Wnt11 (Wnt family member 11) - Rat Genome Database

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Gene: Wnt11 (Wnt family member 11) Rattus norvegicus
Analyze
Symbol: Wnt11
Name: Wnt family member 11
RGD ID: 621463
Description: Predicted to enable cytokine activity; frizzled binding activity; and protein kinase activator activity. Involved in cell differentiation and response to nutrient levels. Predicted to be located in cytoplasm; extracellular matrix; and extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human WNT11 (Wnt family member 11); PARTICIPATES IN the Wnt/calcium signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: wingless-related MMTV integration site 11; wingless-type MMTV integration site family, member 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81162,545,660 - 162,565,456 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1162,545,680 - 162,564,660 (+)EnsemblGRCr8
mRatBN7.21153,134,503 - 153,154,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,138,197 - 153,154,294 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1161,133,836 - 161,149,936 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,314,007 - 168,330,107 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,187,522 - 161,203,622 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,794,136 - 163,813,756 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,797,660 - 163,813,756 (+)Ensemblrn6Rnor6.0
Rnor_5.01169,997,286 - 170,016,829 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41156,125,969 - 156,142,065 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,224,671 - 151,240,729 (+)NCBICelera
RGSC_v3.11156,213,816 - 156,216,652 (+)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cannabidiol  (EXP)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
fenfluramine  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycerol 2-phosphate  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
nickel atom  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
retinyl acetate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEA,ISO)
artery morphogenesis  (ISO)
atrial septum development  (IEA,ISO)
bicellular tight junction assembly  (ISO)
bone mineralization  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cell differentiation  (IEP)
cell fate commitment  (IBA)
cellular response to mechanical stimulus  (ISO)
cloacal septation  (IEA,ISO)
convergent extension involved in axis elongation  (ISO)
embryonic skeletal system development  (IEA,ISO)
epithelial to mesenchymal transition  (ISO)
intracellular signal transduction  (IEA,ISO)
kidney development  (ISO)
lung-associated mesenchyme development  (IEA,ISO)
maintenance of epithelial cell apical/basal polarity  (ISO)
mesonephric duct development  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of fibroblast growth factor production  (ISO)
negative regulation of mesenchymal cell proliferation  (ISO)
neuroendocrine cell differentiation  (IEA,ISO)
neuron differentiation  (IBA)
non-canonical Wnt signaling pathway  (ISO)
notochord morphogenesis  (ISO)
osteoblast differentiation  (ISO)
outflow tract morphogenesis  (ISO)
paraxial mesoderm formation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of transforming growth factor beta2 production  (ISO)
primary heart field specification  (IEA,ISO)
response to nutrient levels  (IEP)
roof of mouth development  (ISO)
secondary heart field specification  (IEA,ISO)
secondary palate development  (IEA,ISO)
signal transduction  (IEA,ISO)
somite development  (ISO)
ureteric bud morphogenesis  (IEA,ISO)
ventricular septum development  (IEA,ISO)
ventricular septum morphogenesis  (ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mechanisms of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expression. Abdel-Hakeem AK, etal., Am J Obstet Gynecol. 2008 Sep;199(3):252.e1-7. Epub 2008 Jul 17.
2. Insights from studies with oral cleft genes suggest associations between WNT-pathway genes and risk of oral cancer. Andrade Filho PA, etal., J Dent Res. 2011 Jun;90(6):740-6. doi: 10.1177/0022034511401622. Epub 2011 Mar 10.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Molecular cloning and characterization of human WNT11. Kirikoshi H, etal., Int J Mol Med. 2001 Dec;8(6):651-6.
6. Wnt signal pathways and neural stem cell differentiation. Lange C, etal., Neurodegener Dis. 2006;3(1-2):76-86.
7. Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Majumdar A, etal., Development 2003 Jul;130(14):3175-85.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells. Ouko L, etal., J Biol Chem 2004 Jun 18;279(25):26707-15. Epub 2004 Apr 14.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs. Ricken A, etal., Endocrinology 2002 Jul;143(7):2741-9.
17. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
18. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
19. Analysis of Wnt gene expression in prostate cancer: mutual inhibition by WNT11 and the androgen receptor. Zhu H, etal., Cancer Res. 2004 Nov 1;64(21):7918-26.
