Cyb5b (cytochrome b5 type B) - Rat Genome Database

Name: Cyb5b
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Cyb5b (cytochrome b5 type B) Rattus norvegicus

Analyze

Symbol:

Cyb5b

Name:

cytochrome b5 type B

RGD ID:

621551

Description:

Enables enzyme activator activity. Predicted to be involved in nitric oxide biosynthetic process. Located in mitochondrial outer membrane. Orthologous to human CYB5B (cytochrome b5 type B); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Cyb5m; cytochrome b5 outer mitochondrial membrane isoform; cytochrome b5 type B (outer mitochondrial membrane); cytochrome b5, outer mitochondrial membrane isoform; omb5

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CYB5B (cytochrome b5 type B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cyb5b (cytochrome b5 type B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	LOC102026979 (cytochrome b5 type B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100977441 (cytochrome b5 type B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CYB5B (cytochrome b5 type B (outer mitochondrial membrane))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101972623 (cytochrome b5 type B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CYB5B (cytochrome b5 type B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103233210 (cytochrome b5 type B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	LOC101712938 (cytochrome b5 type B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Cyb5b (cytochrome b5 type B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CYB5B (cytochrome b5 type B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cyb5b (cytochrome b5 type B)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder)
Saccharomyces cerevisiae (baker's yeast):	CYB5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Cyt-b5	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cytb-5.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cyb5b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	51,972,611 - 52,006,477 (+)	NCBI		GRCr8
mRatBN7.2	19	35,062,871 - 35,096,741 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	35,062,813 - 35,098,249 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	41,878,337 - 41,912,205 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	42,531,689 - 42,565,561 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	44,836,503 - 44,870,428 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	39,357,814 - 39,391,680 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	39,357,791 - 39,393,189 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	50,221,836 - 50,255,701 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	37,016,959 - 37,050,722 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	37,021,839 - 37,055,599 (+)	NCBI
Celera	19	34,486,613 - 34,520,473 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant dyskeratosis congenita 6 (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-methylcholanthrene (ISO)

acetamide (EXP)

acrolein (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

atrazine (ISO)

benzamidoxime (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

cisplatin (ISO)

clofibrate (ISO)

clozapine (EXP)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

diquat (ISO)

diuron (ISO)

dorsomorphin (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

fumonisin B1 (ISO)

hydrogen peroxide (ISO)

inulin (ISO)

ivermectin (ISO)

lead diacetate (ISO)

methamphetamine (EXP)

methyl methanesulfonate (ISO)

Methylazoxymethanol acetate (EXP)

methylmercury chloride (ISO)

miconazole (ISO)

monosodium L-glutamate (ISO)

N(4)-hydroxycytidine (ISO)

N-Nitrosodi-n-butylamine (ISO)

N-Nitrosodi-n-propylamine (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (ISO)

NAD zwitterion (ISO)

NAD(+) (ISO)

nickel atom (ISO)

nimesulide (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenethyl isothiocyanate (ISO)

phenobarbital (EXP)

pirinixic acid (ISO)

piroxicam (ISO)

potassium dichromate (ISO)

progesterone (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium fluoride (ISO)

Soman (EXP)

sulfamethoxazole hydroxylamine (ISO)

sulindac sulfide (ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

thapsigargin (EXP,ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nitric oxide biosynthetic process (ISO)

proton transmembrane transport (IEA)

Cellular Component

intracellular membrane-bounded organelle (IBA)

membrane (IEA)

mitochondrial outer membrane (IBA,IDA,IEA)

nitric-oxide synthase complex (ISO)

Molecular Function

enzyme activator activity (IDA)

heme binding (IBA,IEA,ISO)

metal ion binding (IEA)

nitrite reductase (NO-forming) activity (ISO)

protein binding (ISO)

ubiquinol-cytochrome-c reductase activity (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	The targeting information of the mitochondrial outer membrane isoform of cytochrome b5 is contained within the carboxyl-terminal region.	De Silvestris M, etal., FEBS Lett 1995 Aug 14;370(1-2):69-74.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Two homologous cytochromes b5 in a single cell.	Lederer F, etal., Eur J Biochem. 1983 Apr 15;132(1):95-102.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells.	Ogishima T, etal., J Biol Chem. 2003 Jun 6;278(23):21204-11. Epub 2003 Mar 31.
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:8973214	PMID:9484218	PMID:11197480	PMID:11583146	PMID:12767127	PMID:12865426	PMID:15486098	PMID:15489334	PMID:15666805	PMID:16807901	PMID:18614015	PMID:19946888
PMID:20861021	PMID:21574570	PMID:22203676

Genomics

Comparative Map Data

Cyb5b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	51,972,611 - 52,006,477 (+)	NCBI		GRCr8
mRatBN7.2	19	35,062,871 - 35,096,741 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	35,062,813 - 35,098,249 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	41,878,337 - 41,912,205 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	42,531,689 - 42,565,561 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	44,836,503 - 44,870,428 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	39,357,814 - 39,391,680 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	39,357,791 - 39,393,189 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	50,221,836 - 50,255,701 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	37,016,959 - 37,050,722 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	37,021,839 - 37,055,599 (+)	NCBI
Celera	19	34,486,613 - 34,520,473 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

CYB5B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	69,424,619 - 69,466,264 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	69,398,402 - 69,466,264 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	69,458,522 - 69,500,167 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	68,015,999 - 68,057,668 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	68,016,063 - 68,055,208	NCBI
Celera	16	53,973,073 - 54,014,760 (+)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	55,336,597 - 55,378,285 (+)	NCBI		HuRef
CHM1_1	16	70,866,498 - 70,908,170 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	75,226,795 - 75,268,458 (+)	NCBI		T2T-CHM13v2.0

Cyb5b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	107,877,293 - 107,914,102 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	107,877,272 - 107,914,103 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	107,150,661 - 107,187,470 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	107,150,640 - 107,187,471 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	109,674,561 - 109,711,370 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	110,039,790 - 110,076,599 (+)	NCBI		MGSCv36	mm8
Celera	8	111,377,448 - 111,414,325 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.71	NCBI

LOC102026979
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	7,237,906 - 7,271,123 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	7,239,364 - 7,270,639 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100977441
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	78,971,502 - 79,027,929 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	84,883,151 - 84,923,041 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	49,801,900 - 49,843,698 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	69,187,541 - 69,226,744 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	69,187,541 - 69,226,744 (+)	Ensembl	panpan1.1		panPan2

CYB5B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	80,204,211 - 80,224,288 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	80,192,689 - 80,231,299 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	80,634,998 - 80,674,838 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	5	80,463,026 - 80,501,679 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	80,151,322 - 80,190,353 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	80,785,370 - 80,824,317 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101972623
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	40,011,922 - 40,046,742 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	19,542,115 - 19,577,678 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	19,542,378 - 19,577,192 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYB5B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	17,519,289 - 17,558,181 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	17,522,587 - 17,558,030 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	16,469,821 - 16,505,266 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103233210
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	57,939,055 - 57,978,240 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	57,937,176 - 57,978,449 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	20,669,858 - 20,709,376 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101712938
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624746	16,905,967 - 16,942,861 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cyb5b
91 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	236
Count of miRNA genes:	176
Interacting mature miRNAs:	198
Transcripts:	ENSRNOT00000015006
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	1	36824771	Rat
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	1	36824771	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	36824771	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	1	36824771	Rat
9589102	Slep13	Serum leptin concentration QTL 13	4.63	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	19	569374	45569374	Rat
8694186	Bw152	Body weight QTL 152	3.34	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	569374	45569374	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2187927	46708701	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	2316121	47316121	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	3204777	48204777	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	7457249	42983518	Rat
724565	Tcas5	Tongue tumor susceptibility QTL 5	10.04		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	19	9977753	39654489	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10827970	43544039	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	15605023	46559041	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	24817978	39654489	Rat
1354600	Salc2	Saline consumption QTL 2	9.91	0.001	drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	19	27530207	37947399	Rat
1354607	Gmadr1	Adrenal mass QTL 1	5.83		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	19	27530207	37947399	Rat
1354633	Bw28	Body weight QTL 28	6.04		body mass (VT:0001259)	body weight (CMO:0000012)	19	27530207	37947399	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	19	33838214	55283146	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	33838214	55283146	Rat

Markers in Region

RH130021

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	35,096,524 - 35,096,706 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	39,391,464 - 39,391,645	NCBI	Rnor6.0
Rnor_5.0	19	50,255,485 - 50,255,666	UniSTS	Rnor5.0
RGSC_v3.4	19	37,050,506 - 37,050,687	UniSTS	RGSC3.4
Celera	19	34,520,257 - 34,520,438	UniSTS
RH 3.4 Map	19	305.2	UniSTS
Cytogenetic Map	19	q12	UniSTS

RH143182

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	35,064,875 - 35,065,036 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	39,359,817 - 39,359,977	NCBI	Rnor6.0
Rnor_5.0	19	50,223,839 - 50,223,999	UniSTS	Rnor5.0
RGSC_v3.4	19	37,018,962 - 37,019,122	UniSTS	RGSC3.4
Celera	19	34,488,616 - 34,488,776	UniSTS
RH 3.4 Map	19	293.9	UniSTS
Cytogenetic Map	19	q12	UniSTS

