Cyp3a18 (cytochrome P450, family 3, subfamily a, polypeptide 18) - Rat Genome Database

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Gene: Cyp3a18 (cytochrome P450, family 3, subfamily a, polypeptide 18) Rattus norvegicus
Analyze
Symbol: Cyp3a18
Name: cytochrome P450, family 3, subfamily a, polypeptide 18
RGD ID: 628709
Description: Enables testosterone 16-alpha-hydroxylase activity and testosterone 6-beta-hydroxylase activity. Predicted to be involved in oxidative demethylation and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP3A43 (cytochrome P450 family 3 subfamily A member 43); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; linoleic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CYPIIIA18; cytochrome P450 3A18; cytochrome P450(6)beta-2; cytochrome P450, 3a18; P450(6)beta-2
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,994,312 - 14,044,185 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1213,994,311 - 14,045,788 (+)EnsemblGRCr8
mRatBN7.2128,880,509 - 8,930,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,880,528 - 8,930,381 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx129,678,389 - 9,728,392 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,301,584 - 10,351,575 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,325,028 - 9,375,015 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01210,636,294 - 10,684,273 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1210,636,275 - 10,684,278 (+)Ensemblrn6Rnor6.0
Rnor_5.01212,738,271 - 12,787,784 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4129,086,752 - 9,136,606 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1210,707,212 - 10,757,562 (+)NCBICelera
RGSC_v3.1129,116,679 - 9,166,534 (-)NCBI
Cytogenetic Map12p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP)
bosentan  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
dexamethasone  (EXP)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diuron  (EXP)
endosulfan  (EXP)
ethoxyquin  (EXP)
fipronil  (EXP,ISO)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
furan  (EXP)
Ginkgolide A  (EXP)
glafenine  (EXP)
methapyrilene  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
obeticholic acid  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
riddelliine  (EXP)
rotenone  (EXP)
senecionine  (ISO)
tebuconazole  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
triadimefon  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP)
verapamil  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations. Nagata K, etal., Pharmacogenetics 1996 Feb;6(1):103-11.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. A novel CYP3 gene from female rats. Strotkamp D, etal., Biochim Biophys Acta 1995 Feb 21;1260(3):341-4.
Additional References at PubMed
PMID:3259858   PMID:14559847   PMID:15039299   PMID:15256616   PMID:15327587   PMID:15546903   PMID:15680923   PMID:16401082   PMID:18356043   PMID:18446064   PMID:18619574   PMID:19219744  


Genomics

Comparative Map Data
Cyp3a18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,994,312 - 14,044,185 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1213,994,311 - 14,045,788 (+)EnsemblGRCr8
mRatBN7.2128,880,509 - 8,930,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,880,528 - 8,930,381 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx129,678,389 - 9,728,392 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,301,584 - 10,351,575 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,325,028 - 9,375,015 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01210,636,294 - 10,684,273 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1210,636,275 - 10,684,278 (+)Ensemblrn6Rnor6.0
Rnor_5.01212,738,271 - 12,787,784 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4129,086,752 - 9,136,606 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1210,707,212 - 10,757,562 (+)NCBICelera
RGSC_v3.1129,116,679 - 9,166,534 (-)NCBI
Cytogenetic Map12p11NCBI
CYP3A43
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,828,013 - 99,866,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,827,922 - 99,867,305 (+)Ensemblhg38GRCh38
GRCh37799,425,636 - 99,463,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,263,572 - 99,302,109 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34799,070,286 - 99,108,824NCBI
Celera794,159,885 - 94,198,421 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,061,564 - 94,099,614 (+)NCBIHuRef
CHM1_1799,355,683 - 99,393,889 (+)NCBICHM1_1
T2T-CHM13v2.07101,067,527 - 101,105,595 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,785,456 - 98,823,546 (+)NCBI
CYP3A43
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26117,746,741 - 117,785,619 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,011,375 - 166,050,250 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0791,862,437 - 91,903,033 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,296,111 - 105,335,958 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,296,111 - 105,335,958 (+)EnsemblpanPan2panpan1.1
CYP3A43
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,217,123 - 13,256,859 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2813,216,548 - 13,257,015 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660703,012,292 - 3,052,631 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cyp3a18
312 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000001285
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)121186960016966542Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
16 5 23 28 74 76 53 14 53 3 147 50 15 23 37 23

