Ncr1 (natural cytotoxicity triggering receptor 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ncr1 (natural cytotoxicity triggering receptor 1) Rattus norvegicus
Analyze
Symbol: Ncr1
Name: natural cytotoxicity triggering receptor 1
RGD ID: 621288
Description: Predicted to be involved in immune response-regulating signaling pathway. Predicted to act upstream of or within defense response to virus and detection of virus. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human NCR1 (natural cytotoxicity triggering receptor 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activating receptor 1; KILR-1; Ly94; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor, NK-p46); lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor); lymphocyte antigen 94 homolog (activating NK-receptor, NK-p46); natural killer cell p46-related protein; NK receptor KILR-1; Nk-p46; NK-p46); NKACTR; Nkp46; rAR-1; rat-activating receptor 1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,657,409 - 78,665,255 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,659,262 - 78,703,273 (-)EnsemblGRCr8
mRatBN7.2169,614,744 - 69,622,594 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,616,601 - 69,660,558 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx174,973,640 - 74,981,482 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,537,946 - 83,545,788 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,696,172 - 76,704,003 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,178,917 - 73,226,504 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,179,013 - 73,226,777 (-)Ensemblrn6Rnor6.0
Rnor_5.0175,322,402 - 75,325,886 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0175,365,547 - 75,367,860 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4168,964,774 - 68,972,654 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,512,442 - 67,520,261 (+)NCBICelera
RGSC_v3.1169,042,885 - 69,050,765 (-)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (ISO)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Killing of avian and Swine influenza virus by natural killer cells. Achdout H, etal., J Virol. 2010 Apr;84(8):3993-4001. doi: 10.1128/JVI.02289-09. Epub 2010 Feb 3.
2. Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance. Alter G, etal., J Hepatol. 2011 Aug;55(2):278-88. doi: 10.1016/j.jhep.2010.11.030. Epub 2010 Dec 17.
3. Neuraminidase-mediated, NKp46-dependent immune-evasion mechanism of influenza viruses. Bar-On Y, etal., Cell Rep. 2013 Apr 25;3(4):1044-50. doi: 10.1016/j.celrep.2013.03.034. Epub 2013 Apr 18.
4. Increased CD56(bright) NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype. Bhardwaj S, etal., Virol J. 2016 Apr 18;13:67. doi: 10.1186/s12985-016-0507-5.
5. Activating NK cell receptor expression/function (NKp30, NKp46, DNAM-1) during chronic viraemic HCV infection is associated with the outcome of combined treatment. Bozzano F, etal., Eur J Immunol. 2011 Oct;41(10):2905-14. doi: 10.1002/eji.201041361.
6. Chronic HCV infection affects the NK cell phenotype in the blood more than in the liver. Cosgrove C, etal., PLoS One. 2014 Aug 22;9(8):e105950. doi: 10.1371/journal.pone.0105950. eCollection 2014.
7. The natural cytotoxicity receptor 1 contribution to early clearance of Streptococcus pneumoniae and to natural killer-macrophage cross talk. Elhaik-Goldman S, etal., PLoS One. 2011;6(8):e23472. doi: 10.1371/journal.pone.0023472. Epub 2011 Aug 22.
8. Identification of the rat homologue of the human NKp46 triggering receptor. Falco M, etal., Immunol Lett 1999 Jun 1;68(2-3):411-4.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Expression, Function, and Molecular Properties of the Killer Receptor Ncr1-Noé. Glasner A, etal., J Immunol. 2015 Oct 15;195(8):3959-69. doi: 10.4049/jimmunol.1501234. Epub 2015 Sep 14.
11. Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection. Golden-Mason L, etal., J Virol. 2007 Sep;81(17):9292-8. doi: 10.1128/JVI.00834-07. Epub 2007 Jun 6.
12. Association of NKG2A with treatment for chronic hepatitis C virus infection. Harrison RJ, etal., Clin Exp Immunol. 2010 Aug;161(2):306-14. doi: 10.1111/j.1365-2249.2010.04169.x. Epub 2010 Jun 9.
13. Cutting Edge: Check Your Mice-A Point Mutation in the Ncr1 Locus Identified in CD45.1 Congenic Mice with Consequences in Mouse Susceptibility to Infection. Jang Y, etal., J Immunol. 2018 Mar 15;200(6):1982-1987. doi: 10.4049/jimmunol.1701676. Epub 2018 Feb 9.
14. High frequencies of CD158b+ NK cells are associated with persistent hepatitis C virus infections. Ji HF, etal., Ann Hepatol. 2013 Jul-Aug;12(4):539-47.
15. Direct antiviral agents upregulate natural killer cell potential activity in chronic hepatitis C patients. Jiang HJ, etal., Clin Exp Med. 2019 Aug;19(3):299-308. doi: 10.1007/s10238-019-00564-9. Epub 2019 Jun 20.
16. Natural Killer p46 Controls Hepatitis B Virus Replication and Modulates Liver Inflammation. Li W, etal., PLoS One. 2015 Aug 20;10(8):e0135874. doi: 10.1371/journal.pone.0135874. eCollection 2015.
17. NK-associated regulatory receptors in a structured HAART interruption of HIV-1-positive individuals. Luque J, etal., AIDS Res Hum Retroviruses. 2008 Aug;24(8):1037-42. doi: 10.1089/aid.2007.0285.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation. Miletic A, etal., Eur J Immunol. 2017 Sep;47(9):1443-1456. doi: 10.1002/eji.201646763. Epub 2017 Jul 21.
20. Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Narni-Mancinelli E, etal., Science. 2012 Jan 20;335(6066):344-8. doi: 10.1126/science.1215621.
21. Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Nattermann J, etal., Gut. 2006 Jun;55(6):869-77. doi: 10.1136/gut.2005.076463. Epub 2005 Dec 1.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection. Pallmer K, etal., PLoS Pathog. 2019 Apr 17;15(4):e1007725. doi: 10.1371/journal.ppat.1007725. eCollection 2019 Apr.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Information Derived from GenBank Report RGD, Sept. 2003
28. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
29. Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study. Terra Junior ON, etal., ScientificWorldJournal. 2016;2016:2085871. doi: 10.1155/2016/2085871. Epub 2016 Jun 13.
30. NK Cell Recognition of Candida glabrata through Binding of NKp46 and NCR1 to Fungal Ligands Epa1, Epa6, and Epa7. Vitenshtein A, etal., Cell Host Microbe. 2016 Oct 12;20(4):527-534. doi: 10.1016/j.chom.2016.09.008.
31. HBsAg stimulates NKG2D receptor expression on natural killer cells and inhibits hepatitis C virus replication. Wang XX, etal., Hepatobiliary Pancreat Dis Int. 2018 Jun;17(3):233-240. doi: 10.1016/j.hbpd.2018.03.010. Epub 2018 Mar 26.
32. Decreased NKp46 and NKG2D and elevated PD-1 are associated with altered NK-cell function in pediatric transplant patients with PTLD. Wiesmayr S, etal., Eur J Immunol. 2012 Feb;42(2):541-50. doi: 10.1002/eji.201141832. Epub 2011 Dec 16.
33. Frequency and role of NKp46 and NKG2A in hepatitis B virus infection. Yoshioka T, etal., PLoS One. 2017 Mar 22;12(3):e0174103. doi: 10.1371/journal.pone.0174103. eCollection 2017.
Additional References at PubMed
PMID:15356098   PMID:20818394   PMID:21106845   PMID:22615821  


Genomics

Comparative Map Data
Ncr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,657,409 - 78,665,255 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,659,262 - 78,703,273 (-)EnsemblGRCr8
mRatBN7.2169,614,744 - 69,622,594 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,616,601 - 69,660,558 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx174,973,640 - 74,981,482 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,537,946 - 83,545,788 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,696,172 - 76,704,003 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,178,917 - 73,226,504 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,179,013 - 73,226,777 (-)Ensemblrn6Rnor6.0
Rnor_5.0175,322,402 - 75,325,886 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0175,365,547 - 75,367,860 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4168,964,774 - 68,972,654 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,512,442 - 67,520,261 (+)NCBICelera
RGSC_v3.1169,042,885 - 69,050,765 (-)NCBI
Cytogenetic Map1q12NCBI
NCR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381954,898,198 - 54,938,208 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1954,906,148 - 54,916,140 (+)Ensemblhg38GRCh38
GRCh371955,417,506 - 55,424,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,109,338 - 60,116,251 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341960,109,319 - 60,119,197NCBI
Celera1952,458,112 - 52,465,042 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,740,149 - 51,747,079 (+)NCBIHuRef
CHM1_11955,411,170 - 55,418,097 (+)NCBICHM1_1
T2T-CHM13v2.01957,992,503 - 58,033,237 (+)NCBIT2T-CHM13v2.0
Ncr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,340,714 - 4,348,183 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,340,723 - 4,348,163 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3874,337,715 - 4,345,184 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,337,724 - 4,345,164 (+)Ensemblmm10GRCm38
MGSCv3774,289,326 - 4,296,766 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3673,940,811 - 3,948,251 (+)NCBIMGSCv36mm8
Celera74,091,092 - 4,098,545 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.5NCBI
NCR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,044,490 - 61,056,708 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,773,870 - 62,786,155 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01951,951,496 - 51,957,433 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,645,677 - 60,652,274 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,645,677 - 60,652,274 (+)EnsemblpanPan2panpan1.1
NCR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,686,058 - 102,690,350 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,686,058 - 102,690,620 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1102,749,705 - 102,753,997 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01103,352,595 - 103,356,887 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1103,352,595 - 103,356,966 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,972,307 - 102,976,598 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,676,410 - 102,680,704 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,448,618 - 103,452,910 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
NCR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,092,911 - 59,099,990 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1659,092,258 - 59,099,992 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,195,830 - 54,203,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,521,488 - 47,527,713 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,521,956 - 47,530,961 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604574,960 - 81,235 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ncr1
49 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:57
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000025080
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 12 28 76 71 70 39 92 39 6 271 153 11 47 59 66 31 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000025080   ⟹   ENSRNOP00000025080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,659,262 - 78,665,255 (-)Ensembl
mRatBN7.2 Ensembl169,616,601 - 69,622,570 (-)Ensembl
Rnor_6.0 Ensembl173,179,013 - 73,226,777 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000029621   ⟹   ENSRNOP00000028910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,659,262 - 78,703,273 (-)Ensembl
mRatBN7.2 Ensembl169,616,601 - 69,660,558 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147346   ⟹   ENSRNOP00000106283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,659,262 - 78,703,215 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155612   ⟹   ENSRNOP00000100574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,659,262 - 78,665,269 (-)Ensembl
RefSeq Acc Id: NM_057199   ⟹   NP_476547
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,657,409 - 78,665,255 (-)NCBI
mRatBN7.2169,614,744 - 69,622,594 (-)NCBI
Rnor_6.0173,178,917 - 73,226,504 (-)NCBI
Rnor_5.0175,322,402 - 75,325,886 (+)NCBI
Rnor_5.0175,365,547 - 75,367,860 (+)NCBI
RGSC_v3.4168,964,774 - 68,972,654 (-)RGD
Celera167,512,442 - 67,520,261 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476547 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC69890 (Get FASTA)   NCBI Sequence Viewer  
  CAA10161 (Get FASTA)   NCBI Sequence Viewer  
  EDL75826 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000100574
GenBank Protein Q9Z0H5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476547   ⟸   NM_057199
- Peptide Label: precursor
- UniProtKB: Q9Z0H5 (UniProtKB/Swiss-Prot),   A6KNK7 (UniProtKB/TrEMBL),   A0A8L2QED7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025080   ⟸   ENSRNOT00000025080
Ensembl Acc Id: ENSRNOP00000028910   ⟸   ENSRNOT00000029621
Ensembl Acc Id: ENSRNOP00000106283   ⟸   ENSRNOT00000147346
Ensembl Acc Id: ENSRNOP00000100574   ⟸   ENSRNOT00000155612
Protein Domains
Ig-like   Immunoglobulin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0H5-F1-model_v2 AlphaFold Q9Z0H5 1-325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621288 AgrOrtholog
BioCyc Gene G2FUF-60831 BioCyc
Ensembl Genes ENSRNOG00000018458 Ensembl
  ENSRNOG00000027855 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000155612 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig-like_Receptors_ImmuneReg UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
KEGG Report rno:117547 UniProtKB/Swiss-Prot
NCBI Gene 117547 ENTREZGENE
PANTHER MHC CLASS I NK CELL RECEPTOR UniProtKB/Swiss-Prot
  NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1 UniProtKB/Swiss-Prot
Pfam Ig_2 UniProtKB/Swiss-Prot
  PF00047 UniProtKB/Swiss-Prot
PhenoGen Ncr1 PhenoGen
RatGTEx ENSRNOG00000018458 RatGTEx
  ENSRNOG00000027855 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A8L2QED7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L8L1_RAT UniProtKB/TrEMBL
  A0ABK0LWG4_RAT UniProtKB/TrEMBL
  A6KNK7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRL6_RAT UniProtKB/TrEMBL
  NCTR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ncr1  natural cytotoxicity triggering receptor 1    lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46)  Name updated 1299863 APPROVED
2004-09-10 Ncr1  lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46)  Ly94    Symbol and Name updated 1299863 APPROVED
2002-08-07 Ly94  lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46)      Symbol and Name status set to provisional 70820 PROVISIONAL