Bambi (BMP and activin membrane-bound inhibitor) - Rat Genome Database

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Gene: Bambi (BMP and activin membrane-bound inhibitor) Rattus norvegicus
Analyze
Symbol: Bambi
Name: BMP and activin membrane-bound inhibitor
RGD ID: 621831
Description: Predicted to enable frizzled binding activity. Involved in transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BAMBI (BMP and activin membrane bound inhibitor); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BMP and activin membrane-bound inhibitor homolog; BMP and activin membrane-bound inhibitor, homolog; BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis); kinase-deficient TGFbeta superfamily receptor subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81758,816,438 - 58,821,003 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1758,816,442 - 58,821,247 (-)EnsemblGRCr8
mRatBN7.21754,121,251 - 54,125,816 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1754,121,255 - 54,126,060 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1757,288,277 - 57,292,537 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01761,291,313 - 61,295,573 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01755,449,123 - 55,453,381 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01756,905,419 - 56,909,675 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1756,905,112 - 56,909,992 (-)Ensemblrn6Rnor6.0
Rnor_5.01754,939,068 - 54,943,633 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41762,654,385 - 62,658,641 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1750,102,907 - 50,107,163 (-)NCBICelera
RGSC_v3.11762,664,912 - 62,669,718 (-)NCBI
Cytogenetic Map17q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boron nitride  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
cantharidin  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
cocaine  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocin-1  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fucoxanthin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoflavones  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. LPS/TLR4 Signaling Enhances TGF-β Response Through Downregulating BAMBI During Prostatic Hyperplasia. He Y, etal., Sci Rep. 2016 May 31;6:27051. doi: 10.1038/srep27051.
4. Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cells. Loveland KL, etal., Endocrinology 2003 Sep;144(9):4180-6.
5. Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors. Luo X, etal., Diabetes. 2012 Jan;61(1):124-36. doi: 10.2337/db11-0998.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. [Distribution and mRNA Expression of BAMBI in Non-small-cell Lung Cancer.]. Miao S, etal., Zhongguo Fei Ai Za Zhi. 2009 Mar 20;12(3):203-7. doi: 10.3779/j.issn.1009-3419.2009.03.007.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. Togo N, etal., World J Gastroenterol. 2008 Aug 21;14(31):4880-8.
14. BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF-β signaling. Villar AV, etal., Biochim Biophys Acta. 2013 Feb;1832(2):323-35. doi: 10.1016/j.bbadis.2012.11.007. Epub 2012 Nov 17.
15. BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury. Yang Y, etal., Int J Mol Med. 2017 Feb;39(2):423-429. doi: 10.3892/ijmm.2016.2838. Epub 2016 Dec 27.
16. Inhibition of BAMBI reduces the viability and motility of colon cancer via activating TGF-β/Smad pathway in vitro and in vivo. Yu W and Chai H, Oncol Lett. 2017 Oct;14(4):4793-4799. doi: 10.3892/ol.2017.6811. Epub 2017 Aug 24.
17. TGF-β/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease. Zhang JC, etal., Sci Rep. 2016 Aug 23;6:31911. doi: 10.1038/srep31911.
18. Expression of BAMBI and its combination with Smad7 correlates with tumor invasion and poor prognosis in gastric cancer. Zhang Y, etal., Tumour Biol. 2014 Jul;35(7):7047-56. doi: 10.1007/s13277-014-1962-5. Epub 2014 Apr 23.
Additional References at PubMed
PMID:10942595   PMID:14660579   PMID:15489334   PMID:18838381   PMID:19328798   PMID:22406377   PMID:24155898   PMID:29424488   PMID:31636010  


Genomics

Comparative Map Data
Bambi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81758,816,438 - 58,821,003 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1758,816,442 - 58,821,247 (-)EnsemblGRCr8
mRatBN7.21754,121,251 - 54,125,816 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1754,121,255 - 54,126,060 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1757,288,277 - 57,292,537 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01761,291,313 - 61,295,573 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01755,449,123 - 55,453,381 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01756,905,419 - 56,909,675 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1756,905,112 - 56,909,992 (-)Ensemblrn6Rnor6.0
Rnor_5.01754,939,068 - 54,943,633 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41762,654,385 - 62,658,641 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1750,102,907 - 50,107,163 (-)NCBICelera
RGSC_v3.11762,664,912 - 62,669,718 (-)NCBI
Cytogenetic Map17q12.1NCBI
BAMBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381028,677,521 - 28,682,932 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1028,677,510 - 28,682,932 (+)Ensemblhg38GRCh38
GRCh371028,966,450 - 28,971,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361029,006,430 - 29,011,874 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341029,006,458 - 29,011,702NCBI
Celera1028,731,284 - 28,736,727 (+)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1028,685,147 - 28,690,591 (+)NCBIHuRef
CHM1_11028,966,877 - 28,972,320 (+)NCBICHM1_1
T2T-CHM13v2.01028,708,908 - 28,714,318 (+)NCBIT2T-CHM13v2.0
Bambi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39183,507,011 - 3,516,404 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl183,507,923 - 3,516,404 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38183,507,011 - 3,516,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl183,507,923 - 3,516,404 (+)Ensemblmm10GRCm38
MGSCv37183,507,955 - 3,516,402 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36183,507,955 - 3,516,402 (+)NCBIMGSCv36mm8
Celera183,558,647 - 3,567,082 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map182.3NCBI
Bambi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542921,024,374 - 21,025,890 (+)Ensembl
ChiLan1.0NW_00495542921,024,396 - 21,025,890 (+)NCBIChiLan1.0ChiLan1.0
BAMBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2841,354,018 - 41,359,534 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11041,359,721 - 41,364,861 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01028,833,690 - 28,839,164 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11029,187,857 - 29,193,324 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1029,187,857 - 29,193,324 (+)EnsemblpanPan2panpan1.1
BAMBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1217,453,628 - 17,459,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl217,455,243 - 17,462,346 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha214,952,595 - 14,958,681 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0215,700,785 - 15,706,918 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl215,700,785 - 15,710,019 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1215,139,651 - 15,145,733 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0215,026,954 - 15,033,049 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0215,300,265 - 15,306,392 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bambi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093448,547,962 - 8,553,293 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366133,098,159 - 3,103,868 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366133,098,549 - 3,103,868 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAMBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1040,053,355 - 40,060,319 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11040,053,368 - 40,058,590 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21044,241,652 - 44,246,876 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAMBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1928,279,479 - 28,284,825 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl928,279,523 - 28,285,937 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605134,317,547 - 34,323,212 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bambi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248051,967,101 - 1,974,898 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248051,967,174 - 1,973,030 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bambi
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11429,951,485 - 29,956,307 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bambi
47 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:40
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000021801
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174949693265155015Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 89 59 6 353 189 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021801   ⟹   ENSRNOP00000021801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1758,816,442 - 58,821,247 (-)Ensembl
mRatBN7.2 Ensembl1754,121,255 - 54,126,060 (-)Ensembl
Rnor_6.0 Ensembl1756,905,112 - 56,909,992 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105136   ⟹   ENSRNOP00000090807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1758,816,442 - 58,818,826 (-)Ensembl
mRatBN7.2 Ensembl1754,121,255 - 54,124,210 (-)Ensembl
RefSeq Acc Id: NM_139082   ⟹   NP_620782
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,816,747 - 58,821,003 (-)NCBI
mRatBN7.21754,121,560 - 54,125,816 (-)NCBI
Rnor_6.01756,905,419 - 56,909,675 (-)NCBI
Rnor_5.01754,939,068 - 54,943,633 (-)NCBI
RGSC_v3.41762,654,385 - 62,658,641 (-)RGD
Celera1750,102,907 - 50,107,163 (-)RGD
Sequence:
RefSeq Acc Id: XM_039096114   ⟹   XP_038952042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,816,438 - 58,820,880 (-)NCBI
mRatBN7.21754,121,251 - 54,125,723 (-)NCBI
Protein Sequences
Protein RefSeqs NP_620782 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952042 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH70516 (Get FASTA)   NCBI Sequence Viewer  
  AAK67353 (Get FASTA)   NCBI Sequence Viewer  
  EDL87459 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021801
  ENSRNOP00000021801.3
  ENSRNOP00000090807
GenBank Protein Q91XN4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620782   ⟸   NM_139082
- Peptide Label: precursor
- UniProtKB: Q91XN4 (UniProtKB/Swiss-Prot),   A6K9G6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021801   ⟸   ENSRNOT00000021801
RefSeq Acc Id: XP_038952042   ⟸   XM_039096114
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ABP7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090807   ⟸   ENSRNOT00000105136
Protein Domains
BMP and activin membrane-bound inhibitor C-terminal   BMP and activin membrane-bound inhibitor N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91XN4-F1-model_v2 AlphaFold Q91XN4 1-260 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700528
Promoter ID:EPDNEW_R11051
Type:initiation region
Name:Bambi_1
Description:BMP and activin membrane-bound inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01756,909,943 - 56,910,003EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621831 AgrOrtholog
BioCyc Gene G2FUF-8994 BioCyc
Ensembl Genes ENSRNOG00000016066 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021801 ENTREZGENE
  ENSRNOT00000021801.6 UniProtKB/Swiss-Prot
  ENSRNOT00000105136 ENTREZGENE
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100920 IMAGE-MGC_LOAD
InterPro BAMBI UniProtKB/Swiss-Prot
  BAMBI_C UniProtKB/Swiss-Prot
  BAMBI_N UniProtKB/Swiss-Prot
  Snake_toxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:83837 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91477 IMAGE-MGC_LOAD
NCBI Gene 83837 ENTREZGENE
PANTHER PTHR15505:SF1 UniProtKB/Swiss-Prot
  RIIA DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
Pfam BAMBI UniProtKB/Swiss-Prot
  BAMBI_C UniProtKB/Swiss-Prot
PhenoGen Bambi PhenoGen
PIRSF BAMBI UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016066 RatGTEx
Superfamily-SCOP SSF57302 UniProtKB/Swiss-Prot
UniProt A0A8I6ABP7 ENTREZGENE, UniProtKB/TrEMBL
  A6K9G6 ENTREZGENE, UniProtKB/TrEMBL
  BAMBI_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-31 Bambi  BMP and activin membrane-bound inhibitor  Bambi  BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Bambi  BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Bambi  BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in granulosa and thecal cells of adult ovaries, in spermatogonia, spermatocytes, round spermatids, and Sertoli cells of adult testes 632261
gene_homology 89% (nucleic acid) and 95% (amino acid) identical to human homolog 632261