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Gene: Kcns3 (potassium voltage-gated channel, modifier subfamily S, member 3) Rattus norvegicus

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Symbol:

Kcns3

Name:

potassium voltage-gated channel, modifier subfamily S, member 3

RGD ID:

621527

Description:

Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNS3 (potassium voltage-gated channel modifier subfamily S member 3); INTERACTS WITH 17alpha-ethynylestradiol; acetamide; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

delayed-rectifier K(+) channel alpha subunit 3; delayed-rectifier potassium channel regulatory subunit KCNS3; delayed-rectifier potassium channel subunit Kv9.3; Kv9.3; potassium voltage-gated channel subfamily S member 3; potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3; Shab-related delayed-rectifier K+ channel (Kv9.3); voltage-gated potassium channel subunit Kv9.3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	39,527,410 - 39,584,105 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	39,523,777 - 39,618,848 (-)	Ensembl				GRCr8
mRatBN7.2	6	33,808,314 - 33,865,018 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	33,808,216 - 33,865,125 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	34,107,897 - 34,164,483 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	34,423,837 - 34,480,424 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	33,893,342 - 33,951,208 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	36,764,040 - 36,819,810 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	36,764,044 - 36,819,821 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	46,515,725 - 46,571,008 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	34,534,529 - 34,593,882 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	33,214,539 - 33,271,856 (-)	NCBI		Celera
RGSC_v3.1	6	34,537,483 - 34,596,835 (-)	NCBI
Cytogenetic Map	6	q15	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

alpha-Zearalanol (EXP)

amitriptyline (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium sulfate (ISO)

calcitriol (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

fenvalerate (EXP)

folic acid (ISO)

fonofos (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

glyphosate (ISO)

ketamine (EXP)

L-methionine (ISO)

lead(II) chloride (ISO)

lipopolysaccharide (ISO)

Muraglitazar (EXP)

oxaliplatin (EXP)

paracetamol (EXP)

parathion (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

pravastatin (EXP,ISO)

progesterone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

temozolomide (ISO)

terbufos (ISO)

Tesaglitazar (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

troglitazone (EXP)

valproic acid (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

action potential (IBA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

potassium ion transmembrane transport (IBA,IEA)

potassium ion transport (IEA)

protein homooligomerization (IEA)

transmembrane transport (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

membrane (IBA,IEA)

monoatomic ion channel complex (IEA)

plasma membrane (IEA,ISO)

voltage-gated potassium channel complex (IBA,IEA)

Molecular Function

monoatomic ion channel activity (IEA)

potassium channel activity (IEA)

potassium channel regulator activity (IBA)

voltage-gated potassium channel activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes.	Patel AJ, etal., EMBO J 1997 Nov 17;16(22):6615-25.
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain.	Stocker M and Kerschensteiner D, Biochem Biophys Res Commun 1998 Jul 30;248(3):927-34.

Additional References at PubMed

PMID:12744302

Genomics

Comparative Map Data

Kcns3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	39,527,410 - 39,584,105 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	39,523,777 - 39,618,848 (-)	Ensembl				GRCr8
mRatBN7.2	6	33,808,314 - 33,865,018 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	33,808,216 - 33,865,125 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	34,107,897 - 34,164,483 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	34,423,837 - 34,480,424 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	33,893,342 - 33,951,208 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	36,764,040 - 36,819,810 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	36,764,044 - 36,819,821 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	46,515,725 - 46,571,008 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	34,534,529 - 34,593,882 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	33,214,539 - 33,271,856 (-)	NCBI		Celera
RGSC_v3.1	6	34,537,483 - 34,596,835 (-)	NCBI
Cytogenetic Map	6	q15	NCBI

KCNS3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	17,877,847 - 17,932,958 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	17,877,847 - 18,361,616 (+)	Ensembl			hg38	GRCh38
GRCh37	2	18,059,114 - 18,114,225 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	17,923,426 - 17,977,706 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	17,981,572 - 18,035,852	NCBI
Celera	2	17,940,636 - 17,994,899 (+)	NCBI		Celera
Cytogenetic Map	2	p24.2	NCBI
HuRef	2	17,834,922 - 17,889,158 (+)	NCBI		HuRef
CHM1_1	2	17,989,211 - 18,043,592 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	17,909,623 - 17,964,710 (+)	NCBI		T2T-CHM13v2.0

