PTPN4 (protein tyrosine phosphatase non-receptor type 4) - Rat Genome Database

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Gene: PTPN4 (protein tyrosine phosphatase non-receptor type 4) Pan paniscus
Analyze
Symbol: PTPN4
Name: protein tyrosine phosphatase non-receptor type 4
RGD ID: 11933850
Description: ENCODES a protein that exhibits cytoskeletal protein binding (inferred); glutamate receptor binding (inferred); non-membrane spanning protein tyrosine phosphatase activity (inferred); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred); cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein phosphatase non-receptor type 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21321,735,494 - 21,982,547 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B21,750,466 - 21,998,093 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B6,694,192 - 6,917,265 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B120,320,591 - 120,492,423 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B120,320,610 - 120,485,676 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTPN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21321,735,494 - 21,982,547 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B21,750,466 - 21,998,093 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B6,694,192 - 6,917,265 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B120,320,591 - 120,492,423 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B120,320,610 - 120,485,676 (+)Ensemblpanpan1.1panPan2
PTPN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382119,759,922 - 119,984,899 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2119,759,922 - 119,984,899 (+)EnsemblGRCh38hg38GRCh38
GRCh372120,517,498 - 120,742,475 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362120,233,677 - 120,451,507 (+)NCBINCBI36Build 36hg18NCBI36
Build 342120,233,436 - 120,451,267NCBI
Celera2113,842,942 - 114,061,903 (+)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2112,841,586 - 113,066,878 (+)NCBIHuRef
CHM1_12120,520,785 - 120,746,914 (+)NCBICHM1_1
T2T-CHM13v2.02120,193,967 - 120,419,641 (+)NCBIT2T-CHM13v2.0
Ptpn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391119,580,197 - 119,765,281 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1119,580,197 - 119,765,343 (-)EnsemblGRCm39 Ensembl
GRCm381119,652,467 - 119,837,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1119,652,467 - 119,837,613 (-)EnsemblGRCm38mm10GRCm38
MGSCv371121,554,669 - 121,733,648 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361121,487,291 - 121,630,021 (-)NCBIMGSCv36mm8
Celera1122,316,986 - 122,496,376 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.39NCBI
Ptpn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,324,808 - 33,504,957 (-)NCBIGRCr8
mRatBN7.21330,772,012 - 30,952,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1330,776,682 - 30,952,170 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1333,353,328 - 33,533,288 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01334,641,168 - 34,821,122 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01331,915,258 - 32,095,209 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01335,678,240 - 35,858,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1335,678,240 - 35,858,390 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01340,792,728 - 40,972,784 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41332,430,875 - 32,611,163 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11332,475,262 - 32,484,043 (-)NCBI
Celera1330,666,333 - 30,846,454 (-)NCBICelera
Cytogenetic Map13q11NCBI
Ptpn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554599,803,421 - 9,981,392 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554599,803,421 - 9,981,392 (-)NCBIChiLan1.0ChiLan1.0
PTPN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11930,079,221 - 30,285,126 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1930,086,832 - 30,241,064 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1930,335,314 - 30,541,476 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01931,454,630 - 31,662,707 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1931,461,882 - 31,663,169 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11930,140,713 - 30,349,797 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01930,310,819 - 30,517,448 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01931,493,639 - 31,702,636 (-)NCBIUU_Cfam_GSD_1.0
Ptpn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,976,332 - 91,149,472 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646950,470,256 - 50,594,357 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646950,463,473 - 50,641,419 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1531,307,447 - 31,502,923 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11531,305,394 - 31,502,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21536,235,035 - 36,459,764 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11010,325,263 - 10,554,381 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1010,328,766 - 10,554,258 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606112,136,097 - 12,365,467 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473225,108,192 - 25,278,948 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473225,099,327 - 25,301,610 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000008956   ⟹   ENSPPAP00000001802
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B120,320,610 - 120,485,676 (+)Ensembl
RefSeq Acc Id: XM_034953955   ⟹   XP_034809846
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21321,761,096 - 21,982,547 (+)NCBI
NHGRI_mPanPan12B21,776,067 - 21,998,093 (+)NCBI
Mhudiblu_PPA_v02B6,694,428 - 6,917,265 (+)NCBI
RefSeq Acc Id: XM_034953956   ⟹   XP_034809847
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21321,761,096 - 21,982,547 (+)NCBI
NHGRI_mPanPan12B21,776,067 - 21,998,093 (+)NCBI
Mhudiblu_PPA_v02B6,694,429 - 6,909,448 (+)NCBI
RefSeq Acc Id: XM_034953957   ⟹   XP_034809848
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21321,761,096 - 21,982,547 (+)NCBI
NHGRI_mPanPan12B21,776,067 - 21,998,093 (+)NCBI
Mhudiblu_PPA_v02B6,694,429 - 6,909,448 (+)NCBI
RefSeq Acc Id: XM_034953958   ⟹   XP_034809849
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21321,760,454 - 21,982,547 (+)NCBI
NHGRI_mPanPan12B21,776,067 - 21,998,093 (+)NCBI
Mhudiblu_PPA_v02B6,694,192 - 6,916,174 (+)NCBI
RefSeq Acc Id: XM_034953959   ⟹   XP_034809850
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21321,761,096 - 21,982,547 (+)NCBI
NHGRI_mPanPan12B21,776,067 - 21,998,093 (+)NCBI
Mhudiblu_PPA_v02B6,694,428 - 6,909,448 (+)NCBI
RefSeq Acc Id: XM_034953960   ⟹   XP_034809851
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21321,761,096 - 21,982,547 (+)NCBI
NHGRI_mPanPan12B21,776,067 - 21,998,093 (+)NCBI
Mhudiblu_PPA_v02B6,694,430 - 6,909,448 (+)NCBI
RefSeq Acc Id: XM_055108444   ⟹   XP_054964419
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21321,735,494 - 21,982,547 (+)NCBI
NHGRI_mPanPan12B21,750,466 - 21,998,093 (+)NCBI
RefSeq Acc Id: XM_055108445   ⟹   XP_054964420
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21321,735,494 - 21,982,547 (+)NCBI
NHGRI_mPanPan12B21,750,466 - 21,998,093 (+)NCBI
RefSeq Acc Id: XM_055108446   ⟹   XP_054964421
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21321,735,494 - 21,982,547 (+)NCBI
NHGRI_mPanPan12B21,750,466 - 21,998,093 (+)NCBI
RefSeq Acc Id: XM_063595121   ⟹   XP_063451191
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21321,761,096 - 21,982,547 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034809849   ⟸   XM_034953958
- Peptide Label: isoform X4
- UniProtKB: A0A2R8ZAC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034809846   ⟸   XM_034953955
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZAC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034809850   ⟸   XM_034953959
- Peptide Label: isoform X6
- UniProtKB: A0A2R8ZAC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034809848   ⟸   XM_034953957
- Peptide Label: isoform X3
- UniProtKB: A0A2R8ZAC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034809847   ⟸   XM_034953956
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZAC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034809851   ⟸   XM_034953960
- Peptide Label: isoform X7
- UniProtKB: A0A2R8ZAC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000001802   ⟸   ENSPPAT00000008956
RefSeq Acc Id: XP_054964420   ⟸   XM_055108445
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054964419   ⟸   XM_055108444
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054964421   ⟸   XM_055108446
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063451191   ⟸   XM_063595121
- Peptide Label: isoform X5
Protein Domains
FERM   PDZ   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000007018 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000008956.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM-adjacent UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  PTPN3/4_FERM_C UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-3/4 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene PTPN4 ENTREZGENE
PANTHER TYROSINE-PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 4 UniProtKB/TrEMBL
Pfam FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PF08736 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PIRSF Tyr-Ptase_nr3 UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
  SM01195 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A2R8ZAC7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPN4  protein tyrosine phosphatase non-receptor type 4    protein tyrosine phosphatase, non-receptor type 4  Symbol and/or name change 5135510 APPROVED