Sequence


Ensembl Acc Id: ENSRNOT00000001285   ⟹   ENSRNOP00000001285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1213,994,312 - 14,045,788 (+)Ensembl
mRatBN7.2 Ensembl128,880,528 - 8,930,381 (+)Ensembl
Rnor_6.0 Ensembl1210,636,275 - 10,684,276 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075671   ⟹   ENSRNOP00000065082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1210,636,275 - 10,684,278 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107940   ⟹   ENSRNOP00000077873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1213,994,311 - 14,025,161 (+)Ensembl
mRatBN7.2 Ensembl128,880,528 - 8,911,358 (+)Ensembl
RefSeq Acc Id: NM_145782   ⟹   NP_665725
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,994,312 - 14,044,184 (+)NCBI
mRatBN7.2128,880,509 - 8,930,381 (+)NCBI
Rnor_6.01210,636,294 - 10,684,273 (+)NCBI
Rnor_5.01212,738,271 - 12,787,784 (+)NCBI
RGSC_v3.4129,086,752 - 9,136,606 (-)RGD
Celera1210,707,212 - 10,757,562 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089108   ⟹   XP_038945036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,017,103 - 14,044,185 (+)NCBI
mRatBN7.2128,903,304 - 8,930,382 (+)NCBI
Protein Sequences
Protein RefSeqs NP_665725 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945036 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA22526 (Get FASTA)   NCBI Sequence Viewer  
  BAC98809 (Get FASTA)   NCBI Sequence Viewer  
  CAA56312 (Get FASTA)   NCBI Sequence Viewer  
  EDL89594 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001285
GenBank Protein Q64581 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_665725   ⟸   NM_145782
- UniProtKB: Q64581 (UniProtKB/Swiss-Prot),   G3V635 (UniProtKB/TrEMBL),   A6K1D6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065082   ⟸   ENSRNOT00000075671
Ensembl Acc Id: ENSRNOP00000001285   ⟸   ENSRNOT00000001285
RefSeq Acc Id: XP_038945036   ⟸   XM_039089108
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000077873   ⟸   ENSRNOT00000107940

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64581-F1-model_v2 AlphaFold Q64581 1-497 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698409
Promoter ID:EPDNEW_R8934
Type:single initiation site
Name:Cyp3a18_1
Description:cytochrome P450, family 3, subfamily a, polypeptide 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01210,636,275 - 10,636,335EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628709 AgrOrtholog
BioCyc Gene G2FUF-20073 BioCyc
Ensembl Genes ENSRNOG00000000969 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001285 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_3A UniProtKB/Swiss-Prot
KEGG Report rno:252931 UniProtKB/Swiss-Prot
NCBI Gene 252931 ENTREZGENE
PANTHER CYTOCHROME P450 3A25-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 3 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP3A43 RGD
PhenoGen Cyp3a18 PhenoGen
PRINTS EP450II UniProtKB/Swiss-Prot
  EP450IICYP3A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000969 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A8I5YC28_RAT UniProtKB/TrEMBL
  A6K1D6 ENTREZGENE, UniProtKB/TrEMBL
  CP3AI_RAT UniProtKB/Swiss-Prot
  G3V635 ENTREZGENE, UniProtKB/TrEMBL
  Q64581 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp3a18  cytochrome P450, family 3, subfamily a, polypeptide 18  Cyp3a18  cytochrome P450, 3a18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-02-27 Cyp3a18  cytochrome P450, 3a18      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is male-dominant 727620