Additional References at PubMed
PMID:8700530   PMID:9757009   PMID:17767158   PMID:18155657   PMID:18191119   PMID:18413325   PMID:19213727   PMID:19847889   PMID:20103596   PMID:20219091   PMID:21281623   PMID:22569553  
PMID:22829700   PMID:22985995   PMID:23998262   PMID:24474615   PMID:25813538   PMID:25959411   PMID:26193266   PMID:33137935  


Genomics

Comparative Map Data
Wnt11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81162,545,660 - 162,565,456 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1162,545,680 - 162,564,660 (+)EnsemblGRCr8
mRatBN7.21153,134,503 - 153,154,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,138,197 - 153,154,294 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1161,133,836 - 161,149,936 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,314,007 - 168,330,107 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,187,522 - 161,203,622 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,794,136 - 163,813,756 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,797,660 - 163,813,756 (+)Ensemblrn6Rnor6.0
Rnor_5.01169,997,286 - 170,016,829 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41156,125,969 - 156,142,065 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,224,671 - 151,240,729 (+)NCBICelera
RGSC_v3.11156,213,816 - 156,216,652 (+)NCBI
Cytogenetic Map1q32NCBI
WNT11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381176,186,325 - 76,210,761 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1176,186,325 - 76,210,761 (-)Ensemblhg38GRCh38
GRCh371175,897,369 - 75,917,546 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361175,575,018 - 75,595,222 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341175,575,017 - 75,595,222NCBI
Celera1173,205,187 - 73,225,391 (-)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1172,194,546 - 72,214,753 (-)NCBIHuRef
CHM1_11175,780,888 - 75,801,091 (-)NCBICHM1_1
T2T-CHM13v2.01176,116,041 - 76,140,519 (-)NCBIT2T-CHM13v2.0
Wnt11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,484,293 - 98,503,954 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,484,319 - 98,504,402 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38798,835,084 - 98,854,747 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,835,112 - 98,855,195 (+)Ensemblmm10GRCm38
MGSCv377105,987,355 - 106,003,257 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36798,714,037 - 98,728,940 (+)NCBIMGSCv36mm8
Celera799,160,445 - 99,176,286 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.9NCBI
Wnt11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541415,674,940 - 15,694,883 (+)Ensembl
ChiLan1.0NW_00495541415,674,478 - 15,694,758 (+)NCBIChiLan1.0ChiLan1.0
WNT11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2977,110,987 - 77,161,434 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11178,156,064 - 78,180,195 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01171,239,781 - 71,263,915 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11174,540,025 - 74,560,024 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1174,540,169 - 74,560,024 (-)EnsemblpanPan2panpan1.1
WNT11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12122,442,496 - 22,463,040 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2122,446,051 - 22,463,173 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2122,210,200 - 22,227,251 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02122,648,822 - 22,665,821 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2122,648,814 - 22,665,904 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12122,423,226 - 22,440,217 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02122,642,741 - 22,659,738 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02122,561,731 - 22,578,745 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wnt11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494763,309,313 - 63,329,371 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,908,978 - 4,927,165 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364984,909,041 - 4,927,482 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl910,413,263 - 10,435,100 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1910,413,182 - 10,435,158 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2911,487,189 - 11,509,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,393,975 - 67,427,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,399,074 - 67,418,509 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604358,377,747 - 58,402,147 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624817932,970 - 952,326 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624817931,686 - 952,474 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Wnt11
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1297,111,938 - 97,128,000 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Wnt11
243 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:355
Count of miRNA genes:194
