Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aco2
Name: aconitase 2
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aco2affects response to substanceEXP 6480464CTDACO2 protein affects the susceptibility to ParaquatPMID:21517855
Aco2decreases activityEXP 6480464CTDParaquat results in decreased activity of ACO2 proteinPMID:11520895 PMID:21517855
Aco2multiple interactionsEXP 6480464CTDACO2 protein affects the reaction [Paraquat results in increased abundance of Hydrogen Peroxide]; ACO2 protein affects the reaction [Paraquat results in increased abundance of Iron]PMID:21517855
Aco2decreases activityISOACO2 (Homo sapiens)6480464CTDParaquat results in decreased activity of ACO2 proteinPMID:15234109
Aco2multiple interactionsISOAco2 (Mus musculus)6480464CTD[GCLM gene mutant form results in increased susceptibility to Paraquat] which results in decreased activity of ACO2 protein; [Paraquat co-treated with Maneb] results in decreased expression of ACO2 mRNAPMID:18386188 PMID:23704229
Aco2multiple interactionsISOACO2 (Homo sapiens)6480464CTDSNCA protein inhibits the reaction [Paraquat results in decreased activity of ACO2 protein]PMID:15234109
Go Back to source page   Continue to Ontology report