Aco2 (aconitase 2) - Rat Genome Database

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Gene: Aco2 (aconitase 2) Rattus norvegicus
Analyze
Symbol: Aco2
Name: aconitase 2
RGD ID: 621360
Description: Enables 3 iron, 4 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and aconitate hydratase activity. Involved in several processes, including response to isolation stress; tricarboxylic acid cycle; and tricarboxylic acid metabolic process. Predicted to be active in cytosol and mitochondrial matrix. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; INTERACTS WITH (R)-adrenaline; 1,3-dinitrobenzene; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: aconitase 2, mitochondrial; aconitate hydratase, mitochondrial; citrate hydro-lyase; mitochondrial aconitase (nuclear aco2 gene)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,265,816 - 115,308,931 (+)NCBIGRCr8
mRatBN7.27113,385,677 - 113,428,794 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,385,646 - 113,428,261 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7115,148,102 - 115,191,078 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,371,597 - 117,414,574 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,341,038 - 117,384,016 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,102,493 - 123,145,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,102,468 - 123,145,635 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,077,888 - 123,121,003 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,223,788 - 120,266,944 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17120,258,017 - 120,301,166 (+)NCBI
Celera7109,704,354 - 109,747,462 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
alatrofloxacin  (ISO)
aldehydo-D-glucose  (EXP)
aluminium atom  (EXP,ISO)
aluminium(0)  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
citric acid  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
curcumin  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (EXP,ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
ferric ammonium citrate  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glucose  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hemin  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
hydroxyl  (EXP)
indometacin  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
kainic acid  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
linalool  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
menadione  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nicardipine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitroprusside  (ISO)
omeprazole  (EXP)
oxybenzone  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium atom  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
pyridaben  (EXP)
reactive oxygen species  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
sevoflurane  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
T-2 toxin  (EXP)
tebufenpyrad  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
tributylstannane  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA)
mitochondrial matrix  (ISO)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide. Andersson U, etal., Biochem Biophys Res Commun. 1998 Aug 19;249(2):512-6.
2. Redox-dependent modulation of aconitase activity in intact mitochondria. Bulteau AL, etal., Biochemistry. 2003 Dec 23;42(50):14846-55.
3. Reversible redox-dependent modulation of mitochondrial aconitase and proteolytic activity during in vivo cardiac ischemia/reperfusion. Bulteau AL, etal., Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5987-91. Epub 2005 Apr 19.
4. Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity. Bulteau AL, etal., Science 2004 Jul 9;305(5681):242-5.
5. [Aerosol vaccination of broilers against Newcastle disease]. Chernyshev VV, etal., Veterinariia. 1978 Dec;(12):78-80.
6. Induction of aconitate hydratase in hepatocytes of starving rats. Eprintsev AT, etal., Biochemistry (Mosc) 2002 Jul;67(7):795-801.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Developmental changes of rat liver cytoplasmic and mitochondrial aconitate hydratases. Masini A, etal., Ital J Biochem. 1978 Sep-Oct;27(5):300-4.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Social isolation in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase. Zhuravliova E, etal., Behav Brain Res. 2009 Dec 28;205(2):377-83. Epub 2009 Jul 16.
Additional References at PubMed
PMID:1052766   PMID:9630632   PMID:14651853   PMID:15317809   PMID:15489334   PMID:16162655   PMID:16341586   PMID:17322295   PMID:17634366   PMID:18614015   PMID:19153662   PMID:20833797  
PMID:22082260   PMID:24429287   PMID:26296893   PMID:26316108   PMID:29476059   PMID:29867124   PMID:32357304   PMID:36735737  


