RGD Reference Report - Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. - Rat Genome Database

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Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice.

Authors: Lamhamedi-Cherradi, SE  Zheng, SJ  Maguschak, KA  Peschon, J  Chen, YH 
Citation: Lamhamedi-Cherradi SE, etal., Nat Immunol. 2003 Mar;4(3):255-60. Epub 2003 Feb 10.
RGD ID: 2312744
Pubmed: PMID:12577054   (View Abstract at PubMed)
DOI: DOI:10.1038/ni894   (Journal Full-text)

TRAIL, the tumor necrosis factor-related apoptosis-inducing ligand, selectively induces apoptosis of tumor cells, but not most normal cells. Its role in normal, nontransformed tissues is not clear. We report here that mice deficient in TRAIL have a severe defect in thymocyte apoptosis-thus, thymic deletion induced by T cell receptor ligation is severely impaired. TRAIL-deficient mice are also hypersensitive to collagen-induced arthritis and streptozotocin-induced diabetes and develop heightened autoimmune responses. Thus, TRAIL mediates thymocyte apoptosis and is important in the induction of autoimmune diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOTnfsf10 (Mus musculus)2312744; 2312744 RGD 
Experimental Diabetes Mellitus  IAGP 2312744 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnfsf10  (TNF superfamily member 10)

Genes (Mus musculus)
Tnfsf10  (tumor necrosis factor (ligand) superfamily, member 10)

Genes (Homo sapiens)
TNFSF10  (TNF superfamily member 10)


Additional Information