Crabp2 (cellular retinoic acid binding protein 2) - Rat Genome Database

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Gene: Crabp2 (cellular retinoic acid binding protein 2) Rattus norvegicus
Analyze
Symbol: Crabp2
Name: cellular retinoic acid binding protein 2
RGD ID: 62070
Description: Enables retinoic acid binding activity. Involved in retinoic acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. Orthologous to human CRABP2 (cellular retinoic acid binding protein 2); PARTICIPATES IN retinoic acid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-tert-Octylphenol; 9-cis-retinoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cellular lipid-binding protein; cellular retinoic acid binding protein II; cellular retinoic acid-binding protein 2; cellular retinoic acid-binding protein 2-like; cellular retinoic acid-binding protein II; CRABP-II; LOC108348208
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,714,862 - 175,719,208 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2175,707,312 - 175,728,385 (+)EnsemblGRCr8
mRatBN7.22173,417,004 - 173,421,352 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,416,857 - 173,421,379 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2180,561,789 - 180,566,132 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,584,144 - 178,588,487 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,184,231 - 173,188,583 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,322,416 - 187,326,794 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2184,882,969 - 184,883,505 (+)Ensemblrn6Rnor6.0
Rnor_5.02204,274,043 - 204,274,530 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42180,029,801 - 180,034,147 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2167,367,701 - 167,368,833 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (EXP,ISO)
acetic acid  (ISO)
actinomycin D  (ISO)
adapalene  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
delta-tocopherol  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
disulfiram  (ISO)
dorsomorphin  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
etoposide  (ISO)
ferric oxide  (EXP)
flavonoids  (EXP)
flusilazole  (EXP)
furan  (EXP)
furfural  (ISO)
gamma-tocopherol  (ISO)
gentamycin  (EXP)
glucose  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isotretinoin  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
p-tert-Amylphenol  (EXP)
panobinostat  (ISO)
pentane-2,3-dione  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA,IEA,ISO)
cytosol  (IBA,ISO)
endoplasmic reticulum  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of the cellular retinoic acid binding proteins, type II and type I, in mature rat olfactory epithelium. Asson-Batres MA, etal., Cell Tissue Res 2003 Apr;312(1):9-19. Epub 2003 Mar 18.
2. Inducible expression of cellular retinoic acid-binding protein II in rat ovary: gonadotropin regulation during luteal development. Bucco RA, etal., Endocrinology 1995 Jun;136(6):2730-40.
3. Affinity purification of retinoic acid-binding proteins using immobilized 4-(2-hydroxyethoxy)retinoic acid. Chapman JM and Curley RW Jr, Protein Expr Purif. 1990 Sep;1(1):63-9.
4. Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat. Everts HB, etal., Exp Cell Res. 2005 Aug 15;308(2):309-19.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7720575   PMID:9826179   PMID:12482873   PMID:12842898   PMID:15866176   PMID:16723356   PMID:18052984   PMID:19056867   PMID:23376485   PMID:27609837  


Genomics

Comparative Map Data
Crabp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,714,862 - 175,719,208 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2175,707,312 - 175,728,385 (+)EnsemblGRCr8
mRatBN7.22173,417,004 - 173,421,352 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,416,857 - 173,421,379 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2180,561,789 - 180,566,132 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,584,144 - 178,588,487 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,184,231 - 173,188,583 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,322,416 - 187,326,794 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2184,882,969 - 184,883,505 (+)Ensemblrn6Rnor6.0
Rnor_5.02204,274,043 - 204,274,530 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42180,029,801 - 180,034,147 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2167,367,701 - 167,368,833 (+)NCBICelera
Cytogenetic Map2q34NCBI
CRABP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,699,606 - 156,705,784 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,699,597 - 156,708,094 (-)Ensemblhg38GRCh38
GRCh371156,669,398 - 156,675,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,936,027 - 154,941,999 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341153,482,482 - 153,488,448NCBI
Celera1129,740,204 - 129,746,174 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1128,026,950 - 128,033,158 (-)NCBIHuRef
CHM1_11158,065,590 - 158,071,800 (-)NCBICHM1_1
T2T-CHM13v2.01155,836,009 - 155,842,185 (-)NCBIT2T-CHM13v2.0
Crabp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39387,856,000 - 87,860,679 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl387,855,973 - 87,860,683 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38387,948,693 - 87,953,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl387,948,666 - 87,953,376 (+)Ensemblmm10GRCm38
MGSCv37387,752,615 - 87,757,294 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36388,034,620 - 88,039,299 (+)NCBIMGSCv36mm8
Celera387,986,089 - 87,990,775 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.78NCBI
Crabp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,777,474 - 2,782,567 (-)Ensembl
ChiLan1.0NW_0049555452,777,523 - 2,782,567 (-)NCBIChiLan1.0ChiLan1.0
CRABP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,136,641 - 93,145,036 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1192,873,250 - 92,879,530 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01132,043,097 - 132,049,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,864,795 - 135,870,145 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,864,807 - 135,870,145 (-)EnsemblpanPan2panpan1.1
CRABP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,277,580 - 41,282,158 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,277,644 - 41,281,833 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha740,764,747 - 40,769,752 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0741,140,579 - 41,145,585 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,141,033 - 41,145,716 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1740,922,537 - 40,927,542 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0740,975,475 - 40,980,469 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,259,166 - 41,264,171 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Crabp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,830,604 - 26,836,454 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,860,562 - 5,866,856 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,861,051 - 5,866,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRABP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,388,092 - 93,394,155 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1493,388,198 - 93,393,861 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24101,960,067 - 101,965,733 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4q21-q23NCBI
CRABP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,159,022 - 7,164,586 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,159,238 - 7,164,163 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660386,452,658 - 6,458,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crabp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,862,822 - 1,867,726 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248851,862,911 - 1,867,656 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Crabp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1365,603,749 - 65,608,755 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Crabp2
4 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:167
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000025183, ENSRNOT00000072198
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2175279960178247591Rat

Markers in Region
Crabp2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,420,231 - 173,420,615 (+)MAPPERmRatBN7.2
Rnor_6.02184,882,982 - 184,883,365NCBIRnor6.0
Rnor_6.02187,325,642 - 187,326,025NCBIRnor6.0
Rnor_5.02204,274,055 - 204,274,438UniSTSRnor5.0
Rnor_5.02206,728,659 - 206,729,042UniSTSRnor5.0
RGSC_v3.42180,033,027 - 180,033,410UniSTSRGSC3.4
Celera2167,367,713 - 167,368,096UniSTS
Cytogenetic Map2q34UniSTS
RH142909  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,421,747 - 173,421,849 (+)MAPPERmRatBN7.2
Rnor_6.02187,327,158 - 187,327,259NCBIRnor6.0
Rnor_5.02206,730,175 - 206,730,276UniSTSRnor5.0
RGSC_v3.42180,034,543 - 180,034,644UniSTSRGSC3.4
Celera2167,369,229 - 167,369,330UniSTS
RH 3.4 Map21129.2UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 95 232 125 122 76 90 76 12 442 231 11 199 104 135 46 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000025183   ⟹   ENSRNOP00000015134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2175,707,312 - 175,719,235 (+)Ensembl
mRatBN7.2 Ensembl2173,416,857 - 173,421,379 (+)Ensembl
Rnor_6.0 Ensembl2187,322,416 - 187,326,789 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072198   ⟹   ENSRNOP00000067258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2184,882,969 - 184,883,505 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105111   ⟹   ENSRNOP00000086398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,419,429 - 173,421,379 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000121751   ⟹   ENSRNOP00000102215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2175,714,818 - 175,718,769 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156055   ⟹   ENSRNOP00000104346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2175,717,840 - 175,728,385 (+)Ensembl
RefSeq Acc Id: NM_017244   ⟹   NP_058940
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,714,862 - 175,719,208 (+)NCBI
mRatBN7.22173,417,004 - 173,421,352 (+)NCBI
Rnor_6.02187,322,416 - 187,326,762 (+)NCBI
Rnor_5.02204,274,043 - 204,274,530 (+)NCBI
RGSC_v3.42180,029,801 - 180,034,147 (+)RGD
Celera2167,367,701 - 167,368,833 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058940 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA80225 (Get FASTA)   NCBI Sequence Viewer  
  AAP44734 (Get FASTA)   NCBI Sequence Viewer  
  EDM00751 (Get FASTA)   NCBI Sequence Viewer  
  P51673 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058940   ⟸   NM_017244
- UniProtKB: P51673 (UniProtKB/Swiss-Prot),   A0A8L2Q848 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067258   ⟸   ENSRNOT00000072198
Ensembl Acc Id: ENSRNOP00000015134   ⟸   ENSRNOT00000025183
Ensembl Acc Id: ENSRNOP00000086398   ⟸   ENSRNOT00000105111
Ensembl Acc Id: ENSRNOP00000104346   ⟸   ENSRNOT00000156055
Ensembl Acc Id: ENSRNOP00000102215   ⟸   ENSRNOT00000121751
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51673-F1-model_v2 AlphaFold P51673 1-139 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691431
Promoter ID:EPDNEW_R1949
Type:single initiation site
Name:Crabp2_1
Description:cellular retinoic acid binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,322,372 - 187,322,432EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62070 AgrOrtholog
BioCyc Gene G2FUF-52525 BioCyc
Ensembl Genes ENSRNOG00000022101 Ensembl
  ENSRNOG00000048421 Ensembl
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
InterPro Calycin UniProtKB/Swiss-Prot
  Fatty_acid-bd UniProtKB/Swiss-Prot
  ILBP UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
KEGG Report rno:29563 UniProtKB/Swiss-Prot
NCBI Gene 29563 ENTREZGENE
PANTHER PTHR11955 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PhenoGen Crabp2 PhenoGen
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot
PROSITE FABP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000022101 RatGTEx
  ENSRNOG00000048421 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
TIGR TC206343
UniProt A0A8L2Q848 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L497_RAT UniProtKB/TrEMBL
  A0ABK0LPE8_RAT UniProtKB/TrEMBL
  A6J638_RAT UniProtKB/TrEMBL
  P51673 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Crabp2  cellular retinoic acid binding protein 2  LOC108348208  cellular retinoic acid-binding protein 2-like  Data merged from RGD:11355364 737654 PROVISIONAL
2016-08-02 LOC108348208  cellular retinoic acid-binding protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-12-14 Crabp2  cellular retinoic acid binding protein 2      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Crabp2  cellular retinoic acid binding protein 2      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at high levels in the corpus luteum 61557