Sfrp4 (secreted frizzled-related protein 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Sfrp4 (secreted frizzled-related protein 4) Rattus norvegicus
Analyze
Symbol: Sfrp4
Name: secreted frizzled-related protein 4
RGD ID: 621075
Description: Enables Wnt-protein binding activity. Involved in several processes, including decidualization; mammary gland involution; and negative regulation of signal transduction. Located in extracellular space. Human ortholog(s) of this gene implicated in metaphyseal dysplasia. Orthologous to human SFRP4 (secreted frizzled related protein 4); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DDC-4 protein; frizzled related protein; frizzled-related protein; FRP; sFRP-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81749,974,532 - 50,026,448 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1750,015,812 - 50,026,395 (-)EnsemblGRCr8
mRatBN7.21745,278,867 - 45,330,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,234,097 - 45,330,736 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1747,396,966 - 47,407,220 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,156,129 - 52,166,383 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01746,646,527 - 46,656,783 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01747,383,983 - 47,394,065 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1747,297,489 - 47,394,328 (-)Ensemblrn6Rnor6.0
Rnor_5.01756,095,166 - 56,105,248 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41753,121,425 - 53,131,507 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1751,198,532 - 51,208,589 (+)NCBICelera
RGSC_v3.11753,124,265 - 53,134,348 (-)NCBI
Cytogenetic Map17q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
biguanides  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buserelin  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclothiazide  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
finasteride  (EXP)
fonofos  (ISO)
formaldehyde  (EXP)
furan  (EXP)
genistein  (ISO)
glyphosate  (EXP)
linsidomine  (EXP)
methylarsonic acid  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perindopril  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
terbufos  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function
protein binding  (ISO)
Wnt-protein binding  (IBA,IEA,IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. Berndt T, etal., J Clin Invest. 2003 Sep;112(5):785-94.
2. Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Carmon KS and Loose DS, Mol Cancer Res. 2008 Jun;6(6):1017-28.
3. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
4. Differential expression of secreted frizzled-related protein 4 in decidual cells during pregnancy. Fujita M, etal., J Mol Endocrinol 2002 Jun;28(3):213-23.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Placental expression of secreted frizzled related protein-4 in the rat and the impact of glucocorticoid-induced fetal and placental growth restriction. Hewitt DP, etal., Biol Reprod. 2006 Jul;75(1):75-81. Epub 2006 Mar 15.
7. Expression and localization of secreted frizzled-related protein-4 in the rodent ovary: evidence for selective up-regulation in luteinized granulosa cells. Hsieh M, etal., Endocrinology. 2003 Oct;144(10):4597-606. Epub 2003 Jul 10.
8. Secreted frizzled related protein 4 reduces fibrosis scar size and ameliorates cardiac function after ischemic injury. Matsushima K, etal., Tissue Eng Part A. 2010 Jun 9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. DDC-4, an apoptosis-associated gene, is a secreted frizzled relative. Wolf V, etal., FEBS Lett. 1997 Nov 17;417(3):385-9.
15. Transcriptional activity of the promoter region of rat frizzled-related protein gene. Yam JW, etal., Biochem Biophys Res Commun 2001 Aug 10;286(1):94-100.
Additional References at PubMed
PMID:9510961   PMID:11793365   PMID:12815282   PMID:14760084   PMID:15705870   PMID:16151791   PMID:17462603   PMID:18166153   PMID:18452624   PMID:18938133   PMID:18945944   PMID:21120994  
PMID:23200852   PMID:27355534   PMID:33726573  


Genomics

Comparative Map Data
Sfrp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81749,974,532 - 50,026,448 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1750,015,812 - 50,026,395 (-)EnsemblGRCr8
mRatBN7.21745,278,867 - 45,330,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,234,097 - 45,330,736 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1747,396,966 - 47,407,220 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,156,129 - 52,166,383 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01746,646,527 - 46,656,783 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01747,383,983 - 47,394,065 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1747,297,489 - 47,394,328 (-)Ensemblrn6Rnor6.0
Rnor_5.01756,095,166 - 56,105,248 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41753,121,425 - 53,131,507 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1751,198,532 - 51,208,589 (+)NCBICelera
RGSC_v3.11753,124,265 - 53,134,348 (-)NCBI
Cytogenetic Map17q11NCBI
SFRP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38737,905,932 - 37,916,817 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl737,905,932 - 38,025,695 (-)Ensemblhg38GRCh38
GRCh37737,945,534 - 37,956,419 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36737,912,068 - 37,922,902 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34737,718,782 - 37,729,617NCBI
Celera737,930,244 - 37,941,234 (-)NCBICelera
Cytogenetic Map7p14.1NCBI
HuRef737,825,879 - 37,836,854 (-)NCBIHuRef
CHM1_1737,945,489 - 37,956,481 (-)NCBICHM1_1
T2T-CHM13v2.0738,046,940 - 38,057,852 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2737,983,430 - 37,994,420 (-)NCBI
Sfrp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391319,807,345 - 19,816,995 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1319,807,274 - 19,817,164 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381319,623,175 - 19,632,825 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1319,623,104 - 19,632,994 (+)Ensemblmm10GRCm38
MGSCv371319,715,044 - 19,724,694 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361319,630,648 - 19,640,286 (+)NCBIMGSCv36mm8
MGSCv361319,028,703 - 19,038,341 (+)NCBIMGSCv36mm8
Cytogenetic Map13A2NCBI
cM Map136.99NCBI
Sfrp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554605,654,288 - 5,664,219 (+)Ensembl
ChiLan1.0NW_0049554605,654,187 - 5,666,475 (+)NCBIChiLan1.0ChiLan1.0
SFRP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2642,737,648 - 42,747,893 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1791,061,073 - 91,072,628 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0738,542,105 - 38,553,008 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1738,764,146 - 38,774,264 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl738,764,146 - 38,774,264 (-)EnsemblpanPan2panpan1.1
SFRP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11812,018,049 - 12,028,123 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1812,017,978 - 12,027,788 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1811,662,597 - 11,672,449 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01812,289,459 - 12,299,240 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1812,289,459 - 12,298,908 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11812,106,943 - 12,116,697 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01812,027,094 - 12,036,537 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01812,254,578 - 12,264,365 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sfrp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511894,045,401 - 94,055,610 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647813,257,801 - 13,266,701 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647813,257,183 - 13,266,972 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFRP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9108,404,040 - 108,414,307 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19108,404,314 - 108,414,335 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SFRP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12120,601,281 - 20,611,273 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2120,601,396 - 20,612,138 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660621,730,598 - 1,741,385 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sfrp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474023,334,060 - 23,344,124 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474023,333,493 - 23,345,970 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sfrp4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11438,362,223 - 38,455,452 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sfrp4
369 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:80
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000025645
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174949693265155015Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat

Markers in Region
D17Wox29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21745,332,057 - 45,332,213 (+)MAPPERmRatBN7.2
Rnor_6.01747,395,650 - 47,395,805NCBIRnor6.0
Rnor_5.01756,093,426 - 56,093,581UniSTSRnor5.0
RGSC_v3.41753,133,092 - 53,133,247UniSTSRGSC3.4
Celera1751,196,792 - 51,196,947UniSTS
Cytogenetic Map17q11UniSTS
RH137177  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21745,319,946 - 45,320,145 (+)MAPPERmRatBN7.2
Rnor_6.01747,383,542 - 47,383,740NCBIRnor6.0
Rnor_5.01756,105,491 - 56,105,689UniSTSRnor5.0
RGSC_v3.41753,120,984 - 53,121,182UniSTSRGSC3.4
Celera1751,208,832 - 51,209,030UniSTS
Cytogenetic Map17q11UniSTS
RH141728  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21745,320,707 - 45,320,916 (+)MAPPERmRatBN7.2
Rnor_6.01747,384,303 - 47,384,511NCBIRnor6.0
Rnor_5.01756,104,720 - 56,104,928UniSTSRnor5.0
RGSC_v3.41753,121,745 - 53,121,953UniSTSRGSC3.4
Celera1751,208,061 - 51,208,269UniSTS
Cytogenetic Map17q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 12 67 160 77 76 45 69 45 6 282 169 11 139 51 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000079216   ⟹   ENSRNOP00000069552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,234,097 - 45,330,736 (-)Ensembl
Rnor_6.0 Ensembl1747,297,489 - 47,394,328 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079368   ⟹   ENSRNOP00000075046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1750,015,812 - 50,026,395 (-)Ensembl
mRatBN7.2 Ensembl1745,319,764 - 45,330,727 (-)Ensembl
Rnor_6.0 Ensembl1747,383,246 - 47,394,231 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110718   ⟹   ENSRNOP00000094074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,322,299 - 45,330,736 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119265   ⟹   ENSRNOP00000084490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,279,101 - 45,330,736 (-)Ensembl
RefSeq Acc Id: NM_053544   ⟹   NP_445996
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,016,050 - 50,026,298 (-)NCBI
mRatBN7.21745,320,388 - 45,330,639 (-)NCBI
Rnor_6.01747,383,983 - 47,394,065 (-)NCBI
Rnor_5.01756,095,166 - 56,105,248 (+)NCBI
RGSC_v3.41753,121,425 - 53,131,507 (-)RGD
Celera1751,198,532 - 51,208,589 (+)RGD
Sequence:
RefSeq Acc Id: XM_039096132   ⟹   XP_038952060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,974,532 - 50,026,448 (-)NCBI
mRatBN7.21745,278,867 - 45,330,806 (-)NCBI
RefSeq Acc Id: XM_039096133   ⟹   XP_038952061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,016,216 - 50,024,675 (-)NCBI
mRatBN7.21745,319,697 - 45,329,017 (-)NCBI
RefSeq Acc Id: XM_063276786   ⟹   XP_063132856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,017,074 - 50,026,434 (-)NCBI
RefSeq Acc Id: NP_445996   ⟸   NM_053544
- Peptide Label: precursor
- UniProtKB: A6KN49 (UniProtKB/TrEMBL),   G3V8G7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075046   ⟸   ENSRNOT00000079368
Ensembl Acc Id: ENSRNOP00000069552   ⟸   ENSRNOT00000079216
RefSeq Acc Id: XP_038952060   ⟸   XM_039096132
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZG6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952061   ⟸   XM_039096133
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000094074   ⟸   ENSRNOT00000110718
Ensembl Acc Id: ENSRNOP00000084490   ⟸   ENSRNOT00000119265
RefSeq Acc Id: XP_063132856   ⟸   XM_063276786
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GL00 (UniProtKB/TrEMBL),   Q924N2 (UniProtKB/TrEMBL)
Protein Domains
FZ   NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLS4-F1-model_v2 AlphaFold Q9JLS4 1-348 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700500
Promoter ID:EPDNEW_R11024
Type:single initiation site
Name:Sfrp4_1
Description:secreted frizzled-related protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01747,394,239 - 47,394,299EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621075 AgrOrtholog
BioCyc Gene G2FUF-9147 BioCyc
Ensembl Genes ENSRNOG00000054957 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000079368 ENTREZGENE
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot
  2.40.50.120 UniProtKB/Swiss-Prot
InterPro Frizzled/SFRP UniProtKB/Swiss-Prot
  Frizzled_dom UniProtKB/Swiss-Prot
  Frizzled_dom_sf UniProtKB/Swiss-Prot
  Netrin_domain UniProtKB/Swiss-Prot
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
KEGG Report rno:89803 UniProtKB/Swiss-Prot
NCBI Gene 89803 ENTREZGENE
PANTHER PTHR11309 UniProtKB/Swiss-Prot
  PTHR11309:SF7 UniProtKB/Swiss-Prot
Pfam NTR UniProtKB/Swiss-Prot
  PF01392 UniProtKB/Swiss-Prot
PhenoGen Sfrp4 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot
  PS50038 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054957 RatGTEx
SMART C345C UniProtKB/Swiss-Prot
  FRI UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot
  SSF63501 UniProtKB/Swiss-Prot
UniProt A0A8I5ZZG6 ENTREZGENE
  A0A8I6GL00 ENTREZGENE
  A6KN48_RAT UniProtKB/TrEMBL
  A6KN49 ENTREZGENE, UniProtKB/TrEMBL
  G3V8G7 ENTREZGENE, UniProtKB/TrEMBL
  Q924N2 ENTREZGENE, UniProtKB/TrEMBL
  Q9JLS4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O35222 UniProtKB/Swiss-Prot
  Q9JLS5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Sfrp4  secreted frizzled-related protein 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Sfrp4  secreted frizzled-related protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is up-regulated after estrogen treatment in the the pregnant uterus 633927