Aldh5a1 (aldehyde dehydrogenase 5 family, member A1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Aldh5a1 (aldehyde dehydrogenase 5 family, member A1) Rattus norvegicus
Analyze
Symbol: Aldh5a1
Name: aldehyde dehydrogenase 5 family, member A1
RGD ID: 621422
Description: Enables NAD binding activity; carboxylic acid binding activity; and succinate-semialdehyde dehydrogenase (NAD+) activity. Involved in succinate metabolic process. Predicted to be located in synapse. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; acetaldehyde.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase); aldehyde dehydrogenase family 5 member A1; aldehyde dehydrogenase family 5, subfamily A1; NAD(+)-dependent succinic semialdehyde dehydrogenase; Ssadh; succinate-semialdehyde dehydrogenase, mitochondrial; succinic semialdehyde dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,560,373 - 40,586,711 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1740,558,347 - 40,586,714 (+)EnsemblGRCr8
mRatBN7.21740,132,339 - 40,158,677 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,130,883 - 40,158,677 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1740,200,441 - 40,226,804 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,804,498 - 41,830,863 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,087,826 - 40,114,061 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,133,076 - 42,159,413 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,133,076 - 42,159,413 (+)Ensemblrn6Rnor6.0
Rnor_5.01744,000,875 - 44,027,212 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41747,193,407 - 47,216,499 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1739,769,869 - 39,796,199 (+)NCBICelera
RGSC_v3.11747,196,722 - 47,219,340 (+)NCBI
Cytogenetic Map17p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
4-hydroxybutyric acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benomyl  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
decabromodiphenyl ether  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diiodine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
gamma-aminobutyric acid  (EXP)
genistein  (EXP)
glafenine  (EXP)
Heliotrine  (ISO)
indometacin  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
mancozeb  (EXP)
maneb  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
Nonylphenol  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium perchlorate  (EXP)
succinic semialdehyde  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
XL765  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of the mature NAD(+)-dependent succinic semialdehyde dehydrogenase from rat and human. cDNA isolation, evolutionary homology, and tissue expression. Chambliss KL, etal., J Biol Chem 1995 Jan 6;270(1):461-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A). Murphy TC, etal., J Neurochem 2003 Jul;86(2):298-305.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation. Nguyen E and Picklo MJ Sr, Biochim Biophys Acta. 2003 Jan 20;1637(1):107-12.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Kinetic studies with rat-brain succinic-semialdehyde dehydrogenase. Rivett AJ and Tipton KF, Eur J Biochem. 1981 Jun;117(1):187-93.
Additional References at PubMed
PMID:9683595   PMID:11544478   PMID:12065715   PMID:12067239   PMID:14651853   PMID:15037717   PMID:15262267   PMID:16199352   PMID:16504488   PMID:16647690   PMID:17300923   PMID:17303287  
PMID:17854388   PMID:18614015   PMID:18926807   PMID:20833797  


Genomics

Comparative Map Data
Aldh5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,560,373 - 40,586,711 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1740,558,347 - 40,586,714 (+)EnsemblGRCr8
mRatBN7.21740,132,339 - 40,158,677 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,130,883 - 40,158,677 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1740,200,441 - 40,226,804 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,804,498 - 41,830,863 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,087,826 - 40,114,061 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,133,076 - 42,159,413 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,133,076 - 42,159,413 (+)Ensemblrn6Rnor6.0
Rnor_5.01744,000,875 - 44,027,212 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41747,193,407 - 47,216,499 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1739,769,869 - 39,796,199 (+)NCBICelera
RGSC_v3.11747,196,722 - 47,219,340 (+)NCBI
Cytogenetic Map17p11NCBI
ALDH5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38624,494,969 - 24,537,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl624,494,798 - 24,537,207 (+)Ensemblhg38GRCh38
GRCh37624,495,197 - 24,537,435 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36624,603,176 - 24,645,414 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34624,603,175 - 24,645,414NCBI
Celera625,728,607 - 25,770,806 (+)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef624,444,647 - 24,486,850 (+)NCBIHuRef
CHM1_1624,499,400 - 24,541,589 (+)NCBICHM1_1
T2T-CHM13v2.0624,364,950 - 24,407,166 (+)NCBIT2T-CHM13v2.0
Aldh5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391325,091,562 - 25,121,740 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1325,091,562 - 25,121,644 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381324,907,579 - 24,937,661 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1324,907,579 - 24,937,661 (-)Ensemblmm10GRCm38
MGSCv371324,999,448 - 25,029,530 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361324,918,497 - 24,945,126 (-)NCBIMGSCv36mm8
Celera1325,138,248 - 25,168,330 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1310.77NCBI
Aldh5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554832,467,425 - 2,494,416 (-)Ensembl
ChiLan1.0NW_0049554832,467,425 - 2,494,416 (-)NCBIChiLan1.0ChiLan1.0
ALDH5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2539,145,143 - 39,187,630 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1635,144,631 - 35,187,096 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0624,332,093 - 24,370,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1624,665,026 - 24,703,242 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl624,665,026 - 24,705,151 (+)EnsemblpanPan2panpan1.1
ALDH5A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13522,560,005 - 22,590,996 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3522,560,008 - 22,587,875 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3522,524,175 - 22,552,036 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03522,678,366 - 22,704,116 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3522,678,366 - 22,713,142 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13522,483,861 - 22,512,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03522,532,027 - 22,557,461 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03523,968,214 - 23,996,095 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aldh5a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049462,755,755 - 2,777,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936671843,577 - 865,881 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936671843,577 - 865,798 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,351,361 - 19,379,098 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1719,351,485 - 19,375,515 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2720,501,722 - 20,526,975 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH5A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11747,712,785 - 47,746,198 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1747,709,888 - 47,745,830 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604424,427,783 - 24,464,046 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh5a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247562,464,899 - 2,501,130 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247562,464,912 - 2,500,773 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Aldh5a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11443,961,065 - 43,985,374 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aldh5a1
117 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:239
Count of miRNA genes:124
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000031384, ENSRNOT00000050919
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat

Markers in Region
RH142226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21740,154,857 - 40,155,011 (+)MAPPERmRatBN7.2
Rnor_6.01742,155,594 - 42,155,747NCBIRnor6.0
Rnor_5.01744,023,393 - 44,023,546UniSTSRnor5.0
RGSC_v3.41747,216,263 - 47,216,416UniSTSRGSC3.4
Celera1739,792,380 - 39,792,533UniSTS
Cytogenetic Map17p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 86 59 6 350 186 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000031384   ⟹   ENSRNOP00000035601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,559,917 - 40,586,714 (+)Ensembl
mRatBN7.2 Ensembl1740,132,355 - 40,158,677 (+)Ensembl
Rnor_6.0 Ensembl1742,133,076 - 42,159,413 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096987   ⟹   ENSRNOP00000078818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,558,347 - 40,586,714 (+)Ensembl
mRatBN7.2 Ensembl1740,130,883 - 40,158,677 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134364   ⟹   ENSRNOP00000108778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,559,917 - 40,586,714 (+)Ensembl
RefSeq Acc Id: NM_022851   ⟹   NP_074042
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,560,373 - 40,586,711 (+)NCBI
mRatBN7.21740,132,339 - 40,158,677 (+)NCBI
Rnor_6.01742,133,076 - 42,159,413 (+)NCBI
Rnor_5.01744,000,875 - 44,027,212 (+)NCBI
Celera1739,769,869 - 39,796,199 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_074042 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA67058 (Get FASTA)   NCBI Sequence Viewer  
  EDL86492 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000108778
GenBank Protein P51650 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_074042   ⟸   NM_022851
- Peptide Label: precursor
- UniProtKB: P51650 (UniProtKB/Swiss-Prot),   A6KLE7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035601   ⟸   ENSRNOT00000031384
Ensembl Acc Id: ENSRNOP00000078818   ⟸   ENSRNOT00000096987
Ensembl Acc Id: ENSRNOP00000108778   ⟸   ENSRNOT00000134364
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51650-F1-model_v2 AlphaFold P51650 1-523 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700441
Promoter ID:EPDNEW_R10964
Type:initiation region
Name:Aldh5a1_1
Description:aldehyde dehydrogenase 5 family, member A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01742,133,066 - 42,133,126EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621422 AgrOrtholog
BioCyc Gene G2FUF-9426 BioCyc
BioCyc Pathway GLUDEG-I-PWY [GABA shunt] BioCyc
  PWY-6535 [4-aminobutanoate degradation I] BioCyc
BioCyc Pathway Image GLUDEG-I-PWY BioCyc
  PWY-6535 BioCyc
Ensembl Genes ENSRNOG00000023538 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000134364 ENTREZGENE
Gene3D-CATH Aldehyde Dehydrogenase, Chain A, domain 1 UniProtKB/Swiss-Prot
  Aldehyde Dehydrogenase, Chain A, domain 2 UniProtKB/Swiss-Prot
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot
  Aldehyde_DH_dom UniProtKB/Swiss-Prot
  Aldehyde_DH_Superfamily UniProtKB/Swiss-Prot
  Succ_semiAld_DH UniProtKB/Swiss-Prot
NCBI Gene Aldh5a1 ENTREZGENE
PANTHER SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Aldedh UniProtKB/Swiss-Prot
PhenoGen Aldh5a1 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000023538 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot
UniProt A0A8I5ZLJ2_RAT UniProtKB/TrEMBL
  A0ABK0LYL6_RAT UniProtKB/TrEMBL
  A6KLE7 ENTREZGENE, UniProtKB/TrEMBL
  G3V945_RAT UniProtKB/TrEMBL
  P51650 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Aldh5a1  aldehyde dehydrogenase 5 family, member A1  Aldh5a1  aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-19 Aldh5a1  aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)  Aldh5a1  aldehyde dehydrogenase family 5, subfamily A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Aldh5a1  aldehyde dehydrogenase family 5, subfamily A1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Aldh5a1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function oxidizing enzyme for 4-hydroxy-trans-2-nonenal (HNE), a neurotoxic aldehyde in the CNS creating a non-toxic metabolite 1304407
gene_homology shares 83 and 91% identity to human in nucleotide and protein sequence, respectively 632258
gene_product belongs to the aldehyde dehydrogenase superfamily 632258
gene_protein 488 amino acids 632258