Stx12 (syntaxin 12) - Rat Genome Database

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Gene: Stx12 (syntaxin 12) Rattus norvegicus
Analyze
Symbol: Stx12
Name: syntaxin 12
RGD ID: 620977
Description: Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in endocytic recycling; regulation of postsynaptic membrane neurotransmitter receptor levels; and synaptic vesicle to endosome fusion. Located in recycling endosome. Is active in glutamatergic synapse; postsynaptic recycling endosome membrane; and synaptic vesicle membrane. Orthologous to human STX12 (syntaxin 12); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Syn13; syntaxin-12; syntaxin-13
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,347,554 - 150,376,426 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5150,334,836 - 150,376,346 (-)EnsemblGRCr8
mRatBN7.25145,062,978 - 145,092,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,063,587 - 145,092,377 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5147,763,708 - 147,791,950 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,533,297 - 149,561,548 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,522,088 - 149,550,333 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05151,044,050 - 151,072,893 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,044,329 - 151,072,904 (-)Ensemblrn6Rnor6.0
Rnor_5.05154,710,849 - 154,740,301 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45152,261,969 - 152,290,210 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5143,487,210 - 143,515,451 (-)NCBICelera
RGSC_v3.15152,272,085 - 152,298,839 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
aconitine  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
glyphosate  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
morphine  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
paracetamol  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (ISO)
potassium chromate  (ISO)
pyrethrins  (EXP)
rac-lactic acid  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
tetrachloromethane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. Advani RJ, etal., J Biol Chem 1998 Apr 24;273(17):10317-24.
2. The specificity of SNARE pairing in biological membranes is mediated by both proof-reading and spatial segregation. Bethani I, etal., EMBO J. 2007 Sep 5;26(17):3981-92. Epub 2007 Aug 23.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. Hoogenraad CC, etal., PLoS Biol. 2010 Jan 19;8(1):e1000283. doi: 10.1371/journal.pbio.1000283.
5. SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors. Koike S and Jahn R, Nat Commun. 2019 Apr 8;10(1):1608. doi: 10.1038/s41467-019-09617-9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes. Park M, etal., Neuron. 2006 Dec 7;52(5):817-30. doi: 10.1016/j.neuron.2006.09.040.
9. Recycling endosomes supply AMPA receptors for LTP. Park M, etal., Science. 2004 Sep 24;305(5692):1972-5. doi: 10.1126/science.1102026.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Richardson SC, etal., Mol Biol Cell 2004 Mar;15(3):1197-210. Epub 2003 Dec 10.
14. Evidence for early endosome-like fusion of recently endocytosed synaptic vesicles. Rizzoli SO, etal., Traffic. 2006 Sep;7(9):1163-76.
15. Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2. Steiner P, etal., EMBO J. 2005 Aug 17;24(16):2873-84. Epub 2005 Jul 21.
16. Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD. Steiner P, etal., J Cell Biol. 2002 Jun 24;157(7):1197-209. Epub 2002 Jun 17.
17. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
18. Syntaxin 12, a member of the syntaxin family localized to the endosome. Tang BL, etal., J Biol Chem 1998 Mar 20;273(12):6944-50.
Additional References at PubMed
PMID:15469992   PMID:15689499   PMID:19546860   PMID:21700703   PMID:23376485   PMID:24095276   PMID:28131823   PMID:28202235   PMID:31505169   PMID:37830626  


Genomics

Comparative Map Data
Stx12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,347,554 - 150,376,426 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5150,334,836 - 150,376,346 (-)EnsemblGRCr8
mRatBN7.25145,062,978 - 145,092,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,063,587 - 145,092,377 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5147,763,708 - 147,791,950 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,533,297 - 149,561,548 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,522,088 - 149,550,333 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05151,044,050 - 151,072,893 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,044,329 - 151,072,904 (-)Ensemblrn6Rnor6.0
Rnor_5.05154,710,849 - 154,740,301 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45152,261,969 - 152,290,210 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5143,487,210 - 143,515,451 (-)NCBICelera
RGSC_v3.15152,272,085 - 152,298,839 (+)NCBI
Cytogenetic Map5q36NCBI
STX12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,773,219 - 27,824,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,773,195 - 27,824,443 (+)Ensemblhg38GRCh38
GRCh37128,099,730 - 28,150,954 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,972,281 - 28,023,550 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34127,783,924 - 27,834,956NCBI
Celera126,495,339 - 26,546,590 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef126,355,806 - 26,407,148 (+)NCBIHuRef
CHM1_1128,214,883 - 28,266,152 (+)NCBICHM1_1
T2T-CHM13v2.0127,614,513 - 27,665,738 (+)NCBIT2T-CHM13v2.0
Stx12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,581,375 - 132,611,769 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,580,812 - 132,611,820 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384132,854,064 - 132,884,458 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,853,501 - 132,884,509 (-)Ensemblmm10GRCm38
MGSCv374132,409,979 - 132,440,373 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364132,126,140 - 132,156,534 (-)NCBIMGSCv36mm8
Celera4131,015,600 - 131,045,689 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.01NCBI
Stx12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,977,101 - 7,015,281 (+)Ensembl
ChiLan1.0NW_0049554526,977,813 - 7,015,281 (+)NCBIChiLan1.0ChiLan1.0
STX12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21199,026,935 - 199,077,999 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11198,143,414 - 198,194,453 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,035,807 - 27,086,825 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,076,625 - 28,127,666 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,076,625 - 28,130,032 (+)EnsemblpanPan2panpan1.1
STX12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,546,178 - 72,582,706 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,547,608 - 72,582,660 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha269,123,661 - 69,160,555 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0273,107,226 - 73,144,440 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,107,230 - 73,144,560 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,934,023 - 69,970,932 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,944,773 - 70,981,653 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,941,193 - 71,978,103 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Stx12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,194,314 - 46,231,431 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,019,041 - 12,060,213 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,019,099 - 12,057,028 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STX12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,918,678 - 84,960,720 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1684,918,827 - 84,960,235 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2678,460,556 - 78,501,980 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STX12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,966,763 - 105,020,908 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,966,581 - 105,020,901 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603311,443,668 - 11,494,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stx12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476411,620,439 - 11,664,410 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476411,620,527 - 11,665,829 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Stx12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1125,356,734 - 25,385,847 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Stx12
155 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:434
Count of miRNA genes:220
Interacting mature miRNAs:284
Transcripts:ENSRNOT00000017227
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH127369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25145,064,504 - 145,064,708 (+)MAPPERmRatBN7.2
Rnor_6.05151,044,973 - 151,045,176NCBIRnor6.0
Rnor_5.05154,712,376 - 154,712,579UniSTSRnor5.0
RGSC_v3.45152,289,637 - 152,289,840UniSTSRGSC3.4
Celera5143,487,580 - 143,487,783UniSTS
RH 3.4 Map5977.8UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017227   ⟹   ENSRNOP00000017227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5150,348,105 - 150,376,346 (-)Ensembl
mRatBN7.2 Ensembl5145,064,135 - 145,092,377 (-)Ensembl
Rnor_6.0 Ensembl5151,044,603 - 151,072,844 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078048   ⟹   ENSRNOP00000073181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5150,347,962 - 150,376,346 (-)Ensembl
mRatBN7.2 Ensembl5145,063,992 - 145,092,372 (-)Ensembl
Rnor_6.0 Ensembl5151,046,013 - 151,072,766 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085573   ⟹   ENSRNOP00000069420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5150,351,048 - 150,376,346 (-)Ensembl
mRatBN7.2 Ensembl5145,067,078 - 145,092,372 (-)Ensembl
Rnor_6.0 Ensembl5151,044,329 - 151,072,904 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098444   ⟹   ENSRNOP00000077790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5150,334,836 - 150,376,346 (-)Ensembl
mRatBN7.2 Ensembl5145,063,648 - 145,092,353 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100780   ⟹   ENSRNOP00000079839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5150,346,882 - 150,376,346 (-)Ensembl
mRatBN7.2 Ensembl5145,063,587 - 145,092,372 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145273   ⟹   ENSRNOP00000106779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5150,346,679 - 150,376,346 (-)Ensembl
RefSeq Acc Id: NM_022939   ⟹   NP_075228
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,348,105 - 150,376,346 (-)NCBI
mRatBN7.25145,064,135 - 145,092,377 (-)NCBI
Rnor_6.05151,044,603 - 151,072,844 (-)NCBI
Rnor_5.05154,710,849 - 154,740,301 (-)NCBI
RGSC_v3.45152,261,969 - 152,290,210 (+)RGD
Celera5143,487,210 - 143,515,451 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239066   ⟹   XP_006239128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,347,554 - 150,376,426 (-)NCBI
mRatBN7.25145,062,978 - 145,092,423 (-)NCBI
Rnor_6.05151,044,050 - 151,072,893 (-)NCBI
Rnor_5.05154,710,849 - 154,740,301 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063288365   ⟹   XP_063144435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,348,105 - 150,376,397 (-)NCBI
RefSeq Acc Id: NP_075228   ⟸   NM_022939
- UniProtKB: O70319 (UniProtKB/Swiss-Prot),   O88385 (UniProtKB/Swiss-Prot),   G3V7P1 (UniProtKB/Swiss-Prot),   A0A0G2JVB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239128   ⟸   XM_006239066
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000069420   ⟸   ENSRNOT00000085573
Ensembl Acc Id: ENSRNOP00000073181   ⟸   ENSRNOT00000078048
Ensembl Acc Id: ENSRNOP00000017227   ⟸   ENSRNOT00000017227
Ensembl Acc Id: ENSRNOP00000077790   ⟸   ENSRNOT00000098444
Ensembl Acc Id: ENSRNOP00000079839   ⟸   ENSRNOT00000100780
RefSeq Acc Id: XP_063144435   ⟸   XM_063288365
- Peptide Label: isoform X2
- UniProtKB: A0A8I5XWI2 (UniProtKB/TrEMBL),   A0A0G2JVB6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106779   ⟸   ENSRNOT00000145273
Protein Domains
t-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7P1-F1-model_v2 AlphaFold G3V7P1 1-274 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694104
Promoter ID:EPDNEW_R4629
Type:initiation region
Name:Stx12_1
Description:syntaxin 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05151,072,823 - 151,072,883EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620977 AgrOrtholog
BioCyc Gene G2FUF-39654 BioCyc
Ensembl Genes ENSRNOG00000011804 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017227 ENTREZGENE
  ENSRNOT00000017227.5 UniProtKB/Swiss-Prot
  ENSRNOT00000085573 ENTREZGENE
  ENSRNOT00000145273 ENTREZGENE
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot
  1.20.58.70 UniProtKB/Swiss-Prot
InterPro SNARE UniProtKB/Swiss-Prot
  Syntaxin UniProtKB/Swiss-Prot
  Syntaxin/epimorphin_CS UniProtKB/Swiss-Prot
  Syntaxin_N UniProtKB/Swiss-Prot
  T_SNARE_dom UniProtKB/Swiss-Prot
KEGG Report rno:65033 UniProtKB/Swiss-Prot
NCBI Gene 65033 ENTREZGENE
PANTHER PTHR19957 UniProtKB/Swiss-Prot
  SYNTAXIN-12 UniProtKB/Swiss-Prot
Pfam SNARE UniProtKB/Swiss-Prot
  Syntaxin_2 UniProtKB/Swiss-Prot
PhenoGen Stx12 PhenoGen
PROSITE SYNTAXIN UniProtKB/Swiss-Prot
  T_SNARE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011804 RatGTEx
SMART SynN UniProtKB/Swiss-Prot
  t_SNARE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47661 UniProtKB/Swiss-Prot
UniProt A0A0G2JVB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K4U8_RAT UniProtKB/TrEMBL
  A0A8I5XWI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZND6_RAT UniProtKB/TrEMBL
  A0ABK0LX74_RAT UniProtKB/TrEMBL
  G3V7P1 ENTREZGENE
  O70319 ENTREZGENE
  O88385 ENTREZGENE
  STX12_RAT UniProtKB/Swiss-Prot
UniProt Secondary O70319 UniProtKB/Swiss-Prot
  O88385 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Stx12  syntaxin 12      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Stx12  syntaxin 12      Symbol and Name status set to provisional 70820 PROVISIONAL