Septin5 (septin 5) - Rat Genome Database

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Gene: Septin5 (septin 5) Rattus norvegicus
Analyze
Symbol: Septin5
Name: septin 5
RGD ID: 621763
Description: Enables several functions, including guanyl ribonucleotide binding activity; protein homodimerization activity; and syntaxin binding activity. Involved in positive regulation of exocytosis. Located in cleavage furrow; stress fiber; and synaptic vesicle. Part of septin complex. Orthologous to human SEPTIN5 (septin 5); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-Sep; CDCrel-1; CDCrel-1A; cell division control-related protein 1; GP-Ib beta; GPIb-beta; GPIbB; peanut (Drosophila)-like 1; peanut-like 1; peanut-like protein 1; Platelet glycoprotein Ib beta chain; Pnutl1; Sept5; septin-5
RGD Orthologs
Human
Mouse
Dog
Pig
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,877,946 - 95,883,738 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1195,873,864 - 95,883,737 (+)EnsemblGRCr8
mRatBN7.21182,373,601 - 82,379,393 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,369,754 - 82,379,393 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,103,250 - 91,109,040 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,764,456 - 83,770,246 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,817,972 - 82,823,762 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,516,377 - 86,522,169 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,512,797 - 86,522,168 (+)Ensemblrn6Rnor6.0
Rnor_5.01189,616,382 - 89,622,161 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41184,365,193 - 84,370,972 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1181,149,418 - 81,155,210 (+)NCBICelera
RGSC_v3.11184,405,788 - 84,410,228 (+)NCBI
Cytogenetic Map11q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The septin Sept5/CDCrel-1 competes with alpha-SNAP for binding to the SNARE complex. Beites CL, etal., Biochem J. 2005 Jan 15;385(Pt 2):347-53. doi: 10.1042/BJ20041090.
2. The septin CDCrel-1 binds syntaxin and inhibits exocytosis. Beites CL, etal., Nat Neurosci 1999 May;2(5):434-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Sept12 is a component of the mammalian sperm tail annulus. Steels JD, etal., Cell Motil Cytoskeleton. 2007 Oct;64(10):794-807.
9. Reciprocal expression of infant- and adult-preferring transcripts of CDCrel-1 septin gene in the rat neocortex. Toda S, etal., Biochem Biophys Res Commun 2000 Jul 5;273(2):723-8.
10. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
Additional References at PubMed
PMID:11064363   PMID:11739749   PMID:12475938   PMID:14530399   PMID:15214843   PMID:18385322   PMID:18398426   PMID:18809578   PMID:19240081   PMID:20624595   PMID:20680483   PMID:21767234  
PMID:22589251   PMID:24722188   PMID:25416956   PMID:29476059   PMID:31814881  


