E2f5 (E2F transcription factor 5) - Rat Genome Database

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Gene: E2f5 (E2F transcription factor 5) Rattus norvegicus
Analyze
Symbol: E2f5
Name: E2F transcription factor 5
RGD ID: 621357
Description: Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within animal organ morphogenesis and regulation of DNA-templated transcription. Located in sarcoplasm. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human E2F5 (E2F transcription factor 5); PARTICIPATES IN cell cycle pathway, mitotic; G1 phase pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E2f-5; transcription factor E2F5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8288,718,567 - 88,734,143 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl288,718,567 - 88,734,143 (-)EnsemblGRCr8
mRatBN7.2286,997,331 - 87,012,908 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl286,997,332 - 87,012,990 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx293,326,917 - 93,342,470 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,447,920 - 91,463,473 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,504,739 - 86,520,292 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,350,764 - 88,366,913 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,351,361 - 88,366,115 (-)Ensemblrn6Rnor6.0
Rnor_5.02108,121,172 - 108,137,052 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4288,346,236 - 88,361,733 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera282,587,783 - 82,594,655 (-)NCBICelera
RGSC_v3.1288,291,198 - 88,306,581 (-)NCBI
Cytogenetic Map2q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methoxyethanol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
dimethyl sulfoxide  (ISO)
emodin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
flavonoids  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
GW 7647  (EXP)
hydrogen chloride  (ISO)
Lasiocarpine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
monocrotaline  (ISO)
nicotine  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
riddelliine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells. Fujita N, etal., Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H204-12.
2. E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Gaubatz S, etal., Mol Cell 2000 Sep;6(3):729-35.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated muscle. Gill RM and Hamel PA, J Cell Biol. 2000 Mar 20;148(6):1187-201.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Comparative genomics on MCM8 orthologous genes reveals the transcriptional regulation by transcription factor E2F. Hayashi R, etal., Gene. 2006 Feb 15;367:126-34. Epub 2005 Dec 1.
7. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. Itoh A, etal., Cell Mol Biol Res 1995;41(3):147-54.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to prostate carcinogenesis. Qi JC, etal., J Exp Clin Cancer Res. 2021 Jan 4;40(1):2. doi: 10.1186/s13046-020-01814-5.
12. Reactome: A Knowledgebase of Biological Processes Reactome
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Inhibition of E2F abrogates the development of cardiac myocyte hypertrophy. Vara D, etal., J Biol Chem. 2003 Jun 13;278(24):21388-94. Epub 2003 Apr 6.
Additional References at PubMed
PMID:9553039   PMID:10783242   PMID:11591818   PMID:16172982   PMID:16360038   PMID:17062573   PMID:17102628   PMID:18541936   PMID:31257477  


Genomics

Comparative Map Data
E2f5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8288,718,567 - 88,734,143 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl288,718,567 - 88,734,143 (-)EnsemblGRCr8
mRatBN7.2286,997,331 - 87,012,908 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl286,997,332 - 87,012,990 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx293,326,917 - 93,342,470 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,447,920 - 91,463,473 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,504,739 - 86,520,292 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,350,764 - 88,366,913 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,351,361 - 88,366,115 (-)Ensemblrn6Rnor6.0
Rnor_5.02108,121,172 - 108,137,052 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4288,346,236 - 88,361,733 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera282,587,783 - 82,594,655 (-)NCBICelera
RGSC_v3.1288,291,198 - 88,306,581 (-)NCBI
Cytogenetic Map2q23NCBI
E2F5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38885,177,154 - 85,214,518 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl885,177,154 - 85,217,158 (+)Ensemblhg38GRCh38
GRCh37886,089,389 - 86,126,753 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36886,276,871 - 86,314,005 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34886,276,876 - 86,314,002NCBI
Celera882,094,939 - 82,131,798 (+)NCBICelera
Cytogenetic Map8q21.2NCBI
HuRef881,583,766 - 81,620,799 (+)NCBIHuRef
CHM1_1886,141,195 - 86,178,340 (+)NCBICHM1_1
T2T-CHM13v2.0885,615,754 - 85,653,117 (+)NCBIT2T-CHM13v2.0
E2f5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,638,370 - 14,671,369 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl314,643,701 - 14,671,369 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38314,578,602 - 14,606,309 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,578,641 - 14,606,309 (+)Ensemblmm10GRCm38
MGSCv37314,578,671 - 14,606,309 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36314,555,415 - 14,583,053 (+)NCBIMGSCv36mm8
Celera314,586,826 - 14,614,448 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.1NCBI
E2f5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554173,145,570 - 3,155,233 (+)Ensembl
ChiLan1.0NW_0049554173,131,282 - 3,155,872 (+)NCBIChiLan1.0ChiLan1.0
E2F5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27100,914,168 - 100,950,576 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1876,546,751 - 76,583,160 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0881,703,423 - 81,739,827 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1883,314,197 - 83,350,220 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl883,314,176 - 83,350,220 (+)EnsemblpanPan2panpan1.1
E2F5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12931,745,211 - 31,754,940 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2931,746,384 - 31,754,265 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2932,010,179 - 32,037,439 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02931,876,597 - 31,904,670 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2931,876,391 - 31,904,682 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12931,931,443 - 31,958,633 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02931,949,625 - 31,977,358 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02932,333,466 - 32,361,295 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
E2f5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530347,639,377 - 47,667,600 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936544125,360 - 152,670 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936544124,243 - 153,325 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
E2F5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl451,478,050 - 51,512,718 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1451,478,399 - 51,512,617 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2456,493,996 - 56,528,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
E2F5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1880,542,390 - 80,587,888 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl880,542,580 - 80,587,226 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603960,512,505 - 60,557,770 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
E2f5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247446,468,512 - 6,492,356 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
E2f5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13157,585,114 - 157,602,008 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in E2f5
121 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:80
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000044847
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)278269809104744824Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH129797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2166,075,259 - 66,075,471 (+)MAPPERmRatBN7.2
mRatBN7.2286,997,437 - 86,997,649 (+)MAPPERmRatBN7.2
Rnor_6.0164,640,947 - 64,641,158NCBIRnor6.0
Rnor_6.0288,350,871 - 88,351,082NCBIRnor6.0
Rnor_5.02108,121,279 - 108,121,490UniSTSRnor5.0
Rnor_5.0163,632,884 - 63,633,095UniSTSRnor5.0
RGSC_v3.4164,400,317 - 64,400,528UniSTSRGSC3.4
RGSC_v3.4288,346,343 - 88,346,554UniSTSRGSC3.4
Celera282,587,890 - 82,588,101UniSTS
Celera163,796,300 - 63,796,511UniSTS
RH 3.4 Map1742.29UniSTS
Cytogenetic Map2q23UniSTS
Cytogenetic Map1q12UniSTS
AI008886  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2287,003,463 - 87,003,666 (+)MAPPERmRatBN7.2
Rnor_6.0288,356,897 - 88,357,099NCBIRnor6.0
Rnor_5.02108,127,305 - 108,127,507UniSTSRnor5.0
RGSC_v3.4288,352,371 - 88,352,573UniSTSRGSC3.4
Celera282,593,908 - 82,594,110UniSTS
RH 3.4 Map2548.7UniSTS
Cytogenetic Map2q23UniSTS


