Slc38a3 (solute carrier family 38, member 3) - Rat Genome Database

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Gene: Slc38a3 (solute carrier family 38, member 3) Rattus norvegicus
Analyze
Symbol: Slc38a3
Name: solute carrier family 38, member 3
RGD ID: 628620
Description: Enables sodium ion transmembrane transporter activity. Involved in carboxylic acid transport; female pregnancy; and positive regulation of glutamine transport. Located in basolateral plasma membrane. Biomarker of metabolic acidosis. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 102. Orthologous to human SLC38A3 (solute carrier family 38 member 3); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC93143; N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; Nat1; Sn1; Snat3; sodium-coupled neutral amino acid transporter 3; solute carrier family 38 member 3; system N amino acid transporter 1; system N1 amino acid transporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,202,534 - 117,220,310 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,202,536 - 117,218,630 (-)EnsemblGRCr8
mRatBN7.28108,323,889 - 108,339,959 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,323,894 - 108,339,988 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,950,584 - 113,966,611 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,149,742 - 112,165,769 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,992,524 - 110,008,551 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,406,258 - 116,423,752 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,406,241 - 116,422,366 (-)Ensemblrn6Rnor6.0
Rnor_5.08115,761,368 - 115,779,081 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,898,405 - 112,914,444 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8107,630,163 - 107,646,202 (-)NCBICelera
RGSC_v3.18112,917,859 - 112,933,899 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
GW 4064  (ISO)
hydrogen chloride  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
lactacystin  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
methamphetamine  (ISO)
methidathion  (ISO)
methylarsonic acid  (ISO)
Moniliformin  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
propofol  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IEA,ISO)
basolateral plasma membrane  (IDA,IEA)
membrane  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Highly differential expression of SN1, a bidirectional glutamine transporter, in astroglia and endothelium in the developing rat brain. Boulland JL, etal., Glia 2003 Feb;41(3):260-75.
2. Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions. Bröer A, etal., J Physiol. 2002 Feb 15;539(Pt 1):3-14. doi: 10.1113/jphysiol.2001.013303.
3. Mutation of asparagine 76 in the center of glutamine transporter SNAT3 modulates substrate-induced conductances and Na+ binding. Bröer S, etal., J Biol Chem. 2009 Sep 18;284(38):25823-31. doi: 10.1074/jbc.M109.031013. Epub 2009 Jul 13.
4. Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. Chaudhry FA, etal., Cell 1999 Dec 23;99(7):769-80.
5. Coupled and uncoupled proton movement by amino acid transport system N. Chaudhry FA, etal., EMBO J. 2001 Dec 17;20(24):7041-51. doi: 10.1093/emboj/20.24.7041.
6. Differential molecular regulation of glutamate in kindling resistant rats. Doi T, etal., Brain Res. 2011 Feb 23;1375:1-6. doi: 10.1016/j.brainres.2010.11.085. Epub 2010 Dec 4.
7. PKC-Mediated Modulation of Astrocyte SNAT3 Glutamine Transporter Function at Synapses in Situ. Dong W, etal., Int J Mol Sci. 2018 Mar 21;19(4). pii: ijms19040924. doi: 10.3390/ijms19040924.
8. Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter. Fei YJ, etal., J Biol Chem. 2000 Aug 4;275(31):23707-17.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Regulation of expression of the SN1 transporter during renal adaptation to chronic metabolic acidosis in rats. Karinch AM, etal., Am J Physiol Renal Physiol 2002 Nov;283(5):F1011-9.
12. Glucocorticoids have a role in renal cortical expression of the SNAT3 glutamine transporter during chronic metabolic acidosis. Karinch AM, etal., Am J Physiol Renal Physiol. 2007 Jan;292(1):F448-55. Epub 2006 Sep 5.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Protein kinase C-mediated phosphorylation of a single serine residue on the rat glial glutamine transporter SN1 governs its membrane trafficking. Nissen-Meyer LS, etal., J Neurosci. 2011 Apr 27;31(17):6565-75. doi: 10.1523/JNEUROSCI.3694-10.2011.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Heterologous expression of the glutamine transporter SNAT3 in Xenopus oocytes is associated with four modes of uncoupled transport. Schneider HP, etal., J Biol Chem. 2007 Feb 9;282(6):3788-98. Epub 2006 Dec 5.