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000021674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Mgh8  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81162,548,015 - 162,548,132 (+)Marker Load Pipeline
mRatBN7.21153,136,852 - 153,136,969 (+)MAPPERmRatBN7.2
Rnor_6.01163,796,316 - 163,796,432NCBIRnor6.0
Rnor_5.01169,999,389 - 169,999,505UniSTSRnor5.0
RGSC_v3.41156,124,624 - 156,124,741RGDRGSC3.4
RGSC_v3.41156,124,625 - 156,124,741UniSTSRGSC3.4
Celera1151,223,327 - 151,223,443UniSTS
RGSC_v3.11156,203,030 - 156,203,147RGD
RH 3.4 Map11215.0RGD
RH 3.4 Map11215.0UniSTS
RH 2.0 Map1788.6RGD
Cytogenetic Map1q32UniSTS
RP_L27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,154,521 - 153,154,640 (+)MAPPERmRatBN7.2
Rnor_6.01163,813,984 - 163,814,102NCBIRnor6.0
Rnor_5.01170,017,057 - 170,017,175UniSTSRnor5.0
RGSC_v3.41156,142,293 - 156,142,411UniSTSRGSC3.4
Celera1151,240,957 - 151,241,075UniSTS
Cytogenetic Map1q32UniSTS
UniSTS:471854  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,145,737 - 153,145,942 (+)MAPPERmRatBN7.2
Rnor_6.01163,805,200 - 163,805,404NCBIRnor6.0
Rnor_5.01170,008,273 - 170,008,477UniSTSRnor5.0
RGSC_v3.41156,133,509 - 156,133,713UniSTSRGSC3.4
Celera1151,232,211 - 151,232,415UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 140 71 70 39 45 39 6 288 145 11 119 80 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000021674   ⟹   ENSRNOP00000021674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1162,545,680 - 162,564,660 (+)Ensembl
mRatBN7.2 Ensembl1153,138,197 - 153,154,294 (+)Ensembl
Rnor_6.0 Ensembl1163,797,660 - 163,813,756 (+)Ensembl
RefSeq Acc Id: NM_080401   ⟹   NP_536326
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,549,360 - 162,565,456 (+)NCBI
mRatBN7.21153,138,197 - 153,154,294 (+)NCBI
Rnor_6.01163,797,660 - 163,813,756 (+)NCBI
Rnor_5.01169,997,286 - 170,016,829 (+)NCBI
RGSC_v3.41156,125,969 - 156,142,065 (+)RGD
Celera1151,224,671 - 151,240,729 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229718   ⟹   XP_006229780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,545,660 - 162,564,758 (+)NCBI
mRatBN7.21153,134,503 - 153,153,554 (+)NCBI
Rnor_6.01163,794,136 - 163,813,751 (+)NCBI
Rnor_5.01169,997,286 - 170,016,829 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229720   ⟹   XP_006229782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,547,414 - 162,564,758 (+)NCBI
mRatBN7.21153,136,144 - 153,153,554 (+)NCBI
Rnor_6.01163,794,543 - 163,813,751 (+)NCBI
Rnor_5.01169,997,286 - 170,016,829 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759667   ⟹   XP_008757889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,556,967 - 162,564,758 (+)NCBI
mRatBN7.21153,138,460 - 153,153,554 (+)NCBI
Rnor_6.01163,797,923 - 163,813,561 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063270171   ⟹   XP_063126241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,546,552 - 162,564,758 (+)NCBI
RefSeq Acc Id: NP_536326   ⟸   NM_080401
- UniProtKB: G3V819 (UniProtKB/TrEMBL),   A6I6F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229780   ⟸   XM_006229718
- Peptide Label: isoform X1
- UniProtKB: G3V819 (UniProtKB/TrEMBL),   A6I6F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229782   ⟸   XM_006229720
- Peptide Label: isoform X1
- UniProtKB: G3V819 (UniProtKB/TrEMBL),   A6I6F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757889   ⟸   XM_008759667
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000021674   ⟸   ENSRNOT00000021674
RefSeq Acc Id: XP_063126241   ⟸   XM_063270171
- Peptide Label: isoform X1
- UniProtKB: A6I6F2 (UniProtKB/TrEMBL),   G3V819 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V819-F1-model_v2 AlphaFold G3V819 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621463 AgrOrtholog
BioCyc Gene G2FUF-58414 BioCyc
Ensembl Genes ENSRNOG00000015982 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021674 ENTREZGENE
  ENSRNOT00000021674.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_grthfactor_CS UniProtKB/TrEMBL
KEGG Report rno:140584 UniProtKB/TrEMBL
NCBI Gene 140584 ENTREZGENE
PANTHER PTHR12027:SF7 UniProtKB/TrEMBL
  Wnt UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PhenoGen Wnt11 PhenoGen
PRINTS WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015982 RatGTEx
SMART WNT1 UniProtKB/TrEMBL
UniProt A6I6F2 ENTREZGENE, UniProtKB/TrEMBL
  G3V819 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt11  Wnt family member 11  Wnt11  wingless-type MMTV integration site family, member 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt11  wingless-type MMTV integration site family, member 11  Wnt11  wingless-related MMTV integration site 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Wnt11  wingless-related MMTV integration site 11  Wnt11  wingless-type MMTV integration site family, member 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-08-07 Wnt11  wingless-type MMTV integration site family, member 11      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the Wnt family of secreted glycoproteins 727217