Map4k3 (mitogen-activated protein kinase kinase kinase kinase 3) - Rat Genome Database

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Pathways
Gene: Map4k3 (mitogen-activated protein kinase kinase kinase kinase 3) Rattus norvegicus
Analyze
Symbol: Map4k3
Name: mitogen-activated protein kinase kinase kinase kinase 3
RGD ID: 621280
Description: Enables SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Predicted to be active in cytoplasm. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8620,029,246 - 20,198,583 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl620,029,397 - 20,198,583 (+)EnsemblGRCr8
mRatBN7.2614,276,623 - 14,446,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl614,277,121 - 14,446,334 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx614,582,521 - 14,745,689 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0614,897,736 - 15,066,918 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0614,393,979 - 14,563,171 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.063,276,732 - 3,444,519 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl63,276,738 - 3,444,519 (-)Ensemblrn6Rnor6.0
Rnor_5.063,247,181 - 3,414,716 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.463,473,694 - 3,642,461 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera613,956,412 - 14,123,546 (+)NCBICelera
RGSC_v3.163,475,028 - 3,642,293 (-)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. Ramjaun AR, etal., J Biol Chem 2001 Aug 3;276(31):28913-9.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation. Zhang M, etal., Apoptosis. 2013 Apr;18(4):423-34. doi: 10.1007/s10495-013-0811-0.
Additional References at PubMed
PMID:8889548   PMID:9275185   PMID:28731988  


Genomics

Comparative Map Data
Map4k3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8620,029,246 - 20,198,583 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl620,029,397 - 20,198,583 (+)EnsemblGRCr8
mRatBN7.2614,276,623 - 14,446,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl614,277,121 - 14,446,334 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx614,582,521 - 14,745,689 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0614,897,736 - 15,066,918 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0614,393,979 - 14,563,171 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.063,276,732 - 3,444,519 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl63,276,738 - 3,444,519 (-)Ensemblrn6Rnor6.0
Rnor_5.063,247,181 - 3,414,716 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.463,473,694 - 3,642,461 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera613,956,412 - 14,123,546 (+)NCBICelera
RGSC_v3.163,475,028 - 3,642,293 (-)NCBI
Cytogenetic Map6q12NCBI
MAP4K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38239,249,266 - 39,437,285 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl239,249,266 - 39,437,324 (-)Ensemblhg38GRCh38
GRCh37239,476,407 - 39,664,426 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36239,329,926 - 39,517,723 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34239,388,073 - 39,575,870NCBI
Celera239,317,367 - 39,505,201 (-)NCBICelera
Cytogenetic Map2p22.1NCBI
HuRef239,215,530 - 39,403,591 (-)NCBIHuRef
CHM1_1239,406,810 - 39,594,778 (-)NCBICHM1_1
T2T-CHM13v2.0239,258,084 - 39,446,168 (-)NCBIT2T-CHM13v2.0
Map4k3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,887,942 - 81,039,118 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1780,887,941 - 81,035,914 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381780,580,513 - 80,728,806 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1780,580,512 - 80,728,485 (-)Ensemblmm10GRCm38
MGSCv371780,979,852 - 81,127,433 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361780,488,838 - 80,636,419 (-)NCBIMGSCv36mm8
MGSCv361779,860,491 - 80,008,566 (-)NCBIMGSCv36mm8
Celera1784,897,744 - 85,059,626 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1750.97NCBI
Map4k3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554416,846,719 - 6,956,418 (-)Ensembl
ChiLan1.0NW_0049554416,843,066 - 6,956,443 (-)NCBIChiLan1.0ChiLan1.0
MAP4K3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21287,032,042 - 87,220,052 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A87,036,010 - 87,224,027 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A39,286,787 - 39,474,780 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A40,040,492 - 40,228,109 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A40,040,497 - 40,228,109 (-)EnsemblpanPan2panpan1.1
MAP4K3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11731,253,632 - 31,439,148 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1731,254,941 - 31,439,118 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1731,006,278 - 31,200,097 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01731,910,677 - 32,098,182 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1731,910,926 - 32,098,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11731,131,531 - 31,319,037 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01731,201,764 - 31,389,216 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01731,415,443 - 31,602,890 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map4k3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629240,456,473 - 40,633,948 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650811,884,684 - 12,064,066 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650811,885,066 - 12,062,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP4K3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3100,887,143 - 101,084,677 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13100,887,148 - 101,084,667 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAP4K3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11467,931,906 - 68,121,640 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1467,931,940 - 68,122,556 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604543,860,848 - 43,989,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map4k3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473820,715,296 - 20,875,393 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473820,716,430 - 20,874,930 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Map4k3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1712,337,138 - 12,506,265 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Map4k3
1056 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:193
Count of miRNA genes:141
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000010366
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat

Markers in Region
D6Rat56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,404,162 - 14,404,306 (-)MAPPERmRatBN7.2
Rnor_6.063,318,804 - 3,318,947NCBIRnor6.0
Rnor_5.063,289,093 - 3,289,236UniSTSRnor5.0
RGSC_v3.463,515,636 - 3,515,780RGDRGSC3.4
RGSC_v3.463,515,637 - 3,515,780UniSTSRGSC3.4
Celera614,081,473 - 14,081,616UniSTS
RGSC_v3.163,515,636 - 3,515,780RGD
RH 2.0 Map6147.8RGD
FHH x ACI Map613.73RGD
Cytogenetic Map6q11UniSTS
RH127652  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,445,723 - 14,445,903 (-)MAPPERmRatBN7.2
Rnor_6.063,277,156 - 3,277,335NCBIRnor6.0
Rnor_5.063,247,605 - 3,247,784UniSTSRnor5.0
RGSC_v3.463,474,112 - 3,474,291UniSTSRGSC3.4
Celera614,122,949 - 14,123,128UniSTS
Cytogenetic Map6q11UniSTS
RH131821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,403,508 - 14,403,704 (-)MAPPERmRatBN7.2
Rnor_6.063,319,406 - 3,319,601NCBIRnor6.0
Rnor_5.063,289,695 - 3,289,890UniSTSRnor5.0
RGSC_v3.463,516,239 - 3,516,434UniSTSRGSC3.4
Celera614,080,818 - 14,081,013UniSTS
Cytogenetic Map6q11UniSTS
AU047952  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,371,915 - 14,372,207 (-)MAPPERmRatBN7.2
Rnor_6.063,350,603 - 3,350,894NCBIRnor6.0
Rnor_5.063,320,253 - 3,320,544UniSTSRnor5.0
RGSC_v3.463,547,922 - 3,548,213UniSTSRGSC3.4
Celera614,049,980 - 14,050,271UniSTS
Cytogenetic Map6q11UniSTS
AU046365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,417,735 - 14,417,963 (-)MAPPERmRatBN7.2
Rnor_6.063,305,147 - 3,305,372NCBIRnor6.0
Rnor_5.063,275,631 - 3,275,856UniSTSRnor5.0
RGSC_v3.463,502,254 - 3,502,479UniSTSRGSC3.4
Celera614,094,967 - 14,095,192UniSTS
Cytogenetic Map6q11UniSTS
PMC16375P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,297,928 - 14,298,396 (-)MAPPERmRatBN7.2
Rnor_6.063,423,247 - 3,423,714NCBIRnor6.0
Rnor_5.063,393,444 - 3,393,911UniSTSRnor5.0
RGSC_v3.463,621,189 - 3,621,656UniSTSRGSC3.4
Cytogenetic Map6q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA819812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF312224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI502900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK474868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV716943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010366   ⟹   ENSRNOP00000010366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl620,029,397 - 20,198,583 (+)Ensembl
mRatBN7.2 Ensembl614,277,121 - 14,446,321 (+)Ensembl
Rnor_6.0 Ensembl63,276,738 - 3,444,519 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078044   ⟹   ENSRNOP00000070735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl620,078,161 - 20,198,583 (+)Ensembl
mRatBN7.2 Ensembl614,325,888 - 14,446,321 (+)Ensembl
Rnor_6.0 Ensembl63,276,756 - 3,395,954 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084602   ⟹   ENSRNOP00000069683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl620,029,397 - 20,198,583 (+)Ensembl
mRatBN7.2 Ensembl614,277,121 - 14,446,321 (+)Ensembl
Rnor_6.0 Ensembl63,278,073 - 3,355,339 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110847   ⟹   ENSRNOP00000090754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl620,029,397 - 20,198,583 (+)Ensembl
mRatBN7.2 Ensembl614,277,121 - 14,446,334 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113666   ⟹   ENSRNOP00000081073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl620,078,161 - 20,198,583 (+)Ensembl
mRatBN7.2 Ensembl614,325,888 - 14,446,321 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118971   ⟹   ENSRNOP00000097492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl620,029,397 - 20,198,583 (+)Ensembl
mRatBN7.2 Ensembl614,277,121 - 14,446,321 (+)Ensembl
RefSeq Acc Id: NM_133407   ⟹   NP_596898
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,397 - 20,198,583 (+)NCBI
mRatBN7.2614,277,121 - 14,446,321 (+)NCBI
Rnor_6.063,276,738 - 3,444,519 (-)NCBI
Rnor_5.063,247,181 - 3,414,716 (-)NCBI
RGSC_v3.463,473,694 - 3,642,461 (-)RGD
Celera613,956,412 - 14,123,546 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239656   ⟹   XP_006239718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,249 - 20,198,583 (+)NCBI
mRatBN7.2614,276,632 - 14,446,321 (+)NCBI
Rnor_6.063,276,732 - 3,444,514 (-)NCBI
Rnor_5.063,247,181 - 3,414,716 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594019   ⟹   XP_017449508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,247 - 20,198,583 (+)NCBI
mRatBN7.2614,276,625 - 14,446,321 (+)NCBI
Rnor_6.063,276,732 - 3,444,514 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594020   ⟹   XP_017449509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,248 - 20,198,583 (+)NCBI
mRatBN7.2614,276,628 - 14,446,321 (+)NCBI
Rnor_6.063,276,732 - 3,444,514 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594021   ⟹   XP_017449510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,247 - 20,198,583 (+)NCBI
mRatBN7.2614,276,625 - 14,446,321 (+)NCBI
Rnor_6.063,276,732 - 3,444,514 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111726   ⟹   XP_038967654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,246 - 20,198,583 (+)NCBI
mRatBN7.2614,276,623 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111727   ⟹   XP_038967655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,247 - 20,198,583 (+)NCBI
mRatBN7.2614,276,626 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111728   ⟹   XP_038967656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,246 - 20,198,583 (+)NCBI
mRatBN7.2614,276,624 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111729   ⟹   XP_038967657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,247 - 20,198,583 (+)NCBI
mRatBN7.2614,276,627 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111730   ⟹   XP_038967658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,249 - 20,198,583 (+)NCBI
mRatBN7.2614,276,630 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111731   ⟹   XP_038967659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,046,595 - 20,198,583 (+)NCBI
mRatBN7.2614,294,252 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111732   ⟹   XP_038967660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,102,582 - 20,198,583 (+)NCBI
mRatBN7.2614,350,313 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_039111733   ⟹   XP_038967661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,131,701 - 20,198,583 (+)NCBI
mRatBN7.2614,379,424 - 14,446,321 (+)NCBI
RefSeq Acc Id: XM_063261504   ⟹   XP_063117574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,249 - 20,198,583 (+)NCBI
RefSeq Acc Id: XM_063261505   ⟹   XP_063117575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,029,248 - 20,198,583 (+)NCBI
RefSeq Acc Id: XM_063261506   ⟹   XP_063117576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,119,741 - 20,198,583 (+)NCBI
RefSeq Acc Id: NP_596898   ⟸   NM_133407
- UniProtKB: Q924I2 (UniProtKB/Swiss-Prot),   A6H9Q1 (UniProtKB/TrEMBL),   R9PXT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239718   ⟸   XM_006239656
- Peptide Label: isoform X10
- UniProtKB: A0A0G2JVZ8 (UniProtKB/TrEMBL),   A0A8I6AV17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449510   ⟸   XM_017594021
- Peptide Label: isoform X7
- UniProtKB: R9PXT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449509   ⟸   XM_017594020
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AV17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449508   ⟸   XM_017594019
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AV17 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069683   ⟸   ENSRNOT00000084602
Ensembl Acc Id: ENSRNOP00000070735   ⟸   ENSRNOT00000078044
Ensembl Acc Id: ENSRNOP00000010366   ⟸   ENSRNOT00000010366
RefSeq Acc Id: XP_038967654   ⟸   XM_039111726
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AV17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967656   ⟸   XM_039111728
- Peptide Label: isoform X4
- UniProtKB: R9PXT4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967655   ⟸   XM_039111727
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AV17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967657   ⟸   XM_039111729
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AV17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967658   ⟸   XM_039111730
- Peptide Label: isoform X11
- UniProtKB: R9PXT4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967659   ⟸   XM_039111731
- Peptide Label: isoform X12
- UniProtKB: A0A0G2JYP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967660   ⟸   XM_039111732
- Peptide Label: isoform X14
- UniProtKB: A0A0G2JYP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967661   ⟸   XM_039111733
- Peptide Label: isoform X15
- UniProtKB: A0A0G2JYP2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081073   ⟸   ENSRNOT00000113666
Ensembl Acc Id: ENSRNOP00000090754   ⟸   ENSRNOT00000110847
Ensembl Acc Id: ENSRNOP00000097492   ⟸   ENSRNOT00000118971
RefSeq Acc Id: XP_063117575   ⟸   XM_063261505
- Peptide Label: isoform X9
- UniProtKB: R9PXT4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117574   ⟸   XM_063261504
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AV17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117576   ⟸   XM_063261506
- Peptide Label: isoform X13
- UniProtKB: A0A0G2JYP2 (UniProtKB/TrEMBL)
Protein Domains
CNH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924I2-F1-model_v2 AlphaFold Q924I2 1-873 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621280 AgrOrtholog
BIND 130461
BioCyc Gene G2FUF-38531 BioCyc
Ensembl Genes ENSRNOG00000007172 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010366 ENTREZGENE
  ENSRNOT00000010366.8 UniProtKB/Swiss-Prot
  ENSRNOT00000084602 ENTREZGENE
  ENSRNOT00000110847 ENTREZGENE
  ENSRNOT00000118971 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Citron UniProtKB/Swiss-Prot
  Kinase-like_dom UniProtKB/Swiss-Prot
  MAPKKKK UniProtKB/Swiss-Prot
  Prot_kinase_cat_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  STE20/SPS1-PAK UniProtKB/Swiss-Prot
KEGG Report rno:170920 UniProtKB/Swiss-Prot
NCBI Gene 170920 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3 UniProtKB/Swiss-Prot
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/Swiss-Prot
Pfam CNH UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Map4k3 PhenoGen
PIRSF MAPKKKK UniProtKB/Swiss-Prot
PROSITE CNH UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007172 RatGTEx
SMART CNH UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP Kinase_like UniProtKB/Swiss-Prot
UniProt A0A0G2JVZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JYP2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRP2_RAT UniProtKB/TrEMBL
  A0A8I6AAR5_RAT UniProtKB/TrEMBL
  A0A8I6AV17 ENTREZGENE, UniProtKB/TrEMBL
  A6H9Q1 ENTREZGENE, UniProtKB/TrEMBL
  M4K3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  R9PXT4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Map4k3  mitogen-activated protein kinase kinase kinase kinase 3      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Map4k3  mitogen-activated protein kinase kinase kinase kinase 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds to endophilin I 727317
gene_regulation may be activated by endophilin I binding 727317