Related Rat Strains
The following Strains have been annotated to E2f5
SD    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000044847   ⟹   ENSRNOP00000044464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl288,718,567 - 88,734,143 (-)Ensembl
mRatBN7.2 Ensembl286,997,332 - 87,012,990 (-)Ensembl
Rnor_6.0 Ensembl288,351,361 - 88,366,115 (-)Ensembl
RefSeq Acc Id: NM_001398639   ⟹   NP_001385568
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,718,567 - 88,734,143 (-)NCBI
mRatBN7.2286,997,331 - 87,012,908 (-)NCBI
RefSeq Acc Id: XM_063281166   ⟹   XP_063137236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,719,267 - 88,734,136 (-)NCBI
RefSeq Acc Id: XM_063281167   ⟹   XP_063137237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,718,567 - 88,725,329 (-)NCBI
RefSeq Acc Id: XM_063281168   ⟹   XP_063137238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,721,184 - 88,734,136 (-)NCBI
RefSeq Acc Id: XM_063281169   ⟹   XP_063137239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,718,567 - 88,733,840 (-)NCBI
RefSeq Acc Id: XR_010063578
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,719,166 - 88,734,136 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385568 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137236 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137237 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137238 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137239 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB00180 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044464
GenBank Protein Q62814 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000044464   ⟸   ENSRNOT00000044847
RefSeq Acc Id: NP_001385568   ⟸   NM_001398639
- UniProtKB: Q62814 (UniProtKB/Swiss-Prot),   F1LRB5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137239   ⟸   XM_063281169
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AF40 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137237   ⟸   XM_063281167
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137236   ⟸   XM_063281166
- Peptide Label: isoform X1
- UniProtKB: Q62814 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137238   ⟸   XM_063281168
- Peptide Label: isoform X3
Protein Domains
E2F/DP family winged-helix DNA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62814-F1-model_v2 AlphaFold Q62814 1-300 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621357 AgrOrtholog
BioCyc Gene G2FUF-53803 BioCyc
Ensembl Genes ENSRNOG00000010760 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000044847 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  6.10.250.540 UniProtKB/Swiss-Prot
InterPro E2F UniProtKB/Swiss-Prot
  E2F-DP_heterodim UniProtKB/Swiss-Prot
  E2F_CC-MB UniProtKB/Swiss-Prot
  E2F_WHTH_DNA-bd_dom UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
NCBI Gene 116651 ENTREZGENE
PANTHER PTHR12081 UniProtKB/Swiss-Prot
  PTHR12081:SF35 UniProtKB/Swiss-Prot
Pfam E2F_CC-MB UniProtKB/Swiss-Prot
  E2F_TDP UniProtKB/Swiss-Prot
PhenoGen E2f5 PhenoGen
RatGTEx ENSRNOG00000010760 RatGTEx
SMART E2F_TDP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF144074 UniProtKB/Swiss-Prot
  SSF46785 UniProtKB/Swiss-Prot
UniProt A0A8I6AF40 ENTREZGENE
  E2F5_RAT UniProtKB/Swiss-Prot
  F1LRB5 ENTREZGENE, UniProtKB/TrEMBL
  Q62814 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 E2f5  E2F transcription factor 5      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 E2f5  E2F transcription factor 5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease associated with atherosclerosis, hypertension, and restenosis after injury 625751
gene_expression expressed in vascular smooth muscle cells, fibroblasts and Saos-2 cell line 625751
gene_function acts as transcriptional repressor 625751
gene_process controls G1/S transition of eukaryotic cells by monitoring the regulation of transcription of growth-related genes 625751
gene_process can maintain cells in G0/G1 phase by downregulating genes which promote development 625751
gene_process may be involved in feedback regulation of cellular functions during cell proliferation 625751
gene_product member of transcriptional factor family 625751
gene_regulation fetal bovine serum (FBS) activated RNA expression in a time-dependent manner 625751
gene_regulation RNA expression levels were downregulated in quiescent cells 625751