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Gene: Foxq1 (forkhead box Q1) Rattus norvegicus

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Symbol:

Foxq1

Name:

forkhead box Q1

RGD ID:

621572

Description:

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hair follicle morphogenesis. Predicted to be located in nucleus. Orthologous to human FOXQ1 (forkhead box Q1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

forkhead box protein Q1; hepatocyte nuclear factor 3 forkhead homolog 1; Hfh-1; Hfh1; HNF-3/forkhead homolog-1; HNF-3/forkhead-like protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FOXQ1 (forkhead box Q1)	HGNC	HomoloGene, NCBI, Panther
Mus musculus (house mouse):	Foxq1 (forkhead box Q1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Foxq1 (forkhead box Q1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FOXQ1 (forkhead box Q1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FOXQ1 (forkhead box Q1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Foxq1 (forkhead box Q1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FOXQ1 (forkhead box Q1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FOXQ1 (forkhead box Q1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Foxq1 (forkhead box Q1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Foxq1 (forkhead box Q1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FOXQ1 (forkhead box Q1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Foxq1 (forkhead box Q1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	foxq1a (forkhead box Q1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	foxq1b (forkhead box Q1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	FKH1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	foxq1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	foxq1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	33,121,454 - 33,124,087 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	33,121,545 - 33,123,720 (-)	Ensembl				GRCr8
mRatBN7.2	17	32,912,744 - 32,915,377 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	32,914,460 - 32,915,008 (+)	Ensembl				mRatBN7.2
mRatBN7.2 Ensembl	17	32,912,744 - 32,915,377 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	32,760,502 - 32,763,135 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	34,364,329 - 34,366,962 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	32,756,308 - 32,758,941 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	34,224,308 - 34,226,941 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	34,224,818 - 34,226,453 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	36,108,677 - 36,111,310 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	39,332,906 - 39,334,655 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	32,462,463 - 32,465,096 (-)	NCBI		Celera
RGSC_v3.1	17	39,335,746 - 39,337,496 (-)	NCBI
Cytogenetic Map	17	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetaldehyde (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

aflatoxin M1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antimonite (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bleomycin A2 (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chloroprene (EXP,ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

clofibrate (ISO)

clofibric acid (EXP)

cobalt dichloride (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (EXP,ISO)

diallyl trisulfide (ISO)

dibutyl phthalate (EXP,ISO)

dimethyl sulfoxide (ISO)

dimethylarsinic acid (EXP)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

dorsomorphin (ISO)

epoxiconazole (ISO)

ethanol (EXP)

fenofibrate (ISO)

folic acid (ISO)

gentamycin (EXP)

indometacin (ISO)

inulin (ISO)

L-methionine (ISO)

leflunomide (ISO)

lipopolysaccharide (EXP)

mifepristone (EXP)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine (EXP)

nickel dichloride (EXP)

nitrofen (EXP)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

permethrin (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

ranitidine (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sotorasib (ISO)

sulforaphane (ISO)

tamoxifen (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trametinib (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anatomical structure morphogenesis (IBA)

cell differentiation (IBA)

hair follicle morphogenesis (ISO)

morphogenesis of an epithelium (IEA)

negative regulation of DNA-templated transcription (IEA)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA,ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.	Clevidence DE, etal., Proc Natl Acad Sci U S A 1993 May 1;90(9):3948-52.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10896677	PMID:11309849	PMID:12477932

Genomics

Comparative Map Data

Foxq1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	33,121,454 - 33,124,087 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	33,121,545 - 33,123,720 (-)	Ensembl				GRCr8
mRatBN7.2	17	32,912,744 - 32,915,377 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	32,914,460 - 32,915,008 (+)	Ensembl				mRatBN7.2
mRatBN7.2 Ensembl	17	32,912,744 - 32,915,377 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	32,760,502 - 32,763,135 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	34,364,329 - 34,366,962 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	32,756,308 - 32,758,941 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	34,224,308 - 34,226,941 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	34,224,818 - 34,226,453 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	36,108,677 - 36,111,310 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	39,332,906 - 39,334,655 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	32,462,463 - 32,465,096 (-)	NCBI		Celera
RGSC_v3.1	17	39,335,746 - 39,337,496 (-)	NCBI
Cytogenetic Map	17	p12	NCBI

FOXQ1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	1,312,098 - 1,314,758 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	1,312,098 - 1,314,758 (+)	Ensembl			hg38	GRCh38
GRCh37	6	1,312,333 - 1,314,993 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	1,257,675 - 1,259,993 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	1,257,674 - 1,259,981	NCBI
Celera	6	2,541,803 - 2,544,121 (+)	NCBI		Celera
Cytogenetic Map	6	p25.3	NCBI
HuRef	6	1,184,067 - 1,186,513 (+)	NCBI		HuRef
CHM1_1	6	1,314,768 - 1,317,086 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	1,175,612 - 1,178,272 (+)	NCBI		T2T-CHM13v2.0

Foxq1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	31,742,153 - 31,744,959 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	31,740,117 - 31,744,959 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	31,558,170 - 31,560,976 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	31,556,134 - 31,560,976 (+)	Ensembl			mm10	GRCm38
MGSCv37	13	31,650,039 - 31,652,845 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	31,565,902 - 31,567,935 (+)	NCBI		MGSCv36	mm8
Celera	13	31,770,932 - 31,773,738 (+)	NCBI		Celera
Cytogenetic Map	13	A3.2	NCBI
cM Map	13	13.46	NCBI

Foxq1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955465	11,802,947 - 11,803,381 (-)	NCBI	ChiLan1.0	ChiLan1.0

FOXQ1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	15,929,875 - 15,932,677 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	11,926,497 - 11,928,563 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	1,134,672 - 1,137,323 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

FOXQ1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	35	1,765,832 - 1,767,751 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	1,712,280 - 1,714,198 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	35	1,687,881 - 1,689,801 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	1,708,373 - 1,710,275 (+)	NCBI		UNSW_CanFamBas_1.0

Foxq1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	24,159,597 - 24,162,251 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936633	2,459,047 - 2,460,260 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936633	2,458,473 - 2,460,990 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FOXQ1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	664,373 - 665,563 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	664,360 - 666,401 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	864,128 - 866,825 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FOXQ1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	70,824,812 - 70,827,737 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	70,826,264 - 70,827,478 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666044	1,256,352 - 1,258,997 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Foxq1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	23,269,235 - 23,271,802 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624756	23,265,721 - 23,271,954 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Foxq1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	50,573,651 - 50,576,627 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Foxq1
6 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	129
Count of miRNA genes:	89
Interacting mature miRNAs:	96
Transcripts:	ENSRNOT00000039482
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	43999106	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9266755	40968173	Rat
70210	Cm15	Cardiac mass QTL 15	6.5		heart right ventricle mass (VT:0007033)	heart right ventricle wet weight (CMO:0000072)	17	30066472	75066472	Rat
8552966	Pigfal18	Plasma insulin-like growth factor 1 level QTL 18	8.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	12860942	57860942	Rat
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2120843	42054133	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	33104645	78104645	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	6221998	58177198	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22660799	55604694	Rat
9589151	Insul30	Insulin level QTL 30	8.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	12860942	57860942	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	32199534	49497050	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21498994	50592236	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27233445	83975845	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4733534	49733534	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23286322	64246472	Rat
9589057	Scfw6	Subcutaneous fat weight QTL 6	8.62	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	17	12860942	57860942	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	26522051	71522051	Rat
9590154	Scort9	Serum corticosterone level QTL 9	23.57	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	12860942	57860942	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	22019705	67019705	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24390595	84432719	Rat
9590088	Insglur7	Insulin/glucose ratio QTL 7	20.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	17	12860942	57860942	Rat
2313854	Bp343	Blood pressure QTL 343	3.9		life span trait (VT:0005372)	age at time of death (CMO:0001193)	17	32199534	55604694	Rat
2317053	Aia25	Adjuvant induced arthritis QTL 25	2.69		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	10604694	55604694	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	1	36045694	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15537025	60531414	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	33104645	78104645	Rat
7411666	Foco31	Food consumption QTL 31	11.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	17	12860942	57860942	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4733534	49733534	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23858926	68858926	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23858926	68858926	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27233445	65155015	Rat
4889891	Eae32	Experimental allergic encephalomyelitis QTL 32	4.8	0.0002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	27233445	72233445	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23858926	68858926	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38037084	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23858926	68858926	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23858926	68858926	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	43999106	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	32199534	86201342	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	43999106	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			24136127	84432719	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat

Markers in Region

RH143264

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	32,913,331 - 32,913,565 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	34,224,896 - 34,225,129	NCBI	Rnor6.0
Rnor_5.0	17	36,109,265 - 36,109,498	UniSTS	Rnor5.0
RGSC_v3.4	17	39,332,984 - 39,333,217	UniSTS	RGSC3.4
Celera	17	32,463,051 - 32,463,284	UniSTS
RH 3.4 Map	17	376.6	UniSTS
Cytogenetic Map	17	p14-p12	UniSTS

Hfh1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	32,914,212 - 32,914,315 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	34,225,777 - 34,225,879	NCBI	Rnor6.0
Rnor_5.0	17	36,110,146 - 36,110,248	UniSTS	Rnor5.0
RGSC_v3.4	17	39,333,865 - 39,333,967	UniSTS	RGSC3.4
Celera	17	32,463,932 - 32,464,034	UniSTS
Cytogenetic Map	17	p14-p12	UniSTS

Hfh1l

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	32,914,545 - 32,914,710 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	34,226,110 - 34,226,274	NCBI	Rnor6.0
Rnor_5.0	17	36,110,479 - 36,110,643	UniSTS	Rnor5.0
RGSC_v3.4	17	39,334,198 - 39,334,362	UniSTS	RGSC3.4
Celera	17	32,464,265 - 32,464,429	UniSTS
Cytogenetic Map	17	p14-p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	5	52	150	81	86	55	56	55	6	283	128	8	134	81	91	31	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC161861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L13201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000039482

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	32,914,460 - 32,915,008 (+)	Ensembl
Rnor_6.0 Ensembl	17	34,224,818 - 34,226,453 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109136 ⟹ ENSRNOP00000077510

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	33,121,545 - 33,123,720 (-)	Ensembl
mRatBN7.2 Ensembl	17	32,912,744 - 32,915,377 (-)	Ensembl

RefSeq Acc Id:

NM_022858 ⟹ NP_074049

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	33,121,454 - 33,124,087 (-)	NCBI
mRatBN7.2	17	32,912,744 - 32,915,377 (-)	NCBI
Rnor_6.0	17	34,224,308 - 34,226,941 (-)	NCBI
Rnor_5.0	17	36,108,677 - 36,111,310 (-)	NCBI
RGSC_v3.4	17	39,332,906 - 39,334,655 (-)	RGD
Celera	17	32,462,463 - 32,465,096 (-)	NCBI

Sequence:

show sequence

CCGGCCAGCGCTGACATGCTGCCGGGGAGGCCAGAGGTGGCAAGGCGGCTGCGGGTGCGGCGGC
CTCGGAGACTCCTTTCTATGGGCTCTCGAGGCTGAAGACGTCTTATCCTCAAAAGTAGCGGGTG
CCCCATCAGAGGTCAGCTCGGTGTCTAAGACCTAGACATCCAGCGAAGGAACACTTTTGGACGC
CTGGACGGAGAGCAGATGCGCTGGCTCTTTCCTCCCAGCACGAAATTCTAAGGCTTGCGTGTCC
TGGCCCCCGCTTCGCAGGGTGGCCCCTCATTCCTCGCTTGTCTTCCGCCCAAAGTCTCCAAACC
TCGGAGTAAGGACAGCATTGCACCAACTTCTACTACTCCACTCCTCAGTTCACTCAACACTCAC
AACCCCTCCAAAGAAACATTCCAGCGGAGGACAACCTTACGGAAAAGCGTCTCTCTCCGAAAGA
CGCAGGAGCGGTCCTTCCTGGGAGAAGATAGCCTGAGCGGGCCACGGGATCGCCACTCGCTTCC
TACGACCTCGCAGGAAAGGGGTAATAGCGCCGGACGGGAAGCACCAGAGCCGGCATGAAATTGG
AGGTATTTGCCCCACGCGCAGCCCACGGGGACAAGATGGGCAGTGACCTGGAGGGGGCCGGCAG
CAGCGACGTGCCATCTCCGCTGTCCGCGGCTGGCGACGACTCCTTAGGCTCTGACGGGGACTGT
GCAGCCAACAGCCCGGCGGCGGGCAGAGGCGCCGTGGATCTGGAAGGCGGCGGCGGCGAGAGGA
ATTCGAGTGGCGGGGCGAGCACCCAAGACGATCCCGAGGTGACCGATGGCAGCAGAACGCAGGC
CTCCCCGGTGGGGCCGTGCGCGGGCAGCGTGGGCGGCGGTGAGGGCGCGCGCAGCAAGCCGTAC
ACGCGGCGGCCCAAGCCCCCCTACTCCTACATCGCACTCATCGCCATGGCCATCCGCGACTCCG
CGGGCGGACGCCTGACGCTGGCCGAGATCAACGAGTACCTCATGGGCAAGTTCCCCTTTTTCCG
GGGCAGCTACACGGGCTGGCGCAACTCCGTGCGCCACAACCTCTCGCTCAACGACTGTTTCGTC
AAGGTGCTGCGCGACCCCTCGCGGCCCTGGGGCAAGGACAATTACTGGATGCTCAACCCCAACA
GCGAATACACCTTCGCCGACGGGGTCTTCCGCCGCCGCCGCAAGCGCCTCAGCCACCGGACCAC
AGTCTCCGCATCGGGGCTACGGCCGGAGGAAGCCCCACCCGGACCTGCGGGGACCCCGCAGCCC
GCGCCCACCGCCGGCTCCTCCCCAATCGCGCGCTCGCCCGCTCGCCAGGAGGAGGGCTCCAGCC
CGGCGAGCAAGTTCTCCAGCTCCTTCGCCATCGACAGCATCCTCAGCAAGCCGTTTCGCAGCCG
CCGCGACGGCGACCCGGCTCTGGGGGTGCAGCTACCCTGGAGCGCTGCTCCCTGCCCGCCGCTG
CGCGCCTATCCCGCGCTCCTTCCCGCGTCGTCCGGCGGTGCCCTGCTGCCGCTCTGTGCTTACG
GCGCGGGCGAGCCCACGCTGCTGGCGTCGCGCGGGGCCGAGGTGCAGCCCGCGGCGCCCCTGTT
GCTGGCGCCCCTCTCCACCGCGGCCCCAGCCAAGCCATTTCGAGGTCCGGAGACCGCCGGCGCG
GCGCACCTGTACTGCCCCCTACGGCTGCCCACGGCCCTGCAGGCGGCCGCGGCCTGCGGTCCGG
GTCCGCACCTGTCCTACCGGGTGGAGACGCTGCTAGCTTGACAGGAGCTTGGAGCTCTGCTGGT
GGGTCTAGGGTGGAGTTGGGAGCACCTTTTGTCATGGAGGGCACCTTTTGTCATGGAGGTTGGA
ATGCGGGCTCCAGGGCTGTGCACTTTCCACCTTCCCCGAGGAATAGAGATTTTTTTTTCAACTC
TCCATCAAATGTGCCTTAAAGTTAAGCATTTTGTCCCAAGTGTTTTAACTTAGTCCAGAATAGT
TCCTTTGTCTTTTCTAACTTTACAGAGGATCAAAGCTGTTCTTTTCTATTTCATGGCCAGGCCT
GTACTCTCCCGCAAAGAGGCTTTCCTCTCCCTCCTATTGTGTTGCACCTTCTGCTGATTTTTCT
TCCCCACCCACGAAAAAAGAAAAAAAGAAAAAAAAATGAACATCAGGGAACCATTCCATGGGGA
TAAATGGTGACTACTGTTTGGGGTTTTGAGACTCCGCTGGGTGTAAATGTGTGTCTTTCACAGG
AGTGACTGCGTGTGAGAGAGCTGTCAATCTTCCAGTCATTTTCTCTGCTATCAACCAATGCTTC
ACTGTGCCAAAAACAAGGGGAAATGTTGTTGGGTTTTTGTAATTAAATTATTTATATATTTTTG
AAACCTGAATTGAAATGTTGCAGGCAACGGCTACAGCTTTATTAGTGGTTACCTAACTGTGGTC
TTCTTGGGCCGAGCAATTTCTTTAAAGGAAAAGTTAACATATGTTTGTGGGGTGCCAGGGCCAC
CACCACGTGAAACCAAGTGTGATTTTTATTTTAATATTATTTGTGTCTGTATATATATTCGTGT
ATAAATTTTATGAAGCCCAGGCATACTACTTGTTTTTTTTTTTTTAATAAAATTCACAATTGAT
CTACAAAACA

hide sequence

Protein Sequences


Protein RefSeqs	NP_074049	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA74561	(Get FASTA)	NCBI Sequence Viewer
	AAI61861	(Get FASTA)	NCBI Sequence Viewer
	EDL98355	(Get FASTA)	NCBI Sequence Viewer
	Q63244	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_074049 ⟸ NM_022858

- UniProtKB:

Q63244 (UniProtKB/Swiss-Prot), A0A8I5Y7M5 (UniProtKB/TrEMBL), A6J7K5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKLEVFAPRAAHGDKMGSDLEGAGSSDVPSPLSAAGDDSLGSDGDCAANSPAAGRGAVDLEGGG
GERNSSGGASTQDDPEVTDGSRTQASPVGPCAGSVGGGEGARSKPYTRRPKPPYSYIALIAMAI
RDSAGGRLTLAEINEYLMGKFPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWML
NPNSEYTFADGVFRRRRKRLSHRTTVSASGLRPEEAPPGPAGTPQPAPTAGSSPIARSPARQEE
GSSPASKFSSSFAIDSILSKPFRSRRDGDPALGVQLPWSAAPCPPLRAYPALLPASSGGALLPL
CAYGAGEPTLLASRGAEVQPAAPLLLAPLSTAAPAKPFRGPETAGAAHLYCPLRLPTALQAAAA
CGPGPHLSYRVETLLA

hide sequence

Ensembl Acc Id:

ENSRNOP00000077510 ⟸ ENSRNOT00000109136

Protein Domains

Fork-head

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63244-F1-model_v2	AlphaFold	Q63244	1-399	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621572	AgrOrtholog
BioCyc Gene	G2FUF-9553	BioCyc
Ensembl Genes	ENSRNOG00000021752	Ensembl
	ENSRNOG00000062314	Ensembl
Gene3D-CATH	1.10.10.10	UniProtKB/Swiss-Prot
InterPro	FH_FOXQ1	UniProtKB/Swiss-Prot
	Fork_head_dom	UniProtKB/Swiss-Prot
	FOX_domain-containing	UniProtKB/Swiss-Prot
	TF_fork_head_CS_1	UniProtKB/Swiss-Prot
	TF_fork_head_CS_2	UniProtKB/Swiss-Prot
	WH-like_DNA-bd_sf	UniProtKB/Swiss-Prot
	WH_DNA-bd_sf	UniProtKB/Swiss-Prot
NCBI Gene	64826	ENTREZGENE
PANTHER	FORKHEAD BOX PROTEIN	UniProtKB/Swiss-Prot
	FORKHEAD BOX PROTEIN Q1	UniProtKB/Swiss-Prot
Pfam	Forkhead	UniProtKB/Swiss-Prot
PhenoGen	Foxq1	PhenoGen
PRINTS	FORKHEAD	UniProtKB/Swiss-Prot
PROSITE	FORK_HEAD_1	UniProtKB/Swiss-Prot
	FORK_HEAD_2	UniProtKB/Swiss-Prot
	FORK_HEAD_3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000021752	RatGTEx
	ENSRNOG00000062314	RatGTEx
SMART	SM00339	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF46785	UniProtKB/Swiss-Prot
UniProt	A0A8I5Y7M5	ENTREZGENE, UniProtKB/TrEMBL
	A6J7K5	ENTREZGENE, UniProtKB/TrEMBL
	FOXQ1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-11-17	Foxq1	forkhead box Q1		HNF-3/forkhead homolog-1	Name updated	1299863	APPROVED
2004-09-10	Foxq1	HNF-3/forkhead homolog-1	Hfh1		Symbol and Name updated	1299863	APPROVED
2002-08-07	Hfh1	HNF-3/forkhead homolog-1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains a DNA-binding-domain	632667

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD