Espn (espin) - Rat Genome Database

Name: Espn
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Espn (espin) Rattus norvegicus

Analyze

Symbol:

Espn

Name:

espin

RGD ID:

620652

Description:

Enables SH3 domain binding activity and actin filament binding activity. Predicted to be involved in microvillar actin bundle assembly and negative regulation of cytoskeleton organization. Predicted to act upstream of or within locomotory behavior; parallel actin filament bundle assembly; and positive regulation of filopodium assembly. Located in several cellular components, including actin cytoskeleton; brush border; and microvillus. Part of filamentous actin. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 36. Orthologous to human ESPN (espin); PARTICIPATES IN auditory mechanotransduction pathway; INTERACTS WITH acrylamide; ammonium chloride; bis(2-ethylhexyl) phthalate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

actin cytoskeletal regulatory protein; ectoplasmic specialization protein; Je; Jerker deafness locus; Jerker, deafness locus

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ESPN (espin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):	Espn (espin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Espn (espin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ESPN (espin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ESPN (espin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Espn (espin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ESPN (espin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ESPN (espin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Espn (espin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TCF7L2 (transcription factor 7 like 2)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Espn (espin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ESPN (espin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	espn (espin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	f	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	espn	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	167,909,271 - 167,943,168 (-)	NCBI		GRCr8
mRatBN7.2	5	162,626,560 - 162,660,439 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	162,626,560 - 162,660,256 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	165,329,492 - 165,363,610 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	167,151,038 - 167,185,203 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	167,113,244 - 167,147,401 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	169,293,356 - 169,331,338 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	169,293,904 - 169,331,163 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	172,851,807 - 172,885,845 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	169,349,723 - 169,382,076 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	169,359,914 - 169,392,264 (-)	NCBI
Celera	5	160,858,704 - 160,892,256 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive nonsyndromic deafness (ISO)

autosomal recessive nonsyndromic deafness 36 (ISO)

chromosome 1p36 deletion syndrome (ISO)

Deafness (ISO)

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

sensorineural hearing loss (ISO)

Usher syndrome type 1 (ISO)

Usher Syndrome Type 1M (ISO)

vestibular disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

Benzo[ghi]perylene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

butanal (ISO)

Butylbenzyl phthalate (EXP)

C60 fullerene (EXP)

caffeine (ISO)

carbon nanotube (ISO)

carmustine (EXP)

CGP 52608 (ISO)

choline (ISO)

chromium(6+) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

daidzein (ISO)

dibutyl phthalate (EXP)

diethyl phthalate (EXP)

diethylstilbestrol (ISO)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

diquat (ISO)

endosulfan (ISO)

flavonoids (EXP)

folic acid (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

glycitein (ISO)

inulin (ISO)

L-methionine (ISO)

lead(0) (ISO)

Licochalcone B (ISO)

methapyrilene (ISO)

methotrexate (EXP,ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (ISO)

N-Nitrosopyrrolidine (ISO)

O-methyleugenol (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

quercetin (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

tioguanine (EXP)

triclosan (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament bundle assembly (IBA,IEA,ISO,NAS)

actin filament organization (NAS)

locomotory behavior (ISO)

microvillar actin bundle assembly (IEA,ISO)

negative regulation of cytoskeleton organization (ISO)

parallel actin filament bundle assembly (ISO)

positive regulation of filopodium assembly (ISO)

sensory perception of sound (IEA)

Cellular Component

actin cytoskeleton (IDA,ISO,TAS)

anchoring junction (IEA)

brush border (IDA,ISO)

cytoplasm (IBA,IDA,IEA)

dendritic spine (IEA)

filamentous actin (IDA)

microvillus (IDA,IEA,ISO)

stereocilium (IEA,ISO)

stereocilium bundle (ISO)

stereocilium tip (ISO,ISS)

Molecular Function

actin binding (IEA)

actin filament binding (IBA,IDA,IEA)

protein binding (ISO)

SH3 domain binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

auditory mechanotransduction pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli.	Bartles JR, etal., J Cell Biol 1998 Oct 5;143(1):107-19.
2.	Identification and characterization of espin, an actin-binding protein localized to the F-actin-rich junctional plaques of Sertoli cell ectoplasmic specializations.	Bartles JR, etal., J Cell Sci 1996 Jun;109 ( Pt 6):1229-39.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Mechanotransduction by hair cells: models, molecules, and mechanisms.	Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Review series: The cell biology of hearing.	Schwander M, etal., J Cell Biol. 2010 Jul 12;190(1):9-20. doi: 10.1083/jcb.201001138.
11.	Differential expression of espin isoforms during epithelial morphogenesis, stereociliogenesis and postnatal maturation in the developing inner ear.	Sekerkova G, etal., Dev Biol. 2006 Mar 1;291(1):83-95. Epub 2006 Jan 17.
12.	Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53.	Sekerkova G, etal., J Neurosci 2003 Feb 15;23(4):1310-9.
13.	The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins.	Zheng L, etal., Cell 2000 Aug 4;102(3):377-85.

Additional References at PubMed

PMID:10588661	PMID:15190118	PMID:15477377	PMID:16962269	PMID:17409466	PMID:18551532	PMID:19287378	PMID:20016102	PMID:20510926	PMID:22114352	PMID:22264607	PMID:26754646
PMID:29572253

Genomics

Comparative Map Data

Espn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	167,909,271 - 167,943,168 (-)	NCBI		GRCr8
mRatBN7.2	5	162,626,560 - 162,660,439 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	162,626,560 - 162,660,256 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	165,329,492 - 165,363,610 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	167,151,038 - 167,185,203 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	167,113,244 - 167,147,401 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	169,293,356 - 169,331,338 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	169,293,904 - 169,331,163 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	172,851,807 - 172,885,845 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	169,349,723 - 169,382,076 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	169,359,914 - 169,392,264 (-)	NCBI
Celera	5	160,858,704 - 160,892,256 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

ESPN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	6,424,776 - 6,461,370 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	6,424,776 - 6,461,367 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	6,484,836 - 6,521,004 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	6,407,435 - 6,443,591 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	6,419,113 - 6,455,255	NCBI
Celera	1	5,599,359 - 5,635,452 (+)	NCBI		Celera
Cytogenetic Map	1	p36.31	NCBI
HuRef	1	5,632,355 - 5,668,547 (+)	NCBI		HuRef
CHM1_1	1	6,473,408 - 6,509,542 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	5,950,417 - 5,987,012 (+)	NCBI		T2T-CHM13v2.0

Espn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	152,204,788 - 152,236,871 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	152,204,788 - 152,236,828 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	152,120,331 - 152,152,414 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	152,120,331 - 152,152,371 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	151,494,985 - 151,526,316 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	150,964,677 - 150,996,007 (-)	NCBI		MGSCv36	mm8
Celera	4	154,407,406 - 154,438,512 (-)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	82.9	NCBI

Espn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955486	6,130,190 - 6,156,859 (-)	NCBI	ChiLan1.0	ChiLan1.0

ESPN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	221,766,953 - 221,804,885 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	220,409,018 - 220,446,247 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	5,184,666 - 5,222,473 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	6,440,951 - 6,475,253 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

ESPN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	60,285,185 - 60,316,261 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	60,285,312 - 60,315,676 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	60,295,201 - 60,325,841 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	60,501,302 - 60,531,937 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	60,501,302 - 60,531,352 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	60,500,632 - 60,531,235 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	60,367,399 - 60,398,004 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	60,768,952 - 60,799,595 (+)	NCBI		UU_Cfam_GSD_1.0

Espn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	30,735,187 - 30,764,505 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936623	1,220,593 - 1,248,993 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936623	1,220,435 - 1,249,743 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ESPN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	67,284,079 - 67,316,591 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	67,284,106 - 67,316,577 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	62,236,643 - 62,268,608 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ESPN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	125,282,283 - 125,320,436 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	125,278,313 - 125,320,365 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	29,337,935 - 29,376,129 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Espn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	5,016,019 - 5,042,724 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	5,015,275 - 5,042,862 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Espn
205 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	312
Count of miRNA genes:	109
Interacting mature miRNAs:	120
Transcripts:	ENSRNOT00000000084, ENSRNOT00000013646, ENSRNOT00000042301, ENSRNOT00000047601
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	151113452	164465185	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	154828214	166875058	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3									34	21
Low			4	2	2	2			12	1	18	3
Below cutoff		23	30	20	17	20	3	5	38		2	8	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019622	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110681	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF076856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF540946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF540947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF540948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF540949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY587568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY587569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U46007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000013646 ⟹ ENSRNOP00000013645

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	162,627,108 - 162,634,934 (-)	Ensembl
Rnor_6.0 Ensembl	5	169,293,904 - 169,301,728 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000042301 ⟹ ENSRNOP00000039445

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	162,627,350 - 162,660,256 (-)	Ensembl
Rnor_6.0 Ensembl	5	169,293,904 - 169,331,163 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116345 ⟹ ENSRNOP00000080896

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	162,626,560 - 162,642,512 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117287 ⟹ ENSRNOP00000097437

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	162,626,560 - 162,660,256 (-)	Ensembl

RefSeq Acc Id:

NM_019622 ⟹ NP_062568

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	167,909,271 - 167,942,984 (-)	NCBI
mRatBN7.2	5	162,626,560 - 162,660,256 (-)	NCBI
Rnor_6.0	5	169,293,356 - 169,331,163 (-)	NCBI
Rnor_5.0	5	172,851,807 - 172,885,845 (-)	NCBI
RGSC_v3.4	5	169,349,723 - 169,382,076 (-)	RGD
Celera	5	160,858,704 - 160,892,256 (-)	NCBI

Sequence:

show sequence

GCCGAGGGTGACACCATGGCCCTGGAACAGGCGATGCAGGCGGCACGGCGGGGCGACCTGGACG
TGCTGAGGTCCCTGCACGCCGCCGGCCTGCTGGGGCCTTCTCTGCGCGACCCGCTAGACGCCCT
GCCGGTGCACCATGCGGCCCGCTCAGGCAAGCTGCACTGTTTGCGCTACTTGGTGGAGGAGGTT
GCCCTCCCAGCTGTGTCCCGCGCGCGCAACGGCGCCACACCAGCCCATGATGCCGCTGCCACGG
GCTACCTCTCTTGCCTGCAGTGGCTGCTCACACAGGGTGGCTGCAGGGTGCAGGAAAAAGATAA
CTCTGGTGCCACGGTCCTGCACCTGGCTGCCCGCTTTGGCCACCCGGACGTGGTGAACTGGCTG
CTGTACCAGGGCGGTGCGAACTCTGCCATCACCACAGACACGGGCGCCCTGCCTATCCACTATG
CTGCCGCCAAAGGAGATCTCCCCTCCATGAAGCTTCTTGTCGGGCACTACCCTGAGGGAGTGAA
TGCCCAAACCAACAACGGTGCCACGCCCCTGTACCTGGCGTGCCAGGAGGGCCACCTGGAAGTG
ACGAAGTACCTTGTGCAGGAGTGCAGTGCAGATCCGCACCTGCGCGCCCAAGACGGCATGACCC
CCCTGCATGCCGCGGCGCAGATGGGCCACAACCCAGTCCTGGTGTGGCTGGTGAGCTTTGCGGA
CGTGAGCTTTTCGGAGCAGGACCACGACGGCGCCACAGCCATGCACTTTGCAGCCAGCCGCGGC
CACACCAAAGTGCTCAGCTGGCTCCTGCTGCACGGCGCAGAGATCTCCCAGGACCTGTGGGGCG
GGACCCCGCTGCATGATGCTGCTGAGAACGGGGAACTGGAGTGCTGCCAGATCCTCGCGGTGAA
TGGTGCGGGGCTGGACGTCCGCGACCACGATGGGTATACGGCTGCGGACCTGGCTGATTTCAAT
GGCCACACCCACTGCTCCCGCTACCTACGTACGGTGCAAACCCTGAGCTTGGAACACCGAGTCC
TGTCCCGGGATCCATCCATGGACCTGGAGGCAAAGCAGCCGGACTCAGGCATGTCTTCACCCAA
CACCACCATGTCGGTCCAGCCGCCGAACTTTGACCTTGGCTCACCCACCAGCACCCTCTCCAAC
TATGACTCCTGCTCCTCCAGCCATTCCAGCAGCAAGGGTCAGCGCTCTACTCGAGGTGCCAGAT
CCTCAGACTTACAGAGCTACATGGACATGCTGAACCCAGAGCCTCGGAGCAAGCAAGGGAAGCC
TTCATCTCTACCACCACCGCCACCACCAAGCTTCCCTCCACCACCACCCCCAGGCACACAGCTG
CCCCCACCTCCACCAGGCTACCCAGCTCCCAATCCCCCTGTGGGGCTGCATTTGGATAACATTT
ACATGCAGACCAAGAACAAACTCCGCCACGTGGAGGTGGACTCCCTCAAGAAGGAGCCGAGCTC
CGGCGACGGCTACTCGGGGCTACGCAGGCAGGATTCCGGGCTGCTCAGGCAGGATTCGGAGCTG
CTGCTCAGGCACAACACCGGACTGCGCAGGCAGGACTCCGACCGCAAACAGCGTTCATTCAGTA
AACAGCCCAGCACGGGGGACTACTACCGCCAGCTGGGCCGCAGCCCGGGGGAGCCGCTGGCCGC
ACGCCCGGGCATGGCCCACAGCGAGGAGGCGGCGCTGCTCCCCGGGAACCACGTGCACAACGGC
TGCTCCGCGGACTCCAAAGCGTCCAGGGAGCTGCCGCCGCCACCGCCGCCGCCGCCCCTGCCCG
AGGCCCTGAGTTCGCCGCCACCCGCCCCACCTCTGCCCATCGAGGGCGCGGGCGCAGCCTGCGG
ACAGCGGCGTTCCTCATCTTCTACTGGCAGCACCAAATCTTTCAACATGATGTCCCCAACGGGT
GACAACTCGGAGTTGCTGGCTGAAATAAAAGCAGGCAAGAGTCTGAAACCAACACCGCAGAGCA
AGGGGCTGACAACAGTGTTCTCAGGCAGCGGGCAGCCAGCCTCCCAGCCTGAGTCACCACAGCC
TGCGGTGTCACCTGGGCCATCTCGGGCCCGGAGCCCCACCCCACCAGCCTCTGGGCCTCAGCCA
CTGCTCAATGGCAGCATAGTACCGGCACCACCTGCCACCCTAGCACCAGGAGTGCATCTGGATG
TGGAGGCCCTCATCCCCACACTTGATGAGCAGGGCCGGCCCATCCCGGAGTGGAAGCGCCAGGT
GATGGTCCGGAAGCTGCAGCAGAAAATGCAGGAGGAAGAGGAGCAGCGGAGGAAGGAAGAAGAG
GAGGAGGCCCGGCTGGCCAGCCTGCCCGCCTGGAGACGAGACATTCTTAGGAAGAAGCTGGAGG
AGGAGAGGGAGCAGAAGCGAAAAGAGGAGGAGCGGCAGAAGCTGGAGGAAATCCAGAGGGCGAA
AGAACAGTCGGAGAAGCTGCGGACACTAGGATACGACGAGGCCAAGCTCGCGCCCTGGCAGCGA
CAGGTCATCTTGAAGAAGGGGGAGATCCCTAAGTAATAGGAGTCTCGGCCTCTTGCGTGTAGCC
TCACGAGCTCTGAGAAATGGGGAGCGGCCCCCAGCCCCCGCCCCATCCTGTCAGGTTGGTGCGG
AAGGGTGGGAGCCTTGAGCCCTTCCCTTCGGTGCCTGCCGGAATCTTCCCTATTCCCCTCCCTG
GCCCCACATCCCCAACCCTGCTGCTGGAGTGCTCTCGCGAACCCCTGCTGTCGCCTGGAAAAAA
AAAGTGCCCAGGCTGCTGACGCAAAAAGAAAAAAAGAGAAAGAAAAAAGATGCTCATTTGCATG
CTCACTTACATATATTTGCATGTTCACCGACCCAGCCGGAGCTCGCCCCAGCCTCGTGGGTGGT
GACTTTTCCTGCAGGGCGCACGCCCTGCTGCAGCCCCCTCCCCCGCAGCCCGGAACCCACATTG
CTGGCGCATCCTGGGTGGAGGCAGACCCCGAGCTCGGGGAAGGGGTTTTCCTCCCTCCACGACC
CAGATCTGTGCTGGCCAAAGTTGCTGCGTTTCTTATCCCCTGCGAGGGTTTCCTCTCAGTCATT
TGTTTACCAGAAAGGATGAAACTTGCCTGTAGGGGCGGAGCTGTCGCTCCTGAGGGGCCCCACC
TTTACACGTACCACCCCCTCCCCCCGCCCCAGTTACGCCTTCCAAGTTCCCAGTCAGGCCCTTA
GCTTCCCTGACCCTTTCACTGCCTCAATGGTATAAGTGGAGGGCCAGGGATCCCGCAATTGTAC
CTGCTCCTCACCCTATCCCCCACCCCCTTCCTTCCCCCATTAAACCTCTATCCGCCAA

hide sequence

RefSeq Acc Id:

XM_008764377 ⟹ XP_008762599

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	167,909,271 - 167,943,168 (-)	NCBI
mRatBN7.2	5	162,626,560 - 162,660,439 (-)	NCBI
Rnor_6.0	5	169,293,356 - 169,331,338 (-)	NCBI

Sequence:

show sequence

CCAGAGCGCCGCTGAGCTGGAGTTGAGTCCCCGGGATCGCAGAGCCGGAGCCGGCTGGCAGCCG
CTCTGCCTCCCGGGTCCGCACTCCTCCTCCGACTGCACCGCCGGGTTGCTCTTGGAGCCCGGGG
CCACCTGCATGACGCCCCGGGCGACCCACTGAGCGCGGGATCGCGGCGCCGAGGGTGACACCAT
GGCCCTGGAACAGGCGATGCAGGCGGCACGGCGGGGCGACCTGGACGTGCTGAGGTCCCTGCAC
GCCGCCGGCCTGCTGGGGCCTTCTCTGCGCGACCCGCTAGACGCCCTGCCGGTGCACCATGCGG
CCCGCTCAGGCAAGCTGCACTGTTTGCGCTACTTGGTGGAGGAGGTTGCCCTCCCAGCTGTGTC
CCGCGCGCGCAACGGCGCCACACCAGCCCATGATGCCGCTGCCACGGGCTACCTCTCTTGCCTG
CAGTGGCTGCTCACACAGGGTGGCTGCAGGGTGCAGGAAAAAGATAACTCTGGTGCCACGGTCC
TGCACCTGGCTGCCCGCTTTGGCCACCCGGACGTGGTGAACTGGCTGCTGTACCAGGGCGGTGC
GAACTCTGCCATCACCACAGACACGGGCGCCCTGCCTATCCACTATGCTGCCGCCAAAGGAGAT
CTCCCCTCCATGAAGCTTCTTGTCGGGCACTACCCTGAGGGAGTGAATGCCCAAACCAACAACG
GTGCCACGCCCCTGTACCTGGCGTGCCAGGAGGGCCACCTGGAAGTGACGAAGTACCTTGTGCA
GGAGTGCAGTGCAGATCCGCACCTGCGCGCCCAAGACGGCATGACCCCCCTGCATGCCGCGGCG
CAGATGGGCCACAACCCAGTCCTGGTGTGGCTGGTGAGCTTTGCGGACGTGAGCTTTTCGGAGC
AGGACCACGACGGCGCCACAGCCATGCACTTTGCAGCCAGCCGCGGCCACACCAAAGTGCTCAG
CTGGCTCCTGCTGCACGGCGCAGAGATCTCCCAGGACCTGTGGGGCGGGACCCCGCTGCATGAT
GCTGCTGAGAACGGGGAACTGGAGTGCTGCCAGATCCTCGCGGTGAATGGTGCGGGGCTGGACG
TCCGCGACCACGATGGGTATACGGCTGCGGACCTGGCTGATTTCAATGGCCACACCCACTGCTC
CCGCTACCTACGTACGGTGCAAACCCTGAGCTTGGAACACCGAGTCCTGTCCCGGGATCCATCC
ATGGACCTGGAGGCAAAGCAGCCGGACTCAGGCATGTCTTCACCCAACACCACCATGTCGGTCC
AGCCGCCGAACTTTGACCTTGGCTCACCCACCAGCACCCTCTCCAACTATGACTCCTGCTCCTC
CAGCCATTCCAGCAGCAAGGGTCAGCGCTCTACTCGAGGGGTTCCAGGTGCCAGATCCTCAGAC
TTACAGAGCTACATGGACATGCTGAACCCAGAGCCTCGGAGCAAGCAAGGGAAGCCTTCATCTC
TACCACCACCGCCACCACCAAGCTTCCCTCCACCACCACCCCCAGGCACACAGCTGCCCCCACC
TCCACCAGGCTACCCAGCTCCCAATCCCCCTGTGGGGCTGCATTTGGATAACATTTACATGCAG
ACCAAGAACAAACTCCGCCACGTGGAGGTGGACTCCCTCAAGAAGGAGCCGAGCTCCGGCGACG
GCTACTCGGGGCTACGCAGGCAGGATTCCGGGCTGCTCAGGCAGGATTCGGAGCTGCTGCTCAG
GCACAACACCGGACTGCGCAGGCAGGACTCCGACCGCAAACAGCGTTCATTCAGTAAACAGCCC
AGCACGGGGGACTACTACCGCCAGCTGGGCCGCAGCCCGGGGGAGCCGCTGGCCGCACGCCCGG
GCATGGCCCACAGCGAGGAGGTGCGTGTCCACCAGCCCGCACCTGCGGGCTGCACAGGATCGAA
CCCTGTCTCACACTCCTCACTCTCTGGCCCCTCTGCTCCCCCGCAGGCGGCGCTGCTCCCCGGG
AACCACGTGCACAACGGCTGCTCCGCGGACTCCAAAGCGTCCAGGGAGCTGCCGCCGCCACCGC
CGCCGCCGCCCCTGCCCGAGGCCCTGAGTTCGCCGCCACCCGCCCCACCTCTGCCCATCGAGGG
CGCGGGCGCAGCCTGCGGACAGCGGCGTTCCTCATCTTCTACTGGCAGCACCAAATCTTTCAAC
ATGATGTCCCCAACGGGTGACAACTCGGAGTTGCTGGCTGAAATAAAAGCAGGCAAGAGTCTGA
AACCAACACCGCAGAGCAAGGGGCTGACAACAGTGTTCTCAGGCAGCGGGCAGCCAGCCTCCCA
GCCTGAGTCACCACAGCCTGCGGTGTCACCTGGGCCATCTCGGGCCCGGAGCCCCACCCCACCA
GCCTCTGGGCCTCAGCCACTGCTCAATGGCAGCATAGTACCGGCACCACCTGCCACCCTAGCAC
CAGGAGTGCATCTGGATGTGGAGGCCCTCATCCCCACACTTGATGAGCAGGGCCGGCCCATCCC
GGAGTGGAAGCGCCAGGTGATGGTCCGGAAGCTGCAGCAGAAAATGCAGGAGGAAGAGGAGCAG
CGGAGGAAGGAAGAAGAGGAGGAGGCCCGGCTGGCCAGCCTGCCCGCCTGGAGACGAGACATTC
TTAGGAAGAAGCTGGAGGAGGAGAGGGAGCAGAAGCGAAAAGAGGAGGAGCGGCAGAAGCTGGA
GGAAATCCAGAGGGCGAAAGAACAGTCGGAGAAGCTGCGGACACTAGGATACGACGAGGCCAAG
CTCGCGCCCTGGCAGCGACAGGTCATCTTGAAGAAGGGGGAGATCCCTAAGTAATAGGAGTCTC
GGCCTCTTGCGTGTAGCCTCACGAGCTCTGAGAAATGGGGAGCGGCCCCCAGCCCCCGCCCCAT
CCTGTCAGGTTGGTGCGGAAGGGTGGGAGCCTTGAGCCCTTCCCTTCGGTGCCTGCCGGAATCT
TCCCTATTCCCCTCCCTGGCCCCACATCCCCAACCCTGCTGCTGGAGTGCTCTCGCGAACCCCT
GCTGTCGCCTGGAAAAAAAAAGTGCCCAGGCTGCTGACGCAAAAAGAAAAAAAGAGAAAGAAAA
AAGATGCTCATTTGCATGCTCACTTACATATATTTGCATGTTCACCGACCCAGCCGGAGCTCGC
CCCAGCCTCGTGGGTGGTGACTTTTCCTGCAGGGCGCACGCCCTGCTGCAGCCCCCTCCCCCGC
AGCCCGGAACCCACATTGCTGGCGCATCCTGGGTGGAGGCAGACCCCGAGCTCGGGGAAGGGGT
TTTCCTCCCTCCACGACCCAGATCTGTGCTGGCCAAAGTTGCTGCGTTTCTTATCCCCTGCGAG
GGTTTCCTCTCAGTCATTTGTTTACCAGAAAGGATGAAACTTGCCTGTAGGGGCGGAGCTGTCG
CTCCTGAGGGGCCCCACCTTTACACGTACCACCCCCTCCCCCCGCCCCAGTTACGCCTTCCAAG
TTCCCAGTCAGGCCCTTAGCTTCCCTGACCCTTTCACTGCCTCAATGGTATAAGTGGAGGGCCA
GGGATCCCGCAATTGTACCTGCTCCTCACCCTATCCCCCACCCCCTTCCTTCCCCCATTAAACC
TCTATCCGCCAA

hide sequence

RefSeq Acc Id:

XM_008764380 ⟹ XP_008762602

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	167,909,271 - 167,943,168 (-)	NCBI
mRatBN7.2	5	162,626,560 - 162,660,438 (-)	NCBI
Rnor_6.0	5	169,293,356 - 169,331,338 (-)	NCBI

Sequence:

show sequence

CCAGAGCGCCGCTGAGCTGGAGTTGAGTCCCCGGGATCGCAGAGCCGGAGCCGGCTGGCAGCCG
CTCTGCCTCCCGGGTCCGCACTCCTCCTCCGACTGCACCGCCGGGTTGCTCTTGGAGCCCGGGG
CCACCTGCATGACGCCCCGGGCGACCCACTGAGCGCGGGATCGCGGCGCCGAGGGTGACACCAT
GGCCCTGGAACAGGCGATGCAGGCGGCACGGCGGGGCGACCTGGACGTGCTGAGGTCCCTGCAC
GCCGCCGGCCTGCTGGGGCCTTCTCTGCGCGACCCGCTAGACGCCCTGCCGGTGCACCATGCGG
CCCGCTCAGGCAAGCTGCACTGTTTGCGCTACTTGGTGGAGGAGGTTGCCCTCCCAGCTGTGTC
CCGCGCGCGCAACGGCGCCACACCAGCCCATGATGCCGCTGCCACGGGCTACCTCTCTTGCCTG
CAGTGGCTGCTCACACAGGGTGGCTGCAGGGTGCAGGAAAAAGATAACTCTGGTGCCACGGTCC
TGCACCTGGCTGCCCGCTTTGGCCACCCGGACGTGGTGAACTGGCTGCTGTACCAGGGCGGTGC
GAACTCTGCCATCACCACAGACACGGGCGCCCTGCCTATCCACTATGCTGCCGCCAAAGGAGAT
CTCCCCTCCATGAAGCTTCTTGTCGGGCACTACCCTGAGGGAGTGAATGCCCAAACCAACAACG
GTGCCACGCCCCTGTACCTGGCGTGCCAGGAGGGCCACCTGGAAGTGACGAAGTACCTTGTGCA
GGAGTGCAGTGCAGATCCGCACCTGCGCGCCCAAGACGGCATGACCCCCCTGCATGCCGCGGCG
CAGATGGGCCACAACCCAGTCCTGGTGTGGCTGGTGAGCTTTGCGGACGTGAGCTTTTCGGAGC
AGGACCACGACGGCGCCACAGCCATGCACTTTGCAGCCAGCCGCGGCCACACCAAAGTGCTCAG
CTGGCTCCTGCTGCACGGCGCAGAGATCTCCCAGGACCTGTGGGGCGGGACCCCGCTGCATGAT
GCTGCTGAGAACGGGGAACTGGAGTGCTGCCAGATCCTCGCGGTGAATGGTGCGGGGCTGGACG
TCCGCGACCACGATGGGTATACGGCTGCGGACCTGGCTGATTTCAATGGCCACACCCACTGCTC
CCGCTACCTACGTACGGTGCAAACCCTGAGCTTGGAACACCGAGTCCTGTCCCGGGATCCATCC
ATGGACCTGGAGGCAAAGCAGCCGGACTCAGGCATGTCTTCACCCAACACCACCATGTCGGTCC
AGCCGCCGAACTTTGACCTTGGCTCACCCACCAGCACCCTCTCCAACTATGACTCCTGCTCCTC
CAGCCATTCCAGCAGCAAGGGTCAGCGCTCTACTCGAGGGGTTCCAGGTGCCAGATCCTCAGAC
TTACAGAGCTACATGGACATGCTGAACCCAGAGCCTCGGAGCAAGCAAGGGAAGCCTTCATCTC
TACCACCACCGCCACCACCAAGCTTCCCTCCACCACCACCCCCAGGCACACAGCTGCCCCCACC
TCCACCAGGCTACCCAGCTCCCAATCCCCCTGTGGGGCTGCATTTGGATAACATTTACATGCAG
ACCAAGAACAAACTCCGCCACGTGGAGGTGGACTCCCTCAAGAAGGAGCCGAGCTCCGGCGACG
GCTACTCGGGGCTACGCAGGCAGGATTCCGGGCTGCTCAGGCAGGATTCGGAGCTGCTGCTCAG
GCACAACACCGGACTGCGCAGGCAGGACTCCGACCGCAAACAGCGTTCATTCAGTAAACAGCCC
AGCACGGGGGACTACTACCGCCAGCTGGGCCGCAGCCCGGGGGAGCCGCTGGCCGCACGCCCGG
GCATGGCCCACAGCGAGGAGGCGGCGCTGCTCCCCGGGAACCACGTGCACAACGGCTGCTCCGC
GGACTCCAAAGCGTCCAGGGAGCTGCCGCCGCCACCGCCGCCGCCGCCCCTGCCCGAGGCCCTG
AGTTCGCCGCCACCCGCCCCACCTCTGCCCATCGAGGGCGCGGGCGCAGCCTGCGGACAGCGGC
GTTCCTCATCTTCTACTGGCAGCACCAAATCTTTCAACATGATGTCCCCAACGGGTGACAACTC
GGAGTTGCTGGCTGAAATAAAAGCAGGCAAGAGTCTGAAACCAACACCGCAGAGCAAGGGGCTG
ACAACAGTGTTCTCAGGCAGCGGGCAGCCAGCCTCCCAGCCTGAGTCACCACAGCCTGCGGTGT
CACCTGGGCCATCTCGGGCCCGGAGCCCCACCCCACCAGCCTCTGGGCCTCAGCCACTGCTCAA
TGGCAGCATAGTACCGGCACCACCTGCCACCCTAGCACCAGGAGTGCATCTGGATGTGGAGGCC
CTCATCCCCACACTTGATGAGCAGGGCCGGCCCATCCCGGAGTGGAAGCGCCAGGTGATGGTCC
GGAAGCTGCAGCAGAAAATGCAGGAGGAAGAGGAGCAGCGGAGGAAGGAAGAAGAGGAGGAGGC
CCGGCTGGCCAGCCTGCCCGCCTGGAGACGAGACATTCTTAGGAAGAAGCTGGAGGAGGAGAGG
GAGCAGAAGCGAAAAGAGGAGGAGCGGCAGAAGCTGGAGGAAATCCAGAGGGCGAAAGAACAGT
CGGAGAAGCTGCGGACACTAGGATACGACGAGGCCAAGCTCGCGCCCTGGCAGCGACAGGTCAT
CTTGAAGAAGGGGGAGATCCCTAAGTAATAGGAGTCTCGGCCTCTTGCGTGTAGCCTCACGAGC
TCTGAGAAATGGGGAGCGGCCCCCAGCCCCCGCCCCATCCTGTCAGGTTGGTGCGGAAGGGTGG
GAGCCTTGAGCCCTTCCCTTCGGTGCCTGCCGGAATCTTCCCTATTCCCCTCCCTGGCCCCACA
TCCCCAACCCTGCTGCTGGAGTGCTCTCGCGAACCCCTGCTGTCGCCTGGAAAAAAAAAGTGCC
CAGGCTGCTGACGCAAAAAGAAAAAAAGAGAAAGAAAAAAGATGCTCATTTGCATGCTCACTTA
CATATATTTGCATGTTCACCGACCCAGCCGGAGCTCGCCCCAGCCTCGTGGGTGGTGACTTTTC
CTGCAGGGCGCACGCCCTGCTGCAGCCCCCTCCCCCGCAGCCCGGAACCCACATTGCTGGCGCA
TCCTGGGTGGAGGCAGACCCCGAGCTCGGGGAAGGGGTTTTCCTCCCTCCACGACCCAGATCTG
TGCTGGCCAAAGTTGCTGCGTTTCTTATCCCCTGCGAGGGTTTCCTCTCAGTCATTTGTTTACC
AGAAAGGATGAAACTTGCCTGTAGGGGCGGAGCTGTCGCTCCTGAGGGGCCCCACCTTTACACG
TACCACCCCCTCCCCCCGCCCCAGTTACGCCTTCCAAGTTCCCAGTCAGGCCCTTAGCTTCCCT
GACCCTTTCACTGCCTCAATGGTATAAGTGGAGGGCCAGGGATCCCGCAATTGTACCTGCTCCT
CACCCTATCCCCCACCCCCTTCCTTCCCCCATTAAACCTCTATCCGCCAA

