Aldh1a3 (aldehyde dehydrogenase 1 family, member A3) - Rat Genome Database

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Gene: Aldh1a3 (aldehyde dehydrogenase 1 family, member A3) Rattus norvegicus
Analyze
Symbol: Aldh1a3
Name: aldehyde dehydrogenase 1 family, member A3
RGD ID: 628662
Description: Enables aldehyde dehydrogenase [NAD(P)+] activity. Involved in several processes, including kidney development; pituitary gland development; and retinoic acid biosynthetic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in isolated microphthalmia 8. Orthologous to human ALDH1A3 (aldehyde dehydrogenase 1 family member A3); PARTICIPATES IN retinoic acid metabolic pathway; beta-alanine metabolic pathway; gluconeogenesis pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde dehydrogenase 6; aldehyde dehydrogenase family 1 member A3; aldehyde dehydrogenase family 1, subfamily A3; Aldh6; RALDH-3; ralDH3; retinaldehyde dehydrogenase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,392,516 - 129,436,552 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1129,392,516 - 129,427,777 (-)EnsemblGRCr8
mRatBN7.21119,982,272 - 120,017,416 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1119,982,277 - 120,017,436 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1127,975,926 - 128,009,224 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,147,379 - 135,180,677 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,957,727 - 127,991,000 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01127,302,920 - 127,337,828 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,301,128 - 127,337,882 (-)Ensemblrn6Rnor6.0
Rnor_5.01128,382,914 - 128,415,160 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41120,847,746 - 120,881,883 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1112,188,129 - 112,221,404 (-)NCBICelera
RGSC_v3.11120,926,088 - 120,960,226 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dichloroaniline  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Bisphenol Z  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
Erionite  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (EXP)
furfural  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
graphite  (EXP)
hypochlorous acid  (ISO)
ifosfamide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (EXP,ISO)
isoflavones  (ISO)
L-methionine  (ISO)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-nitrosodiethylamine  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
okadaic acid  (ISO)
omeprazole  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
picene  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
Tanshinone I  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
thapsigargin  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA,ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat. Everts HB, etal., Exp Cell Res. 2005 Aug 15;308(2):309-19.
2. Expression of retinaldehyde dehydrogenase (RALDH)2 and RALDH3 but not RALDH1 in the developing anterior pituitary glands of rats. Fujiwara K, etal., Cell Tissue Res. 2007 Apr;328(1):129-35. Epub 2006 Dec 19.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Expression of retinoic acid-synthesizing and -metabolizing enzymes during nephrogenesis in the rat. Marlier A and Gilbert T, Gene Expr Patterns. 2004 Dec;5(2):179-85.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Phenobarbital inducibility and differences in protein expression of an animal model. Pappas P, etal., Chem Biol Interact 2001 Jan 30;130-132(1-3):275-83.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. Wang C, etal., J Biol Chem. 2011 Feb 25;286(8):6542-53. Epub 2010 Dec 7.
