 (Homo sapiens)mRNA:decreased expression:skeletal muscle tissue (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mfn2  (mitofusin 2)

Genes (Mus musculus)
Mfn2  (mitofusin 2)

Genes (Homo sapiens)
MFN2  (mitofusin 2)


Additional Information