RGD Reference Report - Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance. - Rat Genome Database

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Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance.

Authors: Alter, Galit  Jost, Stephanie  Rihn, Suzannah  Reyor, Laura L  Nolan, Brian E  Ghebremichael, Musie  Bosch, Ronald  Altfeld, Marcus  Lauer, Georg M 
Citation: Alter G, etal., J Hepatol. 2011 Aug;55(2):278-88. doi: 10.1016/j.jhep.2010.11.030. Epub 2010 Dec 17.
RGD ID: 40400738
Pubmed: PMID:21168454   (View Abstract at PubMed)
PMCID: PMC3729214   (View Article at PubMed Central)
DOI: DOI:10.1016/j.jhep.2010.11.030   (Journal Full-text)


BACKGROUND & AIMS: While the majority of HCV-infected patients progress to chronic hepatitis, a small fraction of individuals are able to clear the virus. Resolution of infection occurs within the first few weeks to months of infection, suggesting that innate immune functions may be critical for early control. Epidemiologic data support a role for particular NK cell receptor bearing populations in this control, yet the mechanism by which NK cells respond to HCV early in infection is unknown.
METHODS: Changes in the phenotype and function of NK cells were investigated in a cohort of 43 individuals identified during various stages of HCV infection with different clinical outcomes.
RESULTS: Acute, chronic, and resolved HCV infections were characterized by an expansion of CD56(neg) NK cells. Furthermore, increased levels of HLA-C-binding KIR(+) NK cells were observed in HCV resolvers, while all stages of HCV infection were associated with reduced percentages of NKG2D(+), NKp30(+), and NKp46(+) NK cells, and a slight increase in the ability of NK cells to respond to target cells bearing the ligands for these receptors. In contrast, NKG2A(+) and CD94(+) NK cells were elevated in acute and chronic HCV infection, but not in resolved infection. Most importantly, in acute infection, lower frequencies of NKp30(+), NKp46(+), CD161(+), and NKG2D(+) NK cells were observed in patients who were subsequently able to clear HCV infection than in those becoming chronically infected.
CONCLUSIONS: These data implicate particular populations of NK cells in the early control and clearance of HCV infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
KLRK1HumanChronic Hepatitis C disease_progressionIEP protein:increased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
Klrk1RatChronic Hepatitis C disease_progressionISOKLRK1 (Homo sapiens)protein:increased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
Klrk1MouseChronic Hepatitis C disease_progressionISOKLRK1 (Homo sapiens)protein:increased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
NCR1HumanChronic Hepatitis C disease_progressionIEP protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
NCR3HumanChronic Hepatitis C disease_progressionIEP protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
Ncr1RatChronic Hepatitis C disease_progressionISONCR1 (Homo sapiens)protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
Ncr1MouseChronic Hepatitis C disease_progressionISONCR1 (Homo sapiens)protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
Ncr3RatChronic Hepatitis C disease_progressionISONCR3 (Homo sapiens)protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
Ncr3-psMouseChronic Hepatitis C disease_progressionISONCR3 (Homo sapiens)protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Klrk1  (killer cell lectin like receptor K1)
Ncr1  (natural cytotoxicity triggering receptor 1)
Ncr3  (natural cytotoxicity triggering receptor 3)

Genes (Mus musculus)
Klrk1  (killer cell lectin-like receptor subfamily K, member 1)
Ncr1  (natural cytotoxicity triggering receptor 1)
Ncr3-ps  (natural cytotoxicity triggering receptor 3, pseudogene)

Genes (Homo sapiens)
KLRK1  (killer cell lectin like receptor K1)
NCR1  (natural cytotoxicity triggering receptor 1)
NCR3  (natural cytotoxicity triggering receptor 3)


Additional Information