Genomics

Comparative Map Data
Septin5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,877,946 - 95,883,738 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1195,873,864 - 95,883,737 (+)EnsemblGRCr8
mRatBN7.21182,373,601 - 82,379,393 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,369,754 - 82,379,393 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,103,250 - 91,109,040 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,764,456 - 83,770,246 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,817,972 - 82,823,762 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,516,377 - 86,522,169 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,512,797 - 86,522,168 (+)Ensemblrn6Rnor6.0
Rnor_5.01189,616,382 - 89,622,161 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41184,365,193 - 84,370,972 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1181,149,418 - 81,155,210 (+)NCBICelera
RGSC_v3.11184,405,788 - 84,410,228 (+)NCBI
Cytogenetic Map11q23NCBI
SEPTIN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,714,503 - 19,723,319 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,714,467 - 19,724,224 (+)Ensemblhg38GRCh38
GRCh372219,702,026 - 19,710,842 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map22q11.21NCBI
HuRef223,322,278 - 3,330,831 (+)NCBIHuRef
CHM1_12219,701,568 - 19,710,409 (+)NCBICHM1_1
T2T-CHM13v2.02220,091,294 - 20,100,110 (+)NCBIT2T-CHM13v2.0
Septin5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,440,561 - 18,448,688 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,439,252 - 18,448,704 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381618,621,811 - 18,629,938 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,620,502 - 18,629,954 (-)Ensemblmm10GRCm38
MGSCv371618,621,904 - 18,630,031 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361618,535,374 - 18,543,501 (-)NCBIMGSCv36mm8
Celera1619,195,904 - 19,204,004 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.53NCBI
SEPTIN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,568,776 - 29,573,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,569,586 - 29,573,842 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2629,525,805 - 29,534,528 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02630,972,530 - 30,980,666 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,971,910 - 30,980,677 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,019,021 - 29,027,743 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,644,701 - 28,653,412 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,730,245 - 29,738,980 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SEPTIN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,252,815 - 51,261,244 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11451,252,815 - 51,260,851 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,892,042 - 54,900,148 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Septin5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v143,873,065 - 3,881,305 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:191
Count of miRNA genes:113
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000041168, ENSRNOT00000050412, ENSRNOT00000051680
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
RH133449  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,379,234 - 82,379,386 (+)MAPPERmRatBN7.2
Rnor_6.01186,522,011 - 86,522,162NCBIRnor6.0
Rnor_5.01189,622,003 - 89,622,154UniSTSRnor5.0
RGSC_v3.41184,370,814 - 84,370,965UniSTSRGSC3.4
Celera1181,155,052 - 81,155,203UniSTS
RH 3.4 Map11700.1UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000040954   ⟹   ENSRNOP00000043041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1195,877,959 - 95,883,737 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000041168   ⟹   ENSRNOP00000039995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1195,877,944 - 95,883,736 (+)Ensembl
mRatBN7.2 Ensembl1182,373,601 - 82,379,393 (+)Ensembl
Rnor_6.0 Ensembl1186,516,390 - 86,522,168 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000051680   ⟹   ENSRNOP00000042895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1195,873,864 - 95,882,397 (+)Ensembl
mRatBN7.2 Ensembl1182,369,754 - 82,379,393 (+)Ensembl
Rnor_6.0 Ensembl1186,512,797 - 86,519,915 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000154250   ⟹   ENSRNOP00000103412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1195,874,090 - 95,882,397 (+)Ensembl
RefSeq Acc Id: NM_053931   ⟹   NP_446383
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,877,946 - 95,883,738 (+)NCBI
mRatBN7.21182,373,601 - 82,379,393 (+)NCBI
Rnor_6.01186,516,377 - 86,522,169 (+)NCBI
Rnor_5.01189,616,382 - 89,622,161 (+)NCBI
RGSC_v3.41184,365,193 - 84,370,972 (+)RGD
Celera1181,149,418 - 81,155,210 (+)NCBI
Sequence:
RefSeq Acc Id: NP_446383   ⟸   NM_053931
- UniProtKB: D3ZDH8 (UniProtKB/TrEMBL),   A6JSF4 (UniProtKB/TrEMBL),   A6JSF3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039995   ⟸   ENSRNOT00000041168
Ensembl Acc Id: ENSRNOP00000042895   ⟸   ENSRNOT00000051680
Ensembl Acc Id: ENSRNOP00000043041   ⟸   ENSRNOT00000040954
Ensembl Acc Id: ENSRNOP00000103412   ⟸   ENSRNOT00000154250
Protein Domains
Septin-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJM9-F1-model_v2 AlphaFold Q9JJM9 1-369 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698302
Promoter ID:EPDNEW_R8823
Type:initiation region
Name:Sept5_1
Description:septin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8824  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,512,712 - 86,512,772EPDNEW
RGD ID:13698299
Promoter ID:EPDNEW_R8824
Type:multiple initiation site
Name:Sept5_2
Description:septin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8823  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,516,377 - 86,516,437EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621763 AgrOrtholog
BioCyc Gene G2FUF-20667 BioCyc
Ensembl Genes ENSRNOG00000029912 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041168 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro G_SEPTIN_dom UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Septin UniProtKB/Swiss-Prot
NCBI Gene 116728 ENTREZGENE
PANTHER SEPTIN UniProtKB/Swiss-Prot
Pfam Septin UniProtKB/Swiss-Prot
PhenoGen Septin5 PhenoGen
PIRSF Septin UniProtKB/Swiss-Prot
PROSITE G_SEPTIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029912 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0ABK0LIT6_RAT UniProtKB/TrEMBL
  A6JSF3 ENTREZGENE, UniProtKB/TrEMBL
  A6JSF4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDH8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZT07_RAT UniProtKB/TrEMBL
  Q9JJM9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8R2F7 UniProtKB/Swiss-Prot
  Q9JJM8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Septin5  septin 5  Sept5  septin 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-05-02 Sept5  septin 5  Pnutl1  peanut (Drosophila)-like 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-08-07 Pnutl1  peanut (Drosophila)-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL