Pdcd4 (programmed cell death 4) - Rat Genome Database

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Gene: Pdcd4 (programmed cell death 4) Rattus norvegicus
Analyze
Symbol: Pdcd4
Name: programmed cell death 4
RGD ID: 620816
Description: Predicted to enable RNA binding activity. Involved in several processes, including epithelial to mesenchymal transition involved in cardiac fibroblast development; regulation of apoptotic process; and response to alkaloid. Located in nucleus. Orthologous to human PDCD4 (programmed cell death 4); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: death up-regulated gene protein; death-upregulated; death-upregulated gene; Dug; programmed cell death protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   F344.GK-(D1Swe8-D1Gpam-1)/Swe  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81262,912,659 - 262,949,581 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1262,926,656 - 262,950,189 (+)EnsemblGRCr8
mRatBN7.21252,921,342 - 252,944,278 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1252,921,392 - 252,944,275 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1261,114,567 - 261,132,951 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,820,643 - 267,839,027 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01260,475,980 - 260,494,373 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01274,616,625 - 274,648,204 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,625,224 - 274,648,204 (+)Ensemblrn6Rnor6.0
Rnor_5.01282,029,865 - 282,061,732 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41260,183,648 - 260,202,032 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1248,639,428 - 248,657,812 (+)NCBICelera
RGSC_v3.11260,394,692 - 260,413,077 (+)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(-)-citrinin  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-mannitol  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
erianin  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
fenhexamid  (ISO)
fenthion  (ISO)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
fludioxonil  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
maslinic acid  (ISO)
mechlorethamine  (ISO)
melatonin  (EXP)
menadione  (ISO)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (EXP)
motexafin gadolinium  (ISO)
mycophenolic acid  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
niclosamide  (ISO)
nifedipine  (ISO)
nimesulide  (EXP)
NS-398  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
oxycodone  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
scopolamine  (EXP)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
T-2 toxin  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
tolbutamide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
Tungsten carbide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (IBA,IEA,ISO,ISS)
nucleus  (IBA,IDA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1. Bronnum H, etal., PLoS One. 2013;8(2):e56280. doi: 10.1371/journal.pone.0056280. Epub 2013 Feb 18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. DUG is a novel homologue of translation initiation factor 4G that binds eIF4A. Goke A, etal., Biochem Biophys Res Commun 2002 Sep 13;297(1):78-82.
4. Expression and clinicopathological significance of microRNA-21 and programmed cell death 4 in malignant melanoma. Jiao J, etal., J Int Med Res. 2015 Oct;43(5):672-8. doi: 10.1177/0300060515583707. Epub 2015 Jul 6.
5. An essential role of PDCD4 in vascular smooth muscle cell apoptosis and proliferation: implications for vascular disease. Liu X, etal., Am J Physiol Cell Physiol. 2010 Jun;298(6):C1481-8. doi: 10.1152/ajpcell.00413.2009. Epub 2010 Mar 31.
6. Berberine regulates the microRNA-21-ITGΒ4-PDCD4 axis and inhibits colon cancer viability. Lü Y, etal., Oncol Lett. 2018 Apr;15(4):5971-5976. doi: 10.3892/ol.2018.7997. Epub 2018 Feb 8.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Identifying Involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in Treating Pulmonary Hypertension with Melatonin. Wang R, etal., Mol Ther Nucleic Acids. 2018 Dec 7;13:44-54. doi: 10.1016/j.omtn.2018.08.015. Epub 2018 Aug 24.
12. Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats. Zargar S, etal., Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E986-92. doi: 10.1152/ajpendo.00642.2010. Epub 2011 Mar 15.
Additional References at PubMed
PMID:12054647   PMID:12477932   PMID:15062553   PMID:16357133   PMID:17114484   PMID:18548003   PMID:18850008   PMID:19158092   PMID:19946272   PMID:20219857   PMID:20533548   PMID:20871477  
PMID:22757755   PMID:24405715   PMID:24646523   PMID:24732886   PMID:25097194   PMID:26621219   PMID:26659076   PMID:27231854   PMID:27336721   PMID:27832626   PMID:28522568   PMID:28656242  
PMID:28750063   PMID:28807003   PMID:28899909   PMID:29241069   PMID:30861181   PMID:31210325   PMID:31253757   PMID:31870893   PMID:32308118   PMID:32371529   PMID:32747606   PMID:33610591  
PMID:33831322   PMID:34506261   PMID:35051553   PMID:37549728  


Genomics

Comparative Map Data
Pdcd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81262,912,659 - 262,949,581 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1262,926,656 - 262,950,189 (+)EnsemblGRCr8
mRatBN7.21252,921,342 - 252,944,278 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1252,921,392 - 252,944,275 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1261,114,567 - 261,132,951 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,820,643 - 267,839,027 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01260,475,980 - 260,494,373 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01274,616,625 - 274,648,204 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,625,224 - 274,648,204 (+)Ensemblrn6Rnor6.0
Rnor_5.01282,029,865 - 282,061,732 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41260,183,648 - 260,202,032 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1248,639,428 - 248,657,812 (+)NCBICelera
RGSC_v3.11260,394,692 - 260,413,077 (+)NCBI
Cytogenetic Map1q55NCBI
PDCD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810110,871,928 - 110,900,006 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10110,871,795 - 110,900,006 (+)Ensemblhg38GRCh38
GRCh3710112,631,686 - 112,659,764 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,621,586 - 112,649,754 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410112,621,585 - 112,649,753NCBI
Celera10106,363,204 - 106,391,372 (+)NCBICelera
Cytogenetic Map10q25.2NCBI
HuRef10106,260,410 - 106,288,621 (+)NCBIHuRef
CHM1_110112,913,378 - 112,941,587 (+)NCBICHM1_1
T2T-CHM13v2.010111,755,712 - 111,783,789 (+)NCBIT2T-CHM13v2.0
Pdcd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391953,880,662 - 53,926,024 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1953,880,662 - 53,918,291 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381953,892,231 - 53,937,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1953,892,231 - 53,929,860 (+)Ensemblmm10GRCm38
MGSCv371953,966,721 - 54,004,351 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361953,956,779 - 53,983,162 (+)NCBIMGSCv36mm8
Celera1956,087,143 - 56,124,829 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1948.73NCBI
Pdcd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955485529,860 - 553,601 (-)Ensembl
ChiLan1.0NW_004955485530,642 - 553,508 (-)NCBIChiLan1.0ChiLan1.0
PDCD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28122,752,649 - 122,779,571 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110122,754,657 - 122,784,907 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010107,465,084 - 107,493,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110110,914,222 - 110,942,394 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10110,914,222 - 110,942,394 (+)EnsemblpanPan2panpan1.1
PDCD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12822,198,274 - 22,227,184 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2822,198,322 - 22,226,717 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2822,350,385 - 22,379,252 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02822,722,838 - 22,751,713 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2822,722,897 - 22,752,395 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12822,282,298 - 22,310,940 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02822,289,098 - 22,317,724 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02822,423,221 - 22,451,894 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pdcd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721323,855,886 - 23,877,135 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364861,684,135 - 1,705,715 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364861,684,167 - 1,705,387 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDCD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14121,305,629 - 121,338,740 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114121,271,824 - 121,334,767 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214132,232,416 - 132,261,645 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDCD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19103,809,005 - 103,836,402 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9103,813,211 - 103,836,002 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604865,014,586 - 65,042,439 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdcd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473735,414,078 - 35,451,023 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pdcd4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1253,344,434 - 53,367,464 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir21rno-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19158092
Mir21rno-miR-21-5pMirtarbaseexternal_infoWestern blot//qRT-PCR//GFP reporter assay//LuciferFunctional MTI19336275
Mir21rno-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI19167416
Mir21rno-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI21154462
Mir21rno-miR-21-5pMirtarbaseexternal_infoImmunocytochemistry//Immunofluorescence//LuciferasFunctional MTI22565856

Predicted Target Of
Summary Value
Count of predictions:480
Count of miRNA genes:202
Interacting mature miRNAs:241
Transcripts:ENSRNOT00000020155, ENSRNOT00000059153
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat

Markers in Region
RH133731  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81262,948,736 - 262,949,555 (+)Marker Load Pipeline
mRatBN7.21252,943,433 - 252,944,252 (+)MAPPERmRatBN7.2
Rnor_6.01274,647,363 - 274,648,181NCBIRnor6.0
Rnor_5.01282,060,891 - 282,061,709UniSTSRnor5.0
RGSC_v3.41260,201,992 - 260,202,810UniSTSRGSC3.4
Celera1248,657,772 - 248,658,590UniSTS
RH 3.4 Map11673.1UniSTS
Cytogenetic Map1q55UniSTS
BE112877  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21252,942,920 - 252,943,124 (+)MAPPERmRatBN7.2
Rnor_6.01274,646,850 - 274,647,053NCBIRnor6.0
Rnor_5.01282,060,378 - 282,060,581UniSTSRnor5.0
RGSC_v3.41260,201,479 - 260,201,682UniSTSRGSC3.4
Celera1248,657,259 - 248,657,462UniSTS
RH 3.4 Map11685.2UniSTS
Cytogenetic Map1q55UniSTS


Related Rat Strains
The following Strains have been annotated to Pdcd4
F344.GK-(D1Swe8-D1Gpam-1)/Swe    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_351142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF239739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC167751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000020155   ⟹   ENSRNOP00000020155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,926,656 - 262,949,580 (+)Ensembl
mRatBN7.2 Ensembl1252,921,447 - 252,944,275 (+)Ensembl
Rnor_6.0 Ensembl1274,625,224 - 274,648,204 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097657   ⟹   ENSRNOP00000091790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,926,676 - 262,949,578 (+)Ensembl
mRatBN7.2 Ensembl1252,921,392 - 252,944,275 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104317   ⟹   ENSRNOP00000076788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,927,135 - 262,950,189 (+)Ensembl
mRatBN7.2 Ensembl1252,926,673 - 252,944,275 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119971   ⟹   ENSRNOP00000076366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,927,131 - 262,949,579 (+)Ensembl
mRatBN7.2 Ensembl1252,921,392 - 252,944,275 (+)Ensembl
RefSeq Acc Id: NM_022265   ⟹   NP_071601
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,926,695 - 262,949,581 (+)NCBI
mRatBN7.21252,921,391 - 252,944,278 (+)NCBI
Rnor_6.01274,629,019 - 274,647,403 (+)NCBI
Rnor_5.01282,029,865 - 282,061,732 (+)NCBI
RGSC_v3.41260,183,648 - 260,202,032 (+)RGD
Celera1248,639,428 - 248,657,812 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231615   ⟹   XP_006231677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,926,843 - 262,949,581 (+)NCBI
mRatBN7.21252,921,750 - 252,944,275 (+)NCBI
Rnor_6.01274,625,710 - 274,648,204 (+)NCBI
Rnor_5.01282,029,865 - 282,061,732 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231616   ⟹   XP_006231678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,926,860 - 262,949,581 (+)NCBI
mRatBN7.21252,921,726 - 252,944,275 (+)NCBI
Rnor_6.01274,625,703 - 274,648,204 (+)NCBI
Rnor_5.01282,029,865 - 282,061,732 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063272661   ⟹   XP_063128731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,929,829 - 262,949,581 (+)NCBI
RefSeq Acc Id: XM_063272662   ⟹   XP_063128732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,926,842 - 262,949,581 (+)NCBI
RefSeq Acc Id: XM_063272663   ⟹   XP_063128733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,912,659 - 262,949,581 (+)NCBI
RefSeq Acc Id: XR_010056939
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,926,884 - 262,949,581 (+)NCBI
RefSeq Acc Id: XR_010056940
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,926,842 - 262,949,581 (+)NCBI
RefSeq Acc Id: XR_010056941
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,927,051 - 262,949,581 (+)NCBI
RefSeq Acc Id: XR_010056942
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,926,886 - 262,949,581 (+)NCBI
RefSeq Acc Id: XR_010056946
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,912,659 - 262,949,581 (+)NCBI
RefSeq Acc Id: XR_351142
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,926,645 - 262,949,581 (+)NCBI
mRatBN7.21252,921,342 - 252,944,278 (+)NCBI
Rnor_6.01274,625,131 - 274,648,204 (+)NCBI
Rnor_5.01282,029,865 - 282,061,732 (+)NCBI
Sequence:
RefSeq Acc Id: NP_071601   ⟸   NM_022265
- UniProtKB: Q9JID1 (UniProtKB/Swiss-Prot),   B3DM93 (UniProtKB/TrEMBL),   A0A8L2QAG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231678   ⟸   XM_006231616
- Peptide Label: isoform X1
- UniProtKB: Q9JID1 (UniProtKB/Swiss-Prot),   B3DM93 (UniProtKB/TrEMBL),   A0A8L2QAG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231677   ⟸   XM_006231615
- Peptide Label: isoform X1
- UniProtKB: Q9JID1 (UniProtKB/Swiss-Prot),   B3DM93 (UniProtKB/TrEMBL),   A0A8L2QAG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020155   ⟸   ENSRNOT00000020155
Ensembl Acc Id: ENSRNOP00000076788   ⟸   ENSRNOT00000104317
Ensembl Acc Id: ENSRNOP00000091790   ⟸   ENSRNOT00000097657
Ensembl Acc Id: ENSRNOP00000076366   ⟸   ENSRNOT00000119971
RefSeq Acc Id: XP_063128733   ⟸   XM_063272663
- Peptide Label: isoform X1
- UniProtKB: Q9JID1 (UniProtKB/Swiss-Prot),   B3DM93 (UniProtKB/TrEMBL),   A0A8L2QAG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128732   ⟸   XM_063272662
- Peptide Label: isoform X1
- UniProtKB: Q9JID1 (UniProtKB/Swiss-Prot),   B3DM93 (UniProtKB/TrEMBL),   A0A8L2QAG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128731   ⟸   XM_063272661
- Peptide Label: isoform X1
- UniProtKB: Q9JID1 (UniProtKB/Swiss-Prot),   B3DM93 (UniProtKB/TrEMBL),   A0A8L2QAG2 (UniProtKB/TrEMBL)
Protein Domains
MI

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JID1-F1-model_v2 AlphaFold Q9JID1 1-469 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690995
Promoter ID:EPDNEW_R1519
Type:multiple initiation site
Name:Pdcd4_1
Description:programmed cell death 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01274,625,258 - 274,625,318EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620816 AgrOrtholog
BioCyc Gene G2FUF-55376 BioCyc
Ensembl Genes ENSRNOG00000014779 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020155 ENTREZGENE
  ENSRNOT00000097657.1 UniProtKB/Swiss-Prot
  ENSRNOT00000119971 ENTREZGENE
  ENSRNOT00000119971.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.180 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9027822 IMAGE-MGC_LOAD
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  Initiation_fac_eIF4g_MI UniProtKB/Swiss-Prot
  PDCD4 UniProtKB/Swiss-Prot
KEGG Report rno:64031 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187330 IMAGE-MGC_LOAD
NCBI Gene 64031 ENTREZGENE
PANTHER PROGRAMMED CELL DEATH PROTEIN 4 UniProtKB/Swiss-Prot
  PTHR12626 UniProtKB/Swiss-Prot
Pfam MA3 UniProtKB/Swiss-Prot
PhenoGen Pdcd4 PhenoGen
PROSITE PS51366 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014779 RatGTEx
SMART MA3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
UniProt A0A8I5Y727_RAT UniProtKB/TrEMBL
  A0A8L2QAG2 ENTREZGENE, UniProtKB/TrEMBL
  B3DM93 ENTREZGENE, UniProtKB/TrEMBL
  PDCD4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Pdcd4  programmed cell death 4      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Pdcd4  programmed cell death 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains two nuclear localization signals, several protein kinase phosphorylation sites, and two MA3 domains 633555
gene_expression displays increased expression in apoptotic cells 633555