Tff2 (trefoil factor 2) - Rat Genome Database

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Gene: Tff2 (trefoil factor 2) Rattus norvegicus
Analyze
Symbol: Tff2
Name: trefoil factor 2
RGD ID: 620709
Description: Predicted to enable CXCR4 chemokine receptor binding activity. Predicted to be involved in chemokine-mediated signaling pathway; maintenance of gastrointestinal epithelium; and negative regulation of gastric acid secretion. Predicted to act upstream of or within several processes, including calcium-mediated signaling; negative regulation of macrophage activation; and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human TFF2 (trefoil factor 2); INTERACTS WITH 17beta-estradiol; 4-tert-Octylphenol; acetylsalicylic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: SP; spasmolytic polypeptide; trefoil factor 2 (spasmolytic protein 1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,217,110 - 9,220,979 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl209,217,121 - 9,220,979 (-)EnsemblGRCr8
mRatBN7.2209,215,750 - 9,219,619 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,215,761 - 9,219,619 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx209,910,943 - 9,914,170 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,272,115 - 9,275,340 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,746,322 - 9,750,448 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,872,669 - 9,876,008 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,872,680 - 9,876,008 (-)Ensemblrn6Rnor6.0
Rnor_5.02012,052,826 - 12,055,719 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4209,492,341 - 9,510,558 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2010,741,364 - 10,743,813 (-)NCBICelera
RGSC_v3.1209,492,567 - 9,510,785 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gastric TFF1 Expression from Acute to Chronic Helicobacter Infection. Esposito R, etal., Front Cell Infect Microbiol. 2017 Oct 9;7:434. doi: 10.3389/fcimb.2017.00434. eCollection 2017.
2. Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting-refeeding. Fernandez-Estivariz C, etal., Am J Physiol Regul Integr Comp Physiol 2003 Feb;284(2):R564-73.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Spasmolytic polypeptide: a trefoil peptide secreted by rat gastric mucous cells. Jeffrey GP, etal., Gastroenterology 1994 Feb;106(2):336-45.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Plasma levels of trefoil factors are increased in patients with advanced prostate cancer. Vestergaard EM, etal., Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):807-12.
12. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. Wills-Karp M, etal., J Exp Med. 2012 Mar 12;209(3):607-22. doi: 10.1084/jem.20110079. Epub 2012 Feb 13.
13. Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation. Xia HH, etal., J Clin Pathol. 2004 Aug;57(8):861-6.
Additional References at PubMed
PMID:11805131   PMID:12918118   PMID:17101660   PMID:17982128   PMID:18813976   PMID:19064997   PMID:19741170   PMID:20138039   PMID:23376485   PMID:24588600  


Genomics

Comparative Map Data
Tff2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,217,110 - 9,220,979 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl209,217,121 - 9,220,979 (-)EnsemblGRCr8
mRatBN7.2209,215,750 - 9,219,619 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,215,761 - 9,219,619 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx209,910,943 - 9,914,170 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,272,115 - 9,275,340 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,746,322 - 9,750,448 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,872,669 - 9,876,008 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,872,680 - 9,876,008 (-)Ensemblrn6Rnor6.0
Rnor_5.02012,052,826 - 12,055,719 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4209,492,341 - 9,510,558 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2010,741,364 - 10,743,813 (-)NCBICelera
RGSC_v3.1209,492,567 - 9,510,785 (-)NCBI
Cytogenetic Map20p12NCBI
TFF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382142,346,357 - 42,350,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2142,346,357 - 42,350,997 (-)Ensemblhg38GRCh38
GRCh372143,766,466 - 43,771,103 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,639,535 - 42,644,176 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342142,639,537 - 42,644,176NCBI
Celera2128,915,432 - 28,920,174 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2129,183,694 - 29,188,435 (-)NCBIHuRef
CHM1_12143,326,640 - 43,331,381 (-)NCBICHM1_1
T2T-CHM13v2.02140,735,793 - 40,740,430 (-)NCBIT2T-CHM13v2.0
Tff2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,360,036 - 31,363,256 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,360,023 - 31,363,256 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381731,141,062 - 31,144,282 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,141,049 - 31,144,282 (-)Ensemblmm10GRCm38
MGSCv371731,278,007 - 31,281,227 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361730,868,074 - 30,871,294 (-)NCBIMGSCv36mm8
Celera1732,058,241 - 32,061,428 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
Tff2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540739,379,526 - 39,382,420 (+)Ensembl
ChiLan1.0NW_00495540739,379,669 - 39,382,367 (+)NCBIChiLan1.0ChiLan1.0
TFF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22238,401,702 - 38,406,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12133,254,057 - 33,258,423 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,653,077 - 28,657,709 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,973,111 - 41,977,227 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,973,111 - 41,977,227 (-)EnsemblpanPan2panpan1.1
TFF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,665,647 - 36,668,423 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,665,514 - 36,668,440 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3135,816,559 - 35,819,335 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03136,182,110 - 36,184,886 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3136,181,998 - 36,184,901 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13136,075,148 - 36,077,920 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03136,055,254 - 36,058,029 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,550,333 - 36,553,110 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
TFF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,669,014 - 205,672,324 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113205,669,014 - 205,672,319 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,071,494 - 216,074,772 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1286,223,113 - 86,228,964 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605414,183,687 - 14,187,624 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tff2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1182,733,677 - 2,736,590 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tff2
64 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:89
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000001537
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 2 10 26 29 19 12 19 6 44 13 4 2 30 10 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000001537   ⟹   ENSRNOP00000001537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl209,217,121 - 9,220,979 (-)Ensembl
mRatBN7.2 Ensembl209,215,761 - 9,219,619 (-)Ensembl
Rnor_6.0 Ensembl209,872,680 - 9,876,008 (-)Ensembl
RefSeq Acc Id: NM_053844   ⟹   NP_446296
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,217,110 - 9,220,979 (-)NCBI
mRatBN7.2209,215,750 - 9,219,619 (-)NCBI
Rnor_6.0209,872,669 - 9,876,008 (-)NCBI
Rnor_5.02012,052,826 - 12,055,719 (-)NCBI
RGSC_v3.4209,492,341 - 9,510,558 (-)RGD
Celera2010,741,364 - 10,743,813 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446296 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19025 (Get FASTA)   NCBI Sequence Viewer  
  EDL96999 (Get FASTA)   NCBI Sequence Viewer  
  EDL97000 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001537
GenBank Protein Q09030 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446296   ⟸   NM_053844
- Peptide Label: precursor
- UniProtKB: Q09030 (UniProtKB/Swiss-Prot),   G3V643 (UniProtKB/TrEMBL),   A6JJY3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001537   ⟸   ENSRNOT00000001537
Protein Domains
P-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q09030-F1-model_v2 AlphaFold Q09030 1-129 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701471
Promoter ID:EPDNEW_R11995
Type:multiple initiation site
Name:Tff2_1
Description:trefoil factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0209,876,013 - 9,876,073EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620709 AgrOrtholog
BioCyc Gene G2FUF-4327 BioCyc
Ensembl Genes ENSRNOG00000001162 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001537 ENTREZGENE
Gene3D-CATH 4.10.110.10 UniProtKB/Swiss-Prot
InterPro P_trefoil_chordata UniProtKB/Swiss-Prot
  P_trefoil_CS UniProtKB/Swiss-Prot
  P_trefoil_dom UniProtKB/Swiss-Prot
  P_trefoil_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:116592 UniProtKB/Swiss-Prot
NCBI Gene 116592 ENTREZGENE
PANTHER PTHR13826 UniProtKB/Swiss-Prot
  TREFOIL FACTOR 2 UniProtKB/Swiss-Prot
Pfam Trefoil UniProtKB/Swiss-Prot
PhenoGen Tff2 PhenoGen
PRINTS PTREFOIL UniProtKB/Swiss-Prot
PROSITE P_TREFOIL_1 UniProtKB/Swiss-Prot
  P_TREFOIL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001162 RatGTEx
SMART SM00018 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57492 UniProtKB/Swiss-Prot
UniProt A6JJY3 ENTREZGENE, UniProtKB/TrEMBL
  A6JJY4_RAT UniProtKB/TrEMBL
  G3V643 ENTREZGENE, UniProtKB/TrEMBL
  Q09030 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Tff2  trefoil factor 2  Tff2  trefoil factor 2 (spasmolytic protein 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tff2  trefoil factor 2 (spasmolytic protein 1)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tff2  trefoil factor 2 (spasmolytic protein 1)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains the trefoil motif, a 40-amino acid domain characterized by three conserved disulfides 730014
gene_expression mRNA expressed throughout the digestrive tract, protein in the gastric mucosa 730014
gene_process high concentration in gastric mucosa suggests it's a structural peptide secreted by antral mucous cells 730014
gene_regulation keratinocyte growth factor enhances Tff2 mRNA expression independent of food uptake 730068