Kcns3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	11,140,738 - 11,201,186 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	11,140,203 - 11,201,057 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	11,090,202 - 11,151,168 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	11,090,202 - 11,151,056 (-)	Ensembl			mm10	GRCm38
MGSCv37	12	11,097,008 - 11,157,648 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	11,116,545 - 11,176,716 (-)	NCBI		MGSCv36	mm8
Celera	12	11,445,677 - 11,499,189 (-)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	5.58	NCBI

Kcns3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	675,032 - 727,666 (+)	Ensembl
ChiLan1.0	NW_004955469	675,032 - 727,666 (+)	NCBI	ChiLan1.0	ChiLan1.0

KCNS3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	108,592,973 - 108,652,322 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	108,596,939 - 108,656,288 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	17,858,153 - 17,913,221 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	17,985,982 - 18,040,875 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	18,038,922 - 18,040,397 (+)	Ensembl			panPan2	panpan1.1

KCNS3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	13,297,242 - 13,338,319 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	13,336,374 - 13,337,849 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	13,249,151 - 13,290,532 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	13,433,935 - 13,478,839 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	13,433,984 - 13,478,836 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	13,292,424 - 13,333,593 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	13,303,284 - 13,344,480 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	13,329,484 - 13,370,661 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Kcns3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	57,744,965 - 57,787,563 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	13,052,037 - 13,094,609 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	13,052,037 - 13,094,786 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KCNS3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	119,951,106 - 119,989,366 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	119,951,110 - 119,989,541 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

KCNS3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	89,740,867 - 89,791,645 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	89,742,363 - 89,743,838 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	22,436,654 - 22,484,826 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kcns3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	841,459 - 863,366 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624738	834,779 - 863,400 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Kcns3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	31,097,039 - 31,144,334 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Kcns3
435 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	278
Count of miRNA genes:	189
Interacting mature miRNAs:	210
Transcripts:	ENSRNOT00000006499
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1975879	46975879	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	39028659	63457441	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	22653889	67653889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	31185002	76185002	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	3239989	48239989	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1975879	46975879	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1975879	46975879	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	44788383	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1975879	46975879	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1975879	46975879	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	3239989	48239989	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	3239989	48239989	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	33328841	78328841	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	30937632	75937632	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	1	40163351	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	33328841	78328841	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	39028659	86867923	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	3239989	48239989	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	22288257	67288257	Rat

Markers in Region

D6Rat84

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	39,571,146 - 39,571,358 (+)	Marker Load Pipeline
Celera	6	33,259,123 - 33,259,316	UniSTS
RH 3.4 Map	6	126.08	RGD
RH 3.4 Map	6	126.08	UniSTS
RH 2.0 Map	6	271.9	RGD
SHRSP x BN Map	6	28.5199	RGD
FHH x ACI Map	6	30.3999	RGD
Cytogenetic Map	6	q14	UniSTS

D12Ertd137e

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	33,808,616 - 33,808,819 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	36,764,343 - 36,764,545	NCBI	Rnor6.0
Rnor_5.0	6	46,516,028 - 46,516,230	UniSTS	Rnor5.0
RGSC_v3.4	6	34,534,832 - 34,535,034	UniSTS	RGSC3.4
Celera	6	33,214,842 - 33,215,044	UniSTS
Cytogenetic Map	6	q14	UniSTS

UniSTS:236805

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	33,809,865 - 33,810,103 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	36,765,592 - 36,765,829	NCBI	Rnor6.0
Rnor_5.0	6	46,517,277 - 46,517,514	UniSTS	Rnor5.0
RGSC_v3.4	6	34,536,081 - 34,536,318	UniSTS	RGSC3.4
Celera	6	33,216,091 - 33,216,328	UniSTS
Cytogenetic Map	6	q14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	151	91	90	59	84	59	6	348	184	11	130	81	92	31	8	8

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001389230	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_031778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF029056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Y17607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006499 ⟹ ENSRNOP00000006499

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,527,411 - 39,584,476 (-)	Ensembl
mRatBN7.2 Ensembl	6	33,808,316 - 33,865,125 (-)	Ensembl
Rnor_6.0 Ensembl	6	36,764,044 - 36,819,821 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095301 ⟹ ENSRNOP00000095367

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,526,786 - 39,584,005 (-)	Ensembl
mRatBN7.2 Ensembl	6	33,808,216 - 33,864,762 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108088 ⟹ ENSRNOP00000080054

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,527,271 - 39,583,353 (-)	Ensembl
mRatBN7.2 Ensembl	6	33,808,314 - 33,844,994 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112607 ⟹ ENSRNOP00000091305

