Imported Disease Annotations - ClinVarObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Map4k3 | Rat | Ependymomas | | ISO | MAP4K3 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Ependymoma | ClinVar | | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - ClinVarObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Map4k3 | Rat | Ependymomas | | ISO | MAP4K3 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Ependymoma | ClinVar | | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| # | Reference Title | Reference Citation |
| 1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 2. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 3. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 4. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 5. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 6. | Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. | Ramjaun AR, etal., J Biol Chem 2001 Aug 3;276(31):28913-9. |
| 7. | GOA pipeline | RGD automated data pipeline |
| 8. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 9. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 10. | Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation. | Zhang M, etal., Apoptosis. 2013 Apr;18(4):423-34. doi: 10.1007/s10495-013-0811-0. |
| Map4k3 (Rattus norvegicus - Norway rat) |
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| MAP4K3 (Homo sapiens - human) |
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| Map4k3 (Mus musculus - house mouse) |
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| Map4k3 (Chinchilla lanigera - long-tailed chinchilla) |
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| MAP4K3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| MAP4K3 (Canis lupus familiaris - dog) |
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| Map4k3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| MAP4K3 (Sus scrofa - pig) |
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| MAP4K3 (Chlorocebus sabaeus - green monkey) |
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| Map4k3 (Heterocephalus glaber - naked mole-rat) |
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| Map4k3 (Rattus rattus - black rat) |
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Variants in Map4k3
1056 total Variants
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| The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
| D6Rat56 |
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| RH127652 |
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| RH131821 |
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| AU047952 |
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| AU046365 |
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| PMC16375P1 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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musculoskeletal system
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nervous system
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renal system
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reproductive system
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respiratory system
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sensory system
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visual system
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 16 | 12 | 67 | 165 | 91 | 90 | 59 | 92 | 59 | 6 | 356 | 192 | 11 | 144 | 81 | 92 | 31 | 17 | 17 |
| RefSeq Transcripts | NM_133407 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006239656 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017594019 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017594020 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017594021 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017594022 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039111726 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039111727 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039111728 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039111729 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039111730 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039111731 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039111732 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039111733 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_063261504 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_063261505 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_063261506 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AA819812 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AF312224 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AI502900 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473947 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CK474868 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| DV716943 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JAXUCZ010000006 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| Ensembl Acc Id: | ENSRNOT00000010366 ⟹ ENSRNOP00000010366 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000078044 ⟹ ENSRNOP00000070735 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000084602 ⟹ ENSRNOP00000069683 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000110847 ⟹ ENSRNOP00000090754 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000113666 ⟹ ENSRNOP00000081073 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000118971 ⟹ ENSRNOP00000097492 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_133407 ⟹ NP_596898 | ||||||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_006239656 ⟹ XP_006239718 | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_017594019 ⟹ XP_017449508 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_017594020 ⟹ XP_017449509 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_017594021 ⟹ XP_017449510 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_039111726 ⟹ XP_038967654 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039111727 ⟹ XP_038967655 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039111728 ⟹ XP_038967656 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039111729 ⟹ XP_038967657 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039111730 ⟹ XP_038967658 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039111731 ⟹ XP_038967659 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039111732 ⟹ XP_038967660 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039111733 ⟹ XP_038967661 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_063261504 ⟹ XP_063117574 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | XM_063261505 ⟹ XP_063117575 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | XM_063261506 ⟹ XP_063117576 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| Protein RefSeqs | NP_596898 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006239718 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017449508 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017449509 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017449510 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038967654 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038967655 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038967656 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038967657 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038967658 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038967659 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038967660 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038967661 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_063117574 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_063117575 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_063117576 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAK53214 | (Get FASTA) | NCBI Sequence Viewer |
| EDM02756 | (Get FASTA) | NCBI Sequence Viewer | |
| Ensembl Protein | ENSRNOP00000010366 | ||
| ENSRNOP00000010366.7 | |||
| ENSRNOP00000069683 | |||
| ENSRNOP00000090754 | |||
| ENSRNOP00000097492 | |||
| GenBank Protein | Q924I2 | (Get FASTA) | NCBI Sequence Viewer |
| RefSeq Acc Id: | NP_596898 ⟸ NM_133407 |
| - UniProtKB: | Q924I2 (UniProtKB/Swiss-Prot), A6H9Q1 (UniProtKB/TrEMBL), R9PXT4 (UniProtKB/TrEMBL) |
| - Sequence: |
| RefSeq Acc Id: | XP_006239718 ⟸ XM_006239656 |
| - Peptide Label: | isoform X10 |
| - UniProtKB: | A0A0G2JVZ8 (UniProtKB/TrEMBL), A0A8I6AV17 (UniProtKB/TrEMBL) |
| - Sequence: |
| RefSeq Acc Id: | XP_017449510 ⟸ XM_017594021 |
| - Peptide Label: | isoform X7 |
| - UniProtKB: | R9PXT4 (UniProtKB/TrEMBL) |
| - Sequence: |
| RefSeq Acc Id: | XP_017449509 ⟸ XM_017594020 |
| - Peptide Label: | isoform X5 |
| - UniProtKB: | A0A8I6AV17 (UniProtKB/TrEMBL) |
| - Sequence: |
| RefSeq Acc Id: | XP_017449508 ⟸ XM_017594019 |
| - Peptide Label: | isoform X2 |
| - UniProtKB: | A0A8I6AV17 (UniProtKB/TrEMBL) |
| - Sequence: |
| Ensembl Acc Id: | ENSRNOP00000069683 ⟸ ENSRNOT00000084602 |
| Ensembl Acc Id: | ENSRNOP00000070735 ⟸ ENSRNOT00000078044 |
| Ensembl Acc Id: | ENSRNOP00000010366 ⟸ ENSRNOT00000010366 |
| RefSeq Acc Id: | XP_038967654 ⟸ XM_039111726 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | A0A8I6AV17 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_038967656 ⟸ XM_039111728 |
| - Peptide Label: | isoform X4 |
| - UniProtKB: | R9PXT4 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_038967655 ⟸ XM_039111727 |
| - Peptide Label: | isoform X3 |
| - UniProtKB: | A0A8I6AV17 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_038967657 ⟸ XM_039111729 |
| - Peptide Label: | isoform X6 |
| - UniProtKB: | A0A8I6AV17 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_038967658 ⟸ XM_039111730 |
| - Peptide Label: | isoform X11 |
| - UniProtKB: | R9PXT4 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_038967659 ⟸ XM_039111731 |
| - Peptide Label: | isoform X12 |
| - UniProtKB: | A0A0G2JYP2 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_038967660 ⟸ XM_039111732 |
| - Peptide Label: | isoform X14 |
| - UniProtKB: | A0A0G2JYP2 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_038967661 ⟸ XM_039111733 |
| - Peptide Label: | isoform X15 |
| - UniProtKB: | A0A0G2JYP2 (UniProtKB/TrEMBL) |
| Ensembl Acc Id: | ENSRNOP00000081073 ⟸ ENSRNOT00000113666 |
| Ensembl Acc Id: | ENSRNOP00000090754 ⟸ ENSRNOT00000110847 |
| Ensembl Acc Id: | ENSRNOP00000097492 ⟸ ENSRNOT00000118971 |
| RefSeq Acc Id: | XP_063117575 ⟸ XM_063261505 |
| - Peptide Label: | isoform X9 |
| - UniProtKB: | R9PXT4 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_063117574 ⟸ XM_063261504 |
| - Peptide Label: | isoform X8 |
| - UniProtKB: | A0A8I6AV17 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_063117576 ⟸ XM_063261506 |
| - Peptide Label: | isoform X13 |
| - UniProtKB: | A0A0G2JYP2 (UniProtKB/TrEMBL) |
| Name | Modeler | Protein Id | AA Range | Protein Structure |
| AF-Q924I2-F1-model_v2 | AlphaFold | Q924I2 | 1-873 | view protein structure |
| eQTL | View at Phenogen | |
| WGCNA | View at Phenogen | |
| Tissue/Strain Expression | View at Phenogen |
| Database | Acc Id | Source(s) |
| AGR Gene | RGD:621280 | AgrOrtholog |
| BIND | 130461 | |
| BioCyc Gene | G2FUF-38531 | BioCyc |
| Ensembl Genes | ENSRNOG00000007172 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000010366 | ENTREZGENE |
| ENSRNOT00000010366.8 | UniProtKB/Swiss-Prot | |
| ENSRNOT00000084602 | ENTREZGENE | |
| ENSRNOT00000110847 | ENTREZGENE | |
| ENSRNOT00000118971 | ENTREZGENE | |
| Gene3D-CATH | Transferase(Phosphotransferase) domain 1 | UniProtKB/Swiss-Prot |
| InterPro | Citron | UniProtKB/Swiss-Prot |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| MAPKKKK | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| STE20/SPS1-PAK | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:170920 | UniProtKB/Swiss-Prot |
| NCBI Gene | 170920 | ENTREZGENE |
| PANTHER | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3 | UniProtKB/Swiss-Prot |
| STERILE20-LIKE KINASE, ISOFORM B-RELATED | UniProtKB/Swiss-Prot | |
| Pfam | CNH | UniProtKB/Swiss-Prot |
| Pkinase | UniProtKB/Swiss-Prot | |
| PhenoGen | Map4k3 | PhenoGen |
| PIRSF | MAPKKKK | UniProtKB/Swiss-Prot |
| PROSITE | CNH | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| RatGTEx | ENSRNOG00000007172 | RatGTEx |
| SMART | CNH | UniProtKB/Swiss-Prot |
| S_TKc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| UniProt | A0A0G2JVZ8 | ENTREZGENE, UniProtKB/TrEMBL |
| A0A0G2JYP2 | ENTREZGENE, UniProtKB/TrEMBL | |
| A0A8I5ZRP2_RAT | UniProtKB/TrEMBL | |
| A0A8I6AAR5_RAT | UniProtKB/TrEMBL | |
| A0A8I6AV17 | ENTREZGENE, UniProtKB/TrEMBL | |
| A6H9Q1 | ENTREZGENE, UniProtKB/TrEMBL | |
| M4K3_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
| R9PXT4 | ENTREZGENE, UniProtKB/TrEMBL |
| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-02-26 | Map4k3 | mitogen-activated protein kinase kinase kinase kinase 3 | Symbol and Name status set to approved | 625702 | APPROVED | ||
| 2002-08-07 | Map4k3 | mitogen-activated protein kinase kinase kinase kinase 3 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
| Note Type | Note | Reference |
|---|---|---|
| gene_physical_interaction | binds to endophilin I | 727317 |
| gene_regulation | may be activated by endophilin I binding | 727317 |