Tnfsf10 (TNF superfamily member 10) - Rat Genome Database

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Gene: Tnfsf10 (TNF superfamily member 10) Rattus norvegicus
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Symbol: Tnfsf10
Name: TNF superfamily member 10
RGD ID: 628734
Description: Predicted to enable several functions, including TRAIL binding activity; signaling receptor binding activity; and zinc ion binding activity. Involved in male gonad development; positive regulation of apoptotic process; and response to insulin. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Biomarker of osteoarthritis and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF superfamily member 10); PARTICIPATES IN Trail mediated signaling pathway; apoptotic cell death pathway; cytokine mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Tnlg6a; Trail; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor ligand 6a; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82112,136,550 - 112,155,903 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.22110,199,835 - 110,227,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,207,916 - 110,225,135 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2116,863,492 - 116,880,479 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02114,976,052 - 114,993,034 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02109,691,219 - 109,708,034 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,008,008 - 113,026,899 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,007,549 - 113,026,899 (+)Ensemblrn6Rnor6.0
Rnor_5.02132,726,333 - 132,742,550 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42113,204,303 - 113,221,550 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2105,412,626 - 105,429,375 (+)NCBICelera
RGSC_v3.12113,149,265 - 113,166,510 (+)NCBI
Cytogenetic Map2q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-matairesinol  (ISO)
(R)-lipoic acid  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
alvocidib  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
Auriculasin  (ISO)
Azoxymethane  (EXP)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bepridil  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
bromoacetate  (ISO)
bufalin  (ISO)
Bufotalin  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
carmustine  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
chlorotoluron  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
chrysene  (ISO)
chrysin  (ISO)
cibenzoline  (ISO)
cisplatin  (EXP,ISO)
cocaine  (EXP)
coformycin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dabrafenib  (ISO)
dacarbazine  (ISO)
daunorubicin  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (ISO)
dicrotophos  (ISO)
dicyclanil  (ISO)
diethylstilbestrol  (ISO)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enniatin  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenoldopam  (EXP)
flavonoids  (EXP)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
furosemide  (EXP)
Fusarenone X  (ISO)
gadolinium trichloride  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gingerol  (ISO)
glucose  (ISO)
Glutathione ethyl ester  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
Ilimaquinone  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflurane  (EXP)
isoprenaline  (EXP)
isotretinoin  (ISO)
ketoconazole  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lenvatinib  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
Maduramicin  (EXP)
masoprocol  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methyltestosterone  (ISO)
mevalonic acid  (ISO)
mifepristone  (ISO)
mithramycin  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morphine  (ISO)
Myrtucommulone A  (ISO)
N,N-dimethylformamide  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naled  (ISO)
naproxen  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
NS-398  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
orlistat  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
Protolichesterinic acid  (ISO)
pyrethrins  (ISO)
quartz  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
reactive nitrogen species  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
ribavirin  (ISO)
riddelliine  (EXP)
rifampicin  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SM-164  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
styrene  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sumatriptan  (EXP)
Sunset Yellow FCF  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tranilast  (EXP)
triclosan  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
venom  (ISO)
Vernodalol  (ISO)
Vicanicin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. [Effects of valsartan, mycophenolate mofetil and their combined application on TRAIL and nuclear factor-kappaB expression in the kidneys of diabetic rats] Chen B, etal., Zhonghua Yi Xue Za Zhi. 2008 Feb 26;88(8):540-5.
2. Insulin down-regulates TRAIL expression in vascular smooth muscle cells both in vivo and in vitro. Corallini F, etal., J Cell Physiol. 2007 Jul;212(1):89-95.
3. Adenovirus-Mediated TRAIL Gene (Ad5hTRAIL) Delivery into Pancreatic Islets Prolongs Normoglycemia in Streptozotocin-Induced Diabetic Rats. Dirice E, etal., Hum Gene Ther. 2009 Aug 21.
4. TRAIL signalling: decisions between life and death. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Expression of tumor necrosis factor-alpha-related apoptosis-inducing ligand and its receptors in rat testis during development. Grataroli R, etal., Biol Reprod 2002 Jun;66(6):1707-15.
7. Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. Lamhamedi-Cherradi SE, etal., Nat Immunol. 2003 Mar;4(3):255-60. Epub 2003 Feb 10.
8. TRAIL induces apoptosis of chondrocytes and influences the pathogenesis of experimentally induced rat osteoarthritis. Lee SW, etal., Arthritis Rheum. 2004 Feb;50(2):534-42.
9. The death ligand TRAIL in diabetic nephropathy. Lorz C, etal., J Am Soc Nephrol. 2008 May;19(5):904-14. Epub 2008 Feb 20.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Blockade of tumor necrosis factor-related apoptosis-inducing ligand exacerbates type 1 diabetes in NOD mice. Mi QS, etal., Diabetes. 2003 Aug;52(8):1967-75.
12. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Increased expression of TRAIL and its receptors on peripheral T-cells in type 1 diabetic patients. Salehi E, etal., Iran J Immunol. 2007 Dec;4(4):197-205.
20. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Secchiero P, etal., Circulation. 2006 Oct 3;114(14):1522-30. Epub 2006 Sep 25.
21. Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis. Tang X, etal., Life Sci. 2009 Apr 10;84(15-16):552-7.
22. [Therapeutic effects of recombinant mutant human tumor necrosis factor-related apoptosis-inducing ligand on non-small lung cell cancer: an experimental with rats] Tang YM, etal., Zhonghua Yi Xue Za Zhi. 2005 Aug 3;85(29):2021-5.
23. Apoptosis and expression of protein TRAIL in granulosa cells of rats with polycystic ovarian syndrome. Zhang J, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Jun;27(3):311-4.
Additional References at PubMed
PMID:12466268   PMID:12573821   PMID:12761501   PMID:15632112   PMID:16178278   PMID:17627577   PMID:18362891   PMID:19199708   PMID:20097879   PMID:21459798   PMID:21525171   PMID:22266862  
PMID:22286051   PMID:22520731   PMID:23274391   PMID:24097299   PMID:25032854   PMID:26333348   PMID:26457518   PMID:26646413   PMID:26802603   PMID:28073079   PMID:28392572   PMID:29484366  
PMID:29635023   PMID:33875613   PMID:36344842  


Genomics

Comparative Map Data
Tnfsf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82112,136,550 - 112,155,903 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.22110,199,835 - 110,227,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,207,916 - 110,225,135 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2116,863,492 - 116,880,479 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02114,976,052 - 114,993,034 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02109,691,219 - 109,708,034 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,008,008 - 113,026,899 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,007,549 - 113,026,899 (+)Ensemblrn6Rnor6.0
Rnor_5.02132,726,333 - 132,742,550 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42113,204,303 - 113,221,550 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2105,412,626 - 105,429,375 (+)NCBICelera
RGSC_v3.12113,149,265 - 113,166,510 (+)NCBI
Cytogenetic Map2q24NCBI
TNFSF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383172,505,508 - 172,523,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3172,505,508 - 172,523,476 (-)Ensemblhg38GRCh38
GRCh373172,223,298 - 172,241,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,706,158 - 173,723,963 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343173,706,166 - 173,723,971NCBI
Celera3170,621,889 - 170,639,888 (-)NCBICelera
Cytogenetic Map3q26.31NCBI
HuRef3169,593,908 - 169,611,904 (-)NCBIHuRef
CHM1_13172,186,184 - 172,204,170 (-)NCBICHM1_1
T2T-CHM13v2.03175,290,584 - 175,308,501 (-)NCBIT2T-CHM13v2.0
Tnfsf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39327,371,226 - 27,393,814 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl327,371,177 - 27,396,576 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38327,317,077 - 27,339,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,317,028 - 27,342,427 (+)Ensemblmm10GRCm38
MGSCv37327,215,999 - 27,238,587 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36327,508,150 - 27,530,738 (+)NCBIMGSCv36mm8
Celera327,279,765 - 27,300,536 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map310.82NCBI
Tnfsf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554202,549,142 - 2,566,564 (-)Ensembl
ChiLan1.0NW_0049554202,550,392 - 2,566,448 (-)NCBIChiLan1.0ChiLan1.0
TNFSF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22170,387,678 - 170,406,039 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13170,392,401 - 170,410,764 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03169,512,491 - 169,530,706 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13177,693,860 - 177,712,137 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3177,694,021 - 177,712,137 (-)EnsemblpanPan2panpan1.1
TNFSF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13436,719,249 - 36,734,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3436,670,849 - 36,735,060 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3445,731,787 - 45,747,520 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03436,803,929 - 36,819,723 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3436,802,389 - 36,820,029 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13436,742,701 - 36,758,427 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03436,711,390 - 36,727,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03436,969,308 - 36,985,009 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tnfsf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602103,391,320 - 103,422,437 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936593212,532 - 230,651 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936593212,642 - 230,645 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFSF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13110,983,298 - 111,038,324 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113111,021,952 - 111,103,060 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213119,874,763 - 119,882,251 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNFSF10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11516,934,982 - 16,953,155 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1516,934,962 - 16,954,860 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606325,697,846 - 25,715,823 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfsf10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473050,531,915 - 50,550,528 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473050,534,284 - 50,550,279 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tnfsf10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13127,369,263 - 127,385,999 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tnfsf10
126 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:26
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000017758
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 57 134 87 86 55 91 55 6 341 181 11 112 81 89 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000017758   ⟹   ENSRNOP00000017758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2113,007,549 - 113,026,899 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118000   ⟹   ENSRNOP00000082857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2110,207,916 - 110,225,135 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119330   ⟹   ENSRNOP00000076967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2110,207,916 - 110,225,135 (+)Ensembl
RefSeq Acc Id: NM_145681   ⟹   NP_663714
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82112,136,939 - 112,153,806 (+)NCBI
mRatBN7.22110,208,263 - 110,225,135 (+)NCBI
Rnor_6.02113,008,324 - 113,024,795 (+)NCBI
Rnor_5.02132,726,333 - 132,742,550 (+)NCBI
RGSC_v3.42113,204,303 - 113,221,550 (+)RGD
Celera2105,412,626 - 105,429,375 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590632   ⟹   XP_017446121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82112,136,573 - 112,155,903 (+)NCBI
mRatBN7.22110,207,899 - 110,227,239 (+)NCBI
Rnor_6.02113,008,008 - 113,026,899 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063281308   ⟹   XP_063137378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82112,136,550 - 112,149,640 (+)NCBI
RefSeq Acc Id: NP_663714   ⟸   NM_145681
- UniProtKB: A6IHG6 (UniProtKB/TrEMBL),   A0A0U5J7B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446121   ⟸   XM_017590632
- Peptide Label: isoform X1
- UniProtKB: A0A0U5J7B5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017758   ⟸   ENSRNOT00000017758
Ensembl Acc Id: ENSRNOP00000082857   ⟸   ENSRNOT00000118000
Ensembl Acc Id: ENSRNOP00000076967   ⟸   ENSRNOT00000119330
RefSeq Acc Id: XP_063137378   ⟸   XM_063281308
- Peptide Label: isoform X2
Protein Domains
THD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PU84-F1-model_v2 AlphaFold E9PU84 1-291 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628734 AgrOrtholog
BioCyc Gene G2FUF-53508 BioCyc
Ensembl Genes ENSRNOG00000013269 Ensembl
  ENSRNOG00000067968 Ensembl
  ENSRNOG00000086118 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000127790.1 UniProtKB/TrEMBL
  ENSRNOT00000163193.1 UniProtKB/TrEMBL
  ENSRNOT00000173891 ENTREZGENE
  ENSRNOT00000173891.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro TNF_CS UniProtKB/TrEMBL
  TNF_family UniProtKB/TrEMBL
  TNF_ligand_10/11 UniProtKB/TrEMBL
  Tumour_necrosis_fac-like UniProtKB/TrEMBL
KEGG Report rno:246775 UniProtKB/TrEMBL
NCBI Gene 246775 ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR FAMILY MEMBER UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10 UniProtKB/TrEMBL
Pfam TNF UniProtKB/TrEMBL
PhenoGen Tnfsf10 PhenoGen
PIRSF TNF10_TNF11 UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/TrEMBL
  TNF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013269 RatGTEx
  ENSRNOG00000067968 RatGTEx
  ENSRNOG00000086118 RatGTEx
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt A0A0U5J7B5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LGW2_RAT UniProtKB/TrEMBL
  A0ABK0LPN8_RAT UniProtKB/TrEMBL
  A0ABK0M1M7_RAT UniProtKB/TrEMBL
  A6IHG6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 Tnfsf10  TNF superfamily member 10  Tnfsf10  tumor necrosis factor superfamily member 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-25 Tnfsf10  tumor necrosis factor superfamily member 10  Tnfsf10  tumor necrosis factor (ligand) superfamily, member 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tnfsf10  tumor necrosis factor (ligand) superfamily, member 10      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Tnfsf10  tumor necrosis factor (ligand) superfamily, member 10      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in testis during development; present in the different germ cell types but its receptors predominantly found in the postmeiotic germ cells 634235