Map4k3 (mitogen-activated protein kinase kinase kinase kinase 3) - Rat Genome Database

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Gene: Map4k3 (mitogen-activated protein kinase kinase kinase kinase 3) Ictidomys tridecemlineatus
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Symbol: Map4k3
Name: mitogen-activated protein kinase kinase kinase kinase 3
RGD ID: 12544901
Description: ENCODES a protein that exhibits SH3 domain binding (ortholog); INVOLVED IN intracellular signal transduction (inferred); MAPK cascade (inferred); response to tumor necrosis factor (inferred); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH congenital heart disease (ortholog); high grade glioma (ortholog); Lynch syndrome (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mitogen-activated protein kinase kinase kinase kinase 3, transcript variant X1; mitogen-activated protein kinase kinase kinase kinase 3, transcript variant X2; mitogen-activated protein kinase kinase kinase kinase 3, transcript variant X3; mitogen-activated protein kinase kinase kinase kinase 3, transcript variant X4; mitogen-activated protein kinase kinase kinase kinase 3, transcript variant X5; mitogen-activated protein kinase kinase kinase kinase 3, transcript variant X6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629240,456,473 - 40,633,948 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650811,884,684 - 12,064,066 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650811,885,066 - 12,062,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Map4k3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629240,456,473 - 40,633,948 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650811,884,684 - 12,064,066 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650811,885,066 - 12,062,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP4K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38239,249,266 - 39,437,285 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl239,249,266 - 39,437,301 (-)EnsemblGRCh38hg38GRCh38
GRCh37239,476,407 - 39,664,426 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36239,329,926 - 39,517,723 (-)NCBINCBI36Build 36hg18NCBI36
Build 34239,388,073 - 39,575,870NCBI
Celera239,317,367 - 39,505,201 (-)NCBICelera
Cytogenetic Map2p22.1NCBI
HuRef239,215,530 - 39,403,591 (-)NCBIHuRef
CHM1_1239,406,810 - 39,594,778 (-)NCBICHM1_1
T2T-CHM13v2.0239,258,084 - 39,446,168 (-)NCBIT2T-CHM13v2.0
Map4k3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,887,942 - 81,039,118 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1780,887,941 - 81,035,914 (-)EnsemblGRCm39 Ensembl
GRCm381780,580,513 - 80,728,806 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1780,580,512 - 80,728,485 (-)EnsemblGRCm38mm10GRCm38
MGSCv371780,979,852 - 81,127,433 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361780,488,838 - 80,636,419 (-)NCBIMGSCv36mm8
MGSCv361779,860,491 - 80,008,566 (-)NCBIMGSCv36mm8
Celera1784,897,744 - 85,059,626 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1750.97NCBI
Map4k3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8620,029,246 - 20,198,583 (+)NCBIGRCr8
mRatBN7.2614,276,623 - 14,446,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl614,277,121 - 14,446,334 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx614,582,521 - 14,745,689 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0614,897,736 - 15,066,918 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0614,393,979 - 14,563,171 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.063,276,732 - 3,444,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl63,276,738 - 3,444,519 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.063,247,181 - 3,414,716 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.463,473,694 - 3,642,461 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.163,475,028 - 3,642,293 (-)NCBI
Celera613,956,412 - 14,123,546 (+)NCBICelera
Cytogenetic Map6q12NCBI
Map4k3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554416,846,719 - 6,956,418 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554416,843,066 - 6,956,443 (-)NCBIChiLan1.0ChiLan1.0
MAP4K3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21287,032,042 - 87,220,052 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A87,036,010 - 87,224,027 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A39,286,787 - 39,474,780 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A40,040,492 - 40,228,109 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A40,040,497 - 40,228,109 (-)Ensemblpanpan1.1panPan2
MAP4K3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11731,253,632 - 31,439,148 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1731,254,941 - 31,439,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1731,006,278 - 31,200,097 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01731,910,677 - 32,098,182 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1731,910,926 - 32,098,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11731,131,531 - 31,319,037 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01731,201,764 - 31,389,216 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01731,415,443 - 31,602,890 (-)NCBIUU_Cfam_GSD_1.0
MAP4K3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3100,887,143 - 101,084,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13100,887,148 - 101,084,667 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAP4K3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11467,931,906 - 68,121,640 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1467,931,940 - 68,122,556 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604543,860,848 - 43,989,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map4k3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473820,715,296 - 20,875,393 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473820,716,430 - 20,874,930 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005324537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005324538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021725875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021725876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021725877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021725878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040271104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040271105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040271106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040271107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040271108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040271109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040271110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040271111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040271112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005727304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010001352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000013541   ⟹   ENSSTOP00000012134
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493650811,884,684 - 12,064,066 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000035263   ⟹   ENSSTOP00000023981
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493650811,885,401 - 12,060,897 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000042099   ⟹   ENSSTOP00000029998
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493650811,884,684 - 12,064,066 (+)Ensembl
RefSeq Acc Id: XM_005324537   ⟹   XP_005324594
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,456,483 - 40,633,948 (+)NCBI
SpeTri2.0NW_00493650811,885,066 - 12,062,237 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005324538   ⟹   XP_005324595
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,456,473 - 40,633,948 (+)NCBI
SpeTri2.0NW_00493650811,885,066 - 12,062,237 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040271104   ⟹   XP_040127038
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,456,653 - 40,633,948 (+)NCBI
RefSeq Acc Id: XM_040271105   ⟹   XP_040127039
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,456,654 - 40,633,948 (+)NCBI
RefSeq Acc Id: XM_040271106   ⟹   XP_040127040
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,456,655 - 40,633,948 (+)NCBI
RefSeq Acc Id: XM_040271107   ⟹   XP_040127041
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,456,654 - 40,633,948 (+)NCBI
RefSeq Acc Id: XM_040271108   ⟹   XP_040127042
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,456,655 - 40,633,948 (+)NCBI
RefSeq Acc Id: XM_040271109   ⟹   XP_040127043
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,456,656 - 40,633,948 (+)NCBI
RefSeq Acc Id: XM_040271110   ⟹   XP_040127044
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,456,652 - 40,629,220 (+)NCBI
RefSeq Acc Id: XM_040271111   ⟹   XP_040127045
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,456,651 - 40,629,220 (+)NCBI
RefSeq Acc Id: XM_040271112   ⟹   XP_040127046
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,538,341 - 40,633,948 (+)NCBI
RefSeq Acc Id: XR_005727304
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629240,456,651 - 40,632,273 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005324594   ⟸   XM_005324537
- Peptide Label: isoform X5
- UniProtKB: I3ML72 (UniProtKB/TrEMBL),   A0A287CRS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005324595   ⟸   XM_005324538
- Peptide Label: isoform X9
- UniProtKB: A0A287D8X9 (UniProtKB/TrEMBL),   A0A287CRS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040127045   ⟸   XM_040271111
- Peptide Label: isoform X10
- UniProtKB: A0A287CRS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127044   ⟸   XM_040271110
- Peptide Label: isoform X8
- UniProtKB: A0A287CRS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127038   ⟸   XM_040271104
- Peptide Label: isoform X1
- UniProtKB: A0A287CRS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127039   ⟸   XM_040271105
- Peptide Label: isoform X2
- UniProtKB: A0A287CRS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127041   ⟸   XM_040271107
- Peptide Label: isoform X4
- UniProtKB: A0A287CRS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127040   ⟸   XM_040271106
- Peptide Label: isoform X3
- UniProtKB: A0A287CRS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127042   ⟸   XM_040271108
- Peptide Label: isoform X6
- UniProtKB: A0A287CRS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127043   ⟸   XM_040271109
- Peptide Label: isoform X7
- UniProtKB: A0A287CRS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127046   ⟸   XM_040271112
- Peptide Label: isoform X11
- UniProtKB: A0A287CRS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000023981   ⟸   ENSSTOT00000035263
RefSeq Acc Id: ENSSTOP00000029998   ⟸   ENSSTOT00000042099
RefSeq Acc Id: ENSSTOP00000012134   ⟸   ENSSTOT00000013541
Protein Domains
CNH   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013515 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013541.3 UniProtKB/TrEMBL
  ENSSTOT00000035263.1 UniProtKB/TrEMBL
  ENSSTOT00000042099.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CNH_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MAPKKKK UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
NCBI Gene Map4k3 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3 UniProtKB/TrEMBL
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/TrEMBL
Pfam CNH UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PIRSF MAPKKKK UniProtKB/TrEMBL
PROSITE CNH UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART CNH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287CRS5 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D8X9 ENTREZGENE, UniProtKB/TrEMBL
  I3ML72 ENTREZGENE, UniProtKB/TrEMBL