Gene: CLCNKB (chloride voltage-gated channel Kb) Homo sapiens
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Symbol: CLCNKB
Name: chloride voltage-gated channel Kb
Description: The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chloride channel Kb; chloride channel protein ClC-Kb; chloride channel, kidney, B; chloride channel, voltage-sensitive Kb; ClC-K2; ClC-Kb; CLCKB; hClC-Kb; MGC24087; OTTHUMP00000011120; OTTHUMP00000011121
Orthologs:
Mus musculus (house mouse) : Clcnkb (chloride channel, voltage-sensitive Kb)  MGI
Rattus norvegicus (Norway rat) : Clcnkb (chloride voltage-gated channel Kb)
Canis lupus familiaris (dog) : CLCNKA (chloride voltage-gated channel Ka)
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Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,043,736 - 16,057,326 (+)NCBIGRCh38hg38GRCh38
GRCh37116,370,231 - 16,383,821 (+)NCBIGRCh37hg19GRCh37
Build 36116,242,834 - 16,256,390 (+)NCBINCBI36hg18NCBI36
Build 34116,115,657 - 16,128,782NCBI
Celera114,850,148 - 14,863,702 (+)NCBI
Cytogenetic Map1p36.13NCBImapview
HuRef114,893,788 - 14,902,305 (+)NCBI
CHM1_1116,168,758 - 16,182,434 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

Comparative Map Data
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miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CLCNKB
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
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RGD Object Information
RGD ID: 736095
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2017-05-30
Status: ACTIVE