Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of RFC2 mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | multiple interactions | ISO | Rfc2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RFC2 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | ISO | Rfc2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of RFC2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Rfc2 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of RFC2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | Rfc2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RFC2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of RFC2 mRNA | CTD | PMID:19167446 | 17beta-estradiol | affects expression | EXP | | 6480464 | Estradiol affects the expression of RFC2 mRNA | CTD | PMID:32145629 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Rfc2 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31826744 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Rfc2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RFC2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RFC2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RFC2 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RFC2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RFC2 mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Rfc2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RFC2 mRNA | CTD | PMID:21570461 | 2,3-dimethoxynaphthalene-1,4-dione | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:17547211 | 2-hydroxypropanoic acid | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of RFC2 mRNA | CTD | PMID:30851411 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:23196670 | 5-fluorouracil | affects response to substance | ISO | RFC2 (Homo sapiens) | 6480464 | RFC2 protein affects the susceptibility to Fluorouracil | CTD | PMID:15548681 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of RFC2 mRNA | CTD | PMID:30047161 | all-trans-retinoic acid | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of RFC2 mRNA | CTD | PMID:16249480 and PMID:33167477 | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of RFC2 mRNA | CTD | PMID:30047161 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of RFC2 mRNA | CTD | PMID:16483693 | antimony(0) | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Antimony results in increased expression of RFC2 mRNA | CTD | PMID:17547211 | antirheumatic drug | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of RFC2 mRNA | CTD | PMID:24449571 | arsane | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Arsenic results in increased expression of RFC2 mRNA | CTD | PMID:11134558 | arsenic atom | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Arsenic results in increased expression of RFC2 mRNA | CTD | PMID:11134558 | arsenous acid | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of RFC2 mRNA | CTD | PMID:17547211 | atrazine | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of RFC2 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of RFC2 mRNA | CTD | PMID:33411230 | bisphenol A | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of RFC2 mRNA and bisphenol A results in decreased expression of RFC2 protein | CTD | PMID:29275510 and PMID:37567409 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of RFC2 mRNA | CTD | PMID:32145629 | bisphenol A | affects expression | ISO | RFC2 (Homo sapiens) | 6480464 | bisphenol A affects the expression of RFC2 mRNA | CTD | PMID:30903817 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of RFC2 mRNA | CTD | PMID:25181051 more ... | caffeine | increases phosphorylation | ISO | RFC2 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of RFC2 protein | CTD | PMID:35688186 | calcitriol | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of RFC2 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of RFC2 mRNA | CTD | PMID:21592394 | cannabidiol | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Cannabidiol results in decreased expression of RFC2 mRNA | CTD | PMID:36519830 | CGP 52608 | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to RFC2 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | ISO | Rfc2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of RFC2 mRNA | CTD | PMID:37019170 | chromium atom | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Chromium results in increased expression of RFC2 mRNA | CTD | PMID:17547211 | cisplatin | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of RFC2 mRNA | CTD | PMID:27594783 | clotrimazole | increases expression | EXP | | 6480464 | Clotrimazole results in increased expression of RFC2 mRNA | CTD | PMID:30047161 | cobalt dichloride | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of RFC2 mRNA | CTD | PMID:19320972 and PMID:19376846 | copper atom | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of RFC2 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of RFC2 mRNA | CTD | PMID:20971185 | copper(II) sulfate | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of RFC2 mRNA | CTD | PMID:19549813 | coumarin | increases phosphorylation | ISO | RFC2 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of RFC2 protein | CTD | PMID:35688186 | coumestrol | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | coumestrol | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Coumestrol results in increased expression of RFC2 mRNA | CTD | PMID:19167446 | cyclosporin A | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of RFC2 mRNA | CTD | PMID:20106945 more ... | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of RFC2 mRNA | CTD | PMID:23640034 | diarsenic trioxide | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of RFC2 mRNA | CTD | PMID:17547211 | dibutyl phthalate | decreases expression | ISO | Rfc2 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of RFC2 mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of