Dvl1 (dishevelled segment polarity protein 1) - Rat Genome Database

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Gene: Dvl1 (dishevelled segment polarity protein 1) Rattus norvegicus
Analyze
Symbol: Dvl1
Name: dishevelled segment polarity protein 1
RGD ID: 620632
Description: Enables protein kinase binding activity and small GTPase binding activity. Involved in several processes, including dendritic spine morphogenesis; positive regulation of excitatory postsynaptic potential; and positive regulation of neuron projection arborization. Located in several cellular components, including dendritic spine; growth cone; and postsynaptic density. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to several human genes including DVL1 (dishevelled segment polarity protein 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dishevelled 1; dishevelled, dsh homolog 1; dishevelled, dsh homolog 1 (Drosophila); dishevelled-1; DSH homolog 1; dvl-1; segment polarity protein dishevelled homolog DVL-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,738,911 - 171,750,967 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5171,739,133 - 171,750,966 (+)EnsemblGRCr8
mRatBN7.25166,456,989 - 166,468,733 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,456,686 - 166,468,664 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5169,161,665 - 169,173,332 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,983,086 - 170,994,753 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,945,617 - 170,957,284 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,295,948 - 173,308,014 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,296,270 - 173,307,945 (+)Ensemblrn6Rnor6.0
Rnor_5.05176,771,577 - 176,783,630 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45172,705,951 - 172,717,626 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,657,716 - 164,669,383 (+)NCBICelera
RGSC_v3.15172,716,445 - 172,728,121 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
citalopram  (EXP)
clofibric acid  (EXP)
cocaine  (EXP)
curcumin  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
escitalopram  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
lead diacetate  (ISO)
malathion  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP)
niclosamide  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
proanthocyanidin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tetrachloroethene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon extension  (ISO)
axon guidance  (ISO)
axonogenesis  (ISO)
canonical Wnt signaling pathway  (IBA,IEA,ISO)
cochlea morphogenesis  (ISO)
collateral sprouting  (ISO)
convergent extension involved in neural plate elongation  (ISO)
convergent extension involved in organogenesis  (ISO)
cytoplasmic microtubule organization  (ISO)
dendrite morphogenesis  (ISO)
dendritic spine morphogenesis  (IGI)
heart looping  (IEA,ISO)
intracellular signal transduction  (IEA)
negative regulation of protein phosphorylation  (ISO)
neural tube development  (IEA,ISO)
neuromuscular junction development  (ISO)
neurotransmitter secretion  (ISO)
outflow tract morphogenesis  (IEA,ISO)
positive regulation of excitatory postsynaptic potential  (IGI)
positive regulation of neuron projection arborization  (IGI)
positive regulation of neuron projection development  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
postsynapse organization  (IEA,ISO)
prepulse inhibition  (ISO)
presynapse assembly  (IEA,ISO)
protein localization to microtubule  (ISO)
protein localization to nucleus  (IEA,ISO)
protein stabilization  (IEA,ISO)
receptor clustering  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of postsynapse organization  (IEA,ISO)
regulation of protein localization  (IEA,ISO)
regulation of protein phosphorylation  (ISO)
regulation of synaptic vesicle exocytosis  (IEA,ISO)
skeletal muscle acetylcholine-gated channel clustering  (ISO)
social behavior  (ISO)
synapse organization  (ISO)
Wnt signaling pathway  (IEA,IGI,TAS)
Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)

Cellular Component
axon  (IDA,IEA,ISO)
clathrin-coated vesicle  (IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
cytoplasmic vesicle  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
dendrite  (IDA)
dendritic spine  (IDA)
glutamatergic synapse  (IEA,ISO)
growth cone  (IDA,IEA,ISO)
lateral plasma membrane  (IEA,ISO)
microtubule  (IDA)
microtubule cytoskeleton  (IDA,IEA,ISO)
neuron projection  (IEA,ISO)
neuronal cell body  (IDA)
neuronal dense core vesicle  (IEA,ISO)
plasma membrane  (IEA,ISO,ISS)
postsynaptic density  (IDA,IEA,ISO)
presynapse  (IEA,ISO)
Schaffer collateral - CA1 synapse  (IEA,ISO)
synapse  (IEA,ISO)
Wnt signalosome  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway. Aschenbach WG, etal., Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E152-8. Epub 2006 Feb 14.
2. A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Bian WJ, etal., Dev Neurobiol. 2015 Aug;75(8):805-22. doi: 10.1002/dneu.22250. Epub 2014 Dec 1.
3. Expression of Dishevelled-1 in wound healing after acute myocardial infarction: possible involvement in myofibroblast proliferation and migration. Chen L, etal., J Cell Mol Med. 2004 Apr-Jun;8(2):257-64.
4. Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca(2)(+)/Calmodulin-dependent protein kinase II. Ciani L, etal., Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10732-7. doi: 10.1073/pnas.1018132108. Epub 2011 Jun 13.
5. Mapping and sequencing rat dishevelled-1: a candidate gene for cerebral ischaemic insult in a rat model of stroke. De Lange RP, etal., Neurogenetics 2001 Mar;3(2):99-106.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Lijam N, etal., Cell 1997 Sep 5;90(5):895-905.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome. Pizzuti A, etal., Am J Hum Genet. 1996 Apr;58(4):722-9.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
16. Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Rosso SB, etal., Nat Neurosci. 2005 Jan;8(1):34-42. Epub 2004 Dec 19.
17. Wnt-mediated relocalization of dishevelled proteins. Steitz SA, etal., In Vitro Cell Dev Biol Anim. 1996 Jul-Aug;32(7):441-5.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8817329   PMID:9271238   PMID:10330181   PMID:10409711   PMID:11113207   PMID:11742004   PMID:11742073   PMID:12138115   PMID:12165471   PMID:12556519   PMID:12805222   PMID:14648878  
PMID:14734535   PMID:14747478   PMID:14960015   PMID:14966280   PMID:15454084   PMID:15548427   PMID:16116426   PMID:16571627   PMID:16818724   PMID:17005174   PMID:17027228   PMID:17212654  
PMID:17239604   PMID:17558396   PMID:17593335   PMID:18093802   PMID:18716223   PMID:19008950   PMID:19020093   PMID:19388021   PMID:19625296   PMID:19643732   PMID:20177058   PMID:21189423  
PMID:21718540   PMID:21880741   PMID:22899650   PMID:23074275   PMID:23160799   PMID:24305805   PMID:25674206   PMID:26359454   PMID:26400647   PMID:29510185   PMID:32105766   PMID:36726071  


