Gene: Ptpn4 (protein tyrosine phosphatase, non-receptor type 4) Rattus norvegicus
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Symbol:
Ptpn4
Name:
protein tyrosine phosphatase, non-receptor type 4
RGD ID:
620712
Description:
Predicted to enable glutamate receptor binding activity and non-membrane spanning protein tyrosine phosphatase activity. Predicted to be located in membrane. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Orthologous to human PTPN4 (protein tyrosine phosphatase non-receptor type 4); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC360836; tyrosine-protein phosphatase non-receptor type 4
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
PTPN4 (protein tyrosine phosphatase non-receptor type 4)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Ptpn4 (protein tyrosine phosphatase, non-receptor type 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Ptpn4 (protein tyrosine phosphatase non-receptor type 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PTPN4 (protein tyrosine phosphatase non-receptor type 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PTPN4 (protein tyrosine phosphatase non-receptor type 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ptpn4 (protein tyrosine phosphatase non-receptor type 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PTPN4 (protein tyrosine phosphatase non-receptor type 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
PTPN4 (protein tyrosine phosphatase non-receptor type 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ptpn4 (protein tyrosine phosphatase non-receptor type 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Ptpn4 (protein tyrosine phosphatase non-receptor type 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
PTPN4 (protein tyrosine phosphatase non-receptor type 4)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Ptpn4 (protein tyrosine phosphatase, non-receptor type 4)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
ptpn4b (protein tyrosine phosphatase, non-receptor type 4b)
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
ptpn4a (protein tyrosine phosphatase, non-receptor type 4a)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
ptp-1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
Ptpmeg
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
ptpn4
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
ptpn4
Alliance
DIOPT (Ensembl Compara|OMA|OrthoFinder|PANTHER)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 13 33,324,808 - 33,504,957 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 13 33,324,808 - 33,504,957 (-) Ensembl GRCr8 mRatBN7.2 13 30,772,012 - 30,952,340 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 13 30,776,682 - 30,952,170 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 13 33,353,328 - 33,533,288 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 13 34,641,168 - 34,821,122 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 13 31,915,258 - 32,095,209 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 13 35,678,240 - 35,858,414 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 13 35,678,240 - 35,858,390 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 13 40,792,728 - 40,972,784 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 13 32,430,875 - 32,611,163 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 13 30,666,333 - 30,846,454 (-) NCBI Celera RGSC_v3.1 13 32,475,262 - 32,484,043 (-) NCBI Cytogenetic Map 13 q11 NCBI
JBrowse:
Imported Disease Annotations - ClinVar
Only show annotations with direct experimental evidence (0 objects hidden)
Ptpn4 Rat (-)-epigallocatechin 3-gallate multiple interactions ISO PTPN4 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTPN4 mRNA CTD PMID:22079256 Ptpn4 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Ptpn4 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ptpn4 Rat 1,2-dichloroethane decreases expression ISO Ptpn4 (Mus musculus) 6480464 ethylene dichloride results in decreased expression of PTPN4 mRNA CTD PMID:28960355 Ptpn4 Rat 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of PTPN4 mRNA CTD PMID:30723492 Ptpn4 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Ptpn4 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ptpn4 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Ptpn4 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ptpn4 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Ptpn4 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of PTPN4 mRNA CTD PMID:24680724 Ptpn4 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PTPN4 mRNA CTD PMID:34747641 Ptpn4 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PTPN4 mRNA CTD PMID:32109520|PMID:33387578 Ptpn4 Rat 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of PTPN4 mRNA CTD PMID:32109520 Ptpn4 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Ptpn4 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ptpn4 Rat 3,4-methylenedioxymethamphetamine decreases expression ISO Ptpn4 (Mus musculus) 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PTPN4 mRNA CTD PMID:26251327 Ptpn4 Rat 4-hydroxyphenyl retinamide decreases expression ISO Ptpn4 (Mus musculus) 6480464 Fenretinide results in decreased expression of PTPN4 mRNA CTD PMID:28973697 Ptpn4 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of PTPN4 mRNA CTD PMID:24780913 Ptpn4 Rat acetamide decreases expression EXP 6480464 acetamide results in decreased expression of PTPN4 mRNA CTD PMID:31881176 Ptpn4 Rat aflatoxin B1 decreases methylation ISO PTPN4 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of PTPN4 gene CTD PMID:27153756 Ptpn4 Rat amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of PTPN4 mRNA CTD PMID:30779732 Ptpn4 Rat aristolochic acid A decreases expression ISO PTPN4 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of PTPN4 mRNA CTD PMID:33212167 Ptpn4 Rat benzo[a]pyrene decreases expression ISO PTPN4 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of PTPN4 mRNA CTD PMID:21632981 Ptpn4 Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of PTPN4 gene CTD PMID:28505145 Ptpn4 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PTPN4 mRNA CTD PMID:34947998 Ptpn4 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PTPN4 mRNA CTD PMID:30816183|PMID:33296240 Ptpn4 Rat bisphenol A affects methylation ISO Ptpn4 (Mus musculus) 6480464 bisphenol A affects the methylation of PTPN4 promoter CTD PMID:27334623 Ptpn4 Rat bisphenol F increases expression ISO Ptpn4 (Mus musculus) 6480464 bisphenol F results in increased expression of PTPN4 mRNA CTD PMID:38685157 Ptpn4 Rat cadmium atom multiple interactions ISO PTPN4 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTPN4 more ... CTD PMID:35301059 Ptpn4 Rat cadmium atom multiple interactions ISO Ptpn4 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PTPN4 more ... CTD PMID:37236586 Ptpn4 Rat cadmium dichloride multiple interactions ISO PTPN4 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTPN4 more ... CTD PMID:35301059 Ptpn4 Rat cadmium dichloride multiple interactions ISO Ptpn4 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PTPN4 more ... CTD PMID:37236586 Ptpn4 Rat CGP 52608 multiple interactions ISO PTPN4 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to PTPN4 gene] CTD PMID:28238834 Ptpn4 Rat chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of PTPN4 mRNA CTD PMID:23125180 Ptpn4 Rat chlorpyrifos decreases expression ISO Ptpn4 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of PTPN4 mRNA CTD PMID:37019170 Ptpn4 Rat crocin-1 multiple interactions ISO PTPN4 (Homo sapiens) 6480464 MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]; PTPN4 protein more ... CTD PMID:35085590 Ptpn4 Rat crocin-1 increases expression ISO PTPN4 (Homo sapiens) 6480464 crocin results in increased expression of PTPN4 protein CTD PMID:35085590 Ptpn4 Rat dicrotophos decreases expression ISO PTPN4 (Homo sapiens) 6480464 dicrotophos results in decreased expression of PTPN4 mRNA CTD PMID:28302478 Ptpn4 Rat doxorubicin decreases expression ISO PTPN4 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of PTPN4 mRNA CTD PMID:29803840 Ptpn4 Rat ethanol decreases expression ISO Ptpn4 (Mus musculus) 6480464 Ethanol results in decreased expression of PTPN4 mRNA CTD PMID:29018328 Ptpn4 Rat flutamide increases expression EXP 6480464 Flutamide results in increased expression of PTPN4 mRNA CTD PMID:24793618 Ptpn4 Rat maneb affects activity ISO PTPN4 (Homo sapiens) 6480464 Maneb affects the activity of PTPN4 protein CTD PMID:23611293 Ptpn4 Rat methidathion decreases expression ISO Ptpn4 (Mus musculus) 6480464 methidathion results in decreased expression of PTPN4 mRNA CTD PMID:34813904 Ptpn4 Rat methylmercury chloride decreases expression ISO PTPN4 (Homo sapiens) 6480464 methylmercuric chloride results in decreased expression of PTPN4 mRNA CTD PMID:28001369 Ptpn4 Rat oxybenzone increases expression ISO PTPN4 (Homo sapiens) 6480464 oxybenzone results in increased expression of PTPN4 mRNA CTD PMID:36581016 Ptpn4 Rat paracetamol increases expression ISO PTPN4 (Homo sapiens) 6480464 Acetaminophen results in increased expression of PTPN4 mRNA CTD PMID:26690555 Ptpn4 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of PTPN4 mRNA CTD PMID:33387578 Ptpn4 Rat PCB138 multiple interactions ISO Ptpn4 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ptpn4 Rat pirinixic acid multiple interactions ISO PTPN4 (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... CTD PMID:19710929 Ptpn4 Rat pirinixic acid increases expression ISO Ptpn4 (Mus musculus) 6480464 pirinixic acid results in increased expression of PTPN4 mRNA CTD PMID:18301758 Ptpn4 Rat potassium chromate decreases expression ISO PTPN4 (Homo sapiens) 6480464 potassium chromate(VI) results in decreased expression of PTPN4 mRNA CTD PMID:22079256 Ptpn4 Rat potassium chromate multiple interactions ISO PTPN4 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTPN4 mRNA CTD PMID:22079256 Ptpn4 Rat raloxifene affects expression ISO PTPN4 (Homo sapiens) 6480464 Raloxifene Hydrochloride affects the expression of PTPN4 mRNA CTD PMID:14699072 Ptpn4 Rat silicon dioxide decreases expression ISO PTPN4 (Homo sapiens) 6480464 Silicon Dioxide results in decreased expression of PTPN4 mRNA CTD PMID:25351596 Ptpn4 Rat tamoxifen affects expression ISO PTPN4 (Homo sapiens) 6480464 Tamoxifen affects the expression of PTPN4 mRNA CTD PMID:14699072 Ptpn4 Rat testosterone enanthate affects expression ISO PTPN4 (Homo sapiens) 6480464 testosterone enanthate affects the expression of PTPN4 mRNA CTD PMID:17440010 Ptpn4 Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of PTPN4 mRNA CTD PMID:31150632 Ptpn4 Rat thimerosal increases expression ISO PTPN4 (Homo sapiens) 6480464 Thimerosal results in increased expression of PTPN4 mRNA CTD PMID:27188386 Ptpn4 Rat thiram decreases expression ISO PTPN4 (Homo sapiens) 6480464 Thiram results in decreased expression of PTPN4 mRNA CTD PMID:38568856 Ptpn4 Rat titanium dioxide decreases methylation ISO Ptpn4 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of PTPN4 promoter CTD PMID:35295148 Ptpn4 Rat triphenyl phosphate affects expression ISO PTPN4 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of PTPN4 mRNA CTD PMID:37042841 Ptpn4 Rat triptonide increases expression ISO Ptpn4 (Mus musculus) 6480464 triptonide results in increased expression of PTPN4 mRNA CTD PMID:33045310 Ptpn4 Rat valproic acid decreases expression ISO PTPN4 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of PTPN4 mRNA CTD PMID:23179753|PMID:28001369 Ptpn4 Rat valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of PTPN4 mRNA CTD PMID:29427782 Ptpn4 Rat valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of PTPN4 mRNA CTD PMID:29427782 Ptpn4 Rat vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of PTPN4 mRNA CTD PMID:23034163 Ptpn4 Rat vorinostat increases expression ISO PTPN4 (Homo sapiens) 6480464 vorinostat results in increased expression of PTPN4 mRNA CTD PMID:27188386