RFC2 mRNA | CTD | PMID:21266533 | dioxygen | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Oxygen deficiency results in decreased expression of RFC2 mRNA | CTD | PMID:26516004 | dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Antimony Potassium Tartrate results in increased expression of RFC2 mRNA | CTD | PMID:17547211 | Enterolactone | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RFC2 mRNA | CTD | PMID:19167446 | enzyme inhibitor | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RFC2 protein | CTD | PMID:23301498 | epoxiconazole | increases expression | ISO | Rfc2 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of RFC2 mRNA | CTD | PMID:35436446 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of RFC2 mRNA | CTD | PMID:24793618 | folic acid | multiple interactions | ISO | Rfc2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RFC2 mRNA | CTD | PMID:22206623 | glyphosate | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Glyphosate results in decreased expression of RFC2 mRNA | CTD | PMID:31295307 | ivermectin | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of RFC2 protein | CTD | PMID:32959892 | Lasiocarpine | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RFC2 mRNA | CTD | PMID:33884520 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of RFC2 mRNA | CTD | PMID:30047161 | methyl methanesulfonate | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of RFC2 mRNA | CTD | PMID:23649840 | monocrotaline | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC2 mRNA | CTD | PMID:33884520 | N(4)-hydroxycytidine | decreases expression | ISO | Rfc2 (Mus musculus) | 6480464 | N(4)-hydroxycytidine results in decreased expression of RFC2 mRNA | CTD | PMID:37748715 | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of RFC2 mRNA | CTD | PMID:16026605 | N-nitrosodiethylamine | increases expression | ISO | Rfc2 (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of RFC2 mRNA | CTD | PMID:17854601 | N-nitrosodiethylamine | multiple interactions | ISO | Rfc2 (Mus musculus) | 6480464 | RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RFC2 mRNA] | CTD | PMID:17854601 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of RFC2 mRNA | CTD | PMID:24136188 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of RFC2 mRNA | CTD | PMID:25729387 | paracetamol | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of RFC2 mRNA | CTD | PMID:22230336 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of RFC2 mRNA | CTD | PMID:33387578 | perfluorooctanoic acid | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of RFC2 protein | CTD | PMID:26879310 | piperonyl butoxide | increases expression | EXP | | 6480464 | Piperonyl Butoxide results in increased expression of RFC2 mRNA | CTD | PMID:22484513 | pirinixic acid | increases expression | ISO | Rfc2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of RFC2 mRNA | CTD | PMID:18301758 | piroxicam | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Piroxicam results in decreased expression of RFC2 mRNA | CTD | PMID:21858171 | potassium dichromate | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Potassium Dichromate results in increased expression of RFC2 mRNA | CTD | PMID:17547211 | rac-lactic acid | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of RFC2 mRNA | CTD | PMID:30851411 | resveratrol | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of RFC2 mRNA | CTD | PMID:19167446 | riddelliine | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC2 mRNA | CTD | PMID:33884520 | sodium arsenite | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of RFC2 mRNA | CTD | PMID:12760830 | sodium arsenite | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of RFC2 mRNA | CTD | PMID:17879257 more ... | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of RFC2 mRNA | CTD | PMID:30047161 | sunitinib | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of RFC2 mRNA | CTD | PMID:31533062 | testosterone | multiple interactions | ISO | RFC2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of RFC2 mRNA | CTD | PMID:21592394 | testosterone | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of RFC2 mRNA | CTD | PMID:21592394 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of RFC2 mRNA] | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | Rfc2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of RFC2 mRNA | CTD | PMID:31919559 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of RFC2 mRNA | CTD | PMID:31150632 | thapsigargin | decreases expression | ISO | Rfc2 (Mus musculus) | 6480464 | Thapsigargin results in decreased expression of RFC2 protein | CTD | PMID:24648495 | thioacetamide | affects expression | EXP | | 6480464 | Thioacetamide affects the expression of RFC2 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | Rfc2 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of RFC2 mRNA | CTD | PMID:23557971 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of RFC2 mRNA | CTD | PMID:25729387 | trimellitic anhydride | increases expression | ISO | Rfc2 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of RFC2 mRNA | CTD | PMID:19042947 | troglitazone | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | troglitazone results in decreased expression of RFC2 mRNA | CTD | PMID:19140230 | trovafloxacin | decreases expression | ISO | Rfc2 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of RFC2 mRNA | CTD | PMID:35537566 | urethane | decreases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Urethane results in decreased expression of RFC2 mRNA | CTD | PMID:28818685 | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of RFC2 mRNA | CTD | PMID:24136188 | valproic acid | increases expression | ISO | RFC2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of RFC2 mRNA | CTD | PMID:29154799 | |