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Gene: Sctr (secretin receptor) Rattus norvegicus

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Symbol:

Sctr

Name:

secretin receptor

RGD ID:

621342

Description:

Enables peptide binding activity and secretin receptor activity. Involved in regulation of cAMP/PKA signal transduction. Predicted to be located in cytoplasmic microtubule. Predicted to be active in plasma membrane. Orthologous to human SCTR (secretin receptor); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC93381; SCT-R

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SCTR (secretin receptor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Sctr (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sctr (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SCTR (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SCTR (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sctr (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SCTR (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SCTR (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sctr (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Sctr (secretin receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SCTR (secretin receptor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sctr (secretin receptor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sctr (secretin receptor)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	seb-3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|SonicParanoid)
Caenorhabditis elegans (roundworm):	seb-3	Alliance	DIOPT (InParanoid\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sctr	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	33,680,562 - 33,744,049 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	33,680,627 - 33,733,709 (+)	Ensembl				GRCr8
mRatBN7.2	13	31,127,781 - 31,190,162 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	31,127,858 - 31,180,189 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	33,709,188 - 33,765,504 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	34,997,029 - 35,053,348 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	32,271,626 - 32,327,778 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	36,039,241 - 36,090,515 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	36,039,283 - 36,090,530 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	41,160,339 - 41,201,354 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	13	31,000,848 - 31,067,419 (+)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (EXP)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-acetamidofluorene (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (EXP)

CGP 52608 (ISO)

cobalt dichloride (EXP)

copper atom (EXP)

copper(0) (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dibutyl phthalate (EXP)

dichlorine (EXP)

endosulfan (EXP)

furan (EXP)

genistein (EXP)

gentamycin (EXP)

indole-3-methanol (EXP)

methimazole (EXP)

methoxychlor (EXP)

N-nitrosodiethylamine (EXP,ISO)

nickel atom (ISO)

nickel dichloride (EXP)

Nonylphenol (EXP)

ozone (EXP)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

silicon dioxide (EXP)

testosterone (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA,ISO,ISS)

adenylate cyclase-modulating G protein-coupled receptor signaling pathway (IBA)

cell surface receptor signaling pathway (IEA)

diet induced thermogenesis (ISO,ISS)

G protein-coupled receptor signaling pathway (IEA,ISO)

intracellular water homeostasis (ISO,ISS)

positive regulation of lipid catabolic process (ISO)

regulation of appetite (ISO,ISS)

regulation of cAMP/PKA signal transduction (IMP)

regulation of synaptic plasticity (ISO,ISS)

renal water absorption (ISO)

response to nutrient levels (ISO,ISS)

signal transduction (IEA)

Cellular Component

basolateral plasma membrane (IEA)

cytoplasmic microtubule (IEA,ISO,ISS)

membrane (IEA)

plasma membrane (IBA,IEA)

Molecular Function

G protein-coupled peptide receptor activity (IBA)

G protein-coupled receptor activity (IEA)

peptide binding (IDA,IPI)

peptide hormone binding (IBA,IEA,ISO)

secretin receptor activity (IBA,IDA,IEA,ISO)

transmembrane signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid transport pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus.	Dong M, etal., Mol Endocrinol. 2002 Nov;16(11):2490-501.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Molecular cloning and expression of a cDNA encoding the secretin receptor.	Ishihara T, etal., EMBO J 1991 Jul;10(7):1635-41.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12.	Age-related and regional differences in secretin and secretin receptor mRNA levels in the rat brain.	Tay J, etal., Neurosci Lett. 2004 Aug 12;366(2):176-81.

Additional References at PubMed

PMID:7612008	PMID:15489334	PMID:15664984	PMID:15670850	PMID:15731172	PMID:17008357	PMID:17283064	PMID:17827151	PMID:18467541	PMID:20927047	PMID:21388146	PMID:21566140
PMID:22692904	PMID:23264731	PMID:24273196	PMID:27330080	PMID:30449620

Genomics

Comparative Map Data

Sctr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	33,680,562 - 33,744,049 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	33,680,627 - 33,733,709 (+)	Ensembl				GRCr8
mRatBN7.2	13	31,127,781 - 31,190,162 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	31,127,858 - 31,180,189 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	33,709,188 - 33,765,504 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	34,997,029 - 35,053,348 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	32,271,626 - 32,327,778 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	36,039,241 - 36,090,515 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	36,039,283 - 36,090,530 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	41,160,339 - 41,201,354 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	13	31,000,848 - 31,067,419 (+)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

SCTR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	119,439,843 - 119,524,483 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	119,439,839 - 119,525,301 (-)	Ensembl			hg38	GRCh38
GRCh37	2	120,197,419 - 120,282,059 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	119,913,889 - 119,998,498 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	119,913,650 - 119,998,136	NCBI
Celera	2	113,523,544 - 113,607,897 (-)	NCBI		Celera
Cytogenetic Map	2	q14.2	NCBI
HuRef	2	112,522,346 - 112,606,933 (-)	NCBI		HuRef
CHM1_1	2	120,200,944 - 120,285,215 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	119,873,301 - 119,957,984 (-)	NCBI		T2T-CHM13v2.0

Sctr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	119,934,710 - 119,991,269 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	119,934,624 - 119,991,266 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	120,006,879 - 120,063,539 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	120,006,894 - 120,063,536 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	121,903,557 - 121,960,111 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	121,834,524 - 121,891,084 (+)	NCBI		MGSCv36	mm8
Celera	1	122,666,492 - 122,721,998 (+)	NCBI		Celera
Cytogenetic Map	1	E2.3	NCBI
cM Map	1	52.57	NCBI

Sctr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	10,218,210 - 10,270,212 (+)	Ensembl
ChiLan1.0	NW_004955459	10,192,449 - 10,270,483 (+)	NCBI	ChiLan1.0	ChiLan1.0

SCTR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	21,439,472 - 21,524,924 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	21,454,520 - 21,539,895 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	6,374,400 - 6,458,595 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	119,952,714 - 120,036,326 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	119,952,714 - 120,036,326 (-)	Ensembl			panPan2	panpan1.1

SCTR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	30,505,059 - 30,577,371 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	30,526,055 - 30,577,075 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	30,768,711 - 30,844,497 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	31,890,123 - 31,966,380 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	31,889,725 - 31,961,438 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	30,576,866 - 30,653,075 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	30,743,177 - 30,819,391 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	31,929,956 - 32,001,323 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sctr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	90,701,781 - 90,766,441 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	50,865,115 - 50,915,695 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	50,851,569 - 50,916,183 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SCTR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	31,707,555 - 31,785,955 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	31,707,755 - 31,782,193 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	35,970,285 - 36,021,782 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SCTR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	10,802,156 - 10,883,884 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	10,833,507 - 10,883,605 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666061	11,803,913 - 11,884,184 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sctr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	25,633,149 - 25,686,128 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624732	25,611,603 - 25,687,129 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sctr
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	12,578,342 - 12,633,912 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sctr
604 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	40
Count of miRNA genes:	38
Interacting mature miRNAs:	40
Transcripts:	ENSRNOT00000072088
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317027	Aia22	Adjuvant induced arthritis QTL 22	2.29		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	13	1	34785618	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
2317034	Aia9	Adjuvant induced arthritis QTL 9	4.62		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12285517	34884386	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	43736554	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
2317044	Aia23	Adjuvant induced arthritis QTL 23	2.3		joint integrity trait (VT:0010548)	ankle joint diameter (CMO:0002148)	13	12285517	34884386	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	24335432	55601132	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	6002008	37088115	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
738036	Lnnr4	Liver neoplastic nodule remodeling QTL 4	3.64		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	1	34785618	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Markers in Region

RH142442

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	31,179,836 - 31,179,996 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	36,090,180 - 36,090,339	NCBI	Rnor6.0
Rnor_5.0	13	41,201,019 - 41,201,178	UniSTS	Rnor5.0
Celera	13	31,067,084 - 31,067,243	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
14	11	62	153	91	90	59	32	59	6	281	120	4	134	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X59132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000072088 ⟹ ENSRNOP00000064579

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	33,696,708 - 33,732,959 (+)	Ensembl
mRatBN7.2 Ensembl	13	31,143,940 - 31,180,189 (+)	Ensembl
Rnor_6.0 Ensembl	13	36,039,283 - 36,090,530 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119589 ⟹ ENSRNOP00000092013

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	33,680,627 - 33,732,942 (+)	Ensembl
mRatBN7.2 Ensembl	13	31,127,858 - 31,180,172 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119961 ⟹ ENSRNOP00000077594

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	33,680,627 - 33,732,942 (+)	Ensembl
mRatBN7.2 Ensembl	13	31,127,858 - 31,180,172 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000143096 ⟹ ENSRNOP00000103353

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	33,680,627 - 33,733,709 (+)	Ensembl

RefSeq Acc Id:

NM_031115 ⟹ NP_112377

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,627 - 33,732,942 (+)	NCBI
mRatBN7.2	13	31,127,858 - 31,180,172 (+)	NCBI
Rnor_6.0	13	36,039,241 - 36,090,515 (+)	NCBI
Rnor_5.0	13	41,160,339 - 41,201,354 (+)	NCBI
Celera	13	31,000,848 - 31,067,419 (+)	RGD

Sequence:

show sequence

TTTGTTAACAGTCTTGCCACCTCCTTCAGGGAGCAGCAGCCTCAAGCCTGGCTGTGGATCTGAT
CGGACTGGGTAGGTCCAGCCATGGTCTCTCTGGGCTTGGAGGTCGCCCAGGGTCCTGGACCACG
TGCAGGTCGCTGAGCTGGACGCAGAACCGGCCACCAAGCTCCTGAAGGGGCCAGAACGCAAAGG
GGAGCAACAGTGGGCGGAGCATGCTCAGCACCATGAGACCCCGGCTGTCCCTGCTTCTGCTGAG
GCTGTTGCTGCTCACCAAAGCAGCGCACACCGTTGGAGTTCCGCCCCGACTGTGTGACGTGCGG
CGTGTGCTGCTTGAGGAACGGGCCCACTGCCTACAGCAACTCTCCAAAGAGAAGAAAGGAGCAC
TGGGCCCGGAGACAGCATCAGGCTGTGAGGGGCTTTGGGACAACATGAGCTGCTGGCCCTCCTC
TGCACCAGCACGGACAGTGGAAGTGCAGTGTCCGAAGTTCCTCCTGATGCTCTCAAACAAAAAT
GGGTCTCTGTTCCGGAACTGCACACAAGATGGATGGTCAGAAACCTTCCCCAGGCCTGACCTGG
CCTGTGGGGTCAACATAAACAACTCCTTTAATGAGAGACGGCATGCGTACCTGCTGAAACTCAA
GGTCATGTACACTGTAGGCTACAGTTCCTCCTTGGCCATGCTCCTGGTCGCCCTCAGCATCCTG
TGCTCTTTCCGGAGGCTGCACTGCACTCGCAACTACATCCACATGCACCTGTTCGTGTCCTTCA
TCCTGCGCGCCCTGTCCAACTTCATCAAGGACGCCGTACTCTTCTCCTCGGACGACGTCACCTA
CTGTGATGCCCATAAGGTGGGCTGCAAGCTGGTCATGATCTTCTTCCAGTACTGCATCATGGCC
AACTACGCATGGCTGCTGGTGGAGGGCCTCTACCTTCACACACTCCTTGCCATCTCCTTCTTCT
CAGAAAGGAAGTACCTGCAGGCCTTTGTGCTCCTCGGATGGGGTTCTCCAGCCATTTTTGTTGC
TTTGTGGGCTATCACCAGGCACTTTCTAGAAAATACTGGATGCTGGGACATCAACGCCAATGCT
TCCGTCTGGTGGGTCATTCGAGGGCCTGTGATTCTGTCCATCCTGATCAATTTCATCTTCTTCA
TAAACATTCTAAGAATCCTGATGAGGAAACTTAGAACACAAGAAACAAGAGGAAGTGAAACAAA
CCATTATAAGCGCCTGGCCAAGTCCACCCTCCTGCTGATCCCGCTCTTTGGCATCCACTACATT
GTCTTCGCCTTCTCCCCAGAGGACGCCATGGAGGTCCAGCTGTTCTTCGAACTGGCCCTGGGCT
CCTTCCAGGGTCTGGTGGTAGCTGTCCTTTACTGCTTCCTCAATGGTGAGGTGCAGTTGGAAGT
TCAGAAAAAATGGCGCCAGTGGCACCTTCAAGAGTTCCCGCTGCGCCCTGTGGCCTTCAATAAC
TCCTTCAGCAACGCCACCAACGGCCCCACCCACAGCACCAAGGCTAGCACTGAGCAAAGCCGGA
GCATCCCCAGGGCCAGTATCATCTGAGGCTGCAGCAAGGCGCCAGCGGACGAAGGGTTGGATAT
TCGGTAGGACGGACATCTGTCTGATAGCCATCTCGTGCTCGACTGGCTGAACAGGCTTGTCTCT
CGGGTCCGAGCTTCCTCGGAGATCAAGCAAGAGGAGACTACTAGGTCATCGCGGAGCAGGAAAC
GGACCCATGACTTGGTTTTTCTTGTTCTTCTAAGAAGAGCAATTCAGCAACTCCAGAAGGGGCA
GGGG

hide sequence

RefSeq Acc Id:

XM_039091115 ⟹ XP_038947043

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,564 - 33,732,964 (+)	NCBI
mRatBN7.2	13	31,127,782 - 31,180,194 (+)	NCBI

RefSeq Acc Id:

XM_039091116 ⟹ XP_038947044

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,562 - 33,732,964 (+)	NCBI
mRatBN7.2	13	31,127,781 - 31,180,194 (+)	NCBI

RefSeq Acc Id:

XM_039091118 ⟹ XP_038947046

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,564 - 33,732,964 (+)	NCBI
mRatBN7.2	13	31,127,782 - 31,180,194 (+)	NCBI

RefSeq Acc Id:

XM_039091119 ⟹ XP_038947047

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,562 - 33,744,049 (+)	NCBI
mRatBN7.2	13	31,127,782 - 31,190,162 (+)	NCBI

RefSeq Acc Id:

XM_039091120 ⟹ XP_038947048

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	33,680,565 - 33,732,964 (+)	NCBI
mRatBN7.2	13	31,127,782 - 31,180,194 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_112377	(Get FASTA)	NCBI Sequence Viewer
	XP_038947043	(Get FASTA)	NCBI Sequence Viewer
	XP_038947044	(Get FASTA)	NCBI Sequence Viewer
	XP_038947046	(Get FASTA)	NCBI Sequence Viewer
	XP_038947047	(Get FASTA)	NCBI Sequence Viewer
	XP_038947048	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81781	(Get FASTA)	NCBI Sequence Viewer
	CAA41849	(Get FASTA)	NCBI Sequence Viewer
	EDL87929	(Get FASTA)	NCBI Sequence Viewer
	EDL87930	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064579
	ENSRNOP00000077594
	ENSRNOP00000092013
	ENSRNOP00000092013.1
	ENSRNOP00000103353
GenBank Protein	P23811	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_112377 ⟸ NM_031115
- Peptide Label:	precursor
- UniProtKB:	P23811 (UniProtKB/Swiss-Prot), M0R5B5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLSTMRPRLSLLLLRLLLLTKAAHTVGVPPRLCDVRRVLLEERAHCLQQLSKEKKGALGPETAS GCEGLWDNMSCWPSSAPARTVEVQCPKFLLMLSNKNGSLFRNCTQDGWSETFPRPDLACGVNIN NSFNERRHAYLLKLKVMYTVGYSSSLAMLLVALSILCSFRRLHCTRNYIHMHLFVSFILRALSN FIKDAVLFSSDDVTYCDAHKVGCKLVMIFFQYCIMANYAWLLVEGLYLHTLLAISFFSERKYLQ AFVLLGWGSPAIFVALWAITRHFLENTGCWDINANASVWWVIRGPVILSILINFIFFINILRIL MRKLRTQETRGSETNHYKRLAKSTLLLIPLFGIHYIVFAFSPEDAMEVQLFFELALGSFQGLVV AVLYCFLNGEVQLEVQKKWRQWHLQEFPLRPVAFNNSFSNATNGPTHSTKASTEQSRSIPRASI I hide sequence

Ensembl Acc Id:

ENSRNOP00000064579 ⟸ ENSRNOT00000072088

RefSeq Acc Id:	XP_038947044 ⟸ XM_039091116
- Peptide Label:	isoform X2
- UniProtKB:	M0R5B5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947047 ⟸ XM_039091119
- Peptide Label:	isoform X4
- UniProtKB:	M0R5B5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947043 ⟸ XM_039091115
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5YBX3 (UniProtKB/TrEMBL), M0R5B5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947046 ⟸ XM_039091118
- Peptide Label:	isoform X3
- UniProtKB:	M0R5B5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947048 ⟸ XM_039091120
- Peptide Label:	isoform X5
- UniProtKB:	M0R5B5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000092013 ⟸ ENSRNOT00000119589

Ensembl Acc Id:

ENSRNOP00000077594 ⟸ ENSRNOT00000119961

Ensembl Acc Id:

ENSRNOP00000103353 ⟸ ENSRNOT00000143096

Protein Domains

G-protein coupled receptors family 2 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P23811-F1-model_v2	AlphaFold	P23811	1-449	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698766

Promoter ID:

EPDNEW_R9290

Type:

single initiation site

Name:

Sctr_1

Description:

secretin receptor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	36,039,250 - 36,039,310	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621342	AgrOrtholog
BioCyc Gene	G2FUF-18510	BioCyc
Ensembl Genes	ENSRNOG00000049766	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000072088	ENTREZGENE
	ENSRNOT00000119589	ENTREZGENE
	ENSRNOT00000119589.1	UniProtKB/Swiss-Prot
	ENSRNOT00000119961	ENTREZGENE
	ENSRNOT00000143096	ENTREZGENE
Gene3D-CATH	4.10.1240.10	UniProtKB/Swiss-Prot
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7189388	IMAGE-MGC_LOAD
InterPro	7tmB1_secretin	UniProtKB/Swiss-Prot
	GPCR_2	UniProtKB/Swiss-Prot
	GPCR_2-like	UniProtKB/Swiss-Prot
	GPCR_2_extracell_dom_sf	UniProtKB/Swiss-Prot
	GPCR_2_extracellular_dom	UniProtKB/Swiss-Prot
	GPCR_2_secretin-like	UniProtKB/Swiss-Prot
	GPCR_2_secretin-like_CS	UniProtKB/Swiss-Prot
	GPCR_2_secretin_rcpt	UniProtKB/Swiss-Prot
KEGG Report	rno:81779	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93381	IMAGE-MGC_LOAD
NCBI Gene	81779	ENTREZGENE
PANTHER	PDF RECEPTOR-LIKE PROTEIN-RELATED	UniProtKB/Swiss-Prot
	PTHR45620:SF13	UniProtKB/Swiss-Prot
Pfam	7tm_2	UniProtKB/Swiss-Prot
	HRM	UniProtKB/Swiss-Prot
PhenoGen	Sctr	PhenoGen
PRINTS	GPCRSECRETIN	UniProtKB/Swiss-Prot
	SECRETINR	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F2_1	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F2_2	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F2_3	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F2_4	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000049766	RatGTEx
SMART	HormR	UniProtKB/Swiss-Prot
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
	SSF111418	UniProtKB/Swiss-Prot
UniProt	A0A8I5YBX3	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LJ14_RAT	UniProtKB/TrEMBL
	A6K7Y4_RAT	UniProtKB/TrEMBL
	A6K7Y5_RAT	UniProtKB/TrEMBL
	M0R5B5	ENTREZGENE, UniProtKB/TrEMBL
	P23811	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Sctr	secretin receptor			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Sctr	secretin receptor			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)