Hyou1 (hypoxia up-regulated 1) - Rat Genome Database

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Gene: Hyou1 (hypoxia up-regulated 1) Rattus norvegicus
Analyze
Symbol: Hyou1
Name: hypoxia up-regulated 1
RGD ID: 621146
Description: Predicted to enable ATP binding activity; adenyl-nucleotide exchange factor activity; and protein-folding chaperone binding activity. Involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway and response to hypoxia. Located in smooth endoplasmic reticulum. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 150 kDa oxygen-regulated protein; Cab140; hypoxia up-regulated protein 1; ORP-150; Orp150; oxygen regulated protein (150kD)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,602,882 - 53,614,998 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl853,602,604 - 53,614,997 (+)EnsemblGRCr8
mRatBN7.2844,706,073 - 44,718,189 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,706,263 - 44,718,186 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx850,202,146 - 50,214,290 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,480,862 - 48,493,006 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,351,091 - 46,363,246 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,699,796 - 48,711,912 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,699,769 - 48,711,910 (+)Ensemblrn6Rnor6.0
Rnor_5.0847,318,767 - 47,330,883 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4847,346,753 - 47,358,869 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera844,292,303 - 44,304,419 (+)NCBICelera
RGSC_v3.1847,355,708 - 47,366,413 (+)NCBI
Cytogenetic Map8q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
alpha-pinene  (ISO)
aminoglutethimide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
ceruletide  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
inulin  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kojic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
Mesaconitine  (EXP)
metformin  (EXP)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
orotic acid  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (EXP)
progesterone  (ISO)
Propiverine  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. An interaction map of endoplasmic reticulum chaperones and foldases. Jansen G, etal., Mol Cell Proteomics. 2012 Sep;11(9):710-23. doi: 10.1074/mcp.M111.016550. Epub 2012 Jun 4.
3. Purification and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain. Kuwabara K, etal., J Biol Chem 1996 Mar 1;271(9):5025-32.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. ORP150 protects against hypoxia/ischemia-induced neuronal death. Tamatani M, etal., Nat Med. 2001 Mar;7(3):317-23.
Additional References at PubMed
PMID:9006956   PMID:9020069   PMID:9748521   PMID:10037731   PMID:10837345   PMID:12475965   PMID:14960622   PMID:15733911   PMID:16955111   PMID:17116640   PMID:18094145   PMID:19199708  
PMID:19946888   PMID:21423176   PMID:21536389   PMID:23707263   PMID:24625528   PMID:28028074   PMID:29098793   PMID:29476059   PMID:30053369   PMID:30361391   PMID:31505169  


Genomics

Comparative Map Data
Hyou1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,602,882 - 53,614,998 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl853,602,604 - 53,614,997 (+)EnsemblGRCr8
mRatBN7.2844,706,073 - 44,718,189 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,706,263 - 44,718,186 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx850,202,146 - 50,214,290 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,480,862 - 48,493,006 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,351,091 - 46,363,246 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,699,796 - 48,711,912 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,699,769 - 48,711,910 (+)Ensemblrn6Rnor6.0
Rnor_5.0847,318,767 - 47,330,883 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4847,346,753 - 47,358,869 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera844,292,303 - 44,304,419 (+)NCBICelera
RGSC_v3.1847,355,708 - 47,366,413 (+)NCBI
Cytogenetic Map8q22NCBI
HYOU1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811119,044,188 - 119,057,205 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11119,044,185 - 119,057,252 (-)Ensemblhg38GRCh38
GRCh3711118,914,899 - 118,927,916 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,420,110 - 118,433,122 (-)NCBIBuild 36Build 36hg18NCBI36
Celera11116,072,540 - 116,085,596 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11114,854,557 - 114,867,575 (-)NCBIHuRef
CHM1_111118,801,167 - 118,814,197 (-)NCBICHM1_1
T2T-CHM13v2.011119,064,550 - 119,077,556 (-)NCBIT2T-CHM13v2.0
Hyou1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,290,840 - 44,303,662 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,290,787 - 44,303,666 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38944,379,490 - 44,392,369 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,379,490 - 44,392,369 (+)Ensemblmm10GRCm38
MGSCv37944,187,573 - 44,200,452 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36944,130,580 - 44,143,364 (+)NCBIMGSCv36mm8
Celera941,627,066 - 41,639,919 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
Hyou1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,148,953 - 20,161,172 (-)Ensembl
ChiLan1.0NW_00495541220,149,104 - 20,161,378 (-)NCBIChiLan1.0ChiLan1.0
HYOU1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29119,749,015 - 119,762,064 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111120,852,712 - 120,865,769 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011113,882,418 - 113,895,438 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111117,812,050 - 117,825,091 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11117,812,975 - 117,824,005 (-)EnsemblpanPan2panpan1.1
HYOU1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,795,750 - 14,808,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,795,750 - 14,807,262 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha514,848,571 - 14,860,968 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0514,738,891 - 14,751,288 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl514,738,464 - 14,751,437 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1514,876,904 - 14,889,447 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0514,780,910 - 14,793,451 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0514,821,311 - 14,832,539 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hyou1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947101,084,483 - 101,101,869 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365424,005,610 - 4,018,135 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365424,005,616 - 4,018,135 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HYOU1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,264,933 - 46,276,995 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1946,264,929 - 46,277,056 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,300,063 - 51,312,075 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HYOU1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,418,497 - 110,431,636 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,417,942 - 110,431,590 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604315,603,358 - 15,616,849 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hyou1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478414,427,130 - 14,439,038 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478414,427,297 - 14,439,027 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hyou1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1838,926,722 - 38,938,845 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hyou1
82 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir27arno-miR-27a-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:231
Count of miRNA genes:142
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000044613
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000044613   ⟹   ENSRNOP00000039172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl853,602,604 - 53,614,997 (+)Ensembl
mRatBN7.2 Ensembl844,706,263 - 44,718,186 (+)Ensembl
Rnor_6.0 Ensembl848,699,769 - 48,711,910 (+)Ensembl
RefSeq Acc Id: NM_001034028   ⟹   NP_001029200
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,602,882 - 53,614,998 (+)NCBI
mRatBN7.2844,706,073 - 44,718,189 (+)NCBI
Rnor_6.0848,699,796 - 48,711,912 (+)NCBI
Rnor_5.0847,318,767 - 47,330,883 (+)NCBI
RGSC_v3.4847,346,753 - 47,358,869 (+)RGD
Celera844,292,303 - 44,304,419 (+)RGD
Sequence:
RefSeq Acc Id: NM_138867   ⟹   NP_620222
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,603,072 - 53,614,998 (+)NCBI
mRatBN7.2844,706,263 - 44,718,189 (+)NCBI
Rnor_6.0848,699,986 - 48,711,912 (+)NCBI
Rnor_5.0847,318,767 - 47,330,883 (+)NCBI
RGSC_v3.4847,346,753 - 47,358,869 (+)RGD
Celera844,292,493 - 44,304,419 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242884   ⟹   XP_006242946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,602,923 - 53,614,996 (+)NCBI
mRatBN7.2844,706,122 - 44,718,189 (+)NCBI
Rnor_6.0848,699,845 - 48,711,910 (+)NCBI
Rnor_5.0847,318,767 - 47,330,883 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242885   ⟹   XP_006242947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,602,922 - 53,614,996 (+)NCBI
mRatBN7.2844,706,127 - 44,718,187 (+)NCBI
Rnor_6.0848,699,844 - 48,711,910 (+)NCBI
Rnor_5.0847,318,767 - 47,330,883 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001029200   ⟸   NM_001034028
- Peptide Label: precursor
- UniProtKB: Q6P136 (UniProtKB/TrEMBL),   F1LN18 (UniProtKB/TrEMBL),   A0A8J8XLC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_620222   ⟸   NM_138867
- Peptide Label: precursor
- UniProtKB: Q6P136 (UniProtKB/TrEMBL),   F1LN18 (UniProtKB/TrEMBL),   A0A8J8XLC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242946   ⟸   XM_006242884
- Peptide Label: isoform X1
- UniProtKB: Q6P136 (UniProtKB/TrEMBL),   F1LN18 (UniProtKB/TrEMBL),   A0A8J8XLC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242947   ⟸   XM_006242885
- Peptide Label: isoform X1
- UniProtKB: Q6P136 (UniProtKB/TrEMBL),   F1LN18 (UniProtKB/TrEMBL),   A0A8J8XLC6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039172   ⟸   ENSRNOT00000044613

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63617-F1-model_v2 AlphaFold Q63617 1-999 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695893
Promoter ID:EPDNEW_R6417
Type:initiation region
Name:Hyou1_1
Description:hypoxia up-regulated 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0848,699,786 - 48,699,846EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621146 AgrOrtholog
BioCyc Gene G2FUF-30722 BioCyc
Ensembl Genes ENSRNOG00000010944 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000044613 ENTREZGENE
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot
  3.30.30.30 UniProtKB/Swiss-Prot
  3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
  Substrate Binding Domain Of DNAk, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621638 IMAGE-MGC_LOAD
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Heat_shock_70_CS UniProtKB/Swiss-Prot
  HSP70_C_sf UniProtKB/Swiss-Prot
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot
  Hsp_70_fam UniProtKB/Swiss-Prot
KEGG Report rno:192235 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72301 IMAGE-MGC_LOAD
NCBI Gene 192235 ENTREZGENE
PANTHER HSC70CB, ISOFORM G-RELATED UniProtKB/Swiss-Prot
  HYPOXIA UP-REGULATED PROTEIN 1 UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot
PhenoGen Hyou1 PhenoGen
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot
PROSITE HSP70_2 UniProtKB/Swiss-Prot
  HSP70_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010944 RatGTEx
Superfamily-SCOP SSF100934 UniProtKB/Swiss-Prot
  SSF53067 UniProtKB/Swiss-Prot
UniProt A0A8J8XLC6 ENTREZGENE, UniProtKB/TrEMBL
  F1LN18 ENTREZGENE
  HYOU1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P136 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hyou1  hypoxia up-regulated 1  Orp150  oxygen regulated protein (150kD)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Orp150  oxygen regulated protein (150kD)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum 633350
gene_expression expressed only in hypoxic astrocytes 633350