RH137527

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	35,064,855 - 35,065,051 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	39,359,797 - 39,359,992	NCBI	Rnor6.0
Rnor_5.0	19	50,223,819 - 50,224,014	UniSTS	Rnor5.0
RGSC_v3.4	19	37,018,942 - 37,019,137	UniSTS	RGSC3.4
Celera	19	34,488,596 - 34,488,791	UniSTS
Cytogenetic Map	19	q12	UniSTS

RH140205

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	35,094,423 - 35,094,632 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	39,389,363 - 39,389,571	NCBI	Rnor6.0
Rnor_5.0	19	50,253,384 - 50,253,592	UniSTS	Rnor5.0
RGSC_v3.4	19	37,048,405 - 37,048,613	UniSTS	RGSC3.4
Celera	19	34,518,156 - 34,518,364	UniSTS
RH 3.4 Map	19	305.1	UniSTS
Cytogenetic Map	19	q12	UniSTS

AI009319

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	35,094,724 - 35,094,846 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	39,389,664 - 39,389,785	NCBI	Rnor6.0
Rnor_5.0	19	50,253,685 - 50,253,806	UniSTS	Rnor5.0
RGSC_v3.4	19	37,048,706 - 37,048,827	UniSTS	RGSC3.4
Celera	19	34,518,457 - 34,518,578	UniSTS
RH 3.4 Map	19	304.4	UniSTS
Cytogenetic Map	19	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	39	11	8
Low											2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_030586	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC124839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC072535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X96392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Y12517	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000015006 ⟹ ENSRNOP00000015006

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	35,062,813 - 35,096,731 (+)	Ensembl
Rnor_6.0 Ensembl	19	39,357,814 - 39,391,722 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000086435 ⟹ ENSRNOP00000069128

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	35,062,838 - 35,094,892 (+)	Ensembl
Rnor_6.0 Ensembl	19	39,357,791 - 39,393,189 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099870 ⟹ ENSRNOP00000093641

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	35,062,861 - 35,098,249 (+)	Ensembl

RefSeq Acc Id:

NM_030586 ⟹ NP_085075

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	51,972,611 - 52,006,477 (+)	NCBI
mRatBN7.2	19	35,062,871 - 35,096,741 (+)	NCBI
Rnor_6.0	19	39,357,814 - 39,391,680 (+)	NCBI
Rnor_5.0	19	50,221,836 - 50,255,701 (+)	NCBI
RGSC_v3.4	19	37,016,959 - 37,050,722 (+)	RGD
Celera	19	34,486,613 - 34,520,473 (+)	RGD

Sequence:

show sequence

GATCCAATGGCGACCCCAGAGGCCAGCGGCAGCGGCAGGAATGGCCAGGGCTCCGACCCCGCCG
TCACCTACTACCGGCTGGAGGAGGTGGCGAAGCGAAATACCGCGGAGGAGACGTGGATGGTGAT
CCACGGGCGAGTCTACGATATCACCCGCTTCCTCAGCGAGCATCCTGGTGGAGAAGAGGTTCTA
CTGGAACAAGCTGGTGCCGATGCAACTGAAAGCTTTGAAGATGTCGGCCACTCCCCTGATGCCA
GGGAGATGCTAAAGCAGTACTACATTGGTGATGTCCATCCGAATGACCTTAAACCTAAAGATGG
TGACAAGGACCCTTCAAAAAACAATTCATGCCAAAGTTCCTGGGCATATTGGATTGTCCCCATC
GTGGGTGCTATTCTTATAGGTTTCCTGTATCGTCACTTCTGGGCTGACAGCAAATCCTCCTGAG
GAGGCCACGTTGAAGTGTCGGAGCACATCTCCTGGGAGTGAGAGGTGGAGACTTGTGTGGAGGC
TGCAGGGTGCTCCTTCCTTGGATCCTGCCAGTTGTTTTCTTTCCCCTTGGAGCCAAGATGGTTG
ACCAGATATCTATCCTCCTTCAATGCAGGACCAGAATCTGTCCATCAGCCTGAGCCTGACGCCC
AAAGCACCTGCTCACGTTGTGTCCTTGTCAGGGTTTCTTCTCACTGGTTCCCACTCATTCCCTT
CATTTCAACAGTTGATGCCAATGACTTAGAGTTCCTTTGTTGTAGTGACATGGCCTTTGGGGAC
AGTACATGATTTCTGATACTTTGAATTCACAGTAGACATAGTTAAGGGAACAGCGGTCTAGTTT
TGAGTCTTTCCCCATTTTTCTTTTAAGTAAATTTTTTTAATTCTGATTTAATTTTGTCATTCAT
GATGATAAGGGATTTAATTCATGAAGTTGTGTAGCTCTTGTTTCAAACACAGCTGCCAAATGAT
CTTACTTATGATTGTTAGAAGTAAGGAGCCAGCAAAATGGCTCACTGGATAAAAGCAATTGCAG
AAAAACCAATGACCTGTGTTTGAGTCCCTGTACCCACAGGGTAGAAGGAAGAGAACCAGTTCCC
AAAAGTTGTCCTCTGACTTCCACATGTGTGCTGTGGTCTTTGTGTACACACACACACACACACA
CACACACACACACACACCCCAGATGTAAATTTTAAAAATAGAATACAACAGTGGTTGTCTTCCT
CCCAGATAGTGTAGCTGATGGCCCCTCCTGTCTTTTTTCCCATGAGTATGTCACCAAACTGTGC
ATCCCTTTGATTTTTTAGGGGTATAAGAGCTGAAGAAGGGCCAACTTGAGAATAATCTCATTTA
CAAAAAGAACCAAACACTACTTATAGGCTAGCAGTCTAAAAAGTGACTGGCATGCACTCTCTGG
TCTGCCCTTGGTCCCTGACCGTCTTCCGTCCTGGCTGTCTTTACTGGTGGAAGTTGAAGGTGTG
GGTATCCATGGGACTTCTGTCCGGTCCGGTCCGCGGGGCTTCACAAGAGGCTTGCTGCTTTTCT
GTTTACTGATTAGCAAGTTTCTGTTTCCCTGTTTGAAAGTAAGAGACTCAAGTTTGATCTTCCG
TTTCTCTCAGTAAATAACTCACATGTAAATGTCATTGTCCACACACCATTTCTGATCGGGAGAC
CATGCCAAGAGACTTCTGTTTTCATTTGGGCTCTACCTCCATGGCTCCAGGTTGGTGATTTTGT
CCTACTTTTGAGGATAATGATAAATCTGGAAGCTTTTTTCCCCCTTGGATATGAATTTCATTGG
AAAGTAGGCAGTCATTTAAAATTCCTTTTCTTACTGGTCCAGGCATTTTCCTGGCATCTCTGAC
TGTATTCTCTCTCCCTGTGGCAGTGCCCGACAGTACCCAGCTGTTTCTTAGTTTCTATGATTTT
CCTTCACATGTTTGGTCATTGCTAGTCAGCTTCTGAGCTGGTGTCACATCCAGTAGGAAGCCAT
GGAATCCCAGCGGGACCAGAGATATTGGGAAGTGTCCTCCTGCTTCCCTTCTACCCTGCCAGGG
GCTTGACAAGACAGGACACTACACAGTACACCAGTCTGCCCAAGCAAACTGTTTTAAAAAAAGT
TCAGCCCAGGACTTTTATCCTGTGATTTTAGCAGTTGAATGAATTCAGAAGTCATCAAAATAAC
ATTAGCCTTTTCCTTGCATACTTGGATATGATATTTTAGAGTGATTTCTAGGTGACTTTTATAC
ATCGAAGATGAAGGCTTAACCTTTCATTTTTAGAACGTCTGTAATACTGTGTCACTTATTGACA
GCGTTGTCACTCTGTAACAGCAGTGGCATGCCCAGCGCACCTCCACTTAAAGGCAGGGAAGGCT
TGTGTGCAGGGAGGCTGGGATCCACTTTTGAGGATAGCCAAGTCACATGGAGTATATGGAGTAT
GCTGGGTAAGAGGAAAGGACGAGAGTGTGGGATGGGGGCGTTCCAGCCAATACCAAACCTGATG
GTGTGCCTAGTGAAAACACCTGGCATAGGAAATTAGGTAAAGAACTACATTTTTGGCTGGGCAT
GTTGATGCACACCTTTAATCCCAGTATAAGAGAAGCAGGGGCTGGAAAATCTCTTGAGTTATTG
CCAGCCTGCTCTACATAGCAAGTTCTAGGACAGTCAGGGCTACATGGAGAGACCATGTCACAAC
CACTCCACCAAATAAAAGAACTGTATTTTCAAGTAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_085075	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH72535	(Get FASTA)	NCBI Sequence Viewer
	CAA65256	(Get FASTA)	NCBI Sequence Viewer
	CAA73117	(Get FASTA)	NCBI Sequence Viewer
	EDL92471	(Get FASTA)	NCBI Sequence Viewer
	EDL92472	(Get FASTA)	NCBI Sequence Viewer
	EDL92473	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015006.5
	ENSRNOP00000069128.2
	ENSRNOP00000093641
	ENSRNOP00000093641.1
	ENSRNOP00055028504
	ENSRNOP00060017635
	ENSRNOP00065015317
GenBank Protein	P04166	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_085075 ⟸ NM_030586
- Peptide Label:	precursor
- UniProtKB:	Q9QWG1 (UniProtKB/Swiss-Prot), P04166 (UniProtKB/Swiss-Prot), A6IYZ3 (UniProtKB/TrEMBL), A0A8L2Q7E2 (UniProtKB/TrEMBL), A0A8L2R080 (UniProtKB/TrEMBL)
- Sequence:	show sequence MATPEASGSGRNGQGSDPAVTYYRLEEVAKRNTAEETWMVIHGRVYDITRFLSEHPGGEEVLLE QAGADATESFEDVGHSPDAREMLKQYYIGDVHPNDLKPKDGDKDPSKNNSCQSSWAYWIVPIVG AILIGFLYRHFWADSKSS hide sequence

RefSeq Acc Id:

ENSRNOP00000069128 ⟸ ENSRNOT00000086435

RefSeq Acc Id:

ENSRNOP00000015006 ⟸ ENSRNOT00000015006

RefSeq Acc Id:

ENSRNOP00000093641 ⟸ ENSRNOT00000099870

Protein Domains

Cytochrome b5 heme-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P04166-F1-model_v2	AlphaFold	P04166	1-146	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701132

Promoter ID:

EPDNEW_R11647

Type:

initiation region

Name:

Cyb5b_1

Description:

cytochrome b5 type B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	39,357,750 - 39,357,810	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621551	AgrOrtholog
BioCyc Gene	G2FUF-5762	BioCyc
Ensembl Genes	ENSRNOG00000011142	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055020594	UniProtKB/Swiss-Prot
	ENSRNOG00060013054	UniProtKB/Swiss-Prot
	ENSRNOG00065012275	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000015006.7	UniProtKB/TrEMBL
	ENSRNOT00000086435.3	UniProtKB/TrEMBL
	ENSRNOT00000099870	ENTREZGENE
	ENSRNOT00000099870.1	UniProtKB/Swiss-Prot
	ENSRNOT00055035170	UniProtKB/Swiss-Prot
	ENSRNOT00060022248	UniProtKB/Swiss-Prot
	ENSRNOT00065019970	UniProtKB/Swiss-Prot
Gene3D-CATH	3.10.120.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7103272	IMAGE-MGC_LOAD
InterPro	Aquaporin-like	UniProtKB/TrEMBL
	Cyt_B5-like_heme/steroid-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyt_B5-like_heme/steroid_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyt_B5_heme-BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:80773	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:91666	IMAGE-MGC_LOAD
NCBI Gene	80773	ENTREZGENE
PANTHER	CYTOCHROME B5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CYTOCHROME B5 TYPE B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Cyt-b5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cyb5b	PhenoGen
PRINTS	CYTOCHROMEB5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	CYTOCHROME_B5_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CYTOCHROME_B5_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011142	RatGTEx
	ENSRNOG00055020594	RatGTEx
	ENSRNOG00060013054	RatGTEx
	ENSRNOG00065012275	RatGTEx
SMART	Cyt-b5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF55856	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF81338	UniProtKB/TrEMBL
UniProt	A0A8L2Q7E2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2R080	ENTREZGENE, UniProtKB/TrEMBL
	A6IYZ3	ENTREZGENE, UniProtKB/TrEMBL
	A6IYZ4_RAT	UniProtKB/TrEMBL
	A6IYZ5_RAT	UniProtKB/TrEMBL
	CYB5B_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9QWG1	ENTREZGENE
UniProt Secondary	Q9QWG1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-29	Cyb5b	cytochrome b5 type B	Cyb5b	cytochrome b5 type B (outer mitochondrial membrane)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Cyb5b	cytochrome b5 type B (outer mitochondrial membrane)	Cyb5b	cytochrome b5 type B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Cyb5b	cytochrome b5 type B	Cyb5m	cytochrome b5, outer mitochondrial membrane isoform	Symbol and Name updated	1299863	APPROVED
2005-01-20	Cyb5m	cytochrome b5, outer mitochondrial membrane isoform	omb5		Symbol updated	1299863	APPROVED
2002-08-07	omb5	cytochrome b5, outer mitochondrial membrane isoform			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar