Clcnkb (chloride voltage-gated channel Kb) - Rat Genome Database

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Gene: Clcnkb (chloride voltage-gated channel Kb) Rattus norvegicus
Analyze
Symbol: Clcnkb
Name: chloride voltage-gated channel Kb
RGD ID: 628639
Description: Enables chloride channel activity. Involved in chloride transport. Predicted to be located in basolateral plasma membrane. Predicted to be part of chloride channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; and hypertension. Orthologous to human CLCNKB (chloride voltage-gated channel Kb); INTERACTS WITH (4-chloro-2-methylphenoxy)acetic acid; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chloride channel K1-like; chloride channel K2; chloride channel Kb; chloride channel protein ClC-Kb; chloride channel, voltage-sensitive Kb; clC-K2; ClC-K2L; Clck2; Clcnk1l
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,993,073 - 159,005,618 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5158,993,074 - 159,004,900 (-)EnsemblGRCr8
mRatBN7.25153,710,086 - 153,733,162 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,710,094 - 153,732,153 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5156,396,936 - 156,408,682 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,170,222 - 158,181,968 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,159,402 - 158,171,149 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5158,608,479 - 158,620,225 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive5160,598,733 - 160,610,483 (-)NCBILyon_Normotensive
Lyon_Hypertensive5159,774,242 - 159,785,988 (-)NCBILyon_Hypertensive
F344_StmMcwi5153,343,168 - 153,354,914 (-)NCBIF344_StmMcwi
Rnor_6.05159,950,384 - 159,973,576 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,950,392 - 159,962,676 (-)Ensemblrn6Rnor6.0
Rnor_5.05163,670,926 - 163,694,123 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45160,294,294 - 160,305,991 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5152,071,911 - 152,083,591 (-)NCBICelera
RGSC_v3.15160,304,482 - 160,316,179 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney. Adachi S, etal., J Biol Chem. 1994 Jul 1;269(26):17677-83.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension. Jeck N, etal., Hypertension. 2004 Jun;43(6):1175-81. Epub 2004 May 17.
5. Mutations in the chloride channel gene, CLCNKB, leading to a mixed Bartter-Gitelman phenotype. Jeck N, etal., Pediatr Res 2000 Dec;48(6):754-8.
6. Two highly homologous members of the ClC chloride channel family in both rat and human kidney. Kieferle S, etal., Proc Natl Acad Sci U S A 1994 Jul 19;91(15):6943-7.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Simon DB, etal., Nat Genet 1997 Oct;17(2):171-8.
12. No association with hypertension of CLCNKB and TNFRSF1B polymorphisms at a hypertension locus on chromosome 1p36. Speirs HJ, etal., J Hypertens. 2005 Aug;23(8):1491-6.
Additional References at PubMed
PMID:12111250   PMID:12477932   PMID:12761627   PMID:18480177   PMID:27748841  


Genomics

Comparative Map Data
Clcnkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,993,073 - 159,005,618 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5158,993,074 - 159,004,900 (-)EnsemblGRCr8
mRatBN7.25153,710,086 - 153,733,162 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,710,094 - 153,732,153 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5156,396,936 - 156,408,682 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,170,222 - 158,181,968 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,159,402 - 158,171,149 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5158,608,479 - 158,620,225 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive5160,598,733 - 160,610,483 (-)NCBILyon_Normotensive
Lyon_Hypertensive5159,774,242 - 159,785,988 (-)NCBILyon_Hypertensive
F344_StmMcwi5153,343,168 - 153,354,914 (-)NCBIF344_StmMcwi
Rnor_6.05159,950,384 - 159,973,576 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,950,392 - 159,962,676 (-)Ensemblrn6Rnor6.0
Rnor_5.05163,670,926 - 163,694,123 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45160,294,294 - 160,305,991 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5152,071,911 - 152,083,591 (-)NCBICelera
RGSC_v3.15160,304,482 - 160,316,179 (-)NCBI
Cytogenetic Map5q36NCBI
CLCNKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,043,782 - 16,057,326 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,040,252 - 16,057,367 (+)Ensemblhg38GRCh38
GRCh37116,370,277 - 16,383,821 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,242,834 - 16,256,390 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34116,115,657 - 16,128,782NCBI
Celera114,850,148 - 14,863,702 (+)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef114,890,406 - 14,902,282 (+)NCBIHuRef
CHM1_1116,168,758 - 16,182,434 (+)NCBICHM1_1
T2T-CHM13v2.0115,485,085 - 15,498,707 (+)NCBIT2T-CHM13v2.0
Clcnkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,131,668 - 141,143,440 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,131,664 - 141,143,325 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384141,404,357 - 141,416,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,404,353 - 141,416,014 (-)Ensemblmm10GRCm38
MGSCv374140,960,272 - 140,971,903 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364140,676,436 - 140,688,057 (-)NCBIMGSCv36mm8
Celera4143,220,859 - 143,232,479 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map474.02NCBI
CLCNKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21210,863,650 - 210,876,660 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,112,249 - 210,125,260 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0115,180,858 - 15,194,757 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,174,570 - 16,188,166 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,174,570 - 16,188,166 (+)EnsemblpanPan2panpan1.1
CLCNK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,612,382 - 81,627,742 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,147,805 - 78,164,129 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0282,257,988 - 82,274,363 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,258,044 - 82,270,102 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1279,011,176 - 79,027,530 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0280,028,343 - 80,044,678 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,096,037 - 81,112,388 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CLCNKB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,264,633 - 116,277,468 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,241,569 - 116,254,280 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236673223,144 - 17,233 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Clcnkb
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:98
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000013550, ENSRNOT00000050729
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
BI279792  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85158,993,206 - 158,993,537 (+)Marker Load Pipeline
mRatBN7.25153,710,226 - 153,710,557 (+)MAPPERmRatBN7.2
Rnor_6.05159,950,525 - 159,950,855NCBIRnor6.0
Rnor_5.05163,671,067 - 163,671,397UniSTSRnor5.0
RGSC_v3.45160,294,428 - 160,294,758UniSTSRGSC3.4
Celera5152,072,045 - 152,072,375UniSTS
RH 3.4 Map51053.7UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 13 76 174 75 74 43 147 43 6 448 266 22 141 116 120 31 27 27

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_173103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB029158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC120594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ437671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ437672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ437673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ437674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ437675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ437676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z30663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013550   ⟹   ENSRNOP00000013550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5153,710,094 - 153,732,153 (-)Ensembl
Rnor_6.0 Ensembl5159,950,392 - 159,962,676 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000050729   ⟹   ENSRNOP00000049598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5158,993,074 - 159,004,900 (-)Ensembl
mRatBN7.2 Ensembl5153,710,094 - 153,721,923 (-)Ensembl
Rnor_6.0 Ensembl5159,950,392 - 159,962,218 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080462   ⟹   ENSRNOP00000074402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5159,960,720 - 159,961,560 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101714   ⟹   ENSRNOP00000082436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5158,993,074 - 159,004,254 (-)Ensembl
mRatBN7.2 Ensembl5153,710,094 - 153,721,277 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118065   ⟹   ENSRNOP00000097182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5153,710,094 - 153,721,923 (-)Ensembl
RefSeq Acc Id: NM_173103   ⟹   NP_775126
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,993,073 - 159,004,846 (-)NCBI
mRatBN7.25153,710,093 - 153,721,869 (-)NCBI
Dahl_SR_JrHsd5158,608,479 - 158,620,225 (-)NCBI
Lyon_Normotensive5160,598,733 - 160,610,483 (-)NCBI
Lyon_Hypertensive5159,774,242 - 159,785,988 (-)NCBI
F344_StmMcwi5153,343,168 - 153,354,914 (-)NCBI
Rnor_6.05159,950,391 - 159,962,164 (-)NCBI
Rnor_5.05163,670,926 - 163,694,123 (-)NCBI
RGSC_v3.45160,294,294 - 160,305,991 (-)RGD
Celera5152,071,911 - 152,083,591 (-)RGD
Sequence:
RefSeq Acc Id: XM_008764297   ⟹   XP_008762519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,993,073 - 159,004,894 (-)NCBI
mRatBN7.25153,710,086 - 153,721,917 (-)NCBI
Rnor_6.05159,950,384 - 159,963,109 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063288467   ⟹   XP_063144537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,993,073 - 159,005,618 (-)NCBI
RefSeq Acc Id: XM_063288468   ⟹   XP_063144538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,993,073 - 159,004,894 (-)NCBI
RefSeq Acc Id: XM_063288469   ⟹   XP_063144539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,993,073 - 159,004,894 (-)NCBI
RefSeq Acc Id: NP_775126   ⟸   NM_173103
- UniProtKB: P51802 (UniProtKB/Swiss-Prot),   A6ITT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762519   ⟸   XM_008764297
- Peptide Label: isoform X3
- UniProtKB: E9PTA8 (UniProtKB/TrEMBL),   Q1W581 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074402   ⟸   ENSRNOT00000080462
Ensembl Acc Id: ENSRNOP00000013550   ⟸   ENSRNOT00000013550
Ensembl Acc Id: ENSRNOP00000049598   ⟸   ENSRNOT00000050729
Ensembl Acc Id: ENSRNOP00000082436   ⟸   ENSRNOT00000101714
Ensembl Acc Id: ENSRNOP00000097182   ⟸   ENSRNOT00000118065
RefSeq Acc Id: XP_063144537   ⟸   XM_063288467
- Peptide Label: isoform X1
- UniProtKB: A6ITT2 (UniProtKB/TrEMBL),   A6ITT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144539   ⟸   XM_063288469
- Peptide Label: isoform X4
- UniProtKB: Q1W581 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144538   ⟸   XM_063288468
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZU48 (UniProtKB/TrEMBL),   A6ITT3 (UniProtKB/TrEMBL)
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51802-F1-model_v2 AlphaFold P51802 1-687 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694229
Promoter ID:EPDNEW_R4749
Type:single initiation site
Name:Clcnkb_1
Description:chloride voltage-gated channel Kb
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05159,962,182 - 159,962,242EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628639 AgrOrtholog
BioCyc Gene G2FUF-39350 BioCyc
Ensembl Genes ENSRNOG00000009897 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000050729 ENTREZGENE
  ENSRNOT00000101714 ENTREZGENE
Gene3D-CATH 3.10.580.10 UniProtKB/Swiss-Prot
  Clc chloride channel UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109911 IMAGE-MGC_LOAD
InterPro CBS_dom UniProtKB/Swiss-Prot
  CBS_dom_sf UniProtKB/Swiss-Prot
  Cl-channel_core UniProtKB/Swiss-Prot
  Cl-channel_volt-gated UniProtKB/Swiss-Prot
  Cl_channel-K UniProtKB/Swiss-Prot
  Cl_channel_volt-gated UniProtKB/Swiss-Prot
KEGG Report rno:79430 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93079 IMAGE-MGC_LOAD
NCBI Gene 79430 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN 2 UniProtKB/Swiss-Prot
  CHLORIDE CHANNEL PROTEIN CLC-KB UniProtKB/Swiss-Prot
Pfam CBS UniProtKB/Swiss-Prot
  Voltage_CLC UniProtKB/Swiss-Prot
PhenoGen Clcnkb PhenoGen
PRINTS CLCHANNEL UniProtKB/Swiss-Prot
  CLCHANNELKDY UniProtKB/Swiss-Prot
PROSITE CBS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009897 RatGTEx
SMART CBS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54631 UniProtKB/Swiss-Prot
  SSF81340 UniProtKB/Swiss-Prot
UniProt A0A8I5ZU48 ENTREZGENE, UniProtKB/TrEMBL
  A6ITT1_RAT UniProtKB/TrEMBL
  A6ITT2 ENTREZGENE, UniProtKB/TrEMBL
  A6ITT3 ENTREZGENE, UniProtKB/TrEMBL
  A6ITT4_RAT UniProtKB/TrEMBL
  A6ITT5_RAT UniProtKB/TrEMBL
  A6ITT6_RAT UniProtKB/TrEMBL
  CLCKB_RAT UniProtKB/Swiss-Prot
  E9PTA8 ENTREZGENE, UniProtKB/TrEMBL
  P51802 ENTREZGENE
  Q1W581 ENTREZGENE, UniProtKB/TrEMBL
  Q1W583_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Clcnkb  chloride voltage-gated channel Kb  Clcnkb  chloride channel, voltage-sensitive Kb  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Clcnkb  chloride channel, voltage-sensitive Kb  Clcnkb  chloride channel Kb  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Clcnkb  chloride channel Kb  Clcnk1l  chloride channel K1-like  Symbol and Name updated 1299863 APPROVED
2003-02-27 Clcnk1l        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression displays highest expression in the kidney 632474