Genomics

Comparative Map Data
Aco2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,265,816 - 115,308,931 (+)NCBIGRCr8
mRatBN7.27113,385,677 - 113,428,794 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,385,646 - 113,428,261 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7115,148,102 - 115,191,078 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,371,597 - 117,414,574 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,341,038 - 117,384,016 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,102,493 - 123,145,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,102,468 - 123,145,635 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,077,888 - 123,121,003 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,223,788 - 120,266,944 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17120,258,017 - 120,301,166 (+)NCBI
Celera7109,704,354 - 109,747,462 (+)NCBICelera
Cytogenetic Map7q34NCBI
ACO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,469,117 - 41,528,974 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,447,830 - 41,529,273 (+)EnsemblGRCh38hg38GRCh38
GRCh372241,865,121 - 41,924,978 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,195,075 - 40,254,939 (+)NCBINCBI36Build 36hg18NCBI36
Build 342240,189,628 - 40,249,492NCBI
Celera2225,671,513 - 25,731,364 (+)NCBICelera
Cytogenetic Map22q13.2ENTREZGENE
HuRef2224,830,931 - 24,890,807 (+)NCBIHuRef
CHM1_12241,825,012 - 41,884,897 (+)NCBICHM1_1
T2T-CHM13v2.02241,947,611 - 42,007,811 (+)NCBIT2T-CHM13v2.0
Aco2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,756,664 - 81,799,338 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,756,510 - 81,799,334 (+)EnsemblGRCm39 Ensembl
GRCm381581,872,463 - 81,915,137 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,872,309 - 81,915,133 (+)EnsemblGRCm38mm10GRCm38
MGSCv371581,702,893 - 81,745,567 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361581,699,718 - 81,742,392 (+)NCBIMGSCv36mm8
Celera1583,991,539 - 84,036,379 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.26NCBI
Aco2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541327,027,341 - 27,065,227 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541327,027,341 - 27,065,227 (+)NCBIChiLan1.0ChiLan1.0
ACO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22351,299,400 - 51,359,322 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12253,998,677 - 54,058,580 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02222,363,178 - 22,423,041 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12240,450,276 - 40,510,200 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2240,450,276 - 40,510,200 (+)Ensemblpanpan1.1panPan2
ACO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11023,742,284 - 23,798,580 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,742,333 - 23,798,498 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1023,674,973 - 23,731,276 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01024,487,132 - 24,543,453 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,487,133 - 24,543,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11024,203,926 - 24,260,231 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,525,094 - 24,581,120 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,699,242 - 24,755,563 (-)NCBIUU_Cfam_GSD_1.0
Aco2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,397,068 - 7,442,218 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936492407,482 - 452,537 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936492407,482 - 452,538 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,008,719 - 7,071,025 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.157,014,383 - 7,071,023 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,385,951 - 4,443,595 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11924,008,602 - 24,068,346 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1924,008,667 - 24,071,356 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045101,348,982 - 101,410,178 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aco2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247527,074,153 - 7,113,773 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247527,074,148 - 7,113,773 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aco2
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:466
Count of miRNA genes:244
Interacting mature miRNAs:282
Transcripts:ENSRNOT00000038612
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat

Markers in Region
BF392697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,389,495 - 113,389,592 (+)MAPPERmRatBN7.2
Rnor_6.07123,106,312 - 123,106,408NCBIRnor6.0
Rnor_5.07123,081,707 - 123,081,803UniSTSRnor5.0
RGSC_v3.47120,227,607 - 120,227,703UniSTSRGSC3.4
Celera7109,708,173 - 109,708,269UniSTS
RH 3.4 Map7887.3UniSTS
Cytogenetic Map7q34UniSTS
RH134577  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,394,714 - 113,394,906 (+)MAPPERmRatBN7.2
Rnor_6.07125,101,589 - 125,101,780NCBIRnor6.0
Rnor_6.07123,111,530 - 123,111,721NCBIRnor6.0
Rnor_5.07125,090,126 - 125,090,317UniSTSRnor5.0
Rnor_5.07123,086,925 - 123,087,116UniSTSRnor5.0
RGSC_v3.47120,232,825 - 120,233,016UniSTSRGSC3.4
Celera7109,713,382 - 109,713,573UniSTS
RH 3.4 Map7887.3UniSTS
Cytogenetic Map7q34UniSTS
Aco2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,423,821 - 113,425,251 (+)MAPPERmRatBN7.2
Rnor_6.07123,140,636 - 123,142,065NCBIRnor6.0
Rnor_5.07123,116,031 - 123,117,460UniSTSRnor5.0
RGSC_v3.47120,261,972 - 120,263,401UniSTSRGSC3.4
Celera7109,742,490 - 109,743,919UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000038612   ⟹   ENSRNOP00000029144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7113,385,653 - 113,428,261 (+)Ensembl
Rnor_6.0 Ensembl7123,102,493 - 123,145,635 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7123,131,859 - 123,136,040 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7123,102,468 - 123,136,040 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099398   ⟹   ENSRNOP00000078865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7113,401,245 - 113,428,261 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100584   ⟹   ENSRNOP00000085371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7113,385,646 - 113,402,734 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120088   ⟹   ENSRNOP00000094788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7113,385,653 - 113,428,261 (+)Ensembl
RefSeq Acc Id: NM_024398   ⟹   NP_077374
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,265,816 - 115,308,931 (+)NCBI
mRatBN7.27113,385,677 - 113,428,794 (+)NCBI
Rnor_6.07123,102,493 - 123,145,608 (+)NCBI
Rnor_5.07123,077,888 - 123,121,003 (+)NCBI
RGSC_v3.47120,223,788 - 120,266,944 (+)RGD
Celera7109,704,354 - 109,747,462 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_077374   ⟸   NM_024398
- Peptide Label: precursor
- UniProtKB: Q6P6V3 (UniProtKB/Swiss-Prot),   Q9ER34 (UniProtKB/Swiss-Prot),   A6HT25 (UniProtKB/TrEMBL),   A0A8I5ZLT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029144   ⟸   ENSRNOT00000038612
RefSeq Acc Id: ENSRNOP00000085371   ⟸   ENSRNOT00000100584
RefSeq Acc Id: ENSRNOP00000094788   ⟸   ENSRNOT00000120088
RefSeq Acc Id: ENSRNOP00000078865   ⟸   ENSRNOT00000099398
Protein Domains
Aconitase A/isopropylmalate dehydratase small   Aconitase/3-isopropylmalate dehydratase large

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ER34-F1-model_v2 AlphaFold Q9ER34 1-780 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695523
Promoter ID:EPDNEW_R6043
Type:multiple initiation site
Name:Aco2_1
Description:aconitase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07123,102,468 - 123,102,528EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621360 AgrOrtholog
BioCyc Gene G2FUF-32659 BioCyc
BioCyc Pathway PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
BioCyc Pathway Image PWY-5690 BioCyc
Ensembl Genes ENSRNOG00000024128 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055028470 UniProtKB/Swiss-Prot
  ENSRNOG00060030937 UniProtKB/Swiss-Prot
  ENSRNOG00065028891 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038612 ENTREZGENE
  ENSRNOT00000038612.6 UniProtKB/Swiss-Prot
  ENSRNOT00000099398.1 UniProtKB/TrEMBL
  ENSRNOT00000100584.1 UniProtKB/TrEMBL
  ENSRNOT00000120088.1 UniProtKB/TrEMBL
  ENSRNOT00055049384 UniProtKB/Swiss-Prot
  ENSRNOT00060053775 UniProtKB/Swiss-Prot
  ENSRNOT00065049953 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.19.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.499.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1060.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621226 IMAGE-MGC_LOAD
InterPro Acnase/IPM_dHydase_lsu_aba_1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acoase/IPM_deHydtase_lsu_aba UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase/3IPM_dehydase_swvl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_4Fe-4S_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_4Fe-4S_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_mito-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AconitaseA/IPMdHydase_ssu_swvl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79250 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72424 IMAGE-MGC_LOAD
NCBI Gene 79250 ENTREZGENE
PANTHER ACONITATE HYDRATASE B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACONITATE HYDRATASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aconitase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aconitase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aco2 PhenoGen
PRINTS ACONITASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ACONITASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACONITASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024128 RatGTEx
  ENSRNOG00055028470 RatGTEx
  ENSRNOG00060030937 RatGTEx
  ENSRNOG00065028891 RatGTEx
Superfamily-SCOP LeuD/IlvD-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53732 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZLT6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZ31_RAT UniProtKB/TrEMBL
  A0A8I6AIF6_RAT UniProtKB/TrEMBL
  A6HT25 ENTREZGENE, UniProtKB/TrEMBL
  ACON_RAT UniProtKB/Swiss-Prot
  Q6P6V3 ENTREZGENE
  Q9ER34 ENTREZGENE
UniProt Secondary Q6P6V3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Aco2  aconitase 2  Aco2  aconitase 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Aco2  aconitase 2, mitochondrial    mitochondrial aconitase (nuclear aco2 gene)  Name updated 1299863 APPROVED
2002-08-07 Aco2        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction interacts with frataxin in a citrate dependent fashion 1304347
gene_regulation enzyme activity induced in hepatocytes by food deprivation 632269
gene_regulation activity is modulated by frataxin an iron chaperone protein via binding which protects the aconitase [4Fe-4S]2 cluster from disassembly and promotes enzyme reactivation 1304347