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,527,431 - 39,584,005 (-)	Ensembl
mRatBN7.2 Ensembl	6	33,808,216 - 33,864,762 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113996 ⟹ ENSRNOP00000094251

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,527,381 - 39,538,489 (-)	Ensembl
mRatBN7.2 Ensembl	6	33,808,216 - 33,863,711 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000133371 ⟹ ENSRNOP00000102174

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,524,735 - 39,584,354 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000139426 ⟹ ENSRNOP00000105477

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,527,320 - 39,577,485 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000149651 ⟹ ENSRNOP00000101107

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,523,777 - 39,567,008 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000151090 ⟹ ENSRNOP00000099278

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,527,580 - 39,618,848 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000152198 ⟹ ENSRNOP00000105842

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,523,777 - 39,583,779 (-)	Ensembl

RefSeq Acc Id:

NM_001389230 ⟹ NP_001376159

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	39,527,410 - 39,583,394 (-)	NCBI
mRatBN7.2	6	33,808,314 - 33,864,307 (-)	NCBI

RefSeq Acc Id:

NM_031778 ⟹ NP_113966

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	39,527,410 - 39,584,105 (-)	NCBI
mRatBN7.2	6	33,808,314 - 33,865,018 (-)	NCBI
Rnor_6.0	6	36,764,040 - 36,819,810 (-)	NCBI
Rnor_5.0	6	46,515,725 - 46,571,008 (-)	NCBI
RGSC_v3.4	6	34,534,529 - 34,593,882 (-)	RGD
Celera	6	33,214,539 - 33,271,856 (-)	RGD

Sequence:

show sequence

GTCACCGGGAGATGGCTCCTCTCCCATTCTCCTCACCTTTCCACCCAGTTCCTTCCTTTTCTCC
GTCTGAGGTGCATATGCTTGGTGCATAAGTCCAGCCATCTCTTCAGACTTGGTGAACTTCACTT
TGTAGCATCTGCTTTGACTCGCACAACCAGAGGACCACATCCTTCTCTTCTTTGAGCCACTAAA
TGCCGATGCGCACTCCACACTCCAGCAAGGGAAGATGGGAGGAGCTTCTTGGATGACGATGGAT
GGTCCACTGTGCAGGATGAGGGCAGGCTGTGTGACATCGCCACCACGAGGGTTCAGCGTGATCT
TCTGTGTCTCCCTTCTGGGCCAGCACTCTGCCTTCTCAGTCCATCATGGTGTTTGGTGAGTTTT
TCCATCGCCCTGGACAAGATGAGGAACTTGTCAACTTGAACGTGGGGGGTTTTAAACAGTCTGT
GGATCAGAGTACACTCCTGCGGTTCCCCCACACACGACTGGGGAAGCTGCTTACCTGCCACTCT
GAGGAGGCCATTCTGGAGCTGTGTGATGACTACAGCGTGGCAGATAAAGAGTACTACTTCGATC
GGAACCCCTCCCTGTTCAGATACGTTTTGAACTTTTATTACACAGGGAAGCTGCACGTCATGGA
GGAACTGTGTGTCTTCTCCTTTTGCCAGGAGATTGAGTACTGGGGCATCAACGAGCTCTTCATT
GACTCCTGCTGTAGCAGTCGGTACCAGGAGCGCAAGGAGGAGAGCCACGAGAAGGACTGGGACC
AGAAAAGCAATGATGTGAGCACAGACTCCTCCTTTGAGGAATCGTCTCTGTTTGAGAAAGAGCT
GGAGAAGTTTGATGAGCTGAGATTTGGTCAGCTCCGAAAGAAGATCTGGATCCGAATGGAAAAC
CCAGCTTATTGCCTGTCAGCCAAGCTCATCGCCATCTCCTCCTTGAGTGTGGTGCTGGCTTCCA
TCGTGGCCATGTGTGTACACAGCATGTCAGAATTCCAGAACGAGGATGGAGAAGTGGATGACCC
TGTGCTGGAAGGTGTGGAGATTGCCTGCATTGCATGGTTCACCGGTGAGCTGGCCATCCGGCTG
GTTGCTGCTCCATCACAAAAGAAGTTCTGGAAAAACCCTCTGAACATCATTGACTTTGTCTCCA
TCATTCCCTTCTATGCCACGTTGGCTGTGGACACCAAGGAAGAAGAGAGTGAGGACATTGAGAA
CATGGGCAAGGTGGTCCAGATCCTCCGGCTCATGAGGATTTTCCGCATCCTGAAGCTCGCCCGG
CATTCCGTAGGGCTTCGTTCTCTTGGGGCCACGCTGAGGCACAGTTACCACGAAGTGGGGCTAC
TGCTTCTCTTCCTCTCTGTGGGTATCTCCATTTTCTCTGTGCTTATTTACTCTGTGGAGAAAGA
TGAACTCGCGTCCAGTCTCACTAGCATCCCCATCTGCTGGTGGTGGGCCACTATCAGTATGACC
ACAGTGGGCTATGGAGACACCCACCCAGTCACCTTAGCTGGGAAAATCATTGCGAGCACCTGCA
TTATCTGTGGCATCTTAGTGGTAGCCCTTCCCATCACCATCATCTTCAACAAGTTTTCCAAGTA
CTACCAGAAGCAGAAGGACATGGATGTGGACCAGTGCAGCGAGGACCCACCGGAGAAGTGCCAC
GAGCTACCTTACTTTAACATTAGGGACGTTTATGCACAGCAAGTACACGCCTTCATCACCAGTC
TGTCTTCCATTGGCATCGTGGTCAGCGATCCTGACTCCACAGATGCCTCAAGTGTCGAAGACAA
CGAGGATGCTTACAACACCGCATCCCTGGAGAACTGTACTGCAAAATGAGCAGGGGCATTTGCA
CGGACAGCTCATGTCCCTTCCTCACGTTAGGTTAACACAGCTTTATAAACCTCAGTGGGTTTGT
TCAAATCAATCATTTAATTCTCAGGGTGTACCTTTTAGCCATAGTTGGACATTCATTGCCGAAT
TCTGAAATGATAGAATTATCTTTATTTTTCTCAGTGAGATCAATTAAAATGCCTTGTTCTGAAA
TTTATTTTTTAACAAGAGAGAGTTGTAATACGGTTTTTTGGGGGAAAAATGTCAATGATATTGG
GAAGGATTTATTGCTACGGCTTACGCATCATTCTGTATCTGCCATTCACTCACATTGAGCTAAC
TATAAATTACTGATGTTAGAGCAGAGGCCCAGCCGACCGAAGACGACATGCATGTAAGATCTAC
AACATGAGACAATGCATGTAAATCCATGTTCATGTTCCAGACACGGGAATTAGGAGCCCATTAA
ACTTCTAATTCGGTATGGAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AA

