Tgm2 (transglutaminase 2) - Rat Genome Database

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Gene: Tgm2 (transglutaminase 2) Rattus norvegicus
Analyze
Symbol: Tgm2
Name: transglutaminase 2
RGD ID: 621081
Description: Enables several functions, including GTP binding activity; identical protein binding activity; and phospholipase binding activity. Involved in several processes, including isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of smooth muscle cell proliferation. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Located in cytosol and nucleus. Orthologous to human TGM2 (transglutaminase 2); PARTICIPATES IN eicosanoid signaling pathway; Huntington's disease pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutamine gamma-glutamyltransferase 2; isopeptidase TGM2; protein-glutamine deamidase TGM2; protein-glutamine dopaminyltransferase TGM2; protein-glutamine gamma-glutamyltransferase 2; protein-glutamine histaminyltransferase TGM2; protein-glutamine noradrenalinyltransferase TGM2; protein-glutamine serotonyltransferase TGM2; TGase 2; TGase II; TgaseII; TGII; tissue transglutaminase; tissue-type transglutaminase; transglutaminase 2, C polypeptide; transglutaminase II; tTG; tTgase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83167,192,612 - 167,221,845 (-)NCBIGRCr8
mRatBN7.23146,772,684 - 146,801,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3146,772,687 - 146,801,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3150,598,013 - 150,627,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03159,097,613 - 159,126,553 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03156,839,077 - 156,868,039 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03154,597,165 - 154,627,257 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3154,597,168 - 154,627,257 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03160,977,905 - 161,007,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,832,866 - 148,862,385 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13148,738,777 - 148,768,294 (-)NCBI
Celera3145,473,663 - 145,503,117 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hexylbenzene-1,3-diol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
budesonide  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cystamine  (EXP)
daidzein  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
ferric oxide  (ISO)
finasteride  (EXP)
flunisolide  (ISO)
flusilazole  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
graphite  (EXP)
griseofulvin  (ISO)
GTP  (ISO)
hemin  (ISO)
heptachlor  (EXP)
hydrazine  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
isoxazoles  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
microcystin-LR  (ISO)
mitomycin C  (ISO)
mometasone furoate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pinocembrin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
putrescine  (EXP)
quercetin  (EXP,ISO)
quercitrin  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
styrene  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiophenes  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
undecane  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
vitamin K  (EXP)
warfarin  (EXP,ISO)
XL147  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (ISO,ISS)
chromosome  (IEA)
cytoplasm  (IDA)
cytosol  (IDA,IEA,ISO)
endoplasmic reticulum  (IEA)
extracellular matrix  (IEA,ISO)
extracellular region  (IEA)
mitochondrion  (IBA,IEA,ISO)
nucleosome  (IEA,ISO)
nucleus  (IDA,IEA,ISO)
perinuclear region of cytoplasm  (ISO)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease. Andringa G, etal., FASEB J. 2004 May;18(7):932-4. Epub 2004 Mar 4.
2. Small artery remodeling depends on tissue-type transglutaminase. Bakker EN, etal., Circ Res. 2005 Jan 7;96(1):119-26. Epub 2004 Nov 18.
3. Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient. Bernassola F, etal., FASEB J. 2002 Sep;16(11):1371-8.
4. Intron-exon swapping of transglutaminase mRNA and neuronal Tau aggregation in Alzheimer's disease. Citron BA, etal., J Biol Chem. 2001 Feb 2;276(5):3295-301. Epub 2000 Sep 29.
5. Functional coupling of rat myometrial alpha 1-adrenergic receptors to Gh alpha/tissue transglutaminase 2 during pregnancy. Dupuis M, etal., J Biol Chem. 2004 Apr 30;279(18):19257-63. Epub 2004 Feb 17.
6. Immunohistochemical study of the apoptotic mechanisms in the intestinal mucosa during children's coeliac disease. Ehrmann J Jr, etal., Virchows Arch. 2003 May;442(5):453-61. Epub 2003 Apr 16.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Tissue transglutaminase and its substrates in bone. Kaartinen MT, etal., J Bone Miner Res. 2002 Dec;17(12):2161-73.
9. Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1. Kang SK, etal., Biochem Biophys Res Commun 2002 Apr 26;293(1):383-90.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. IFN-gamma induces transglutaminase 2 expression in rat small intestinal cells. Kim SY, etal., J Interferon Cytokine Res 2002 Jun;22(6):677-82.
12. Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain. Kim SY, etal., Neurochem Res. 2005 Oct;30(10):1245-55.
13. Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway in BV-2 microglia. Lee J, etal., J Biol Chem. 2004 Dec 17;279(51):53725-35. Epub 2004 Oct 7.
14. Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression. Li ZY, etal., Parasit Vectors. 2019 Jun 14;12(1):302. doi: 10.1186/s13071-019-3542-4.
15. A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx. Lin YF, etal., Mol Endocrinol. 2006 Oct;20(10):2514-27. Epub 2006 May 18.
16. Increase in extracellular cross-linking by tissue transglutaminase and reduction in expression of MMP-9 contribute differentially to focal segmental glomerulosclerosis in rats. Liu S, etal., Mol Cell Biochem. 2006 Mar;284(1-2):9-17. Epub 2006 Feb 14.
17. Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancer. Mehta K, etal., Clin Cancer Res. 2004 Dec 1;10(23):8068-76.
18. Abnormal accumulation of tTGase products in muscle and erythrocytes of chorea-acanthocytosis patients. Melone MA, etal., J Neuropathol Exp Neurol. 2002 Oct;61(10):841-8.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Phosphorylation of histones by tissue transglutaminase. Mishra S, etal., J Biol Chem. 2006 Mar 3;281(9):5532-8. Epub 2006 Jan 4.
21. Gh: a GTP-binding protein with transglutaminase activity and receptor signaling function. Nakaoka H, etal., Science. 1994 Jun 10;264(5165):1593-6.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells. Ou H, etal., Circ Res 2000 Nov 10;87(10):881-7.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Increases in renal epsilon-(gamma-glutamyl)-lysine crosslinks result from compartment-specific changes in tissue transglutaminase in early experimental diabetic nephropathy: pathologic implications. Skill NJ, etal., Lab Invest. 2001 May;81(5):705-16.
29. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
30. COX-2-dependent cardiac failure in Gh/tTG transgenic mice. Zhang Z, etal., Circ Res 2003 May 30;92(10):1153-61. Epub 2003 Apr 17.
Additional References at PubMed
PMID:2578891   PMID:8105889   PMID:11274171   PMID:15147523   PMID:15581620   PMID:15970210   PMID:16522628   PMID:16707846   PMID:17179049   PMID:17347495   PMID:17657163   PMID:18008394  
PMID:18041095   PMID:19056867   PMID:19614676   PMID:19628791   PMID:19635990   PMID:20004474   PMID:20049854   PMID:20157411   PMID:20448147   PMID:20507850   PMID:20615646   PMID:20817067  
PMID:21067463   PMID:21423176   PMID:22034513   PMID:22183397   PMID:22222252   PMID:22252490   PMID:22382775   PMID:22573678   PMID:22762273   PMID:23001131   PMID:23117658   PMID:23466870  
PMID:23469180   PMID:23533145   PMID:23979707   PMID:24291354   PMID:24349085   PMID:24721796   PMID:24821315   PMID:25143942   PMID:25201980   PMID:25599570   PMID:26603619   PMID:27438265  
PMID:28754379   PMID:29197584   PMID:29282083   PMID:30239049   PMID:30458214   PMID:30943188   PMID:31322240   PMID:33808023   PMID:35041708  


Genomics

Comparative Map Data
Tgm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83167,192,612 - 167,221,845 (-)NCBIGRCr8
mRatBN7.23146,772,684 - 146,801,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3146,772,687 - 146,801,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3150,598,013 - 150,627,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03159,097,613 - 159,126,553 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03156,839,077 - 156,868,039 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03154,597,165 - 154,627,257 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3154,597,168 - 154,627,257 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03160,977,905 - 161,007,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,832,866 - 148,862,385 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13148,738,777 - 148,768,294 (-)NCBI
Celera3145,473,663 - 145,503,117 (-)NCBICelera
Cytogenetic Map3q42NCBI
TGM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382038,127,385 - 38,168,475 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2038,127,385 - 38,166,578 (-)EnsemblGRCh38hg38GRCh38
GRCh372036,755,787 - 36,794,910 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362036,190,277 - 36,227,114 (-)NCBINCBI36Build 36hg18NCBI36
Build 342036,199,764 - 36,227,114NCBI
Celera2033,465,637 - 33,502,475 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2033,493,671 - 33,530,533 (-)NCBIHuRef
CHM1_12036,660,115 - 36,696,950 (-)NCBICHM1_1
T2T-CHM13v2.02039,852,468 - 39,893,578 (-)NCBIT2T-CHM13v2.0
Tgm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392157,958,325 - 157,988,312 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2157,958,322 - 157,988,356 (-)EnsemblGRCm39 Ensembl
GRCm382158,116,405 - 158,146,392 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2158,116,402 - 158,146,436 (-)EnsemblGRCm38mm10GRCm38
MGSCv372157,942,141 - 157,972,128 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362157,807,846 - 157,837,833 (-)NCBIMGSCv36mm8
Celera2164,061,515 - 164,091,498 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.72NCBI
Tgm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544518,544,183 - 18,576,570 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544518,544,192 - 18,576,576 (+)NCBIChiLan1.0ChiLan1.0
TGM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22143,851,557 - 43,889,993 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12043,844,655 - 43,881,956 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02034,450,845 - 34,488,106 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12035,561,819 - 35,599,099 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2035,561,819 - 35,599,042 (-)Ensemblpanpan1.1panPan2
TGM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12426,631,339 - 26,662,723 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2426,628,009 - 26,663,840 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2426,277,181 - 26,308,444 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02427,327,862 - 27,359,126 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2427,295,164 - 27,359,267 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12426,602,350 - 26,633,607 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02426,710,189 - 26,741,409 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02427,198,294 - 27,229,594 (-)NCBIUU_Cfam_GSD_1.0
Tgm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640175,541,933 - 175,571,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365613,178,293 - 3,207,561 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365613,178,244 - 3,207,551 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1741,186,770 - 41,221,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11741,186,765 - 41,221,686 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21746,592,093 - 46,629,982 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TGM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1225,585,827 - 25,623,961 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl225,585,865 - 25,624,280 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605074,426,778 - 74,465,107 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248421,491,584 - 1,522,287 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248421,491,583 - 1,522,293 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgm2
195 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:594
Count of miRNA genes:247
Interacting mature miRNAs:311
Transcripts:ENSRNOT00000018328
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat

Markers in Region
RH129789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23146,772,702 - 146,772,886 (+)MAPPERmRatBN7.2
Rnor_6.03154,597,184 - 154,597,367NCBIRnor6.0
Rnor_5.03161,007,059 - 161,007,242UniSTSRnor5.0
RGSC_v3.43148,832,885 - 148,833,068UniSTSRGSC3.4
Celera3145,473,682 - 145,473,865UniSTS
RH 3.4 Map31358.9UniSTS
Cytogenetic Map3q42UniSTS
Tgm2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23146,784,087 - 146,784,742 (+)MAPPERmRatBN7.2
Rnor_6.03154,608,553 - 154,609,207NCBIRnor6.0
Rnor_5.03160,995,219 - 160,995,873UniSTSRnor5.0
RGSC_v3.43148,844,264 - 148,844,918UniSTSRGSC3.4
Celera3145,485,061 - 145,485,715UniSTS
Cytogenetic Map3q42UniSTS
RH128073  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23146,772,859 - 146,773,061 (+)MAPPERmRatBN7.2
Rnor_6.03154,597,341 - 154,597,542NCBIRnor6.0
Rnor_5.03161,006,884 - 161,007,085UniSTSRnor5.0
RGSC_v3.43148,833,042 - 148,833,243UniSTSRGSC3.4
Celera3145,473,839 - 145,474,040UniSTS
Cytogenetic Map3q42UniSTS
UniSTS:466074  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23146,780,187 - 146,780,256 (+)MAPPERmRatBN7.2
Rnor_6.03154,604,655 - 154,604,723NCBIRnor6.0
Rnor_5.03160,999,702 - 160,999,771NCBIRnor5.0
RGSC_v3.43148,840,366 - 148,840,434UniSTSRGSC3.4
Celera3145,481,163 - 145,481,231UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000018328   ⟹   ENSRNOP00000018328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3146,772,687 - 146,801,981 (-)Ensembl
Rnor_6.0 Ensembl3154,597,168 - 154,627,257 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095177   ⟹   ENSRNOP00000083472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3146,772,687 - 146,799,157 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097236   ⟹   ENSRNOP00000085355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3146,772,687 - 146,799,027 (-)Ensembl
RefSeq Acc Id: NM_019386   ⟹   NP_062259
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83167,192,612 - 167,221,845 (-)NCBI
mRatBN7.23146,772,684 - 146,801,924 (-)NCBI
Rnor_6.03154,597,165 - 154,627,257 (-)NCBI
Rnor_5.03160,977,905 - 161,007,261 (+)NCBI
RGSC_v3.43148,832,866 - 148,862,385 (-)RGD
Celera3145,473,663 - 145,503,117 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105740   ⟹   XP_038961668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83167,192,612 - 167,204,583 (-)NCBI
mRatBN7.23146,772,684 - 146,784,661 (-)NCBI
RefSeq Acc Id: NP_062259   ⟸   NM_019386
- UniProtKB: Q9WVJ6 (UniProtKB/Swiss-Prot),   Q6P6R6 (UniProtKB/Swiss-Prot),   A0A8I6GAT6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018328   ⟸   ENSRNOT00000018328
RefSeq Acc Id: XP_038961668   ⟸   XM_039105740
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000083472   ⟸   ENSRNOT00000095177
Ensembl Acc Id: ENSRNOP00000085355   ⟸   ENSRNOT00000097236
Protein Domains
Transglutaminase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVJ6-F1-model_v2 AlphaFold Q9WVJ6 1-686 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692618
Promoter ID:EPDNEW_R3142
Type:multiple initiation site
Name:Tgm2_1
Description:transglutaminase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03154,627,266 - 154,627,326EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621081 AgrOrtholog
BioCyc Gene G2FUF-47037 BioCyc
Ensembl Genes ENSRNOG00000012956 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00060025818 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018328.6 UniProtKB/Swiss-Prot
  ENSRNOT00000095177.1 UniProtKB/TrEMBL
  ENSRNOT00000097236.1 UniProtKB/TrEMBL
  ENSRNOT00060044772 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.260.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599202 IMAGE-MGC_LOAD
InterPro Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_AS UniProtKB/Swiss-Prot
  Transglutaminase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_CS UniProtKB/TrEMBL
  Transglutaminase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56083 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72474 IMAGE-MGC_LOAD
NCBI Gene 56083 ENTREZGENE
PANTHER PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Transglut_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglut_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglut_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgm2 PhenoGen
PIRSF TGM_EBP42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRANSGLUTAMINASES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012956 RatGTEx
  ENSRNOG00060025818 RatGTEx
SMART TGc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0B5AGL6_RAT UniProtKB/TrEMBL
  A0A8I6A1G8_RAT UniProtKB/TrEMBL
  A0A8I6GAT6 ENTREZGENE, UniProtKB/TrEMBL
  A6JWV1_RAT UniProtKB/TrEMBL
  Q6P6R6 ENTREZGENE
  Q9WVJ6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6P6R6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Tgm2  transglutaminase 2  Tgm2  transglutaminase 2, C polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Tgm2  transglutaminase 2, C polypeptide    tissue-type transglutaminase  Name updated 1299863 APPROVED
2002-08-07 Tgm2  tissue-type transglutaminase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in adult aorta 634391
gene_process mediates smooth muscle cell (SMC) apoptosis 634391
gene_regulation expression in the IEC-6 small intestinal epithelial cell line is reduced 4.5-fold after 24 hours of treatment with TGF-beta, and increased 2-fold after 24 hours and 5-fold after 5 days of treatment with IFN-gamma 634392