hide sequence

RefSeq Acc Id:

XM_039110680 ⟹ XP_038966608

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	167,909,271 - 167,943,168 (-)	NCBI
mRatBN7.2	5	162,626,560 - 162,660,439 (-)	NCBI

RefSeq Acc Id:

XM_039110681 ⟹ XP_038966609

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	167,909,271 - 167,943,168 (-)	NCBI
mRatBN7.2	5	162,626,560 - 162,660,439 (-)	NCBI

RefSeq Acc Id:

XM_039110682 ⟹ XP_038966610

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	167,909,271 - 167,943,168 (-)	NCBI
mRatBN7.2	5	162,626,560 - 162,660,439 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_062568	(Get FASTA)	NCBI Sequence Viewer
	XP_008762599	(Get FASTA)	NCBI Sequence Viewer
	XP_008762602	(Get FASTA)	NCBI Sequence Viewer
	XP_038966608	(Get FASTA)	NCBI Sequence Viewer
	XP_038966609	(Get FASTA)	NCBI Sequence Viewer
	XP_038966610	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC53594	(Get FASTA)	NCBI Sequence Viewer
	AAC69563	(Get FASTA)	NCBI Sequence Viewer
	AAO50330	(Get FASTA)	NCBI Sequence Viewer
	AAO50331	(Get FASTA)	NCBI Sequence Viewer
	AAO50332	(Get FASTA)	NCBI Sequence Viewer
	AAO50333	(Get FASTA)	NCBI Sequence Viewer
	AAT46470	(Get FASTA)	NCBI Sequence Viewer
	AAT46471	(Get FASTA)	NCBI Sequence Viewer
	EDL81221	(Get FASTA)	NCBI Sequence Viewer
	EDL81222	(Get FASTA)	NCBI Sequence Viewer
	EDL81223	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013645.3
	ENSRNOP00000039445
	ENSRNOP00000039445.4
	ENSRNOP00000080896.1
	ENSRNOP00000097437
	ENSRNOP00000097437.1
GenBank Protein	Q63618	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_062568 ⟸ NM_019622

- UniProtKB:

F1LQ34 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MALEQAMQAARRGDLDVLRSLHAAGLLGPSLRDPLDALPVHHAARSGKLHCLRYLVEEVALPAV
SRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGG
ANSAITTDTGALPIHYAAAKGDLPSMKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLV
QECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVL
SWLLLHGAEISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHC
SRYLRTVQTLSLEHRVLSRDPSMDLEAKQPDSGMSSPNTTMSVQPPNFDLGSPTSTLSNYDSCS
SSHSSSKGQRSTRGARSSDLQSYMDMLNPEPRSKQGKPSSLPPPPPPSFPPPPPPGTQLPPPPP
GYPAPNPPVGLHLDNIYMQTKNKLRHVEVDSLKKEPSSGDGYSGLRRQDSGLLRQDSELLLRHN
TGLRRQDSDRKQRSFSKQPSTGDYYRQLGRSPGEPLAARPGMAHSEEAALLPGNHVHNGCSADS
KASRELPPPPPPPPLPEALSSPPPAPPLPIEGAGAACGQRRSSSSTGSTKSFNMMSPTGDNSEL
LAEIKAGKSLKPTPQSKGLTTVFSGSGQPASQPESPQPAVSPGPSRARSPTPPASGPQPLLNGS
IVPAPPATLAPGVHLDVEALIPTLDEQGRPIPEWKRQVMVRKLQQKMQEEEEQRRKEEEEEARL
ASLPAWRRDILRKKLEEEREQKRKEEERQKLEEIQRAKEQSEKLRTLGYDEAKLAPWQRQVILK
KGEIPK

hide sequence

RefSeq Acc Id:

XP_008762602 ⟸ XM_008764380

- Peptide Label:

isoform X5

- Sequence:

show sequence

MALEQAMQAARRGDLDVLRSLHAAGLLGPSLRDPLDALPVHHAARSGKLHCLRYLVEEVALPAV
SRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGG
ANSAITTDTGALPIHYAAAKGDLPSMKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLV
QECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVL
SWLLLHGAEISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHC
SRYLRTVQTLSLEHRVLSRDPSMDLEAKQPDSGMSSPNTTMSVQPPNFDLGSPTSTLSNYDSCS
SSHSSSKGQRSTRGVPGARSSDLQSYMDMLNPEPRSKQGKPSSLPPPPPPSFPPPPPPGTQLPP
PPPGYPAPNPPVGLHLDNIYMQTKNKLRHVEVDSLKKEPSSGDGYSGLRRQDSGLLRQDSELLL
RHNTGLRRQDSDRKQRSFSKQPSTGDYYRQLGRSPGEPLAARPGMAHSEEAALLPGNHVHNGCS
ADSKASRELPPPPPPPPLPEALSSPPPAPPLPIEGAGAACGQRRSSSSTGSTKSFNMMSPTGDN
SELLAEIKAGKSLKPTPQSKGLTTVFSGSGQPASQPESPQPAVSPGPSRARSPTPPASGPQPLL
NGSIVPAPPATLAPGVHLDVEALIPTLDEQGRPIPEWKRQVMVRKLQQKMQEEEEQRRKEEEEE
ARLASLPAWRRDILRKKLEEEREQKRKEEERQKLEEIQRAKEQSEKLRTLGYDEAKLAPWQRQV
ILKKGEIPK

hide sequence

RefSeq Acc Id:	XP_008762599 ⟸ XM_008764377
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6ARF5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALEQAMQAARRGDLDVLRSLHAAGLLGPSLRDPLDALPVHHAARSGKLHCLRYLVEEVALPAV SRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGG ANSAITTDTGALPIHYAAAKGDLPSMKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLV QECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVL SWLLLHGAEISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHC SRYLRTVQTLSLEHRVLSRDPSMDLEAKQPDSGMSSPNTTMSVQPPNFDLGSPTSTLSNYDSCS SSHSSSKGQRSTRGVPGARSSDLQSYMDMLNPEPRSKQGKPSSLPPPPPPSFPPPPPPGTQLPP PPPGYPAPNPPVGLHLDNIYMQTKNKLRHVEVDSLKKEPSSGDGYSGLRRQDSGLLRQDSELLL RHNTGLRRQDSDRKQRSFSKQPSTGDYYRQLGRSPGEPLAARPGMAHSEEVRVHQPAPAGCTGS NPVSHSSLSGPSAPPQAALLPGNHVHNGCSADSKASRELPPPPPPPPLPEALSSPPPAPPLPIE GAGAACGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGSGQPAS QPESPQPAVSPGPSRARSPTPPASGPQPLLNGSIVPAPPATLAPGVHLDVEALIPTLDEQGRPI PEWKRQVMVRKLQQKMQEEEEQRRKEEEEEARLASLPAWRRDILRKKLEEEREQKRKEEERQKL EEIQRAKEQSEKLRTLGYDEAKLAPWQRQVILKKGEIPK hide sequence

RefSeq Acc Id:

ENSRNOP00000039445 ⟸ ENSRNOT00000042301

RefSeq Acc Id:

ENSRNOP00000013645 ⟸ ENSRNOT00000013646

RefSeq Acc Id:	XP_038966609 ⟸ XM_039110681
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038966610 ⟸ XM_039110682
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038966608 ⟸ XM_039110680
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000097437 ⟸ ENSRNOT00000117287

RefSeq Acc Id:

ENSRNOP00000080896 ⟸ ENSRNOT00000116345

Protein Domains

WH2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63618-F1-model_v2	AlphaFold	Q63618	1-837	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694298

Promoter ID:

EPDNEW_R4823

Type:

multiple initiation site

Name:

Espn_1

Description:

espin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	169,301,756 - 169,301,816	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620652	AgrOrtholog
BioCyc Gene	G2FUF-39020	BioCyc
Ensembl Genes	ENSRNOG00000010270	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013646.5	UniProtKB/Swiss-Prot
	ENSRNOT00000042301	ENTREZGENE
	ENSRNOT00000042301.6	UniProtKB/TrEMBL
	ENSRNOT00000116345.1	UniProtKB/TrEMBL
	ENSRNOT00000117287.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH2_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	56227	ENTREZGENE
PANTHER	ESPIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR24153:SF14	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ank_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ank_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Espn	PhenoGen
PROSITE	ANK_REP_REGION	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010270	RatGTEx
SMART	ANK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48403	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZQJ8_RAT	UniProtKB/TrEMBL
	A0A8I6ARF5	ENTREZGENE, UniProtKB/TrEMBL
	A6IUH0_RAT	UniProtKB/TrEMBL
	A6IUH2_RAT	UniProtKB/TrEMBL
	ESPN_RAT	UniProtKB/Swiss-Prot
	F1LQ34	ENTREZGENE, UniProtKB/TrEMBL
	Q63618	ENTREZGENE
UniProt Secondary	Q6GYS2	UniProtKB/Swiss-Prot
	Q6GYS3	UniProtKB/Swiss-Prot
	Q80ZB6	UniProtKB/Swiss-Prot
	Q80ZB7	UniProtKB/Swiss-Prot
	Q80ZB8	UniProtKB/Swiss-Prot
	Q80ZB9	UniProtKB/Swiss-Prot
	Q9Z2B4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2003-04-09	Espn	espin			Symbol and Name updated	629477	APPROVED
2003-03-07	Espn	espin	Je	Jerker, deafness locus	Data merged from RGD:2941	628472	PROVISIONAL
2002-08-07	Espn				Symbol and Name status set to provisional	70820	PROVISIONAL
2002-06-10	Je	Jerker, deafness locus			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the ectoplasmic specializations where Sertoli cells contact the heads of elongated spermatids	632658
gene_process	responsible for function and organization of the ectoplasmic specialization	632658
gene_protein	has a mass of 110 kDa with 8 ankyrin-like repeats in the N-terminal, a potential P-loop, two proline-rich peptides and two peptides with clusters of multiple glutamates	632658

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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