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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aco2
Name: aconitase 2
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aco2decreases activityEXP 6480464CTDmanganese chloride results in decreased activity of ACO2 proteinPMID:9675333
Aco2multiple interactionsEXP 6480464CTDIron inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]PMID:9675333
Aco2decreases activityISOACO2 (Homo sapiens)6480464CTDmanganese chloride results in decreased activity of ACO2 proteinPMID:16625280
Aco2decreases expressionISOACO2 (Homo sapiens)6480464CTDmanganese chloride results in decreased expression of ACO2 mRNA; manganese chloride results in decreased expression of ACO2 proteinPMID:16625280
Aco2multiple interactionsISOACO2 (Homo sapiens)6480464CTDferric ammonium citrate inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]PMID:16625280
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