20. Induction and targeting of the glutamine transporter SN1 to the basolateral membranes of cortical kidney tubule cells during chronic metabolic acidosis suggest a role in pH regulation. Solbu TT, etal., J Am Soc Nephrol. 2005 Apr;16(4):869-77. Epub 2005 Feb 16.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. SNAT3-mediated glutamine transport in perisynaptic astrocytes in situ is regulated by intracellular sodium. Todd AC, etal., Glia. 2017 Jun;65(6):900-916. doi: 10.1002/glia.23133. Epub 2017 Mar 8.
23. Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells. Umapathy NS, etal., Invest Ophthalmol Vis Sci. 2005 Nov;46(11):3980-7. doi: 10.1167/iovs.05-0488.
24. Changes of plasma glutamine concentration and hepatocyte membrane system N transporters expression in early endotoxemia. Wang W, etal., J Surg Res. 2011 Apr;166(2):290-7. doi: 10.1016/j.jss.2009.08.027. Epub 2009 Sep 23.
25. The sodium-bicarbonate cotransporter NBCe1 supports glutamine efflux via SNAT3 (SLC38A3) co-expressed in Xenopus oocytes. Wendel C, etal., Pflugers Arch. 2008 Feb;455(5):885-93. doi: 10.1007/s00424-007-0351-y. Epub 2007 Oct 2.
26. Expression and role of SNAT3 in the placenta. Yoshioka C, etal., Placenta. 2009 Dec;30(12):1071-7. doi: 10.1016/j.placenta.2009.09.009. Epub 2009 Nov 5.
Additional References at PubMed
PMID:10716701   PMID:15489334   PMID:17664347   PMID:19233140   PMID:19458124   PMID:20737472   PMID:20739622   PMID:22871113  


Genomics

Comparative Map Data
Slc38a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,202,534 - 117,220,310 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,202,536 - 117,218,630 (-)EnsemblGRCr8
mRatBN7.28108,323,889 - 108,339,959 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,323,894 - 108,339,988 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,950,584 - 113,966,611 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,149,742 - 112,165,769 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,992,524 - 110,008,551 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,406,258 - 116,423,752 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,406,241 - 116,422,366 (-)Ensemblrn6Rnor6.0
Rnor_5.08115,761,368 - 115,779,081 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,898,405 - 112,914,444 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8107,630,163 - 107,646,202 (-)NCBICelera
RGSC_v3.18112,917,859 - 112,933,899 (-)NCBI
Cytogenetic Map8q32NCBI
SLC38A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,205,271 - 50,221,486 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,202,871 - 50,221,504 (+)Ensemblhg38GRCh38
GRCh37350,242,704 - 50,258,918 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,217,696 - 50,233,410 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34350,217,708 - 50,233,406NCBI
Celera350,215,521 - 50,231,235 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,298,378 - 50,314,094 (+)NCBIHuRef
CHM1_1350,194,967 - 50,210,681 (+)NCBICHM1_1
T2T-CHM13v2.0350,234,602 - 50,250,823 (+)NCBIT2T-CHM13v2.0
Slc38a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,528,353 - 107,546,167 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,527,833 - 107,546,729 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389107,651,154 - 107,668,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,650,634 - 107,669,530 (-)Ensemblmm10GRCm38
MGSCv379107,553,486 - 107,569,705 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369107,509,256 - 107,525,475 (-)NCBIMGSCv36mm8
Celera9107,256,617 - 107,273,287 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.69NCBI
Slc38a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,023,694 - 2,050,708 (+)Ensembl
ChiLan1.0NW_0049555322,023,694 - 2,046,556 (+)NCBIChiLan1.0ChiLan1.0
SLC38A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,188,107 - 50,203,856 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,192,882 - 50,208,631 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,133,631 - 50,149,394 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,367,939 - 51,383,657 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,367,939 - 51,383,657 (+)EnsemblpanPan2panpan1.1
SLC38A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,108,387 - 39,122,526 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,109,211 - 39,114,849 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2039,029,425 - 39,043,601 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02039,464,652 - 39,478,831 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,462,412 - 39,478,967 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,832,227 - 38,846,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,236,334 - 39,250,516 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,515,831 - 39,530,233 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc38a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,989,382 - 65,005,427 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,749,853 - 1,768,476 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,749,919 - 1,765,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC38A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,683,126 - 32,704,535 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11332,683,131 - 32,699,803 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,861,884 - 35,878,403 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC38A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,591,680 - 11,606,291 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,591,717 - 11,606,355 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041155,378,802 - 155,395,004 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc38a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,078,014 - 4,096,080 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247304,078,084 - 4,092,330 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc38a3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1898,968,853 - 98,985,209 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc38a3
162 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:96
Interacting mature miRNAs:111
Transcripts:ENSRNOT00000023623
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH141024  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,323,996 - 108,324,182 (+)MAPPERmRatBN7.2
Rnor_6.08116,406,366 - 116,406,551NCBIRnor6.0
Rnor_5.08115,761,476 - 115,761,661UniSTSRnor5.0
RGSC_v3.48112,898,482 - 112,898,667UniSTSRGSC3.4
Celera8107,630,240 - 107,630,425UniSTS
RH 3.4 Map81120.7UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 30 59 6 294 130 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023623   ⟹   ENSRNOP00000023623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8117,202,536 - 117,218,630 (-)Ensembl
mRatBN7.2 Ensembl8108,323,894 - 108,339,988 (-)Ensembl
Rnor_6.0 Ensembl8116,406,241 - 116,422,366 (-)Ensembl
RefSeq Acc Id: NM_145776   ⟹   NP_665719
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,202,562 - 117,218,601 (-)NCBI
mRatBN7.28108,323,920 - 108,339,959 (-)NCBI
Rnor_6.08116,406,289 - 116,422,328 (-)NCBI
Rnor_5.08115,761,368 - 115,779,081 (-)NCBI
RGSC_v3.48112,898,405 - 112,914,444 (-)RGD
Celera8107,630,163 - 107,646,202 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080872   ⟹   XP_038936800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,202,534 - 117,218,492 (-)NCBI
mRatBN7.28108,323,889 - 108,333,249 (-)NCBI
RefSeq Acc Id: XM_063264946   ⟹   XP_063121016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,202,534 - 117,220,310 (-)NCBI
RefSeq Acc Id: XR_001839153
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,205,571 - 117,210,922 (-)NCBI
mRatBN7.28108,323,889 - 108,332,280 (-)NCBI
Rnor_6.08116,406,258 - 116,423,752 (-)NCBI
Sequence:
RefSeq Acc Id: NP_665719   ⟸   NM_145776
- UniProtKB: Q66HS0 (UniProtKB/Swiss-Prot),   Q9JHZ9 (UniProtKB/Swiss-Prot),   A6I304 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023623   ⟸   ENSRNOT00000023623
RefSeq Acc Id: XP_038936800   ⟸   XM_039080872
- Peptide Label: isoform X2
- UniProtKB: Q9JHZ9 (UniProtKB/Swiss-Prot),   Q66HS0 (UniProtKB/Swiss-Prot),   A6I304 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121016   ⟸   XM_063264946
- Peptide Label: isoform X1
Protein Domains
Amino acid transporter transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHZ9-F1-model_v2 AlphaFold Q9JHZ9 1-504 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696279
Promoter ID:EPDNEW_R6804
Type:multiple initiation site
Name:Slc38a3_1
Description:solute carrier family 38, member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,422,367 - 116,422,427EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628620 AgrOrtholog
BioCyc Gene G2FUF-29181 BioCyc
Ensembl Genes ENSRNOG00000016827 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023623 ENTREZGENE
  ENSRNOT00000023623.8 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7127614 IMAGE-MGC_LOAD
InterPro AA_transpt_TM UniProtKB/Swiss-Prot
KEGG Report rno:252919 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93143 IMAGE-MGC_LOAD
NCBI Gene 252919 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/Swiss-Prot
  SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 3 UniProtKB/Swiss-Prot
Pfam Aa_trans UniProtKB/Swiss-Prot
PhenoGen Slc38a3 PhenoGen
RatGTEx ENSRNOG00000016827 RatGTEx
UniProt A6I304 ENTREZGENE, UniProtKB/TrEMBL
  Q66HS0 ENTREZGENE
  Q9JHZ9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q66HS0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Slc38a3  solute carrier family 38, member 3      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Slc38a3  solute carrier family 38, member 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, brain, skeleton with high expression in kidneys 628371
gene_function sodium-dependent amino acid transporter for glutamine, histidine and asparagine in different tissues 628371
gene_process participates in nitrogen metabolism and synaptic transmission 634178
gene_process may be a part of homeostasis regulation in response to acid-base imbalance in kidneys 628371
gene_regulation acidosis increases transcripts by 10 fold in whole kidney and 100-fold in renal cortex 628371