Genomics

Comparative Map Data
Dvl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,738,911 - 171,750,967 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5171,739,133 - 171,750,966 (+)EnsemblGRCr8
mRatBN7.25166,456,989 - 166,468,733 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,456,686 - 166,468,664 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5169,161,665 - 169,173,332 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,983,086 - 170,994,753 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,945,617 - 170,957,284 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,295,948 - 173,308,014 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,296,270 - 173,307,945 (+)Ensemblrn6Rnor6.0
Rnor_5.05176,771,577 - 176,783,630 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45172,705,951 - 172,717,626 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,657,716 - 164,669,383 (+)NCBICelera
RGSC_v3.15172,716,445 - 172,728,121 (+)NCBI
Cytogenetic Map5q36NCBI
DVL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,335,278 - 1,349,418 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11,335,276 - 1,349,945 (-)Ensemblhg38GRCh38
GRCh3711,270,658 - 1,284,798 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,260,521 - 1,274,358 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411,310,581 - 1,324,438NCBI
Celera11,305,944 - 1,310,484 (+)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1541,861 - 555,565 (-)NCBIHuRef
CHM1_111,257,686 - 1,271,561 (-)NCBICHM1_1
T2T-CHM13v2.01766,863 - 781,044 (-)NCBIT2T-CHM13v2.0
Dvl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,931,829 - 155,943,760 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,931,859 - 155,943,760 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384155,847,402 - 155,859,303 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,847,402 - 155,859,303 (+)Ensemblmm10GRCm38
MGSCv374155,221,521 - 155,233,412 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364154,691,212 - 154,703,103 (+)NCBIMGSCv36mm8
Celera4158,118,352 - 158,130,254 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map487.61NCBI
Dvl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,464,313 - 9,469,984 (+)Ensembl
ChiLan1.0NW_0049554869,464,390 - 9,469,984 (+)NCBIChiLan1.0ChiLan1.0
DVL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,875,118 - 226,889,403 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,573,663 - 225,587,944 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,469 - 106,748 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111,292,052 - 1,300,006 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11,292,052 - 1,301,008 (-)EnsemblpanPan2panpan1.1
DVL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,507,803 - 56,519,382 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,507,739 - 56,519,491 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha556,584,127 - 56,595,703 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0556,710,022 - 56,721,601 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,710,027 - 56,721,542 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,700,763 - 56,712,335 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,593,044 - 56,604,611 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,983,289 - 56,994,870 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dvl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,654,912 - 27,668,618 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367371,797,326 - 1,810,286 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367371,797,348 - 1,811,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DVL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,617,789 - 63,628,913 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1663,617,787 - 63,628,965 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,115,863 - 58,126,973 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DVL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120130,105,032 - 130,118,978 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20130,104,639 - 130,117,139 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605434,662,915 - 34,682,331 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dvl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248188,267,128 - 8,278,725 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248188,267,111 - 8,283,755 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dvl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v114,770,167 - 4,782,237 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:85
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000026439
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat

Markers in Region
RH141334  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,468,498 - 166,468,686 (+)MAPPERmRatBN7.2
Rnor_6.05173,307,780 - 173,307,967NCBIRnor6.0
Rnor_5.05176,783,396 - 176,783,583UniSTSRnor5.0
RGSC_v3.45172,717,461 - 172,717,648UniSTSRGSC3.4
Celera5164,669,218 - 164,669,405UniSTS
RH 3.4 Map51174.5UniSTS
Cytogenetic Map5q36UniSTS
AI406524  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,463,925 - 166,464,075 (+)MAPPERmRatBN7.2
Rnor_6.05173,303,207 - 173,303,356NCBIRnor6.0
Rnor_5.05176,778,823 - 176,778,972UniSTSRnor5.0
RGSC_v3.45172,712,888 - 172,713,037UniSTSRGSC3.4
Celera5164,664,645 - 164,664,794UniSTS
RH 3.4 Map51175.1UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC126156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF143545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF143546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC160920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026439   ⟹   ENSRNOP00000026439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5171,739,133 - 171,750,966 (+)Ensembl
mRatBN7.2 Ensembl5166,456,989 - 166,468,664 (+)Ensembl
Rnor_6.0 Ensembl5173,296,270 - 173,307,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107156   ⟹   ENSRNOP00000085309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,456,686 - 166,468,575 (+)Ensembl
RefSeq Acc Id: NM_031820   ⟹   NP_114008
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,739,223 - 171,750,898 (+)NCBI
mRatBN7.25166,456,989 - 166,468,664 (+)NCBI
Rnor_6.05173,296,270 - 173,307,945 (+)NCBI
Rnor_5.05176,771,577 - 176,783,630 (+)NCBI
RGSC_v3.45172,705,951 - 172,717,626 (+)RGD
Celera5164,657,716 - 164,669,383 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239598   ⟹   XP_006239660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,738,912 - 171,750,967 (+)NCBI
mRatBN7.25166,456,990 - 166,468,733 (+)NCBI
Rnor_6.05173,295,949 - 173,308,014 (+)NCBI
Rnor_5.05176,771,577 - 176,783,630 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110851   ⟹   XP_038966779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,739,273 - 171,750,967 (+)NCBI
mRatBN7.25166,457,025 - 166,468,733 (+)NCBI
RefSeq Acc Id: XM_063288482   ⟹   XP_063144552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,738,911 - 171,749,218 (+)NCBI
RefSeq Acc Id: NP_114008   ⟸   NM_031820
- UniProtKB: Q9QUG5 (UniProtKB/Swiss-Prot),   Q9WVB8 (UniProtKB/Swiss-Prot),   Q9WVB9 (UniProtKB/Swiss-Prot),   A6IUT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239660   ⟸   XM_006239598
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000026439   ⟸   ENSRNOT00000026439
RefSeq Acc Id: XP_038966779   ⟸   XM_039110851
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000085309   ⟸   ENSRNOT00000107156
RefSeq Acc Id: XP_063144552   ⟸   XM_063288482
- Peptide Label: isoform X2
Protein Domains
DEP   DIX   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVB9-F1-model_v2 AlphaFold Q9WVB9 1-695 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620632 AgrOrtholog
BioCyc Gene G2FUF-38893 BioCyc
Ensembl Genes ENSRNOG00000019423 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026439 ENTREZGENE
  ENSRNOT00000026439.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  2.30.42.10 UniProtKB/Swiss-Prot
  2.40.240.130 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599217 IMAGE-MGC_LOAD
  IMAGE:7461890 IMAGE-MGC_LOAD
InterPro DEP_dom UniProtKB/Swiss-Prot
  Dishevelled_C-dom UniProtKB/Swiss-Prot
  Dishevelled_fam UniProtKB/Swiss-Prot
  Dishevelled_protein_dom UniProtKB/Swiss-Prot
  DIX UniProtKB/Swiss-Prot
  DIX_dom_sf UniProtKB/Swiss-Prot
  Dsh/Dvl-rel UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:83721 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188669 IMAGE-MGC_LOAD
  MGC:72382 IMAGE-MGC_LOAD
NCBI Gene 83721 ENTREZGENE
PANTHER PTHR10878 UniProtKB/Swiss-Prot
  PTHR10878:SF5 UniProtKB/Swiss-Prot
Pfam DEP UniProtKB/Swiss-Prot
  Dishevelled UniProtKB/Swiss-Prot
  DIX UniProtKB/Swiss-Prot
  Dsh_C UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
PhenoGen Dvl1 PhenoGen
PRINTS DISHEVELLED UniProtKB/Swiss-Prot
  DISHEVELLED1 UniProtKB/Swiss-Prot
PROSITE DEP UniProtKB/Swiss-Prot
  DIX UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019423 RatGTEx
SMART DAX UniProtKB/Swiss-Prot
  DEP UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt A6IUT5 ENTREZGENE, UniProtKB/TrEMBL
  B1H2A0_RAT UniProtKB/TrEMBL
  DVL1_RAT UniProtKB/Swiss-Prot
  Q9QUG5 ENTREZGENE
  Q9WVB8 ENTREZGENE
  Q9WVB9 ENTREZGENE
UniProt Secondary Q9QUG5 UniProtKB/Swiss-Prot
  Q9WVB8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-05 Dvl1  dishevelled segment polarity protein 1  Dvl1  dishevelled, dsh homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Dvl1  dishevelled, dsh homolog 1 (Drosophila)    dishevelled 1  Name updated 1299863 APPROVED
2002-08-07 Dvl1  dishevelled 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_other excluded as a candidate gene for brain ischemia in the stroke-prone spontaneously hypertensive rat (SHRSP) because sequences in stroke-prone and control rats are identical 634738