Gene: KCNS3 (potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3)
Homo sapiens
Symbol:
KCNS3
Name:
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
Description:
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
delayed-rectifier K(+) channel alpha subunit 3; KV9.3; MGC9481; OTTHUMP00000149986; OTTHUMP00000200487; potassium voltage-gated channel delayed-rectifier protein S3; potassium voltage-gated channel subfamily S member 3; Shab-related delayed-rectifier K+ channel alpha subunit 3; voltage-gated potassium channel protein Kv9.3; voltage-gated potassium channel subunit Kv9.3
Orthologs:
Mus musculus : Kcns3
(potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3)
MGI
Kcns3
(potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 2 18,028,149 - 18,082,497 + NCBI Human Genome Assembly HuRef 2 17,834,922 - 17,889,158 + NCBI Human Genome Assembly GRCh37 2 18,059,945 - 18,114,225 + NCBI Human Celera Assembly 2 17,940,636 - 17,994,899 + NCBI Human Genome Assembly Build 36 2 17,923,426 - 17,977,706 + NCBI Human Cytogenetic Map 2 p24 NCBI Human Genome Assembly 2 17,981,572 - 18,035,852 NCBI
Model
Gene Ontology Annotations
Biological Process energy reserve metabolic process TAS 2290271 Reactome:REACT_1505 Reactome Reactome:REACT_1505 potassium ion transport TAS 2290271 PMID:10484328 PINC PMID:10484328 protein homooligomerization IEA InterPro:IPR003131 2290271 GO_REF:0000002 InterPro GO_REF:0000002 regulation of insulin secretion TAS 2290271 Reactome:REACT_18325 Reactome Reactome:REACT_18325 small molecule metabolic process TAS 2290271 Reactome:REACT_111217 Reactome Reactome:REACT_111217 synaptic transmission TAS 2290271 Reactome:REACT_13685 Reactome Reactome:REACT_13685
2303087 MAMTS41_H Mammary tumor susceptibility QTL 41 (human) 1.2 Mammary tumor susceptibility 2 1 20471506 Human 1643271 BW214_H Body weight QTL 214 (human) 2.12 .0021 Body weight BMI 2 1 21078135 Human 1643370 BW334_H Body weight QTL 334 (human) 2 Body morphometry waist circumference 2 1 21078135 Human 2316730 GLUCO280_H Glucose level QTL 280 (human) 1.9 .00278 Glucose level 2 1 24445579 Human 1643381 BW335_H Body weight QTL 335 (human) 2.45 Body weight BMI 2 1 24606996 Human 1559122 SCL42_H Serum cholesterol level QTL 42 (human) 2.3 .09 Lipid level LDL cholesterol 2 367703 26367703 Human 1559340 SCL85_H Serum cholesterol level QTL 85 (human) 2.17 .0008 Lipid level LDL cholesterol 2 2227411 28227411 Human 1643262 BW207_H Body weight QTL 207 (human) 1.7 .003 Body weight BMI 2 4492026 30492026 Human 2292859 PRSTS25_H Prostate tumor susceptibility QTL 25 (human) Prostate tumor susceptibility early onset 2 4492026 30492026 Human 2316727 GLUCO281_H Glucose level QTL 281 (human) 1.98 .0023 Glucose level 2 6418587 32418587 Human 1559337 SCL86_H Serum cholesterol level QTL 86 (human) 1.54 .004 Lipid level total cholesterol 2 8086103 34086103 Human 2315784 GLUCO164_H Glucose level QTL 164 (human) 1.77 .0022 Glucose level 2 15227294 21086187 Human 2289642 BW507_H Body weight QTL 507 (human) 2.91 Body weight BMI 2 15603469 41603469 Human 2289647 INSUL1_H Insulin level QTL 1 (human) 3 Insulin level fasting 2 15603469 41603469 Human 2289649 BW508_H Body weight QTL 508 (human) 3.43 Body fat amount none 2 15603469 41603469 Human 1357382 SLEP2_H Serum leptin level QTL 2 (human) 4.95 .0000009 Hormone level leptin 2 17491957 68239157 Human
Gene Ontology Annotations
