Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of KCNS3 mRNA | CTD | PMID:24763279 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of KCNS3 mRNA | CTD | PMID:26865667 | 17beta-estradiol | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of KCNS3 mRNA | CTD | PMID:31614463 | 4,4'-sulfonyldiphenol | increases expression | ISO | Kcns3 (Mus musculus) | 6480464 | bisphenol S results in increased expression of KCNS3 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | affects methylation | ISO | KCNS3 (Homo sapiens) | 6480464 | bisphenol S affects the methylation of KCNS3 gene | CTD | PMID:31601247 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Kcns3 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of KCNS3 promoter | CTD | PMID:33297965 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Kcns3 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of KCNS3 mRNA | CTD | PMID:28973697 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of KCNS3 mRNA | CTD | PMID:31881176 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of KCNS3 mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of KCNS3 mRNA | CTD | PMID:22100608 | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of KCNS3 mRNA | CTD | PMID:20488242 | all-trans-retinoic acid | multiple interactions | ISO | Kcns3 (Mus musculus) | 6480464 | [bisphenol A co-treated with Tretinoin] results in decreased expression of KCNS3 mRNA | CTD | PMID:30951980 | amitriptyline | decreases expression | EXP | | 6480464 | Amitriptyline results in decreased expression of KCNS3 mRNA | CTD | PMID:22341215 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KCNS3 mRNA | CTD | PMID:16483693 | aristolochic acid A | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of KCNS3 mRNA | CTD | PMID:33212167 | arsenous acid | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of KCNS3 mRNA | CTD | PMID:26705709 | benzo[a]pyrene | multiple interactions | ISO | Kcns3 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of KCNS3 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | KCNS3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KCNS3 5' UTR and Benzo(a)pyrene affects the methylation of KCNS3 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | KCNS3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of KCNS3 3' UTR | CTD | PMID:27901495 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KCNS3 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of KCNS3 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KCNS3 mRNA | CTD | PMID:34947998 | bisphenol A | multiple interactions | ISO | Kcns3 (Mus musculus) | 6480464 | [bisphenol A co-treated with Tretinoin] results in decreased expression of KCNS3 mRNA | CTD | PMID:30951980 | bisphenol A | increases expression | ISO | Kcns3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of KCNS3 mRNA | CTD | PMID:30951980 | bisphenol F | increases expression | ISO | Kcns3 (Mus musculus) | 6480464 | bisphenol F results in increased expression of KCNS3 mRNA | CTD | PMID:30951980 | butanal | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of KCNS3 mRNA | CTD | PMID:26079696 | cadmium sulfate | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KCNS3 mRNA | CTD | PMID:18654764 | calcitriol | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of KCNS3 mRNA | CTD | PMID:16002434 | choline | multiple interactions | ISO | Kcns3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNS3 gene | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of KCNS3 mRNA | CTD | PMID:27392435 | cobalt dichloride | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KCNS3 mRNA | CTD | PMID:18654764 | copper(II) sulfate | affects expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Copper Sulfate affects the expression of KCNS3 mRNA | CTD | PMID:19549813 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of KCNS3 mRNA | CTD | PMID:26577399 | diarsenic trioxide | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of KCNS3 mRNA | CTD | PMID:26705709 | dibenz[a,h]anthracene | increases expression | ISO | Kcns3 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | dorsomorphin | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of KCNS3 mRNA | CTD | PMID:29391264 | entinostat | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | entinostat results in increased expression of KCNS3 mRNA | CTD | PMID:27188386 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of KCNS3 mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | ISO | Kcns3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNS3 gene | CTD | PMID:20938992 | fonofos | decreases methylation | ISO | KCNS3 (Homo sapiens) | 6480464 | Fonofos results in decreased methylation of KCNS3 promoter | CTD | PMID:22847954 | fulvestrant | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of KCNS3 gene | CTD | PMID:31601247 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of KCNS3 mRNA | CTD | PMID:27387713 | genistein | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Genistein results in increased expression of KCNS3 mRNA | CTD | PMID:26865667 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of KCNS3 mRNA | CTD | PMID:33387578 | glyphosate | increases expression | ISO | Kcns3 (Mus musculus) | 6480464 | Glyphosate results in increased expression of KCNS3 mRNA | CTD | PMID:35897073 | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of KCNS3 mRNA | CTD | PMID:20080153 | L-methionine | multiple interactions | ISO | Kcns3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNS3 gene | CTD | PMID:20938992 | lead(II) chloride | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KCNS3 mRNA | CTD | PMID:18654764 | lipopolysaccharide | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of KCNS3 mRNA | CTD | PMID:35811015 | Muraglitazar | decreases expression | EXP | | 6480464 | muraglitazar results in decreased expression of KCNS3 mRNA | CTD | PMID:21515302 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of KCNS3 mRNA | CTD | PMID:25729387 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of KCNS3 mRNA | CTD | PMID:33387578 | parathion | decreases methylation | ISO | KCNS3 (Homo sapiens) | 6480464 | Parathion results in decreased methylation of KCNS3 promoter | CTD | PMID:22847954 | pentanal | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | pentanal results in increased expression of KCNS3 mRNA | CTD | PMID:26079696 | perfluorohexanesulfonic acid | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | perfluorohexanesulfonic acid results in increased expression of KCNS3 mRNA | CTD | PMID:25812627 | perfluorooctane-1-sulfonic acid | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in increased expression of KCNS3 mRNA | CTD | PMID:25812627 | pravastatin | increases expression | ISO | Kcns3 (Mus musculus) | 6480464 | Pravastatin results in increased expression of KCNS3 mRNA | CTD | PMID:27225895 | pravastatin | increases expression | EXP | | 6480464 | Pravastatin results in increased expression of KCNS3 mRNA | CTD | PMID:27225895 | progesterone | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Progesterone results in increased expression of KCNS3 mRNA | CTD | PMID:21795739 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of KCNS3 mRNA | CTD | PMID:35811015 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of KCNS3 mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of KCNS3 mRNA | CTD | PMID:25895662 | sodium arsenite | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of KCNS3 mRNA | CTD | PMID:34032870 | sodium arsenite | decreases expression | ISO | Kcns3 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of KCNS3 mRNA | CTD | PMID:37682722 | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of KCNS3 mRNA | CTD | PMID:19281266 | temozolomide | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of KCNS3 mRNA | CTD | PMID:31758290 | terbufos | decreases methylation | ISO | KCNS3 (Homo sapiens) | 6480464 | terbufos results in decreased methylation of KCNS3 promoter | CTD | PMID:22847954 | Tesaglitazar | decreases expression | EXP | | 6480464 | tesaglitazar results in decreased expression of KCNS3 mRNA | CTD | PMID:21515302 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of KCNS3 mRNA | CTD | PMID:34492290 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of KCNS3 mRNA | CTD | PMID:25729387 | trichostatin A | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of KCNS3 mRNA | CTD | PMID:26272509 | trichostatin A | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of KCNS3 mRNA | CTD | PMID:24935251 and PMID:27188386 | trichostatin A | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNS3 mRNA | CTD | PMID:27188386 | trimellitic anhydride | decreases expression | ISO | Kcns3 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of KCNS3 mRNA | CTD | PMID:19042947 | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of KCNS3 mRNA | CTD | PMID:21515302 | valproic acid | affects expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of KCNS3 mRNA | CTD | PMID:25979313 | valproic acid | decreases methylation | ISO | KCNS3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of KCNS3 gene | CTD | PMID:29154799 | valproic acid | multiple interactions | ISO | KCNS3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNS3 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of KCNS3 mRNA | CTD | PMID:19101580 more ... | vorinostat | decreases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of KCNS3 mRNA | CTD | PMID:18769122 | vorinostat | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | vorinostat results in increased expression of KCNS3 mRNA | CTD | PMID:27188386 | zoledronic acid | increases expression | ISO | KCNS3 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of KCNS3 mRNA | CTD | PMID:24714768 | |