Fgfr1 (Fibroblast growth factor receptor 1) - Rat Genome Database

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Gene: Fgfr1 (Fibroblast growth factor receptor 1) Rattus norvegicus
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Symbol: Fgfr1
Name: Fibroblast growth factor receptor 1
RGD ID: 620713
Description: Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including cellular response to histamine; neuron development; and positive regulation of cell population proliferation. Located in perinuclear region of cytoplasm. Used to study pulmonary hypertension. Biomarker of several diseases, including ischemia (multiple); mesangial proliferative glomerulonephritis; retinal detachment; sciatic neuropathy; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1); PARTICIPATES IN cerium oxide nanoparticle response pathway; fibroblast growth factor signaling pathway; glypican signaling pathway; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2-amino-2-deoxy-D-glucopyranose; 3,3',5-triiodo-L-thyronine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: basic fibroblast growth factor receptor 1; bFGF-R; bFGF-R-1; c-fgr; FGF receptor-1; FGFR-1; MFR; proto-oncogene c-Fgr
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Fgfr1-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,194,631 - 73,249,855 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1673,194,631 - 73,249,855 (-)EnsemblGRCr8
mRatBN7.21666,491,930 - 66,547,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,494,042 - 66,547,350 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1671,773,130 - 71,812,564 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,179,067 - 75,218,502 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,419,796 - 70,459,385 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,265,390 - 71,319,046 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,266,248 - 71,319,449 (-)Ensemblrn6Rnor6.0
Rnor_5.01670,924,716 - 70,977,998 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41670,869,974 - 70,910,045 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1664,402,647 - 64,442,189 (-)NCBICelera
RGSC_v3.11670,870,238 - 70,910,310 (-)NCBI
Cytogenetic Map16q12.4NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acrocephalosyndactylia  (ISO)
acute myeloid leukemia  (ISO)
Acute Otitis Media  (ISO)
Alzheimer's disease  (ISO)
amenorrhea  (ISO)
atypical chronic myeloid leukemia, BCR-ABL1 negative  (ISO)
Breast Neoplasms  (ISO)
Burns  (IEP)
cerebellar hypoplasia  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Congenital Foot Deformities  (ISO)
Craniofacial Abnormalities  (ISO)
craniosynostosis  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Delayed Puberty  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
Desbuquois dysplasia  (ISO)
Encephalocraniocutaneous Lipomatosis  (ISO)
Experimental Arthritis  (ISO)
Experimental Leukemia  (ISO)
Experimental Liver Cirrhosis  (IMP)
Experimental Seizures  (IEP)
Femoral Fractures  (IEP)
fibrolamellar carcinoma  (ISO)
genetic disease  (ISO)
heart valve disease  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
holoprosencephaly  (ISO)
Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip/Palate  (ISO)
Hypoglossal Nerve Injuries  (IEP)
hypogonadotropic hypogonadism  (ISO)
hypogonadotropic hypogonadism 2 with or without anosmia  (ISO)
hypogonadotropic hypogonadism 7 with or without anosmia  (ISO)
Hypogonadotropic Hypogonadism and Anosmia, Autosomal Dominant  (ISO)
infertility  (ISO)
Jackson-Weiss syndrome  (ISO)
Kallmann syndrome  (ISO)
Klinefelter syndrome  (ISO)
limb ischemia  (IEP)
Liver Metastasis  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
malignant astrocytoma  (ISO)
Martsolf syndrome 1  (ISO)
mesangial proliferative glomerulonephritis  (IEP)
metabolic dysfunction-associated steatotic liver disease  (ISO)
mouth disease  (IEP)
myeloid leukemia  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
Neointima  (IDA)
Neoplasm Metastasis  (ISO)
obesity  (IEP,ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
osteoglophonic dysplasia  (ISO)
otitis media  (ISS)
Penetrating Head Injuries  (IEP)
Pfeiffer syndrome  (ISO,ISS)
pilomyxoid astrocytoma  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
pulmonary hypertension  (IMP)
renal cell carcinoma  (ISO)
retinal detachment  (IEP)
rosette-forming glioneuronal tumor  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (IEP)
squamous cell carcinoma  (ISO)
Stargardt Disease 3  (ISO)
steatotic liver disease  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
transient cerebral ischemia  (IEP)
Trigonocephaly 1  (ISO)
Tympanic Membrane Perforation  (IMP)
type 2 diabetes mellitus  (ISO)
umbilical hernia  (ISO)
vascular dementia  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
AP20187  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (EXP)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
clothianidin  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cycloheximide  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dieldrin  (EXP)
dimethylarsinous acid  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
escitalopram  (EXP)
ethanol  (EXP,ISO)
ethyl trans-caffeate  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
heparan sulfate  (ISO)
heparin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
kainic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lenalidomide  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
okadaic acid  (ISO)
orantinib  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
PD-166866  (EXP,ISO)
PD173074  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
peroxynitrous acid  (EXP)
piperine  (ISO)
pirinixic acid  (EXP)
pomalidomide  (ISO)
ponatinib  (ISO)
resveratrol  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
urea  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ development  (IEA)
auditory receptor cell development  (ISO)
blood vessel morphogenesis  (ISO)
brain development  (ISO)
branching involved in salivary gland morphogenesis  (ISO)
calcium ion homeostasis  (IEA,ISO)
cell maturation  (ISO)
cell projection assembly  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to growth factor stimulus  (IEA)
cellular response to histamine  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cementum mineralization  (IEA,ISO)
central nervous system neuron development  (IMP)
chondrocyte differentiation  (ISO)
diphosphate metabolic process  (IEA,ISO)
ear development  (ISO)
embryonic limb morphogenesis  (ISO)
epithelial to mesenchymal transition  (ISO)
female pregnancy  (IEP)
fibroblast growth factor receptor signaling pathway  (IBA,IEA,ISO,ISS)
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development  (IEA,ISO)
forebrain generation of neurons  (IEA)
gene expression  (IEA,ISO)
generation of neurons  (ISO)
in utero embryonic development  (ISO)
inner ear morphogenesis  (ISO)
lung development  (ISO)
lung-associated mesenchyme development  (ISO)
mesenchymal cell differentiation  (ISO)
midbrain development  (ISO)
middle ear morphogenesis  (ISO)
negative regulation of fibroblast growth factor production  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of osteoblast differentiation  (IMP)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuron projection development  (IDA)
orbitofrontal cortex development  (IEA,ISO)
organ induction  (ISO)
outer ear morphogenesis  (ISO)
paraxial mesoderm development  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cardiac muscle cell proliferation  (IEA,IMP,ISO)
positive regulation of cell cycle  (IEA,ISO)
positive regulation of cell differentiation  (IBA)
positive regulation of cell population proliferation  (IBA,IEA,ISO,ISS)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of fibroblast migration  (IMP)
positive regulation of hepatic stellate cell activation  (IMP)
positive regulation of macromolecule metabolic process  (IEA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of mesenchymal cell proliferation  (IEA,IMP,ISO)
positive regulation of mitotic cell cycle DNA replication  (ISO)
positive regulation of neuron differentiation  (ISO,ISS)
positive regulation of neuron projection development  (IDA,IEA,IMP,ISO)
positive regulation of parathyroid hormone secretion  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
positive regulation of vascular endothelial cell proliferation  (ISO)
postnatal olfactory bulb interneuron migration  (IMP)
protein autophosphorylation  (ISO,ISS)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (ISO)
regulation of cell population proliferation  (IDA,ISO)
regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
regulation of gene expression  (ISO)
regulation of lateral mesodermal cell fate specification  (ISO)
regulation of phosphate transport  (ISO)
regulation of phosphorus metabolic process  (ISO)
regulation of postsynaptic density assembly  (IEA,ISO)
regulation of primary metabolic process  (IEA)
regulation of stem cell proliferation  (IEA,IMP)
response to ischemia  (IEP)
response to nutrient levels  (IEP)
response to sodium phosphate  (IEA,ISO)
salivary gland morphogenesis  (ISO)
sensory perception of sound  (ISO)
stem cell population maintenance  (IMP)
tangential migration from the subventricular zone to the olfactory bulb  (IMP)
ureteric bud development  (ISO)
ventricular zone neuroblast division  (IEA,ISO)
vitamin D3 metabolic process  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition. Acevedo VD, etal., Cancer Cell. 2007 Dec;12(6):559-71.
2. The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site. Bae JH, etal., Cell. 2009 Aug 7;138(3):514-24. doi: 10.1016/j.cell.2009.05.028.
3. Variable expressivity of pfeiffer syndrome in a family with FGFR1 p.Pro252Arg mutation. Bessenyei B, etal., Am J Med Genet A. 2014 Dec;164A(12):3176-9. doi: 10.1002/ajmg.a.36774. Epub 2014 Sep 23.
4. Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Borroto-Escuela DO, etal., Biochem Biophys Res Commun. 2015 Jan 2;456(1):489-93. doi: 10.1016/j.bbrc.2014.11.112. Epub 2014 Dec 6.
5. Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity. Borroto-Escuela DO, etal., Biol Psychiatry. 2012 Jan 1;71(1):84-91. doi: 10.1016/j.biopsych.2011.09.012. Epub 2011 Oct 27.
6. The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity. Borroto-Escuela DO, etal., J Neurosci. 2012 May 2;32(18):6295-303. doi: 10.1523/JNEUROSCI.4203-11.2012.
7. PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder. Chen J, etal., Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14479-84. Epub 2004 Sep 24.
8. FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression. Chen PY, etal., J Biol Chem. 2009 Jun 5;284(23):15980-92. Epub 2009 Apr 1.
9. FGFR1-IIIb is a putative marker of pancreatic progenitor cells. Cras-Meneur C and Scharfmann R, Mech Dev 2002 Aug;116(1-2):205-8.
10. Heparan sulfate mediates the proliferation and differentiation of rat mesenchymal stem cells. Dombrowski C, etal., Stem Cells Dev. 2009 May;18(4):661-70.
11. Dynamic roles of FGF-2 and Anosmin-1 in the migration of neuronal precursors from the subventricular zone during pre- and postnatal development. Garcia-Gonzalez D, etal., Exp Neurol. 2010 Apr;222(2):285-95. Epub 2010 Jan 18.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Expression of fibroblast growth factor-2 and fibroblast growth factor receptor 1 messenger RNAs in spinal ganglia and sciatic nerve: regulation after peripheral nerve lesion. Grothe C, etal., Neuroscience. 1997 Jan;76(1):123-35.
15. FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice. Guasch G, etal., Blood. 2004 Jan 1;103(1):309-12. Epub 2003 Sep 11.
16. Fibroblast growth factor (FGF) soluble receptor 1 acts as a natural inhibitor of FGF2 neurotrophic activity during retinal degeneration. Guillonneau X, etal., Mol Biol Cell 1998 Oct;9(10):2785-802.
17. Decreased expression of FGFR1, SOS1, RAF1 genes in cryptorchidism. Hadziselimovic NO, etal., Urol Int. 2010;84(3):353-61. doi: 10.1159/000288242. Epub 2010 Apr 13.
18. The impact of FGFR1 and FRS2alpha expression on sorafenib treatment in metastatic renal cell carcinoma. Ho TH, etal., BMC Cancer. 2015 Apr 18;15:304. doi: 10.1186/s12885-015-1302-1.
19. 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. Hu Y, etal., J Biol Chem. 2004 Jul 9;279(28):29325-35. Epub 2004 Apr 26.
20. miR-22 inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction. Hu Y, etal., JHEP Rep. 2020 Feb 18;2(2):100093. doi: 10.1016/j.jhepr.2020.100093. eCollection 2020 Apr.
21. Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis. Huang X, etal., Cancer Res. 2006 Feb 1;66(3):1481-90. doi: 10.1158/0008-5472.CAN-05-2412.
22. Expression of fibroblast growth factor-2 in hypoglossal motoneurons is stimulated by peripheral nerve injury. Huber K, etal., J Comp Neurol. 1997 Jun 2;382(2):189-98.
23. A molecular signature predictive of indolent prostate cancer. Irshad S, etal., Sci Transl Med. 2013 Sep 11;5(202):202ra122. doi: 10.1126/scitranslmed.3006408.
24. Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. Izikki M, etal., J Clin Invest. 2009 Mar;119(3):512-23. doi: 10.1172/JCI35070. Epub 2009 Feb 9.
25. Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity. Jiao H, etal., J Clin Endocrinol Metab. 2011 Jun;96(6):E962-6. doi: 10.1210/jc.2010-2639. Epub 2011 Mar 23.
26. Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite. Jiao J, etal., Arch Biochem Biophys 2003 Feb 15;410(2):187-200.
27. Expression of the fibroblast growth factor receptor 1-4 genes in glomeruli in anti-Thy1.1 mesangial proliferative glomerulonephritis. Jyo-Oshiro Y, etal., Virchows Arch. 1999 Nov;435(5):501-8.
28. Inhibition of fibroblast growth factor receptor 1: influence on tympanic membrane wound healing in rats. Kaftan H, etal., Eur Arch Otorhinolaryngol. 2012 Jan;269(1):87-92. doi: 10.1007/s00405-011-1627-6. Epub 2011 May 18.
29. Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia. Kentsis A, etal., Nat Med. 2012 Jul;18(7):1118-22. doi: 10.1038/nm.2819.
30. Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin. Kirschbaum K, etal., J Biol Chem. 2009 Oct 16;284(42):28533-42. Epub 2009 Aug 7.
31. Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Kiselyov VV, etal., Structure (Camb) 2003 Jun;11(6):691-701.
32. Differential gene expression in eyecup and retina of a mouse model of Stargardt-like macular dystrophy (STGD3). Kuny S, etal., Invest Ophthalmol Vis Sci. 2012 Feb 13;53(2):664-75. doi: 10.1167/iovs.11-8418.
33. FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis. Kuo CH, etal., Cardiovasc Res. 2015 Jan 1;105(1):107-17. doi: 10.1093/cvr/cvu239. Epub 2014 Nov 10.
34. Idiopathic hypogonadotropic hypogonadism in a mother and her monozygotic twins born after a single embryo transfer. Laitinen EM, etal., Fertil Steril. 2010 Apr;93(6):2074.e13-6. doi: 10.1016/j.fertnstert.2009.11.013. Epub 2010 Jan 15.
35. Fibroblast growth factor receptor-1 signaling induces osteopontin expression and vascular smooth muscle cell-dependent adventitial fibroblast migration in vitro. Li G, etal., Circulation. 2002 Aug 13;106(7):854-9.
36. NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats. Lin N, etal., Am J Physiol Cell Physiol. 2011 Aug;301(2):C469-77. doi: 10.1152/ajpcell.00452.2010. Epub 2011 May 4.
37. Increased expression and nuclear accumulation of basic fibroblast growth factor in primary cultured astrocytes following ischemic-like insults. Liu X and Zhu XZ, Brain Res Mol Brain Res. 1999 Aug 25;71(2):171-7.
38. Fibroblast growth factor receptor 1 antagonism attenuates lipopolysaccharide-induced activation of hepatic stellate cells via suppressing inflammation. Lou D, etal., Exp Ther Med. 2018 Oct;16(4):2909-2916. doi: 10.3892/etm.2018.6586. Epub 2018 Aug 7.
39. FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. Lu R, etal., J Lipid Res. 2009 Jun;50(6):1156-64. doi: 10.1194/jlr.M800594-JLR200. Epub 2009 Feb 19.
40. Inhibition of accelerated graft arteriosclerosis by gene transfer of soluble fibroblast growth factor receptor-1 in rat aortic transplants. Luo W, etal., Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1081-6. Epub 2004 Apr 8.
41. Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells. Ma DK, etal., Mol Brain. 2009 Jun 8;2(1):16.
42. Self-renewing and differentiating properties of cortical neural stem cells are selectively regulated by basic fibroblast growth factor (FGF) signaling via specific FGF receptors. Maric D, etal., J Neurosci. 2007 Feb 21;27(8):1836-52.
43. Selective induction of fibroblast growth factor receptor-1 mRNA after transient focal ischemia in the cerebral cortex of rats. Masumura M, etal., Neurosci Lett. 1996 Aug 2;213(2):119-22.
44. Fibroblast growth factor receptor 1 in the adrenal gland and PC12 cells: developmental expression and regulation by extrinsic molecules. Meisinger C, etal., Brain Res Mol Brain Res. 1996 Feb;36(1):70-8.
45. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. Messersmith DJ, etal., J Neurosci Res. 2000 Oct 15;62(2):241-56.
46. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
47. Histamine up-regulates fibroblast growth factor receptor 1 and increases FOXP2 neurons in cultured neural precursors by histamine type 1 receptor activation: conceivable role of histamine in neurogenesis during cortical development in vivo. Molina-Hernandez A, etal., Neural Dev. 2013 Mar 7;8:4. doi: 10.1186/1749-8104-8-4.
48. A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Muenke M, etal., Nat Genet. 1994 Nov;8(3):269-74.
49. Spatial and temporal gene expression for fibroblast growth factor type I receptor (FGFR1) during fracture healing in the rat. Nakajima A, etal., Bone. 2001 Nov;29(5):458-66.
50. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
51. Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation. Nichol PF, etal., J Pediatr Surg. 2011 Jan;46(1):90-6. doi: 10.1016/j.jpedsurg.2010.09.066.
52. Correlation of growth factor receptor expression with clinical growth in vestibular schwannomas. O'Reilly BF, etal., Otol Neurotol. 2004 Sep;25(5):791-6.
53. Accelerating effects of basic fibroblast growth factor on wound healing of rat palatal mucosa. Oda Y, etal., J Oral Maxillofac Surg. 2004 Jan;62(1):73-80.
54. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
55. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
56. 1,25-Dihydroxyvitamin D(3) and extracellular inorganic phosphate activate mitogen-activated protein kinase pathway through fibroblast growth factor 23 contributing to hypertrophy and mineralization in osteoarthritic chondrocytes. Orfanidou T, etal., Exp Biol Med (Maywood). 2012 Mar;237(3):241-53. doi: 10.1258/ebm.2011.011301. Epub 2012 Mar 5.
57. Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor. Owczarek S, etal., FASEB J. 2010 Apr;24(4):1139-50. Epub 2009 Dec 1.
58. Rapid upregulation of fibroblast growth factor receptor 1 (flg) by rat photoreceptor cells after injury. Ozaki S, etal., Invest Ophthalmol Vis Sci. 2000 Feb;41(2):568-79.
59. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
60. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
61. Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism. Pitteloud N, etal., J Clin Invest. 2007 Feb;117(2):457-63. Epub 2007 Jan 18.
62. Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes. Pitteloud N, etal., Mol Cell Endocrinol. 2006 Jul 25;254-255:60-9. Epub 2006 Jun 9.
63. Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Pitteloud N, etal., Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6281-6. Epub 2006 Apr 10.
64. Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes. Purushothaman R, etal., Birth Defects Res A Clin Mol Teratol. 2011 Jul;91(7):603-9. doi: 10.1002/bdra.20811. Epub 2011 Apr 28.
65. Investigation of FGF1 and FGFR gene polymorphisms in a group of Iranian patients with nonsyndromic cleft lip with or without cleft palate. Rafiqdoost Z, etal., Int J Pediatr Otorhinolaryngol. 2014 May;78(5):731-6. doi: 10.1016/j.ijporl.2014.01.024. Epub 2014 Jan 27.
66. Genetic fingerprinting of the development and progression of T-cell lymphoma in a murine model of atypical myeloproliferative disorder initiated by the ZNF198-fibroblast growth factor receptor-1 chimeric tyrosine kinase. Ren M, etal., Blood. 2009 Aug 20;114(8):1576-84. doi: 10.1182/blood-2009-03-212704. Epub 2009 Jun 8.
67. Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models. Ren M, etal., Blood. 2013 Aug 8;122(6):1007-16. doi: 10.1182/blood-2013-03-489823. Epub 2013 Jun 18.
68. Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice. Ren M, etal., Int J Cancer. 2016 Aug 15;139(4):836-40. doi: 10.1002/ijc.30100. Epub 2016 May 4.
69. Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities. Ren M, etal., Leukemia. 2013 Jan;27(1):32-40. doi: 10.1038/leu.2012.188. Epub 2012 Jul 11.
70. GOA pipeline RGD automated data pipeline
71. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
72. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
73. Alternative splicing and differential targeting of fibroblast growth factor receptor 1 in the pregnant rat uterus. Rider V, etal., Endocrinology. 1995 Jul;136(7):3137-45.
74. mTORC1 and FGFR1 signaling in fibrolamellar hepatocellular carcinoma. Riehle KJ, etal., Mod Pathol. 2015 Jan;28(1):103-10. doi: 10.1038/modpathol.2014.78. Epub 2014 Jun 13.
75. Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Roumiantsev S, etal., Cancer Cell. 2004 Mar;5(3):287-98.
76. Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo. Sasaki S, etal., PLoS One. 2011 May 9;6(5):e19618. doi: 10.1371/journal.pone.0019618.
77. Gonadotrophin therapy in Kallmann syndrome caused by heterozygous mutations of the gene for fibroblast growth factor receptor 1: report of three families: case report. Sato N, etal., Hum Reprod. 2005 Aug;20(8):2173-8. Epub 2005 Apr 21.
78. Overexpression of the fibroblast growth factor receptor-1 gene correlates with liver metastasis in colorectal cancer. Sato T, etal., Oncol Rep. 2009 Jan;21(1):211-6.
79. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
80. Fibroblast growth factor receptor 1 gene expression is required for cardiomyocyte proliferation and is repressed by Sp3. Seyed M and Dimario JX, J Mol Cell Cardiol. 2008 Mar;44(3):510-9. doi: 10.1016/j.yjmcc.2007.12.008. Epub 2008 Jan 17.
81. Differential expression of fibroblast growth factor-2 and fibroblast growth factor receptor 1 in a scarring and nonscarring model of CNS injury in the rat. Smith C, etal., Eur J Neurosci. 2001 Feb;13(3):443-56.
82. Fibroblast growth factor receptor-1 expression in the cortex and hippocampus in Alzheimer's disease. Takami K, etal., Brain Res. 1998 Aug 17;802(1-2):89-97.
83. Protein expression of fibroblast growth factor receptor-1 in keratinocytes during wound healing in rat skin. Takenaka H, etal., J Invest Dermatol. 1997 Jul;109(1):108-12.
84. Cellular uptake and activity of heparin functionalised cerium oxide nanoparticles in monocytes. Ting SR, etal., Biomaterials. 2013 Jun;34(17):4377-86. doi: 10.1016/j.biomaterials.2013.02.042. Epub 2013 Mar 7.
85. Fibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancer. Tran TN, etal., Lung Cancer. 2013 Sep;81(3):462-467. doi: 10.1016/j.lungcan.2013.05.015. Epub 2013 Jun 24.
86. Novel fibroblast growth factor receptor 1 mutations in patients with congenital hypogonadotropic hypogonadism with and without anosmia. Trarbach EB, etal., J Clin Endocrinol Metab. 2006 Oct;91(10):4006-12. Epub 2006 Aug 1.
87. FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. Trokovic R, etal., EMBO J 2003 Apr 15;22(8):1811-23.
88. Seizure-associated induction of basic fibroblast growth factor and its receptor in the rat brain. Van Der Wal EA, etal., Neuroscience. 1994 May;60(2):311-23.
89. Congenital hypogonadotropic hypogonadism with split hand/foot malformation: a clinical entity with a high frequency of FGFR1 mutations. Villanueva C, etal., Genet Med. 2015 Aug;17(8):651-9. doi: 10.1038/gim.2014.166. Epub 2014 Nov 13.
90. [Effects of moxibustion on the expressions of hippocampal VEGF, flt-1, bFGF, and bFGF-r in vascular dementia rats]. Wang P, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Jan;32(1):97-101.
91. Dynamic changes in the expression of growth factor receptors in the myocardium microvascular endothelium after murine myocardial infarction. Wang XH, etal., Chin Med J (Engl). 2007 Mar 20;120(6):485-90.
92. Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice. Weng T, etal., Arthritis Rheum. 2012 Dec;64(12):3982-92. doi: 10.1002/art.34645.
93. Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation. White KE, etal., Am J Hum Genet. 2005 Feb;76(2):361-7. Epub 2004 Dec 28.
94. Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Wu AL, etal., Sci Transl Med. 2011 Dec 14;3(113):113ra126. doi: 10.1126/scitranslmed.3002669.
95. A mutation in the fibroblast growth factor receptor 1 gene causes fully penetrant normosmic isolated hypogonadotropic hypogonadism. Xu N, etal., J Clin Endocrinol Metab. 2007 Mar;92(3):1155-8. Epub 2007 Jan 2.
96. Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain. Yamanaka H, etal., Neuroscience. 2007 Nov 30;150(1):202-11. Epub 2007 Aug 29.
97. FGFR1 is essential for prostate cancer progression and metastasis. Yang F, etal., Cancer Res. 2013 Jun 15;73(12):3716-24. doi: 10.1158/0008-5472.CAN-12-3274. Epub 2013 Apr 10.
98. The structure and expression of the FGF receptor-1 mRNA isoforms in rat tissues. Yazaki N, etal., Biochim Biophys Acta 1993 Feb 20;1172(1-2):37-42.
99. Anti-tumor angiogenesis with a recombinant ag43/FGFR1 chimeric protein as a model antigen. Zheng S, etal., J Huazhong Univ Sci Technolog Med Sci. 2010 Feb;30(1):25-8. doi: 10.1007/s11596-010-0105-5. Epub 2010 Feb 14.
100. A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Zhou YX, etal., Hum Mol Genet. 2000 Aug 12;9(13):2001-8.
Additional References at PubMed
PMID:2161540   PMID:8381605   PMID:8622701   PMID:8663044   PMID:10373225   PMID:10830168   PMID:12194867   PMID:12421715   PMID:15576401   PMID:15621532   PMID:15630379   PMID:15695515  
PMID:15929978   PMID:16172976   PMID:16207751   PMID:16417571   PMID:16442091   PMID:16540513   PMID:16778080   PMID:16943278   PMID:17086194   PMID:17186267   PMID:17255109   PMID:17544391  
PMID:17687036   PMID:18187602   PMID:18191119   PMID:18337405   PMID:18480409   PMID:18533146   PMID:18559345   PMID:18586016   PMID:18799682   PMID:18824081   PMID:19103603   PMID:19185025  
PMID:19307307   PMID:19696444   PMID:20133753   PMID:20410112   PMID:20816673   PMID:21389209   PMID:21392510   PMID:21515689   PMID:21575685   PMID:21885851   PMID:23263626   PMID:23382219  
PMID:23564461   PMID:23828126   PMID:23867734   PMID:23874817   PMID:24072480   PMID:24121132   PMID:24157794   PMID:24259513   PMID:24571920   PMID:25907855   PMID:25957476   PMID:26154243  
PMID:26234751   PMID:26311115   PMID:26451614   PMID:26535780   PMID:27015635   PMID:27815219   PMID:28515153   PMID:28813681   PMID:32278061   PMID:33470768   PMID:34685716  


Genomics

Comparative Map Data
Fgfr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,194,631 - 73,249,855 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1673,194,631 - 73,249,855 (-)EnsemblGRCr8
mRatBN7.21666,491,930 - 66,547,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,494,042 - 66,547,350 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1671,773,130 - 71,812,564 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,179,067 - 75,218,502 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,419,796 - 70,459,385 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,265,390 - 71,319,046 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,266,248 - 71,319,449 (-)Ensemblrn6Rnor6.0
Rnor_5.01670,924,716 - 70,977,998 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41670,869,974 - 70,910,045 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1664,402,647 - 64,442,189 (-)NCBICelera
RGSC_v3.11670,870,238 - 70,910,310 (-)NCBI
Cytogenetic Map16q12.4NCBI
FGFR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,411,143 - 38,468,635 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,400,215 - 38,468,834 (-)Ensemblhg38GRCh38
GRCh37838,268,661 - 38,326,153 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,387,813 - 38,445,509 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34838,389,448 - 38,445,293NCBI
Celera837,221,633 - 37,279,334 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,802,638 - 36,860,684 (-)NCBIHuRef
CHM1_1838,470,562 - 38,528,261 (-)NCBICHM1_1
T2T-CHM13v2.0838,688,107 - 38,745,588 (-)NCBIT2T-CHM13v2.0
Fgfr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,008,808 - 26,067,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,003,670 - 26,065,734 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38825,518,759 - 25,575,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,513,654 - 25,575,718 (+)Ensemblmm10GRCm38
MGSCv37826,629,244 - 26,686,186 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36826,997,826 - 27,039,466 (+)NCBIMGSCv36mm8
Celera826,986,822 - 27,044,074 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.12NCBI
Fgfr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546314,013,247 - 14,064,111 (-)Ensembl
ChiLan1.0NW_00495546314,013,247 - 14,064,354 (-)NCBIChiLan1.0ChiLan1.0
FGFR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2756,974,947 - 57,034,140 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,691,569 - 32,751,015 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,713,133 - 37,773,098 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,890,147 - 34,948,904 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,890,147 - 34,948,904 (-)EnsemblpanPan2panpan1.1
FGFR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,029,902 - 27,080,514 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,031,588 - 27,078,261 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1627,547,259 - 27,597,845 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01628,928,146 - 28,978,790 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1628,927,382 - 28,977,436 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,151,667 - 27,202,222 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01627,728,739 - 27,779,306 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01627,767,626 - 27,818,261 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fgfr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,645,976 - 49,698,868 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,760,089 - 1,815,508 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,760,365 - 1,815,269 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,053,340 - 48,106,724 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11548,053,895 - 48,106,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,216,111 - 55,269,152 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,426,116 - 36,485,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl836,427,110 - 36,485,508 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660525,502,205 - 5,561,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgfr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247805,161,073 - 5,213,870 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247805,161,245 - 5,212,641 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fgfr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11360,918,566 - 60,973,142 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fgfr1
311 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:54
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000029284, ENSRNOT00000050980
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)166241446475736480Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat

Markers in Region
D16Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,502,991 - 66,503,122 (+)MAPPERmRatBN7.2
Rnor_6.01671,275,197 - 71,275,327NCBIRnor6.0
Rnor_5.01670,934,523 - 70,934,653UniSTSRnor5.0
RGSC_v3.41670,878,893 - 70,879,023UniSTSRGSC3.4
Celera1664,411,568 - 64,411,698UniSTS
Cytogenetic Map16q12.4UniSTS
D16Wox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,502,680 - 66,502,881 (+)MAPPERmRatBN7.2
Rnor_6.01671,274,886 - 71,275,086NCBIRnor6.0
Rnor_5.01670,934,212 - 70,934,412UniSTSRnor5.0
RGSC_v3.41670,878,582 - 70,878,782UniSTSRGSC3.4
Celera1664,411,255 - 64,411,457UniSTS
Cytogenetic Map16q12.4UniSTS
BF400869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,530,553 - 66,530,745 (+)MAPPERmRatBN7.2
Rnor_6.01671,303,253 - 71,303,444NCBIRnor6.0
Rnor_5.01670,962,205 - 70,962,396UniSTSRnor5.0
RGSC_v3.41670,906,999 - 70,907,190UniSTSRGSC3.4
Celera1664,439,143 - 64,439,334UniSTS
RH 3.4 Map16623.8UniSTS
Cytogenetic Map16q12.4UniSTS
AU047379  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81673,205,675 - 73,205,822 (+)Marker Load Pipeline
mRatBN7.21666,502,975 - 66,503,122 (+)MAPPERmRatBN7.2
Rnor_6.01671,275,181 - 71,275,327NCBIRnor6.0
Rnor_5.01670,934,507 - 70,934,653UniSTSRnor5.0
RGSC_v3.41670,878,877 - 70,879,023UniSTSRGSC3.4
Celera1664,411,552 - 64,411,698UniSTS
Cytogenetic Map16q12.4UniSTS
Fgfr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81673,196,848 - 73,197,097 (+)Marker Load Pipeline
mRatBN7.21666,494,147 - 66,494,396 (+)MAPPERmRatBN7.2
Rnor_6.01671,266,354 - 71,266,602NCBIRnor6.0
Rnor_5.01670,925,680 - 70,925,928UniSTSRnor5.0
RGSC_v3.41670,870,050 - 70,870,298UniSTSRGSC3.4
Celera1664,402,723 - 64,402,971UniSTS
Cytogenetic Map16q12.4UniSTS
PMC154461P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,499,858 - 66,500,425 (+)MAPPERmRatBN7.2
Rnor_6.01671,272,065 - 71,272,630NCBIRnor6.0
Rnor_5.01670,931,391 - 70,931,956UniSTSRnor5.0
RGSC_v3.41670,875,761 - 70,876,326UniSTSRGSC3.4
Celera1664,408,434 - 64,408,999UniSTS
Cytogenetic Map16q12.4UniSTS
Fgfr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81673,197,093 - 73,197,892 (+)Marker Load Pipeline
mRatBN7.21666,494,392 - 66,495,191 (+)MAPPERmRatBN7.2
Rnor_6.01671,266,599 - 71,267,397NCBIRnor6.0
Rnor_5.01670,925,925 - 70,926,723UniSTSRnor5.0
Celera1664,402,968 - 64,403,766UniSTS
Cytogenetic Map16q12.4UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 83 59 6 347 183 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF000144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D12498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S54008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000029284   ⟹   ENSRNOP00000036885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1673,194,631 - 73,249,855 (-)Ensembl
mRatBN7.2 Ensembl1666,494,042 - 66,547,350 (-)Ensembl
Rnor_6.0 Ensembl1671,266,745 - 71,319,449 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000050980   ⟹   ENSRNOP00000043459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1673,196,743 - 73,249,431 (-)Ensembl
mRatBN7.2 Ensembl1666,494,042 - 66,546,737 (-)Ensembl
Rnor_6.0 Ensembl1671,266,248 - 71,319,052 (-)Ensembl
RefSeq Acc Id: NM_024146   ⟹   NP_077060
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,194,631 - 73,249,855 (-)NCBI
mRatBN7.21666,491,930 - 66,547,161 (-)NCBI
Rnor_6.01671,266,278 - 71,306,299 (-)NCBI
Rnor_5.01670,924,716 - 70,977,998 (-)NCBI
RGSC_v3.41670,869,974 - 70,910,045 (-)RGD
Celera1664,402,647 - 64,442,189 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253323   ⟹   XP_006253385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,249,359 (-)NCBI
mRatBN7.21666,493,325 - 66,546,664 (-)NCBI
Rnor_6.01671,265,531 - 71,318,932 (-)NCBI
Rnor_5.01670,924,716 - 70,977,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253327   ⟹   XP_006253389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,249,359 (-)NCBI
mRatBN7.21666,493,325 - 66,546,731 (-)NCBI
Rnor_6.01671,265,531 - 71,319,046 (-)NCBI
Rnor_5.01670,924,716 - 70,977,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094851   ⟹   XP_038950779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,249,359 (-)NCBI
mRatBN7.21666,493,325 - 66,546,664 (-)NCBI
RefSeq Acc Id: XM_063275747   ⟹   XP_063131817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,249,359 (-)NCBI
RefSeq Acc Id: XM_063275748   ⟹   XP_063131818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,248,624 (-)NCBI
RefSeq Acc Id: XM_063275749   ⟹   XP_063131819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,249,054 (-)NCBI
RefSeq Acc Id: XM_063275750   ⟹   XP_063131820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,248,849 (-)NCBI
RefSeq Acc Id: XM_063275751   ⟹   XP_063131821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,249,359 (-)NCBI
RefSeq Acc Id: XM_063275752   ⟹   XP_063131822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,248,849 (-)NCBI
RefSeq Acc Id: XM_063275753   ⟹   XP_063131823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,249,359 (-)NCBI
RefSeq Acc Id: XM_063275754   ⟹   XP_063131824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,249,359 (-)NCBI
RefSeq Acc Id: XM_063275755   ⟹   XP_063131825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,195,885 - 73,249,359 (-)NCBI
RefSeq Acc Id: NP_077060   ⟸   NM_024146
- Peptide Label: precursor
- UniProtKB: Q04589 (UniProtKB/Swiss-Prot),   F1LM54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253389   ⟸   XM_006253327
- Peptide Label: isoform X8
- UniProtKB: Q63827 (UniProtKB/TrEMBL),   F1LPM6 (UniProtKB/TrEMBL),   A0A8J8YIL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253385   ⟸   XM_006253323
- Peptide Label: isoform X2
- UniProtKB: Q04589 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036885   ⟸   ENSRNOT00000029284
Ensembl Acc Id: ENSRNOP00000043459   ⟸   ENSRNOT00000050980
RefSeq Acc Id: XP_038950779   ⟸   XM_039094851
- Peptide Label: isoform X4
- UniProtKB: Q04589 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131825   ⟸   XM_063275755
- Peptide Label: isoform X7
- UniProtKB: A0A8J8YIL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131824   ⟸   XM_063275754
- Peptide Label: isoform X6
- UniProtKB: A0A8J8YIL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131823   ⟸   XM_063275753
- Peptide Label: isoform X5
- UniProtKB: A0A8J8YIL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131821   ⟸   XM_063275751
- Peptide Label: isoform X3
- UniProtKB: Q04589 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131817   ⟸   XM_063275747
- Peptide Label: isoform X1
- UniProtKB: Q04589 (UniProtKB/Swiss-Prot),   F1LM54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131819   ⟸   XM_063275749
- Peptide Label: isoform X1
- UniProtKB: Q04589 (UniProtKB/Swiss-Prot),   F1LM54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131822   ⟸   XM_063275752
- Peptide Label: isoform X3
- UniProtKB: Q04589 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131820   ⟸   XM_063275750
- Peptide Label: isoform X1
- UniProtKB: Q04589 (UniProtKB/Swiss-Prot),   F1LM54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131818   ⟸   XM_063275748
- Peptide Label: isoform X1
- UniProtKB: Q04589 (UniProtKB/Swiss-Prot),   F1LM54 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04589-F1-model_v2 AlphaFold Q04589 1-822 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700176
Promoter ID:EPDNEW_R10695
Type:initiation region
Name:Fgfr1_1
Description:Fibroblast growth factor receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01671,319,476 - 71,319,536EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620713 AgrOrtholog
BioCyc Gene G2FUF-10966 BioCyc
Ensembl Genes ENSRNOG00000016050 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000029284 ENTREZGENE
  ENSRNOT00000050980 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro FGF_rcpt_1 UniProtKB/Swiss-Prot
  FGF_rcpt_fam UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RTK UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:79114 UniProtKB/Swiss-Prot
NCBI Gene 79114 ENTREZGENE
PANTHER FIBROBLAST GROWTH FACTOR RECEPTOR 1 UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot
  PF00047 UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
PhenoGen Fgfr1 PhenoGen
PIRSF FGFR UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016050 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8J8YIL8 ENTREZGENE, UniProtKB/TrEMBL
  F1LM54 ENTREZGENE, UniProtKB/TrEMBL
  F1LPM6 ENTREZGENE
  FGFR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63827 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Fgfr1  Fibroblast growth factor receptor 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fgfr1        Symbol and Name status set to provisional 70820 PROVISIONAL