Ccna2 (cyclin A2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ccna2 (cyclin A2) Rattus norvegicus
Analyze
Symbol: Ccna2
Name: cyclin A2
RGD ID: 621059
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity; protein domain specific binding activity; and protein kinase binding activity. Involved in several processes, including cellular response to cocaine; cellular response to estradiol stimulus; and cellular response to peptide hormone stimulus. Predicted to be located in female pronucleus and male pronucleus. Predicted to be part of cyclin A2-CDK1 complex and cyclin A2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Biomarker of myocardial infarction. Orthologous to human CCNA2 (cyclin A2); PARTICIPATES IN G1/S transition pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (-)-citrinin; 1,3-dichloropropan-2-ol; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cyclin-A2; MGC156527
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82121,355,363 - 121,361,762 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2121,355,363 - 121,361,701 (-)EnsemblGRCr8
mRatBN7.22119,427,239 - 119,433,645 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2119,426,089 - 119,433,577 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2125,981,869 - 125,988,202 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,094,364 - 124,100,697 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02118,723,360 - 118,729,693 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,274,727 - 123,282,266 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,275,881 - 123,282,214 (-)Ensemblrn6Rnor6.0
Rnor_5.02142,890,984 - 142,897,322 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42123,062,752 - 123,069,085 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2114,385,123 - 114,391,456 (-)NCBICelera
RGSC_v3.12123,009,712 - 123,013,946 (-)NCBI
Cytogenetic Map2q25NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-citrinin  (EXP)
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-methoxy-17beta-estradiol  (ISO)
2-palmitoylglycerol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-Methoxyflavone  (ISO)
6-O-methylguanine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
Abemaciclib  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
AICA ribonucleotide  (ISO)
all-trans-retinoic acid  (ISO)
allose  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alvocidib  (ISO)
ammonium chloride  (EXP)
amsacrine  (ISO)
andrographolide  (ISO)
androstane  (ISO)
aniline  (EXP)
anthracene  (ISO)
antimycin A  (ISO)
aphidicolin  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Aspidin  (ISO)
atrazine  (ISO)
auraptene  (ISO)
azathioprine  (ISO)
baicalein  (EXP,ISO)
baicalin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bicalutamide  (ISO)
biotin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cicaprost  (ISO)
ciglitazone  (ISO)
cilostazol  (ISO)
Cinobufagin  (ISO)
Cirsimarin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cryptolepine  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin I  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP)
daidzein  (ISO)
DDE  (ISO)
deguelin  (ISO)
DENSPM  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofuran  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethyl maleate  (EXP)
diethyl sulfate  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
diminazene diaceturate  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
doxazosin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
equol  (ISO)
erythromycin estolate  (EXP)
escitalopram  (EXP,ISO)
estragole  (EXP)
etoposide  (ISO)
everolimus  (ISO)
farnesol  (ISO)
fenvalerate  (EXP)
fisetin  (ISO)
flumequine  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fraxetin  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-linolenic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glutathione  (ISO)
glycitein  (ISO)
glyphosate  (ISO)
gossypin  (ISO)
GW 4064  (ISO)
homocysteine  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
iodoacetic acid  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
kaempferol  (EXP)
ketamine  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lapatinib  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lucanthone  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mechlorethamine  (ISO)
MeIQx  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methcathinone  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
metolachlor  (ISO)
mevalonic acid  (EXP)
mifepristone  (ISO)
ML-7  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
N(5)-ethyl-L-glutamine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nicotine  (ISO)
nimesulide  (ISO)
nobiletin  (EXP,ISO)
nonanoic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oligomycin A  (ISO)
omacetaxine mepesuccinate  (ISO)
orlistat  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (ISO)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perillyl alcohol  (ISO)
phenanthrene  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenol  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pinosylvin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
pyrene  (ISO)
pyrimidifen  (ISO)
pyrimidines  (ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
quinazolines  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
Salinomycin  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
senecionine  (EXP)
Senkirkine  (EXP)
SHP099  (ISO)
sildenafil citrate  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sorafenib  (ISO)
SP2509  (ISO)
stilben-4-ol  (ISO)
stilbene-4,4'-diol  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
taiwanin C  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trabectedin  (ISO)
trans-pinosylvin  (ISO)
trans-stilbene-4,4'-diol  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
Tylophorine  (ISO)
valproic acid  (ISO)
verteporfin  (ISO)
vorinostat  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Decreased level of cyclin A2 in rat cochlea development and cochlear stem cell differentiation. Chen J, etal., Neurosci Lett. 2009 Apr 10;453(3):166-9. doi: 10.1016/j.neulet.2009.02.019. Epub 2009 Feb 13.
2. Overexpression of CyclinA2 ameliorates hypoxia-impaired proliferation of cardiomyocytes. Deng H, etal., Exp Ther Med. 2014 Nov;8(5):1513-1517. Epub 2014 Aug 26.
3. cAMP-dependent positive control of cyclin A2 expression during G1/S transition in primary hepatocytes. Desdouets C, etal., Biochem Biophys Res Commun. 1999 Jul 22;261(1):118-22.
4. Leptin-mediated decrease of cyclin A2 and increase of cyclin D1 expression: relevance for the control of prepubertal rat Leydig cell division and differentiation. Fombonne J, etal., Endocrinology. 2007 May;148(5):2126-37. Epub 2007 Feb 15.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Decreased cyclin A2 and increased cyclin G1 levels coincide with loss of proliferative capacity in rat Leydig cells during pubertal development. Ge RS and Hardy MP, Endocrinology. 1997 Sep;138(9):3719-26.
7. Nitric oxide-induced downregulation of Cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells. Guo K, etal., Circulation. 1998 May 26;97(20):2066-72.
8. Red wine polyphenols inhibit proliferation of vascular smooth muscle cells and downregulate expression of cyclin A gene. Iijima K, etal., Circulation. 2000 Feb 22;101(7):805-11.
9. Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice. Kalin TV, etal., Cancer Res. 2006 Feb 1;66(3):1712-20.
10. ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6. Kan Q, etal., Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4757-62. doi: 10.1073/pnas.0706392105. Epub 2008 Mar 20.
11. NFATc1 targets cyclin A in the regulation of vascular smooth muscle cell multiplication during restenosis. Karpurapu M, etal., J Biol Chem. 2008 Sep 26;283(39):26577-90. doi: 10.1074/jbc.M800423200. Epub 2008 Jul 29.
12. Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells. Katabami M, etal., J Biol Chem. 2005 Apr 29;280(17):16728-38. Epub 2005 Feb 28.
13. A mechanism for the inhibition of neural progenitor cell proliferation by cocaine. Lee CT, etal., PLoS Med. 2008 Jun 10;5(6):e117. doi: 10.1371/journal.pmed.0050117.
14. Acute myocardial infarction induced functional cardiomyocytes to re-enter the cell cycle. Li Y, etal., Am J Transl Res. 2013 Apr 19;5(3):327-35. Print 2013.
15. Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors. Liao C, etal., Int J Cancer. 2004 Feb 20;108(5):654-64.
16. Cell cycle basis for the onset and progression of c-Myc-induced, TGFalpha-enhanced mouse mammary gland carcinogenesis. Liao DJ, etal., Oncogene. 2000 Mar 2;19(10):1307-17.
17. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Inhibition of anchorage-independent cell growth, adhesion, and cyclin D1 gene expression by a dominant negative mutant of a tyrosine phosphatase. Mitra SK and Swarup G, Exp Cell Res 2001 Oct 15;270(1):32-44.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Cyclin A2 and c-myc mRNA expression in ethinyl estradiol induced liver proliferation. Payraudeau V, etal., Mol Cell Endocrinol. 1998 Aug 25;143(1-2):107-16.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway. Ren S, etal., Int J Biochem Cell Biol. 2020 Aug;125:105777. doi: 10.1016/j.biocel.2020.105777. Epub 2020 Jun 3.
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
29. Significance of Insulin Signaling in Liver Regeneration Triggered by Portal Vein Ligation. Tseng JH, etal., J Surg Res. 2009 Jul 30.
30. Therapeutic delivery of cyclin A2 induces myocardial regeneration and enhances cardiac function in ischemic heart failure. Woo YJ, etal., Circulation. 2006 Jul 4;114(1 Suppl):I206-13.
31. Myocardial regeneration therapy for ischemic cardiomyopathy with cyclin A2. Woo YJ, etal., J Thorac Cardiovasc Surg. 2007 Apr;133(4):927-33. Epub 2007 Feb 22.
Additional References at PubMed
PMID:1312467   PMID:7739547   PMID:8245034   PMID:8684460   PMID:8889548   PMID:9054499   PMID:11746698   PMID:11981756   PMID:12477932   PMID:15024385   PMID:15159393   PMID:16109376  
PMID:16137671   PMID:16288221   PMID:17234884   PMID:17347653   PMID:23791195   PMID:27414783  


Genomics

Comparative Map Data
Ccna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82121,355,363 - 121,361,762 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2121,355,363 - 121,361,701 (-)EnsemblGRCr8
mRatBN7.22119,427,239 - 119,433,645 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2119,426,089 - 119,433,577 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2125,981,869 - 125,988,202 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,094,364 - 124,100,697 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02118,723,360 - 118,729,693 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,274,727 - 123,282,266 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,275,881 - 123,282,214 (-)Ensemblrn6Rnor6.0
Rnor_5.02142,890,984 - 142,897,322 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42123,062,752 - 123,069,085 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2114,385,123 - 114,391,456 (-)NCBICelera
RGSC_v3.12123,009,712 - 123,013,946 (-)NCBI
Cytogenetic Map2q25NCBI
CCNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384121,816,444 - 121,823,883 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4121,816,444 - 121,823,917 (-)Ensemblhg38GRCh38
GRCh374122,737,599 - 122,745,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364122,957,975 - 122,964,342 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344123,096,129 - 123,102,485NCBI
Celera4120,123,415 - 120,130,904 (-)NCBICelera
Cytogenetic Map4q27NCBI
HuRef4118,464,283 - 118,471,772 (-)NCBIHuRef
CHM1_14122,714,067 - 122,721,556 (-)NCBICHM1_1
T2T-CHM13v2.04125,120,496 - 125,127,935 (-)NCBIT2T-CHM13v2.0
Ccna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39336,619,014 - 36,627,187 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl336,619,014 - 36,626,299 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38336,564,865 - 36,573,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl336,564,865 - 36,572,150 (-)Ensemblmm10GRCm38
MGSCv37336,463,787 - 36,470,918 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36336,756,414 - 36,763,490 (-)NCBIMGSCv36mm8
Celera336,449,044 - 36,457,213 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map317.67NCBI
Ccna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542818,726,062 - 18,732,211 (+)Ensembl
ChiLan1.0NW_00495542818,725,969 - 18,732,478 (+)NCBIChiLan1.0ChiLan1.0
CCNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23119,612,574 - 119,620,418 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14119,881,687 - 119,889,283 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04114,016,917 - 114,024,816 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14125,153,810 - 125,161,370 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,153,810 - 125,161,302 (-)EnsemblpanPan2panpan1.1
CCNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11918,317,866 - 18,324,592 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1918,318,004 - 18,323,691 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1918,534,627 - 18,544,698 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01918,436,112 - 18,446,091 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1918,436,169 - 18,442,776 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11918,387,227 - 18,397,254 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01918,668,909 - 18,678,936 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01919,144,640 - 19,154,711 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ccna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530166,040,643 - 66,046,184 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366621,073,920 - 1,079,136 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366621,073,460 - 1,079,136 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8102,260,215 - 102,266,309 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18102,260,346 - 102,266,274 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28109,455,845 - 109,461,772 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1769,092,410 - 69,100,191 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl769,093,543 - 69,099,497 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603748,053,566 - 48,060,924 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247772,097,002 - 2,104,244 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ccna2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13117,415,041 - 117,421,426 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ccna2
47 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:43
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000021156
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
PMC317048P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22119,429,240 - 119,429,989 (+)MAPPERmRatBN7.2
Rnor_6.02123,277,883 - 123,278,631NCBIRnor6.0
Rnor_5.02142,892,986 - 142,893,734UniSTSRnor5.0
RGSC_v3.42123,064,754 - 123,065,502UniSTSRGSC3.4
Celera2114,387,125 - 114,387,873UniSTS
Cytogenetic Map2q25UniSTS
RH134560  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82121,355,734 - 121,356,540 (+)Marker Load Pipeline
mRatBN7.22119,427,610 - 119,428,416 (+)MAPPERmRatBN7.2
Rnor_6.02123,276,253 - 123,277,058NCBIRnor6.0
Rnor_5.02142,891,356 - 142,892,161UniSTSRnor5.0
RGSC_v3.42123,063,124 - 123,063,929UniSTSRGSC3.4
Celera2114,385,495 - 114,386,300UniSTS
RH 3.4 Map2665.0UniSTS
Cytogenetic Map2q25UniSTS
PMC207566P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22119,432,560 - 119,433,414 (+)MAPPERmRatBN7.2
Rnor_6.02123,281,203 - 123,282,056NCBIRnor6.0
Rnor_5.02142,896,306 - 142,897,159UniSTSRnor5.0
RGSC_v3.42123,068,074 - 123,068,927UniSTSRGSC3.4
Celera2114,390,445 - 114,391,298UniSTS
Cytogenetic Map2q25UniSTS
PMC207566P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22119,433,543 - 119,433,712 (+)MAPPERmRatBN7.2
Rnor_6.02123,282,186 - 123,282,354NCBIRnor6.0
Rnor_5.02142,897,289 - 142,897,457UniSTSRnor5.0
RGSC_v3.42123,069,057 - 123,069,225UniSTSRGSC3.4
Celera2114,391,428 - 114,391,596UniSTS
Cytogenetic Map2q25UniSTS
PMC212738P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2535,477,189 - 35,477,365 (+)MAPPERmRatBN7.2
mRatBN7.22119,427,975 - 119,428,468 (+)MAPPERmRatBN7.2
Rnor_6.02123,276,618 - 123,277,110NCBIRnor6.0
Rnor_6.0536,073,353 - 36,073,528NCBIRnor6.0
Rnor_5.0540,726,097 - 40,726,272UniSTSRnor5.0
Rnor_5.02142,891,721 - 142,892,213UniSTSRnor5.0
RGSC_v3.42123,063,489 - 123,063,981UniSTSRGSC3.4
RGSC_v3.4536,674,479 - 36,674,654UniSTSRGSC3.4
Celera534,490,502 - 34,490,677UniSTS
Celera2114,385,860 - 114,386,352UniSTS
Cytogenetic Map2q25UniSTS
PMC138456P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22119,432,458 - 119,432,576 (+)MAPPERmRatBN7.2
Rnor_6.02123,281,101 - 123,281,218NCBIRnor6.0
Rnor_5.02142,896,204 - 142,896,321UniSTSRnor5.0
RGSC_v3.42123,067,972 - 123,068,089UniSTSRGSC3.4
Celera2114,390,343 - 114,390,460UniSTS
Cytogenetic Map2q25UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 90 59 6 352 190 11 141 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021156   ⟹   ENSRNOP00000021156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2121,355,459 - 121,361,701 (-)Ensembl
mRatBN7.2 Ensembl2119,427,335 - 119,433,577 (-)Ensembl
Rnor_6.0 Ensembl2123,275,881 - 123,282,214 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079745   ⟹   ENSRNOP00000069674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2121,355,363 - 121,361,696 (-)Ensembl
mRatBN7.2 Ensembl2119,426,089 - 119,433,551 (-)Ensembl
Rnor_6.0 Ensembl2123,275,883 - 123,281,856 (-)Ensembl
RefSeq Acc Id: NM_053702   ⟹   NP_446154
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82121,355,363 - 121,361,696 (-)NCBI
mRatBN7.22119,427,239 - 119,433,572 (-)NCBI
Rnor_6.02123,275,881 - 123,282,214 (-)NCBI
Rnor_5.02142,890,984 - 142,897,322 (-)NCBI
RGSC_v3.42123,062,752 - 123,069,085 (-)RGD
Celera2114,385,123 - 114,391,456 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232266   ⟹   XP_006232328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82121,355,454 - 121,361,565 (-)NCBI
mRatBN7.22119,427,326 - 119,433,577 (-)NCBI
Rnor_6.02123,274,727 - 123,282,219 (-)NCBI
Rnor_5.02142,890,984 - 142,897,322 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760903   ⟹   XP_008759125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82121,355,454 - 121,361,762 (-)NCBI
mRatBN7.22119,427,326 - 119,433,645 (-)NCBI
Rnor_6.02123,274,727 - 123,282,266 (-)NCBI
Sequence:
RefSeq Acc Id: NP_446154   ⟸   NM_053702
- UniProtKB: A0A0G2JVY9 (UniProtKB/TrEMBL),   A6IHY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232328   ⟸   XM_006232266
- Peptide Label: isoform X1
- UniProtKB: G3V802 (UniProtKB/TrEMBL),   Q6GX88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759125   ⟸   XM_008760903
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000069674   ⟸   ENSRNOT00000079745
Ensembl Acc Id: ENSRNOP00000021156   ⟸   ENSRNOT00000021156
Protein Domains
Cyclin C-terminal   Cyclin N-terminal   Cyclin-A N-terminal APC/C binding region   Cyclin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V802-F1-model_v2 AlphaFold G3V802 1-418 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691291
Promoter ID:EPDNEW_R1816
Type:initiation region
Name:Ccna2_1
Description:cyclin A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02123,282,245 - 123,282,305EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621059 AgrOrtholog
BioCyc Gene G2FUF-53316 BioCyc
Ensembl Genes ENSRNOG00000015423 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021156 ENTREZGENE
  ENSRNOT00000021156.8 UniProtKB/TrEMBL
  ENSRNOT00000079745 ENTREZGENE
  ENSRNOT00000079745.3 UniProtKB/TrEMBL
Gene3D-CATH Cyclin-like UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8373429 IMAGE-MGC_LOAD
InterPro Cyclin UniProtKB/TrEMBL
  Cyclin-A_N UniProtKB/TrEMBL
  Cyclin-like UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  Cyclin_A/B-like UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
  Cyclins_cyclin-box UniProtKB/TrEMBL
KEGG Report rno:114494 UniProtKB/TrEMBL
MGC_CLONE MGC:156527 IMAGE-MGC_LOAD
NCBI Gene 114494 ENTREZGENE
PANTHER PTHR10177 UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
  Cyclin_N2 UniProtKB/TrEMBL
PharmGKB CCNA2 RGD
PhenoGen Ccna2 PhenoGen
PIRSF Cyclin_A_B_D_E UniProtKB/TrEMBL
PROSITE CYCLINS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015423 RatGTEx
SMART CYCLIN UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
Superfamily-SCOP Cyclin_like UniProtKB/TrEMBL
UniProt A0A0G2JVY9 ENTREZGENE, UniProtKB/TrEMBL
  A0JPK0_RAT UniProtKB/TrEMBL
  A6IHY4 ENTREZGENE, UniProtKB/TrEMBL
  A6IHY5_RAT UniProtKB/TrEMBL
  G3V802 ENTREZGENE, UniProtKB/TrEMBL
  Q6GX88 ENTREZGENE, UniProtKB/TrEMBL
  Q91ZX8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ccna2  cyclin A2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ccna2  cyclin A2      Symbol and Name status set to provisional 70820 PROVISIONAL