Additional References at PubMed
PMID:11013254   PMID:11044606   PMID:11585737   PMID:12390888   PMID:12477932   PMID:14623956   PMID:15465500   PMID:16207763   PMID:16241904   PMID:16611695   PMID:16615129   PMID:17184764  
PMID:17207476   PMID:23533145   PMID:23536097   PMID:27759097  


Genomics

Comparative Map Data
Aldh1a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,392,516 - 129,436,552 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1129,392,516 - 129,427,777 (-)EnsemblGRCr8
mRatBN7.21119,982,272 - 120,017,416 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1119,982,277 - 120,017,436 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1127,975,926 - 128,009,224 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,147,379 - 135,180,677 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,957,727 - 127,991,000 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01127,302,920 - 127,337,828 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,301,128 - 127,337,882 (-)Ensemblrn6Rnor6.0
Rnor_5.01128,382,914 - 128,415,160 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41120,847,746 - 120,881,883 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1112,188,129 - 112,221,404 (-)NCBICelera
RGSC_v3.11120,926,088 - 120,960,226 (-)NCBI
Cytogenetic Map1q22NCBI
ALDH1A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3815100,879,831 - 100,916,626 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl15100,861,924 - 100,916,628 (+)Ensemblhg38GRCh38
GRCh3715101,420,036 - 101,456,831 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361599,237,532 - 99,274,354 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341599,237,583 - 99,274,352NCBI
Celera1577,832,935 - 77,870,170 (+)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1577,542,416 - 77,578,726 (+)NCBIHuRef
CHM1_115101,260,984 - 101,297,814 (+)NCBICHM1_1
T2T-CHM13v2.01598,634,889 - 98,671,163 (+)NCBIT2T-CHM13v2.0
Aldh1a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39766,040,640 - 66,077,225 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl766,040,638 - 66,077,265 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38766,390,892 - 66,427,477 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl766,390,890 - 66,427,517 (-)Ensemblmm10GRCm38
MGSCv37773,535,778 - 73,572,363 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36766,269,842 - 66,313,378 (-)NCBIMGSCv36mm8
Celera763,845,586 - 63,882,073 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map735.73NCBI
Aldh1a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541627,823,611 - 27,858,173 (+)Ensembl
ChiLan1.0NW_00495541627,823,611 - 27,858,112 (+)NCBIChiLan1.0ChiLan1.0
ALDH1A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21690,469,977 - 90,506,962 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11594,170,122 - 94,207,128 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01579,603,893 - 79,640,866 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11598,891,776 - 98,928,286 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1598,891,770 - 98,928,396 (+)EnsemblpanPan2panpan1.1
ALDH1A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1340,130,904 - 40,168,686 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl340,132,726 - 40,168,664 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha342,820,112 - 42,857,782 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0340,522,454 - 40,560,130 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl340,522,340 - 40,560,113 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1340,054,895 - 40,092,579 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0340,292,280 - 40,329,945 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0340,494,117 - 40,531,822 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aldh1a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640143,367,150 - 143,403,705 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364832,930,789 - 2,967,346 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364832,930,781 - 2,967,309 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1139,451,049 - 139,491,511 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11139,451,080 - 139,491,514 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21155,732,334 - 155,751,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH1A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12919,347,101 - 19,383,600 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605927,159,145 - 27,196,034 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh1a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247683,851,257 - 3,885,609 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247683,851,361 - 3,885,609 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Aldh1a3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12133,927,003 - 133,960,515 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aldh1a3
182 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:21
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000043019
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611131244255Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1111404407142582336Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat

Markers in Region
RH136871  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21119,982,506 - 119,982,658 (+)MAPPERmRatBN7.2
Rnor_6.01127,301,370 - 127,301,521NCBIRnor6.0
Rnor_5.01128,381,364 - 128,381,515UniSTSRnor5.0
RGSC_v3.41120,846,196 - 120,846,347UniSTSRGSC3.4
Celera1112,186,579 - 112,186,730UniSTS
RH 3.4 Map11466.19UniSTS
Cytogenetic Map1q22UniSTS
AA848809  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21119,982,648 - 119,982,832 (+)MAPPERmRatBN7.2
Rnor_6.01127,301,512 - 127,301,695NCBIRnor6.0
Rnor_5.01128,381,506 - 128,381,689UniSTSRnor5.0
RGSC_v3.41120,846,338 - 120,846,521UniSTSRGSC3.4
Celera1112,186,721 - 112,186,904UniSTS
RH 3.4 Map11466.19UniSTS
Cytogenetic Map1q22UniSTS
PMC283541P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21119,998,850 - 119,999,135 (+)MAPPERmRatBN7.2
Rnor_6.01127,317,713 - 127,317,997NCBIRnor6.0
Rnor_5.01128,397,656 - 128,397,940UniSTSRnor5.0
RGSC_v3.41120,862,514 - 120,862,798UniSTSRGSC3.4
Celera1112,202,923 - 112,203,207UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 147 91 90 59 38 59 6 301 138 11 126 80 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000085158   ⟹   ENSRNOP00000069212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1129,392,516 - 129,427,643 (-)Ensembl
mRatBN7.2 Ensembl1119,982,277 - 120,017,393 (-)Ensembl
Rnor_6.0 Ensembl1127,301,128 - 127,337,882 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098068   ⟹   ENSRNOP00000087440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1129,392,516 - 129,427,777 (-)Ensembl
mRatBN7.2 Ensembl1119,982,277 - 120,017,436 (-)Ensembl
RefSeq Acc Id: NM_153300   ⟹   NP_695212
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,392,516 - 129,427,643 (-)NCBI
mRatBN7.21119,982,272 - 120,017,401 (-)NCBI
Rnor_6.01127,302,920 - 127,337,828 (-)NCBI
Rnor_5.01128,382,914 - 128,415,160 (-)NCBI
RGSC_v3.41120,847,746 - 120,881,883 (-)RGD
Celera1112,188,129 - 112,221,404 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102407   ⟹   XP_038958335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,392,516 - 129,427,661 (-)NCBI
mRatBN7.21119,982,272 - 120,017,416 (-)NCBI
RefSeq Acc Id: XM_039102413   ⟹   XP_038958341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,392,516 - 129,418,088 (-)NCBI
mRatBN7.21119,982,272 - 120,007,854 (-)NCBI
RefSeq Acc Id: XM_063282400   ⟹   XP_063138470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,392,516 - 129,436,552 (-)NCBI
RefSeq Acc Id: NP_695212   ⟸   NM_153300
- UniProtKB: A0A0G2JUS6 (UniProtKB/TrEMBL),   B2GUU8 (UniProtKB/TrEMBL),   A0A9K3Y6M8 (UniProtKB/TrEMBL),   A9EEP5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069212   ⟸   ENSRNOT00000085158
RefSeq Acc Id: XP_038958335   ⟸   XM_039102407
- Peptide Label: isoform X1
- UniProtKB: Q8K4D8 (UniProtKB/Swiss-Prot),   A0A8I6A4D2 (UniProtKB/TrEMBL),   A9EEP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958341   ⟸   XM_039102413
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000087440   ⟸   ENSRNOT00000098068
RefSeq Acc Id: XP_063138470   ⟸   XM_063282400
- Peptide Label: isoform X2
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4D8-F1-model_v2 AlphaFold Q8K4D8 1-512 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690103
Promoter ID:EPDNEW_R628
Type:single initiation site
Name:Aldh1a3_1
Description:aldehyde dehydrogenase 1 family, member A3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01127,337,893 - 127,337,953EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628662 AgrOrtholog
BioCyc Gene G2FUF-59007 BioCyc
Ensembl Genes ENSRNOG00000052070 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000085158 ENTREZGENE
  ENSRNOT00000098068 ENTREZGENE
Gene3D-CATH Aldehyde Dehydrogenase, Chain A, domain 1 UniProtKB/Swiss-Prot
  Aldehyde Dehydrogenase, Chain A, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9025597 IMAGE-MGC_LOAD
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot
  Aldehyde_DH_dom UniProtKB/Swiss-Prot
KEGG Report rno:266603 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187329 IMAGE-MGC_LOAD
NCBI Gene 266603 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot
Pfam Aldedh UniProtKB/Swiss-Prot
PhenoGen Aldh1a3 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052070 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot
UniProt A0A0G2JUS6 ENTREZGENE
  A0A8I6A4D2 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y6M8 ENTREZGENE, UniProtKB/TrEMBL
  A6JBQ5_RAT UniProtKB/TrEMBL
  A6JBQ6_RAT UniProtKB/TrEMBL
  A6JBQ7_RAT UniProtKB/TrEMBL
  A9EEP5 ENTREZGENE, UniProtKB/TrEMBL
  AL1A3_RAT UniProtKB/Swiss-Prot
  B2GUU8 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4D8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Aldh1a3  aldehyde dehydrogenase 1 family, member A3  Aldh1a3  aldehyde dehydrogenase family 1, subfamily A3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Aldh1a3  aldehyde dehydrogenase family 1, subfamily A3      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Aldh1a3  aldehyde dehydrogenase family 1, subfamily A3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression of Aldh1a3 in response to phenobarbitol differ in two Wistar substrains , suggesting a genetic difference in the basis of phenobarbitol induction 634541