Gucy2f (guanylate cyclase 2F) - Rat Genome Database

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Gene: Gucy2f (guanylate cyclase 2F) Rattus norvegicus
Analyze
Symbol: Gucy2f
Name: guanylate cyclase 2F
RGD ID: 620439
Description: Enables guanylate cyclase activity and identical protein binding activity. Involved in cGMP-mediated signaling. Located in plasma membrane. Orthologous to human GUCY2F (guanylate cyclase 2F, retinal); PARTICIPATES IN visual phototransduction pathway; purine metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GC-F; guanylate cyclase 2F, retinal; guanylate cyclase F; RETGC-2; retinal guanylyl cyclase 2; rod outer segment membrane guanylate cyclase 2; ROS-GC2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X110,507,183 - 110,605,017 (-)NCBIGRCr8
mRatBN7.2X105,710,356 - 105,808,183 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX105,710,356 - 105,808,183 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX107,848,258 - 107,946,084 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X111,347,446 - 111,445,266 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X108,912,156 - 109,010,662 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X113,372,240 - 113,474,210 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX113,372,240 - 113,474,164 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X111,822,417 - 111,920,459 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X36,367,528 - 36,469,112 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X36,420,996 - 36,522,581 (+)NCBI
CeleraX105,123,834 - 105,223,272 (-)NCBICelera
Cytogenetic MapXq33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Photoreceptor signaling: supporting vision across a wide range of light intensities. Arshavsky VY and Burns ME, J Biol Chem. 2012 Jan 13;287(3):1620-6. Epub 2011 Nov 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Application of functional genomic technologies in a mouse model of retinal degeneration. Shearstone JR, etal., Genomics. 2005 Mar;85(3):309-21.
13. Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers. Yang RB and Garbers DL, J Biol Chem. 1997 May 23;272(21):13738-42.
14. Two membrane forms of guanylyl cyclase found in the eye. Yang RB, etal., Proc Natl Acad Sci U S A 1995 Jan 17;92(2):602-6.
Additional References at PubMed
PMID:17255100   PMID:21078983  


Genomics

Comparative Map Data
Gucy2f
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X110,507,183 - 110,605,017 (-)NCBIGRCr8
mRatBN7.2X105,710,356 - 105,808,183 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX105,710,356 - 105,808,183 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX107,848,258 - 107,946,084 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X111,347,446 - 111,445,266 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X108,912,156 - 109,010,662 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X113,372,240 - 113,474,210 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX113,372,240 - 113,474,164 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X111,822,417 - 111,920,459 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X36,367,528 - 36,469,112 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X36,420,996 - 36,522,581 (+)NCBI
CeleraX105,123,834 - 105,223,272 (-)NCBICelera
Cytogenetic MapXq33NCBI
GUCY2F
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X109,372,906 - 109,482,086 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX109,372,906 - 109,482,086 (-)EnsemblGRCh38hg38GRCh38
GRCh37X108,616,135 - 108,725,315 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X108,502,791 - 108,611,941 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X108,422,279 - 108,531,432NCBI
CeleraX109,095,739 - 109,204,892 (-)NCBICelera
Cytogenetic MapXq22.3-q23NCBI
HuRefX98,238,823 - 98,346,954 (-)NCBIHuRef
CHM1_1X108,527,410 - 108,636,553 (-)NCBICHM1_1
T2T-CHM13v2.0X107,820,404 - 107,929,552 (-)NCBIT2T-CHM13v2.0
Gucy2f
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X140,862,282 - 140,980,399 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX140,864,156 - 140,979,927 (-)EnsemblGRCm39 Ensembl
GRCm38X142,079,286 - 142,197,276 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX142,081,160 - 142,196,931 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X138,515,703 - 138,631,474 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X137,327,528 - 137,443,299 (-)NCBIMGSCv36mm8
CeleraX126,078,100 - 126,191,808 (-)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX62.85NCBI
Gucy2f
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554906,331,247 - 6,437,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554906,331,247 - 6,437,563 (+)NCBIChiLan1.0ChiLan1.0
GUCY2F
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X108,864,549 - 108,973,618 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X108,868,153 - 108,977,222 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X98,481,609 - 98,590,680 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X108,952,200 - 109,061,441 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX108,952,200 - 109,061,441 (-)Ensemblpanpan1.1panPan2
GUCY2F
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X82,648,673 - 82,751,394 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX82,649,601 - 82,751,394 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX68,727,019 - 68,829,988 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X84,298,609 - 84,401,821 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX84,299,418 - 84,401,821 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X81,778,827 - 81,877,294 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X83,469,984 - 83,573,170 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X83,301,901 - 83,400,620 (-)NCBIUU_Cfam_GSD_1.0
Gucy2f
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X81,905,232 - 82,004,580 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364995,653,384 - 5,752,732 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCY2F
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X89,557,952 - 89,653,491 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X105,222,491 - 105,268,453 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GUCY2F
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X97,234,564 - 97,349,105 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX97,239,846 - 97,348,853 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606522,440,973 - 22,541,598 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gucy2f
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248036,509,114 - 6,683,046 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248036,510,264 - 6,683,046 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gucy2f
353 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:29
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000046804
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system appendage
High
Medium
Low 3 1
Below cutoff 1 6 5 1 1 51 12 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046804   ⟹   ENSRNOP00000049500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX105,710,356 - 105,808,183 (-)Ensembl
Rnor_6.0 EnsemblX113,372,240 - 113,474,164 (-)Ensembl
RefSeq Acc Id: NM_053831   ⟹   NP_446283
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,507,183 - 110,605,017 (-)NCBI
mRatBN7.2X105,710,356 - 105,808,183 (-)NCBI
Rnor_6.0X113,372,240 - 113,474,164 (-)NCBI
Rnor_5.0X111,822,417 - 111,920,459 (-)NCBI
RGSC_v3.4X36,367,528 - 36,469,112 (+)RGD
CeleraX105,123,834 - 105,223,272 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446283 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA65511 (Get FASTA)   NCBI Sequence Viewer  
  EDL85212 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049500
  ENSRNOP00000049500.2
  ENSRNOP00055034969
  ENSRNOP00060026356
GenBank Protein P51842 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_446283   ⟸   NM_053831
- Peptide Label: precursor
- UniProtKB: P51842 (UniProtKB/Swiss-Prot),   A6KG67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000049500   ⟸   ENSRNOT00000046804
Protein Domains
Guanylate cyclase   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51842-F1-model_v2 AlphaFold P51842 1-1108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620439 AgrOrtholog
BioCyc Gene G2FUF-1520 BioCyc
Ensembl Genes ENSRNOG00000019086 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055024843 UniProtKB/Swiss-Prot
  ENSRNOG00060018767 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046804 ENTREZGENE
  ENSRNOT00000046804.3 UniProtKB/Swiss-Prot
  ENSRNOT00055042821 UniProtKB/Swiss-Prot
  ENSRNOT00060032345 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide cyclase UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB_dom_associated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116556 ENTREZGENE
PANTHER GUANYLYL CYCLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11920:SF349 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PhenoGen Gucy2f PhenoGen
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019086 RatGTEx
  ENSRNOG00055024843 RatGTEx
  ENSRNOG00060018767 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Nucleotide cyclase UniProtKB/TrEMBL
  Periplasmic binding protein-like I UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
  SSF53822 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A6KG67 ENTREZGENE, UniProtKB/TrEMBL
  GUC2F_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-26 Gucy2f  guanylate cyclase 2F  Gucy2f  guanylate cyclase 2f  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gucy2f  guanylate cyclase 2f    guanylate cyclase 2F, retinal  Name updated 1299863 APPROVED
2002-08-07 Gucy2f  guanylate cyclase 2F, retinal      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an extracellular domain, a single membrane-spanning domain, a protein kinase-like domain, and a cyclase catalytic domain 632891
gene_expression mRNA expressed only in the eye 632891
gene_process may be involved with photoreceptor signal transduction 632891
gene_product member of the guanylyl cyclase membrane receptor family 632891