hide sequence

RefSeq Acc Id:

XM_039112997 ⟹ XP_038968925

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	39,527,410 - 39,561,623 (-)	NCBI
mRatBN7.2	6	33,808,314 - 33,842,811 (-)	NCBI

RefSeq Acc Id:

XM_039112998 ⟹ XP_038968926

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	39,527,410 - 39,582,735 (-)	NCBI
mRatBN7.2	6	33,808,314 - 33,864,065 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001376159	(Get FASTA)	NCBI Sequence Viewer
	NP_113966	(Get FASTA)	NCBI Sequence Viewer
	XP_038968925	(Get FASTA)	NCBI Sequence Viewer
	XP_038968926	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB94882	(Get FASTA)	NCBI Sequence Viewer
	CAA76805	(Get FASTA)	NCBI Sequence Viewer
	EDM03095	(Get FASTA)	NCBI Sequence Viewer
	EDM03096	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006499.3
	ENSRNOP00000080054
	ENSRNOP00000080054.1
	ENSRNOP00000091305.1
	ENSRNOP00000094251.1
	ENSRNOP00000095367.1
	ENSRNOP00000102174
	ENSRNOP00000105842
GenBank Protein	O88759	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113966 ⟸ NM_031778

- UniProtKB:

O54900 (UniProtKB/Swiss-Prot), O88759 (UniProtKB/Swiss-Prot), A6HAP0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVAD
KEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSSRYQERKEES
HEKDWDQKSNDVSTDSSFEESSLFEKELEKFDELRFGQLRKKIWIRMENPAYCLSAKLIAISSL
SVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAIRLVAAPSQKKFWKNPLN
IIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHS
YHEVGLLLLFLSVGISIFSVLIYSVEKDELASSLTSIPICWWWATISMTTVGYGDTHPVTLAGK
IIASTCIICGILVVALPITIIFNKFSKYYQKQKDMDVDQCSEDPPEKCHELPYFNIRDVYAQQV
HAFITSLSSIGIVVSDPDSTDASSVEDNEDAYNTASLENCTAK

hide sequence

Ensembl Acc Id:

ENSRNOP00000006499 ⟸ ENSRNOT00000006499

RefSeq Acc Id:	NP_001376159 ⟸ NM_001389230
- UniProtKB:	O88759 (UniProtKB/Swiss-Prot), O54900 (UniProtKB/Swiss-Prot), A6HAP0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968926 ⟸ XM_039112998
- Peptide Label:	isoform X1
- UniProtKB:	O88759 (UniProtKB/Swiss-Prot), O54900 (UniProtKB/Swiss-Prot), A6HAP0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968925 ⟸ XM_039112997
- Peptide Label:	isoform X1
- UniProtKB:	O88759 (UniProtKB/Swiss-Prot), O54900 (UniProtKB/Swiss-Prot), A6HAP0 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000095367 ⟸ ENSRNOT00000095301

Ensembl Acc Id:

ENSRNOP00000080054 ⟸ ENSRNOT00000108088

Ensembl Acc Id:

ENSRNOP00000094251 ⟸ ENSRNOT00000113996

Ensembl Acc Id:

ENSRNOP00000091305 ⟸ ENSRNOT00000112607

Ensembl Acc Id:

ENSRNOP00000101107 ⟸ ENSRNOT00000149651

Ensembl Acc Id:

ENSRNOP00000099278 ⟸ ENSRNOT00000151090

Ensembl Acc Id:

ENSRNOP00000105477 ⟸ ENSRNOT00000139426

Ensembl Acc Id:

ENSRNOP00000102174 ⟸ ENSRNOT00000133371

Ensembl Acc Id:

ENSRNOP00000105842 ⟸ ENSRNOT00000152198

Protein Domains

BTB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88759-F1-model_v2	AlphaFold	O88759	1-491	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621527	AgrOrtholog
BioCyc Gene	G2FUF-38148	BioCyc
Ensembl Genes	ENSRNOG00000004899	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000006499.6	UniProtKB/Swiss-Prot
	ENSRNOT00000095301.1	UniProtKB/Swiss-Prot
	ENSRNOT00000108088	ENTREZGENE
	ENSRNOT00000108088.1	UniProtKB/Swiss-Prot
	ENSRNOT00000112607.1	UniProtKB/Swiss-Prot
	ENSRNOT00000113996.1	UniProtKB/Swiss-Prot
	ENSRNOT00000133371	ENTREZGENE
	ENSRNOT00000152198	ENTREZGENE
Gene3D-CATH	1.10.287.70	UniProtKB/Swiss-Prot
	1.20.120.350	UniProtKB/Swiss-Prot
	Potassium Channel Kv1.1, Chain A	UniProtKB/Swiss-Prot
InterPro	BTB/POZ_dom	UniProtKB/Swiss-Prot
	Ion_trans_dom	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv9	UniProtKB/Swiss-Prot
	SKP1/BTB/POZ_sf	UniProtKB/Swiss-Prot
	T1-type_BTB	UniProtKB/Swiss-Prot
	VG_K_chnl	UniProtKB/Swiss-Prot
	Volt_channel_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:83588	UniProtKB/Swiss-Prot
NCBI Gene	83588	ENTREZGENE
PANTHER	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY S MEMBER 3	UniProtKB/Swiss-Prot
	PTHR11537	UniProtKB/Swiss-Prot
Pfam	BTB_2	UniProtKB/Swiss-Prot
	Ion_trans	UniProtKB/Swiss-Prot
PhenoGen	Kcns3	PhenoGen
PRINTS	KCHANNEL	UniProtKB/Swiss-Prot
	KV9CHANNEL	UniProtKB/Swiss-Prot
	KVCHANNEL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000004899	RatGTEx
SMART	BTB	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF54695	UniProtKB/Swiss-Prot
	Voltage-gated potassium channels	UniProtKB/Swiss-Prot
UniProt	A6HAP0	ENTREZGENE, UniProtKB/TrEMBL
	KCNS3_RAT	UniProtKB/Swiss-Prot
	O54900	ENTREZGENE
	O88759	ENTREZGENE
UniProt Secondary	O54900	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-01-26	Kcns3	potassium voltage-gated channel, modifier subfamily S, member 3	Kcns3	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Kcns3	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3		Shab-related delayed-rectifier K+ channel (Kv9.3)	Name updated	1299863	APPROVED
2002-08-07	Kcns3	Shab-related delayed-rectifier K+ channel (Kv9.3)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_function	by itself it is an electrically silent subunit	729206
gene_physical_interaction	associates with Kv2.1 and modulates its biophysical properties	729206
gene_process	Kv2.1/Kv9.3 heteromultimers may play an important role in hypoxic pulmonary artery vasoconstriction	729206

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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