Hdgfl1 (HDGF like 1) - Rat Genome Database

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Gene: Hdgfl1 (HDGF like 1) Rattus norvegicus
Analyze
Symbol: Hdgfl1
Name: HDGF like 1
RGD ID: 621012
Description: Orthologous to human HDGFL1 (HDGF like 1); INTERACTS WITH 2,5-hexanedione; ammonium chloride; bisphenol A.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: PROVISIONAL
Previously known as: Hdgfrp1; hepatoma derived growth factor-like 1; hepatoma-derived growth factor, related protein 1; hepatoma-derived growth factor-like protein 1; Pwwp1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81738,636,053 - 38,638,049 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1738,636,072 - 38,637,957 (+)EnsemblGRCr8
mRatBN7.21738,207,906 - 38,209,902 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1738,282,163 - 38,284,184 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01739,886,167 - 39,888,188 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01738,169,843 - 38,171,827 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01740,170,522 - 40,172,518 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1740,170,541 - 40,172,426 (+)Ensemblrn6Rnor6.0
Rnor_5.01742,058,386 - 42,060,382 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41745,146,483 - 45,148,479 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1737,888,905 - 37,890,901 (+)NCBICelera
RGSC_v3.11745,149,342 - 45,151,228 (+)NCBI
Cytogenetic Map17p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Hdgfl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81738,636,053 - 38,638,049 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1738,636,072 - 38,637,957 (+)EnsemblGRCr8
mRatBN7.21738,207,906 - 38,209,902 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1738,282,163 - 38,284,184 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01739,886,167 - 39,888,188 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01738,169,843 - 38,171,827 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01740,170,522 - 40,172,518 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1740,170,541 - 40,172,426 (+)Ensemblrn6Rnor6.0
Rnor_5.01742,058,386 - 42,060,382 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41745,146,483 - 45,148,479 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1737,888,905 - 37,890,901 (+)NCBICelera
RGSC_v3.11745,149,342 - 45,151,228 (+)NCBI
Cytogenetic Map17p11NCBI
HDGFL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38622,569,566 - 22,571,666 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl622,569,566 - 22,571,666 (+)Ensemblhg38GRCh38
GRCh37622,569,795 - 22,571,895 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36622,677,657 - 22,678,729 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34622,677,773 - 22,679,871NCBI
Celera623,803,036 - 23,804,108 (+)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef622,512,779 - 22,513,851 (+)NCBIHuRef
CHM1_1622,571,673 - 22,572,745 (+)NCBICHM1_1
T2T-CHM13v2.0622,442,013 - 22,444,113 (+)NCBIT2T-CHM13v2.0
Hdgfl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391326,952,155 - 26,954,148 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1326,952,156 - 26,954,148 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381326,768,172 - 26,770,165 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1326,768,173 - 26,770,165 (-)Ensemblmm10GRCm38
MGSCv371326,860,041 - 26,862,034 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361326,776,255 - 26,777,584 (-)NCBIMGSCv36mm8
Celera1326,996,877 - 26,998,870 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
Hdgfl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554834,215,060 - 4,217,150 (-)NCBIChiLan1.0ChiLan1.0
HDGFL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2536,982,735 - 37,250,583 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1632,982,776 - 33,250,721 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0622,171,445 - 22,437,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1622,734,678 - 22,736,887 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl622,734,809 - 22,735,558 (+)EnsemblpanPan2panpan1.1
HDGFL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13520,914,875 - 20,915,677 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3520,871,267 - 20,872,051 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03521,024,208 - 21,026,228 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UU_Cfam_GSD_1.03522,311,979 - 22,313,997 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
HDGFL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1717,690,873 - 17,697,764 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2718,656,664 - 18,658,638 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HDGFL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11749,654,556 - 49,828,227 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1749,655,854 - 49,656,624 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604422,509,310 - 22,512,082 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdgfl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11445,815,799 - 45,817,819 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hdgfl1
5 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 2 6 36 25 21 7 7 7 6 42 24 23 4 59 14

Sequence


Ensembl Acc Id: ENSRNOT00000085069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1740,170,541 - 40,172,426 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000125131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1738,636,072 - 38,637,957 (+)Ensembl
RefSeq Acc Id: NM_133549   ⟹   NP_598233
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81738,636,053 - 38,638,049 (+)NCBI
mRatBN7.21738,207,906 - 38,209,902 (+)NCBI
Rnor_6.01740,170,522 - 40,172,518 (+)NCBI
Rnor_5.01742,058,386 - 42,060,382 (+)NCBI
RGSC_v3.41745,146,483 - 45,148,479 (+)RGD
Celera1737,888,905 - 37,890,901 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_598233 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85707 (Get FASTA)   NCBI Sequence Viewer  
  AAL29938 (Get FASTA)   NCBI Sequence Viewer  
  AAP97706 (Get FASTA)   NCBI Sequence Viewer  
  EDL86479 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598233   ⟸   NM_133549
- UniProtKB: Q5RKK8 (UniProtKB/TrEMBL),   Q7TNX5 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
PWWP

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621012 AgrOrtholog
BioCyc Gene G2FUF-9442 BioCyc
Ensembl Genes ENSRNOG00000059482 Ensembl
  ENSRNOG00000080253 Ensembl
Gene3D-CATH 2.30.30.140 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132556 IMAGE-MGC_LOAD
InterPro PWWP UniProtKB/TrEMBL
KEGG Report rno:171074 UniProtKB/TrEMBL
MGC_CLONE MGC:93218 IMAGE-MGC_LOAD
NCBI Gene 171074 ENTREZGENE
PANTHER HEPATOMA-DERIVED GROWTH FACTOR-LIKE PROTEIN 1 UniProtKB/TrEMBL
  HEPATOMA-DERIVED GROWTH FACTOR-RELATED UniProtKB/TrEMBL
Pfam PWWP UniProtKB/TrEMBL
PhenoGen Hdgfl1 PhenoGen
PROSITE PWWP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059482 RatGTEx
  ENSRNOG00000080253 RatGTEx
SMART PWWP UniProtKB/TrEMBL
Superfamily-SCOP Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt Q5RKK8 ENTREZGENE, UniProtKB/TrEMBL
  Q7TNX5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-17 Hdgfl1  HDGF like 1  Hdgfl1  hepatoma derived growth factor-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-03-16 Hdgfl1  hepatoma derived growth factor-like 1  Hdgfl1  HDGF like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-10 Hdgfl1  HDGF like 1  Hdgfl1  hepatoma derived growth factor-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Hdgfl1  hepatoma derived growth factor-like 1  Pwwp1  hepatoma-derived growth factor, related protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pwwp1  hepatoma-derived growth factor, related protein 1  Hdgfrp1    Symbol and Name updated 1299863 APPROVED
2002-08-07 Hdgfrp1  hepatoma-derived growth factor, related protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL